Business Unit Health & Nutrition

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1 Business Unit Health & Nutrition

2 4/11/2010 Präsentation H & N Page 2 Health & Nutritio BU Health & Nutrition Health & Nutrition Beste Business Line Biotechnology (BP) Methionine (MT) Exklusiv Synthesis & Amino Acids Catalysts CyPlus Pfefferle Pack Ritzert Eul Harenburg Operation Marketing BP + MT Sales BP + MT Controlling Innovationmanagement HR- Management ESHQ Coordination Kaufmann Jegers N.N. D. Schaufler Bach Lambert / Liese

3 4/11/2010 Präsentation H & N Page 3 Health & Nutritio Health & Nutrition Profile Key figures 2008 Turnover: 1,585 Mio. Employees: 3,580

4 Business is performed in Business Lines 4/11/2010 Präsentation H & N Page 4 Health & Nutritio Methionine Bio Products Exclusive Synthesis & Amino Acids Catalysts CyPlus

5 4/11/2010 Präsentation H & N Page 5 Health & Nutritio Our Business Models (I) Product business Broad customer base with preferred supplier status at key customers Standard product Worldwide sales organisation Project business One to one customer / supplier relationship with selected key customers Customer specific product Dedicated key account management Technical sales and marketing organization Process know how (IP) is solely suppliers property Professional project management Process know how might be to a major extent customers property. Guaranteed IP protection is a key issue

6 4/11/2010 Präsentation H & N Page 6 Health & Nutritio Our Business Models (II) Product business Short-term contracts (3 months) to spot business All process / product development solely in the responsibility of the supplier Feed Amino Acids (Methionine, Lysine, Threonine, Tryptophan) Pharma Amino Acids (Rexim) Magnesium Ethanolat, Raney Nickel Project business Individual mid- to long-term contracts (3 5 years) Risk (and benefits) sharing inbetween customer and supplier Exclusive Synthesis custom manufacturing for products such as active pharmaceutical ingredients Catalysts such as D 3000 for Monsanto, Titansilikalit for Propylenoxide,

7 Catalysts Business Line

8 4/11/2010 Präsentation H & N Page 8 Health & Nutritio Catalysts' Vision and Mission Our Mission Together we bring catalyst ideas to life, creating value by our passion and focus. Our Vision To be globally recognised as the preferred partner for major catalyst users, and to develop and attract talented people for our international team.

9 How Does a Catalyst Work? 4/11/2010 Präsentation H & N Page 9 Health & Nutritio

10 Catalysts is Globally Present, close to Markets and Customers 4/11/2010 Präsentation H & N Page 10 Health & Nutritio

11 4/11/2010 Präsentation H & N Page 11 Health & Nutritio The Markets We serve in Catalysts Markets Life Sciences & Fine Chemicals Industrial Chemicals Polymers Markets Segments Pharmaceuticals Agrochemicals Monomers Solvents Polypropylene Polyethylene Food Plasticizers TDA Dyestuffs Intermediates Processes Slurry / Batch Processes Continuous Processes Continuous Processes

12 The Business Models We Build our Business on in Catalysts 4/11/2010 Präsentation H & N Page 12 Health & Nutritio Model Product business Project business Products 1. Activated Base Metal Catalysts 2. Continuous Process Catalysts 3. Deloxan Metal Scavengers 4. Homogeneous Catalysts 5. Olefin Polymerisation Catalysts 6. Precious Metal Powder Catalysts 1. Toll manufacturing 2. Custom Manufacturing 3. Custom Design 4. Joint Development Services 1. Precious and Base Metal Management 2. Refining Services Management 1. High Throughput Preparation and Screening Services 2. ReacToCat Reaction Engineering Services

13 Our Project Business 4/11/2010 Präsentation H & N Page 13 Health & Nutritio

14 Exclusive Synthesis & Amino Acids Business Line

15 Strategic direction for Exclusive Synthesis & Amino Acids business 4/11/2010 Präsentation H & N Page 15 Health & Nutritio BL EA will become the market leader in chemical custom manufacturing until We create value for our customers by a more efficient utilization of manufacturing assets and improving processes beyond what our customers can do themselves.

