Animal Breeding Programs to Support an Ever-Changing World

Transcription

1 Animal Breeding Programs to Support an Ever-Changing World Mitchell S. Abrahamsen. Ph.D. EVP; Chief Commercial and Scientific Officer

2 Key Messages to Remember More Data is Better DNA genotypes MORE DATA Phenotypes are king Genomic Selection WORKS!

3 Chicken are not Cattle!

4

5 How to feed the world?

6 More People Same Land Mass

7 Innovation We can t solve problems by using the same kind of thinking we used to create them. Insanity: doing the same thing over and over again and expecting different results.

8 A Digression Simple Easy Losing Weight Simple concept Hard to do Complex Hard Driving a Car Complex process Easy to do

9 Genetics Company- Responsibility Facilitate Food Security Meet Current and Future Needs Maintain Multiple Genetic Stocks assure genetic diversity Environmentally Friendly Preserve Resources Maintain Production Potential Economically Viable Input Requirements Desired Output Socially Acceptable Customer and Consumer

10 Number of Animals (In billions) Innovation: Feeding the World BROILER CHICKEN AVAILABILITY 56B with Innovation 6.6B 1961 Today With innovation = continued productivity trend

11 Genetics Has Delivered

12 Number of Animals (In billions) Less More Birds = Less Impact BROILER CHICKEN AVAILABILITY 131B without Innovation 74.6B without Innovation 99.1B with Innovation 32B less 56B with Innovation 6.6B 1961 Today 2050 Without innovation = no productivity increase With innovation = continued productivity trend YEAR

13 Selection Pressure Drives Genetic Progress > 2.0 million pedigree chicks/year 0.3% males ~ 3,000 3 % females ~ 30,000 Gold medal athlete! One in million? (not quite)

14 Production Pipeline A, B, C, D A, B, C, D A, B, C, D AxB, CxD ABCD

15 Growth Improvement 50 g YOY g g g g g

16 FCR Improvement pts YOY

17 Breast Meat Improvement 0.3% YOY % % % % %

18 US Broiler Livability/Field Condemnations (%)

19 Why is chicken consumption growing? - 5 years of genetic progress Improvement 1 Annual Value 1M broilers/week 2 Average Daily Gain (g) +260 g 52 g/year $6.3 Million Feed Conversion -14 points 2.8 pts/year $6.1 Million Eviscerated Yield % +2.95% 0.59% /year $7.6 Million Breast Meat % +2.66% 0.53%/year $4.4 Million Note1: Performance data source - US Industry metrics reporting service Note2: Value calculated with current US meat prices, $300/ton feed, and a balanced product mix

20 Genetic Progress How its done Pedigree Breeding Program: Each Chick is Identified with a Unique Wing Band

21 Find out which bird is the best Capture data for > 50 different physical traits - Doctor s office in a chicken house Cobb_Focus_Two_2014.pdf

22 Find out which bird is the best Capture data for > 50 different physical traits - Doctor s office in a chicken house Skeletal Integrity Blood Oxygen Live yield Cobb_Focus_Two_2014.pdf

23 Find out which bird is the best Capture data for > 50 different physical traits - Doctor s office in a chicken house Feed and Weigh Automated FCR Testing Feeding Behavior

24 Choices Balanced Selection Feed Conversion Growth Rate Meat Yield (Total and Breast) Leg Health Livability (Disease/mortality) Heart and Lung Health Egg Production and Hatch

25 Activists Scientists Sustainability in a Changing World Environmentalists Consumers

26 Competing Interests

27 Changing World good news: chicken FAO estimates 1.8% / yr global increase poultry meat by 2050 Currently, an estimated 450M broiler breeders globally 1.8% annual growth = nearly 855M breeders by 2050

28 Changing World good news

29 Changing World The Challenge

30 Changing World Socially Acceptable

31 Profitability Environment Tax

32 Feed Cost: The Game Has Changed Feed Cost Live Cost Feed Cost as a % of Live Cost 51.6% 66.6% 72%

33 ABF Consumer Movement

34 Information - Disinformation

35 Chicken are GENETICALLY MODIFIED with hormones, carcinogens, GMOs, corn pills, arsenic and drugs so they become LARGER FASTER and as a result they often CRIPPLE under their own weights - See more at: I have one question for the ones who believe that the use of hormones, chemicals, and GMOs in our food have nothing to do with all the chronic diseases we see every day in a friend, close family member or a neighbor. Our DNA hasn t changed for the last few decades but our environment has.

36 Changing World The Challenge

37 Changing World The Challenge

38 Changing World The Challenge

39 What are the trends? Feed costs are consistently increasing Alternative ingredients and fluctuating feed quality will be a challenge moving forward Antibiotics absent in the food production chain New and re-emerging disease challenges Efficient production = profitability and affordability Environmental impact being quantified/taxed Consumer expectations developing/developing markets

40 Sustainability: Driven by Innovation

41 We need to think differently! After all, electricity and the light bulb were not invented by incremental improvements to the candle

42 Genomics = Digitizing Biology -Evaluate DNA sequences drop of blood/hair/tissue/saliva -Relationship between individual animals (chromosomes) based on DNA profiles -DNA information provides more accurate breeding values than estimated family relationships -Provides new opportunities to link phenotypes with genotypes

43 DNA technology (genomics) How does it work? Associate characteristics/traits/performance (phenotypes) with specific DNA sequences (genotypes) Learning! Predict Characteristics (phenotypes) based on DNA Sequence Blue eyes (99%) GCATTAA G TGTCAAGTT GCATTAA G TGTCAAGTT Brown eyes (80%) GCATTAA A TGTCAAGTT GCATTAA A TGTCAAGTT

