Escherichia coli (E. coli) O157. The first vaccine designed to help protect the beef industry from E. coli O157.

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1 Escherichia coli (E. coli) O157 The first vaccine designed to help protect the beef industry from E. coli O157.

2 The first and only vaccine to reduce E. coli O157 at the source. Escherichia Coli Bacterial Extract vaccine* with SRP technology is the first and only vaccine conditionally licensed by the USDA to reduce the amount of E. coli O157 pathogens in the intestines of cattle. This advanced technology: Reduces the amount of the pathogen in cattle before they enter the slaughtering facility Decreases the amount of E. coli O157 shed in the feedlot, to minimize environmental contamination SRP technology: a novel approach to reducing E. coli O157 burdens Siderophore receptors and porins (SRP) are cell wall proteins that transport iron, an essential nutrient, into the bacterial cell. Innovative SRP vaccine technology activates the immune system to produce antibodies that target these key bacterial proteins. Antibodies bind to the siderophore receptors and porins, and help prevent iron from passing through the cell wall. Bacteria are deprived of iron and die.

3 Effective at reducing E. coli O157 in cattle. A recent field study was conducted in commercial feedlots to quantify the efficacy of the Escherichia Coli Bacterial Extract vaccine with SRP technology on reducing the burden of E. coli O157 in feedlot cattle. 3 Percent E. coli O157:H7 prevalence Reduction in E. coli O157:H7 concentration % reduction P=0.28 P=0.13 P< % reduction d0 d42 d98 Concentration on d98 Vaccinates Placebo Vaccinates Placebo Log 10 MPN/g Escherichia Coli Bacterial Extract vaccine with SRP technology reduced the number of cattle testing positive for the bacteria by 85 percent. Those animals still testing positive showed a 98 percent reduction in the concentration of E. coli O157. Preharvest intervention adds another barrier of protection Post-harvest interventions within processing plants, such as steam pasteurization and hot water washes, are designed to help prevent E. coli O157 from reaching the consumer. When the incoming pathogen burden overwhelms the in-plant interventions, the system can potentially fail. Preharvest intervention adds another barrier, to reduce the pathogen burden before it enters the processor, and decrease environmental contamination at the feedlot. Vaccination

4 Administer according to label for comprehensive protection. Administer one dose (2 ml) subcutaneously Booster in two to four weeks, then at least six weeks after the initial dose Do not vaccinate within 60 days of slaughter Together, we can reduce E. coli O157 from the source to the table. Controlling E. coli O157 is good business for everyone in the beef industry With the Escherichia Coli Bacterial Extract vaccine, you can reduce E. coli O157 before cattle reach beef processors, while minimizing environmental contamination at the feedlot Ensuring beef safety helps safeguard consumer confidence, and that makes for a healthier beef industry

5 E. coli O157 contamination has costly implications for all levels of the beef industry. Contamination of beef with Escherichia coli (E. coli) O157 continues to raise concern among consumers As a result of E. coli O157 infection, the Centers for Disease Control and Prevention (CDC) estimates that every year: 1 At least 63,153 Americans are infected Of those, 2,138 are hospitalized and about 20 die 63K Infected 2K Hospitalized While E. coli O157 doesn t make cattle sick, it can profoundly affect consumer confidence in beef $1.60 Billion $2.67 Billion From 1991 to 1999, beef recalls resulted in approximately $1.6 billion in lost demand 2 Between 1994 and 2004, E. coli O157 cost the beef industry an estimated $2.67 billion 2 Fecal shedding of the pathogen also has been linked to contamination of water sources, unpasteurized milk and produce 3

6 For more information about the Escherichia Coli Bacterial Extract vaccine with SRP technology, contact your veterinarian or animal health supplier, or call *This product license is conditional. Efficacy and potency test studies are in progress. LABEL INDICATIONS: For use in healthy cattle 5 months of age or older to reduce prevalence of the E. coli O157 carrier state, and for reduction in the amount of E. coli O157 shed in feces to minimize E. coli O157 exposure and infection of herdmates. 1 Scallan E, Hoekstra RM, Angulo FJ, Tauxe RV, Widdowson M-A, Roy SL, et al. Foodborne illness acquired in the United States major pathogens. Emerg Infect Dis Jan; [Epub ahead of print] 2 Facts for beef producers: A basic look at E. coli O157. National Cattlemen s Beef Association, Available at: Accessed October 15, Thomson DU, Loneragan GH, Thornton AB, Lechtenberg KF, Emery DA, Burkhardt DT, Nagaraja TG. Use of a siderophore receptor and porin proteins-based vaccine to control the burden of Escherichia coli O157:H7 in feedlot cattle. Foodborne Pathogens and Disease 2009;6: All brands are the property of their respective owners Pfizer Inc. All rights reserved. SRP10030.