BASF Plant Science crop productivity from an industry perspective How to translate basic findings to improve crop productivity? BASF Plant Science

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1 1 crop productivity from an industry perspective How to translate basic findings to improve crop productivity? EPSO Workshop Ghent, September 7-8th 2009 Dr. Jürgen Logemann VP

2 Productivity needs to double until 2030 Global Trends Impact for Agriculture 2 Population growth Population [billion] Rising standards of living Caloric intake of animal proteins [kcal] France Germany US Increasing energy demand World oil demand [billion barrel] ,300 2,200 1,800 Brazil China India Total agricultural area per head [m²] GNI/capita [1,000 USD] 2005

3 Significant plant biotechnology market 3 Million hectares Average yearly growth rate 24% million hectares worldwide (= cultivated area in EU 27) 13 million farmers in 25 countries Crops: corn, soybeans, cotton, canola 68% of soybean, 24% of corn is genetically modified Traits: herbicide tolerance and insect resistance Source: ISAAA-Report 2008 Still enormous growth rates

4 Research and development focus 4 Superior agricultural productivity Higher yield Drought tolerance Tolerance against pests and diseases Better and healthier nutrition/ feed Optimized corn for animal feed Healthier fatty acids Plants as renewable raw materials Tailor-made starch Higher oil content BPS: The Trait Technology Partner

5 Plant biotech at 5 Ames Iowa DNA LandMarks RTP North Carolina CropDesign Plant Science Sweden metanomics Limburgerhof SunGene Facts & Figures Verbund of innovative technologies 8 sites in 5 countries founded in 1998 Global R&D network > 700 employees in R&D R&D cooperations worldwide Budget of 400 million ( ) R&D site Major cooperation partners

6 Gene discovery: From model to crop 6 past today future quality, speed, throughput, predictability, chance of success

7 The yield gene pipeline at BPS 7 Gene origin Screening Lead genes Yield crops 100,000 rice plants /y Yield genes Corn Soybean Canola Cotton Rice Wheat Patents chromatograms /y > Genes > Genes > 100 Genes BPS is worldwide leading provider of yield genes

8 Crop Design: Broad pipeline of lead genes for generating the best traits 8 Higher seed yield Larger seeds Larger panicles +50% +30% +30% control BASF control BASF control BASF Increased biomass Increased root biomass +40% +20% +20% control BASF control BASF

9 Metanomics: Discovery, testing, patenting requires sophisticated bioinformatics 9 Samples Metabolite profiling Metabolite validation Metabolome analysis & interpretation MetaMap 110,000 samples p.a. are analyzed by 70 mass spectrometers and robots round the clock the largest platform globally Innovative IT systems ensure the correct identification of all analytical results 320,000 data per day Powerful bioinformatics systems link genes and other factors to metabolite networks. Fully integrated databases drive identification of function

10 The BASF approach to gene discovery Unique technology platform 10 Yield increase in crops Look at plant Look inside CropDesign Plant cell Unique platform to identify and understand the gene functions of plants Combines phenotypic screening with metabolic profiling determining gene function High throughput of 5,000-10,000 genes tested per year

11 BASF Monsanto collaboration Drought-tolerant corn 11 Corn Target : 6-10% yield improvement in water-stress environments Pre-launch phase (IV) First regulatory submissions completed Other cooperation crops: Soybean, Cotton, Canola control optimized Market launch:2012 onward

12 BASF CTC collaboration Higher-yielding and stress-tolerant sugar cane Target: 25% more yield compared to today Traits: improved yieldand drought tolerance Joint development of BASF and Centro de Tecnologia Canavieira (CTC) in Brazil BASF provides genes and regulatory support; CTC provides varieties, transformation and development Value shared between farmers, CTC, and BASF Advantages: Significant higher yield Drought tolerance secures yields Centro de Tecnologia Canavieira (CTC): BPS: The Trait Technology Partner The leading Brazilian sugar cane breeder; CTC varieties cover around 45 % of the Brazilian sugarcane market CTC is owned by sugar mills (164) and farmers (12.000) 12

13 Yield stability also contributes to agricultural efficiency 13 control improved Late blight is a serious potato disease Wild potato resistant against this fungus Resistance genes introduced into commercially grown potato varieties Field trials started in genes can protect potato plants against Phytophthora

14 Strong development pipeline Total market value > $2.5 billion 14 Discovery Identifying genes & POC* up to 6 years Stage I Look for POC II* up to 4 years Stage II Early product development up to 3 years Stage III Advanced product development up to 2 years Stage IV Pre-Launch up to 3 years Market Value Superior agricultural productivity Better and healthier nutrition / feed Yield & stress (corn, soybean, cotton, canola) Herbicide tolerance Fungal resistance Improved amino acid Healthier fatty acids (Omega-3&6) > $2 Bn. < $100 Mio. < $100 Mio. $300 $500 Mio. Plants as renewable raw materials Amylopectin High oil $100 $200 Mio.

15 15 The future is in the genes! Plant Biotechnology at BASF