44 Visualization of thousands of data points

45 Hybridization Pure Lines A B C D X X X X Grand Parents X X Parent Stock X Commercial Product 45

46 Amount Spend money get A LOT of data Data Genomic/infrastructure Investments Time

47 Is More Always Better?

48 Amount Lots of Data - Show me the money! Data Information Genomic/infrast ructure Investments Programming Solutions People/models Knowledge Business Processes Utility Time

49 Genomic Opportunities (species/business specific) Genetic improvement/gain Improved accuracy Increased selection intensity Decreased generation interval Identification of variation Broilers Extremely high selection intensity Traditional Broiler traits are immediately available (generation maximized; rolling breeding population) Accuracy*** (20% improvement select different breeders base on EBV reranking New Traits (variation)***

50 Watching Chromosomes - generations Breeding Values BLUp calculated relationships Full sibs 50% Half Sibs 25% Genomics (SNPs) allow for measuring true relationships Chromosome by Chromosome Parts of Chromosomes Unbiased

51 Estimating vs. True relationships

52 Conclusions (DNA is Data = Better) Genomics/DNA select breeders more accurately Make faster genetic progress Provides opportunity to incorporate new characteristics/measurements into breeding program Selecting for superior performance in antibiotic free environments Selecting for superior performance in commercial environments as a crossbred DNA information links pedigree program to off farm data Select for new traits do things we ve never done before

53 Selection for New Traits Focus on Intestinal Health Relationships between gut health and FCR Changing nutritional programs and nutrient absorption Microbial Genomics selection environments Targeted challenge models Necrotic enteritis Salmonella Coccidiosis Improved performance in suboptimal conditions Tolerance vs Resistance Innate immune function (Off-Farm data) (Off-Farm data)

54 Breeding for a Changing World

55 Next Generation Solutions

56 Next Generation Breeding Technologies To date, all genetic progress is the result of traditional animal breeding programs Mate best animals together Select the best progeny based on data available Repeat Most improvement have been focused on collecting better data and improved analysis (mathematical modeling)

57 Next Generation Breeding Technologies New Animals Breeding Technologies (NABTs) Precision Breeding Directing specific changes in the genome that reflect naturally-occurring variation already identified e.g. Polled (hornless). Common in beef breeds, rare or missing in elite milk breeds

58 Gene Editing

59 Recombinetics R&D Innovations Drive Commercial Breakthroughs Across Three Business Lines Biomedical Research for Human Health Regenerative Medicine to Save Lives Healthy, Safe and Abundant Food Surrogen produces custom-tailored swine models simulate the onset and progression of human disease, enabling effective basic, preclinical, and translational research accelerating the conversion of science to medical solutions. Regenevida is developing pigs as production systems for cultivating patient blood cells, hepatocytes, tissues, and ultimately organs for human therapeutic applications. Nearterm revenues in biomedical testing and disease modeling are leading to long-term market opportunities in lifesaving cell, tissue, and organ transplants. Acceligen uses accelerated, precision breeding to benefit producers, consumers, animals, and the environment. These native traits provide natural livestock disease resistance, improve food productivity, and enhance animal welfare in beef, dairy, pork, and poultry production. The current addressable market is in excess of $3 billion and is predicted to grow at 10% per annum over the next 10 years. Surrogen is currently generating commercial and collaborative revenues. The addressable market size is in excess of $1 trillion dollars globally. Regenevida is currently generating collaborative revenues and has been awarded pioneering competitive research grants. The current addressable market for animal protein alone is in excess of $1 trillion. Acceligen is actively generating collaborative revenues, with commercial contracts currently in negotiation for the development and deployment of founder genetics globally.

60 Acceligen: Healthy, Productive Animals & Safer, More Abundant Food RCI s subsidiary, Acceligen, utilizes proprietary, pioneering methods for precision breeding in beef, dairy, swine, poultry and aquaculture production to: improve animal healty enhance animal welfare Provide for expression of new traits Beef & Dairy Naturally Hornless (Polled) Heat Tolerant (SLICK) BRD (Respiratory Disease) FMDv (Food and Mouth Disease) Meat yield (Double Muscle) Swine PRRSv Disease Resistance Swine Fever Resistance Genetic Castration Tail Docking Poultry Avian Flu Resistance Sex Selection Meat Quality Growth rate Aquaculture Disease Resistance Production Efficiency Meat Characteristics Domestication / evolution

61 RCI/Acceligen s Advanced Breeding Benefits Animal Welfare Natural disease resistance Humane production Precise gender selection Animal comfort Productivity Reduced Mortality Precise breeding outcomes Increased yield & efficiency Higher value animals Sustainability More efficient feed conversion Climate adaptation Genetic diversity GHG / Waste Reduction Consumer & Market Drivers Drug and antibiotic free Sustainably Raised Better product health profile Better appearance

62 Realized Genetically Engineered Success

63 Key Messages to Remember More Data is Better DNA genotypes MORE DATA Phenotypes are king Genomic Selection WORKS! Gene editing providing new opportunities

64 Chicken are not Cattle!

65 A Digression Simple Easy Losing Weight Simple concept Hard to do Complex Hard Driving a Car Complex process Easy to do

66 New World The easy stuff is done It s suppose to be hard. If it wasn t hard, everyone would do it. Jimmy Dugan A League of Their Own

67 Thanks

68 GMO vs. Gene Editing Transgenic