Synthetic biology and the new bio-industrial revolution. Science Programme by:

Transcription

1 Synthetic biology and the new bio-industrial revolution Science Programme by:

2 19 th Century Industrial Revolution 21 st Century Bio-Industrial Revolution Synthetic Biology

3 A UK/European Synthetic Biology Research Centre for fine and speciality chemicals production. Developing an innovative suite of integrated technologies for the synthesis of fine and speciality chemicals founded upon the 300M UK public sector investment in SynBio. application of predictive methods in SynBio. Synthetic Biology Research Centres (SBRCs) DNA synthesis facilities Centres of Doctoral Training National Innovation and Knowledge Centre Manchester Institute of Biotechnology Discovery through innovation

4 Consortium 10 universities (Bergen, Bristol, Darmstadt, Delft, Freiburg, KIT; Ljubljana, Padova, Paris, Southern Denmark) Non-university partners: Austrian Academy of Sciences (technology assessment experts); Rathenau Instituut; Biofaction KG; Woodrow Wilson International Center for Scholars; Zebralog GmbH & Co. KG; LIS Consult; Finnish Bioart Society; The European Network of Science Centres and Museums (ECSITE); GeneArt (now US-owned); European Union of Science Journalists Associations; What Next Forum; Theater Freiburg; Gene Rowe Evaluations; ETC Group 8 science centres or science museums (ECSITE members) Close cooperation with igem Foundation and igem Community

5 Goals ( ) Open dialogue between stakeholders concerning SynBio s potential benefits and risks to explore possibilities for its collaborative shaping on the basis of public participation. An MMLAP (Mobilisation and Mutual Learning Action Plan) involving stakeholders from science, industry, civil society, policy, education, art and other areas. Involving citizens and specific publics well-established or innovative means of engagement, supporting convergence of stakeholders and perspectives. The iterative mutual learning process will be open to change in order to accommodate the dynamics of an emergent field. Significant impacts such as raising public awareness of SynBio, fostering public discourse, and yielding benefits for involved stakeholders and European policy making in an international context.

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7 First Session Speakers: Martin Warren: University of Kent George Chen: CAS Laboratory, Beijing, University of Manchester Rainer Breitling: University of Manchester, SYNBIOCHEM Lionel Clarke: UK Synthetic Biology Leadership Council Sarah O Conner: John Innes Institute/Open Plant SBRC Facilitators: Ros Le Feuvre and Philip Shapira (University of Manchester)

8 Synthetic biology and the new bio-industrial revolution Prof Martin J. Warren University of Kent 25 th July 2016

9 My areas of interest; 1.Biosynthesis of modified tetrapyrroles 2.Compartmentalisation

10 Potential commercial applications of research: 1. Enhanced nutritional sources Co

11 Potential commercial applications of research: Enhance B 12 production in bacteria; Improve B 12 uptake in microalgae Engineer B 12 production into higher plants B 12 -deficiency is a worldwide problem

12 Potential commercial applications of research: 2. Enhanced metabolism for commodity and fine chemicals

13 Potential commercial applications of research: 2. Enhanced metabolism for commodity and fine chemicals through the use of scaffolds within the cell

14 Potential commercial applications of research: 3. Membrane vesicles vaccines and more E. coli E. coli internal membrane E. coli internal vesicles E. coli external vesicles

15 Missing technologies, capabilities or hurdles: Need to understand the science Methanogenesis conversion of CO 2 to methane gas (CH 4 )

16 SynBio delivery to the new bio-industrial revolution: 1. Sustainable, greener production technology 2. Should not overhype or overpromise 3. Bioprocessing 4. Green chemistry 5. Still needs to harness key bioenergy processes, eg photosynthesis or methanogenesis

17 Hurdles to commercial exploitation: 1. Sustained investment ten year programmes 2. Trust 3. Clear benefit (in terms of cost or quality)

18 Acknowledgements: Lab members - old and newpost-docs: Evelyne Deery, Steffi Frank, Andrew Lawrence, Simon Moore, Susie Schroeder, David Palmer, Mingzhi LiangPost-grads: Emi Nemato-Smith, Joe Baker, Rokas Joudeikis, Matthias Meyer, Matt Lee.Academics at Kent: Dan Mulvihill, Wei-Feng XueAcademics elsewhere: Mike Prentice (Cork), Richard Pickersgill (QMUL), Dek Woolfson (Bristol).

19 Synthetic biology and the new bio-industrial revolution Break-out session by:

20 Outline break out session: Introduction - Table arrangement (5 min) - Table task division (2 min) - Golden rules (3 min) Table discussions - Table introduction round (5 min) - Dialogue 1 (15 min) - Dialogue 2 (15 min) Plenary wrap-up (15 min)

21 Table arrangement (5 min) There are two tables for each synbio speaker. Sit down randomly, or at the table of your speaker of choice.

22 Table task division (2 min) 1 table facilitator, 1 note maker: BIGGER is BETTER.

23 Golden rules: Everyone is expert. Talking beyond facts is ok. Appreciation and respect for one another. Quantity versus quality. Postpone judgment. Act as a team. Cheat the rules.

24 Table introduction (10 min) Name, Organization, Job title, Super-power of today. (Not about synbio yet)

25 Dialogue 1 (15 min) Balance, equality Progress, growth, more is better Choose a synbio application domain (as a group): Medical / health Agricultural / environmental Chemical / bio-industry Other, e.g. computational storage. Pick one value card (individually) that you associate most to. Control & predict life Minimize risks Technology determines actions of humans Humans and technology fuse into one world Wild card 1 (your value of choice) Embrace complexity of life Accept risks Humans dominate over technology Humans and technology are separate worlds Wild card 2 (your value of choice) Use it the card to discuss your view of the chosen synbio application domain. Wrap-up the views, based on the note-maker s minutes (flip-over).

26 Dialogue 2 (15 min) Discuss (a selection of) the questions written on the A4 sheet. Make/draw notes on the flip-over sheet!

27 Special thanks go to Martin Warren George Chen Rainer Breitling Lionel Clarke Rosalind Le Feuvre Christopher Coenen Stefano Cabu Philip Shapira

28 Synthetic biology and the new bio-industrial revolution Science Programme by: