INNOVATIVE AND NATURAL ACTIVE MOLECULES FOR HEALTH, NUTRITION AND COSMETICS

Transcription

1 INNOVATIVE AND NATURAL ACTIVE MOLECULES FOR HEALTH, NUTRITION AND COSMETICS ANTIFUNGALS COLORING AGENTS ANTIOXIDANTS NUTRITIONAL ADDITIVES ANTIOXIDANTS BIOACTIVE COMPOUNDS PIGMENTS ANTIBIOTICS 1

2 DEINOVE HARNESSES BIOLOGICAL DIVERSITY TO DEVELOP INNOVATIVE COMPOUNDS FOR SUCCESSFULL APPLICATIONS IN THE HEALTH, NUTRITION AND COSMETICS INDUSTRIES 6,000 proprietary strains 1 cutting-edge technological platform 160 patent applications 50 highly-skilled staff 1,500 m 2 of laboratories 2 development paths Partnerships Self-sustained 3 industrial partners 2

3 A COLLECTION OF 6,000 STRAINS DEINOCOCCUS AND OTHER RARE AND EXTREMOPHILE BACTERIA 4 years of harvesting in numerous hostile environments: beaches, glaciers, hot springs, volcanoes, lagoons 1,200 collection points A patented selection method using UV radiation 6,000 strains available DEINOVE is the sole company leveraging this extraordinary ability displayed by hyper resistant micro-organisms. The Company screens for and recovers compounds that enable the body to better withstand external aggressions. 3

4 A COLLECTION OF 6,000 STRAINS A UNIQUE AND HIGHLY DIVERSIFIED SOURCE OF NOVEL COMPOUNDS Wild-type strains producing novel compounds for a wide range of applications Health Antibiotics Pigments Antioxidants Antifungals Anti-aging Moisturizers Oligosaccharides Proteins Lipids Enzymes Cosmetics Food Feed 4

5 ENGINEERING BIOLOGY NATURE AND TECHNOLOGY WORKING AS ONE COLLECTION AND PRODUCTION OF EXTRACTS CUTTING EDGE ANALYTICAL PLATFORM MOLECULES OF INTEREST 6,000 Deinococccus strains and other rare bacteria Culture, selection and production of extracts Sequencing Determine the structure of compounds produced (antibiotics, carotenoids) Analyze the strain metabolism for optimization purpose SCREENING In vitro and In cellulo Test the strains Identify interesting features, production of compounds of interest AUTOMATED GENETIC ENGINEERING Optimize the strain for end use: yield, biodisponibility FERMENTATION EXTRACTION, PURIFICATION Test and optimize the production process in increasing volumes Produce extracts for testing (efficacy, pharmacological properties ) 5

6 AN AUTOMATED GENETIC ENGINEERING PLATFORM BUILT ON AN UNCOMMON MICROORGANISM AND EXPANDED ON OTHERS Strong link with bioinformatics tools and data A continuously enriched DNA database High-throughput handling of strain constructions Highly standardized Design/Build/Test&Learn pipeline 6

7 A CONSISTENT FERMENTATION TECHNOLOGY PLATFORM FOR PROCESS DEVELOPMENT AND OPTIMIZATION 34 fully instrumented bioreactors From 1 to 20 liters Connected with mass spectrometry Batch Fed-batch - Continuous 7

8 UN LABORATOIRE DE CULTURE CELLULAIRE QUI VALIDE LE POUVOIR DES MOLÉCULES In vitro Spectrophotomètre Incucyte Cicatrisation Cytolyse Extraits bactériens Imagerie en temps réel In cellulo CellInsight CX7 Screening multidimensions 8

9 SOLUTIONS FOR COSMETICS A CATALOG OF COSMETIC ACTIVE EXTRACTS Antioxidant Anti-aging UV protection Healing Anti-aging Damaged skin Lipid storage Moisturizing effet Plumping effect Dozen of DEINOVE s strains with confirmed properties Anti-inflammatory Sensitive/irritated skin Post-operative skin care Lipolysis Slimming Anti-cellulite A partnership with to co-develop and market new active ingredients for skin care 9

10 FOCUS ON CAROTENOIDS FOR FOOD, FEED AND COSMETICS HIGH-VALUE SPECIALTY COMPOUNDS Aim Offer a competitive bio-based alternative Natural carotenoids Supply stability and consistent high quality Conservation of natural resources Cost-effective process Business model: Royalty-based license agreement / Direct sales of compounds (toll-manufacturing) Jan Feb Oct Step I Step II Step III Feb Step IV Q Develop the metabolic pathway: 5 molecules produced at lab-scale Target selection Optimize strains (yield, stability) and fermentation conditions Evaluate the functional properties of compounds Regulatory process Design the extraction and purification process Product formulation Scale-up Goal: 1 st batches marketed in

11 CAROTENOIDS A TWO-PRONG STRATEGY Engineering Extraction Metabolic engineering in order to improve production parameters (yield, productivity ), hence achieving industrial efficiency PERFORMANCE COST-EFFICIENCY Screening among the biodiversity of the microorganism bank in order to find innovative compounds for targeted applications INNOVATION NATURALITY 11

12 CAROTENOIDS KEY ADVANTAGES FOR DEINOCOCCUS 400 strains naturally producing carotenoids among the Deinove library Pathway for carotenoid biosynthesis is already present and active: optimizing the metabolic performances is easier and more cost-efficient High-level production can be obtained by metabolic engineering Fast growing (growth rate= 0,6 h -1 ) High cell density (50-60 g/l) Production from diverse feedstocks (C6 sugars, C5 sugars, polymeric sugars like starch) A story to be told (3.4 billion-year-old bacterium, anti-aging properties ) 12

13 CONTACTS Emmanuel PETIOT CEO Tel.: emmanuel.petiot@deinove.com Montpellier, FRANCE CAP SIGMA ZAC Euromédecine II 1682 rue de la Valsière GRABELS 13