16 BL-EA applies two different business models 4/11/2010 Präsentation H & N Page 16 Health & Nutritio EX Business is based on customer specific solutions 1:1 Customer specific Solutions Products Technologies EX Rexim s business is based on Amino Acids as a Product business Technologies Products 1:1 Customer specific Solutions

17 Critical success factors for the custom manufacturing business 4/11/2010 Präsentation H & N Page 17 Health & Nutritio Competitive asset mix: horizontal integration Portfolio management / Focus on project business Long-term partnership with customers Risk sharing with customers Efficient global project management / technical marketing Intelligent management of multipurpose plants

18 Exclusive Synthesis Sales Split % of the EX portfolio is based on Pharma 4/11/2010 Präsentation H & N Page 18 Health & Nutritio EX sales split by industry, 2007 as % of sales non-life science; 27% APIs; 39% Agro; 9% Standard Intermediates; 5% Advanced Intermediates; 21% Pharma 65%

19 4/11/2010 Präsentation H & N Page 19 Health & Nutritio Evonik Rexim s Strategic Focus Evonik Rexim s core business is the production and sales of pharmaceutical (cgmp controlled) amino acids and amino acid derivatives. Evonik Rexim shall be a key supplier for customers using high quality grades of amino acids and amino acid derivatives worldwide. The REXIM TM amino acid trademark represents to the global market perfect regulatory compliance, highest quality, reliability and competitiveness.

20 Evonik Rexim: Pharmaceutical Amino Acids are the Core Business 4/11/2010 Präsentation H & N Page 20 Health & Nutritio In over 50 years REXIM developed world-class technology to separate complex mixtures and to purify amino acids to the highest standards available to be used as Active Pharmaceutical Ingredients in oral or intravenous applications, for special nutrition and cosmetics markets. Rexim TM Amino Acids & Amino Acid Derivatives for pharma (infusions, medication), special human nutrition (hospitals, baby food), sports nutrition and cosmetics

21 4/11/2010 Präsentation H & N Page 21 Health & Nutritio Evonik Rexim Markets Amino Acids, & Derivatives

22 4/11/2010 Präsentation H & N Page 22 Health & Nutritio Evonik Rexim Production Sites The product line Rexim has two sites: Nanning, China Ham, France

23 4/11/2010 Präsentation H & N Page 23 Health & Nutritio Evonik Rexim Production Network Evonik Rexim Ham / France Purification of crude AA from biotransformation and fermentation L- and D-Amino Acids, Di- Peptides, AA Derivatives Alpha Ketoacids Chemical Synthesis (LP, tleu,...) Exclusive Synthesis (EA-EX) in Hanau-Wolfgang / Germany Organic Synthesis HN Bioproducts in Slovenska Lupca / Slowakia Fermentation Evonik Rexim Nanning / China Biotransformation, Refining C-Amino Acids Enzymatic Resolution

24 Feed Additives Business

25 Growth drivers in amino acid markets 4/11/2010 Präsentation H & N Page 25 Health & Nutritio Population growth Available income for food Preference for meat Meat + Egg consumption Feed volume (tons) Nutrition concepts Available Feedstuffs Consolidation & industrialization of feed and animal production Feed Formulation x Supplementation rate (kg/ton) = Amino acid demand

26 4/11/2010 Präsentation H & N Page 26 Health & Nutritio Products Amino acids Well-balanced nutrition Improved economic returns Reduced animal waste Public acceptance of our products and technologies is essential for us.

27 The complete Feed Amino Acid portfolio offers substantial synergies and competitive advantages 4/11/2010 Präsentation H & N Page 27 Health & Nutritio Source of synergy across amino acid portfolio Product Customer selection Application know-how Service tools Production technology R&D competence Methionine Chemical synthesis Chemical processes Lysine 100 % overlap 100 % overlap 100 % overlap Threonine Biotechnology Fermentation Tryptophan

28 The Building Blocks of Life Amino Acids 4/11/2010 Präsentation H & N Page 28 Health & Nutritio Amino acids are natural All protein is made from amino acids Amino acids are essential nutrients for humans and animals Amino acids in animal nutrition Healthy and sustainable nutrition of animals - Environmental aspects - Ecological aspects - Economics - Consumer protection Every organism comprises: Protein 17% Carbohydrate 1% Fat 17% Water 60% Minerals 5% (Source: VCI, e.g. Humans) Protein chain Lys Thr Ser Ala Met

29 Use of Amino Acids in animal nutrition save natural proteins... 4/11/2010 Präsentation H & N Page 29 Health & Nutritio Supplementing DLM Phe Arg Val Ile Phe Arg Val Ile More soybean or fish meal Phe Arg Val Ile Thr Met Lys Trp Thr Met Lys Trp Thr Met Lys Trp

30 ... and are sustainable Independent Life Cycle Analysis shows: Specific energy consumption is much lower for supplemental methionine (%) Oil mill Transportation Agriculture Chemical production Met from Proteine (Soybean) DL-Methionine Source: ifeu Institute, Heidelberg 4/11/2010 Präsentation H & N Page 30 Health & Nutritio

31 4/11/2010 Präsentation H & N Page 31 Health & Nutritio and deliver a ecological benefit Use of 100,000 t DL-Methionine means Consumption of resources -1,000,000 t Savings in crude oil equivalents NO 3 emissions -790,000 t Reduced nitrates into ground waters NH 3 emissions -800,000 t Reduced ammonia into the air

32 All feed amino acid markets show robust volume growth 4/11/2010 Präsentation H & N Page 32 Health & Nutritio Volume Lysine Methionine Threonine

33 A dedicated global network being in place to implement the Amino Acid solutions concept 4/11/2010 Präsentation H & N Page 33 Health & Nutritio HN- HQ, Hanau-Wolfgang HN- NA, Atlanta HN- LA, Hanau-Wolfgang HN- EMEA, Hanau-Wolfgang HN- Asia North, Bejing HN- Asia South, Singapore Headquarter Hanau Regional Headquarter Regional Office

34 4/11/2010 Präsentation H & N Page 34 Health & Nutritio Feed additives are a Global Business Sales split 2008 ASPAC 42% Latin America 14% Nafta 17% EMEA 27% Customers in more than 115 countries Highest growth in Asia, Latin America and Eastern Europe

35 4/11/2010 Präsentation H & N Page 35 Health & Nutritio Production Sites Worldwide Antwerp Slovenska Lupca Blair Wesseling Kaba Mobile DL-Methionine: Wesseling (D), Antwerp (B), Mobile (USA) 350 kt Biolys : Blair (USA) 90 kt L-Threonine: Slovenska Lupca (SK), Kaba (HUN) 40 kt L-Tryptophan: Slovenska Lupca (SK) 0,7 kt

36 DL-Methionine produces in large scale chemical synthesis plants... 4/11/2010 Präsentation H & N Page 36 Health & Nutritio

37 in 4 plants at 3 sites... Wesseling Antwerp Methionine Acrolein Methylmercaptane HCN Global export Methionine Acrolein Methylmercaptane HCN Europe (+MMP to ANT) Mobile Methionine Acrolein HCN Nafta + Latin America 4/11/2010 Präsentation H & N Page 37 Health & Nutritio

38 Bio products produces by fermentation 4/11/2010 Präsentation H & N Page 38 Health & Nutritio Why fermentation and not chemical synthesis? L-Lysine: L-Threonine: L-Tryptophan: Building blocks of proteins are only L-Amino Acids (in vivo D, L-Methionine can be transferred to L-Methionine) These amino acids can not be produced economically by chemical synthesis (compared to microbical fermentation).

39 ...and uses microorganisms as cellfactories 4/11/2010 Präsentation H & N Page 39 Health & Nutritio + Auxiliary Chemicals Carbon Source Microorganisms as Chemical Reactors Products

40 4/11/2010 Präsentation H & N Page 40 Health & Nutritio Service for the Feed Industry FA services Customer process FA services Animal Nutrition Consulting: Amino acid recommendations Feed formulation Consulting Ingredient prices Availability restrictions Feed formulation (Linear programming) Current formulation Analytical Services: Amino acids in feedstuffs Handling Solutions: Amino acid handling & direct dosing Analytical Services: Total aa content: actual vs. target Grinding / Mixing / Supplementing Complete feed Quality control Analytical Services: Mixer profiles (suppl. AA)

41 Analytical Service for the Feed Industry 4/11/2010 Präsentation H & N Page 41 Health & Nutritio

42 Feed Additives Products & Services for the Future Products Certified production processes Environmentally friendly production Large investments into new plants Innovative processes through R&D Services Focus on customer needs Specialists in amino acids Integrated service packages TSM team close to the markets Integrated service package: Add value to our customer business - Cut production cost - Promote bottom line 04/11/2010 Präsentation H & N Page 42 Health & Nutrition

43 4/11/2010 Präsentation H & N Page 43 Health & Nutritio