FUNDING OPPORTUNITIES FAIRE: NATIONAL INSTITUTES OF HEALTH

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1 FUNDING OPPORTUNITIES FAIRE: NATIONAL INSTITUTES OF HEALTH ERC Biennial Meeting Theme: Preparing Tomorrow s Leaders October 28, 2014 Grace C.Y. Peng, Ph.D.

2 The NIH Mission NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life and reduce illness and disability. An agency of the Department of Health and Human Services, the NIH is the Federal focal point for health research.

3 Non-Hypothesis Driven Research There are two kinds of scientific revolutions, those driven by new tools and those driven by new concepts The effect of a concept-driven revolution is to explain old things in new ways. The effect of a tooldriven revolution is to discover new things that have to be explained. -Freeman Dyson, 1997

4 Francis Elias Collins, Zerhouni, M.D., M.D. Ph.D. Director, NIH National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Alternative Medicine Fogarty International Center National Center for for Advancing Research Translational Resources Sciences National Library of Medicine National Center on Minority Health and Health Disparities Clinical Center Center for Information Technology Center for Scientific Review

5 The NIBIB Vision To profoundly change health care by pushing the frontiers of technology to make the possible a reality.

6 Biomaterials Biomedical Informatics NIBIB Program Areas Drug & Gene Delivery Systems and Devices Mathematical Modeling, Simulation and Analysis Medical Devices and Implant Science (Neuroengineering) Micro-Biomechanics Micro- and Nano Systems; Platform Technologies Nanotechnology Rehabilitation Engineering (Biomechanics, Robotics) Sensors Structural Biology Surgical Tools, Techniques and Systems Telehealth Tissue Engineering Image-Guided Interventions Image Processing, Visual Perception and Displays Magnetic, Biomagnetic and Bioelectric Devices Magnetic Resonance Imaging & Spectroscopy Molecular Imaging Nuclear Medicine Optical Imaging & Spectroscopy Ultrasound: Diagnostic and Interventional Click to view 6 Awesome Technologies video X ray, Electron, and Ion Beam

7 Interagency Modeling and Analysis Group

8 Multiscale Modeling Multi-scale modeling deals with spanning scales from molecular to population and is expected to largely impact the understanding of biological processes and also further the predictive capability in biological, biomedical and environmental systems. Multi-scale modeling encompasses concepts of space, time and state space. Genes mrna Proteins Lipids Carbohydrates Biological Scales Cell structure -function Tissue structure -function Organ structure -function Clinical medicine 30,000+ genes 100,000+ proteins 200+ cell types 4 tissue types 12 organ 1 systems body Courtesy of Peter Hunter

9 Environment Organism Physiological Function Organ Systems Organs Tissues Cells, organelles Pathways Protein Distributed across multiple biological scales understanding physiological systems in health and disease can only be achieved through quantitative modeling and cannot be understood using mental models. RNA DNA Winslow et al., 2012

10 Interagency Modeling and Analysis Group (IMAG)Wiki, (Search: IMAG Wiki)

11 2014 MSM Working Groups Multiscale Systems Biology Working Group Biomechanics Working Group Theoretical and Computational Methods Model and Data Sharing Working Group High Performance Computing Working Group Clinical and Translational Issues Working Group Computational Neuroscience Working Group Population Modeling Working Group Cell-to-Macroscale Working Group

12 Funding Initiatives (FOAs) NIH Bioengineering NIH Biocomputing NIH NRI NIH Big Data NIH BRAIN NIH SPARC Attempting to make a DEEP IMPACT on a field

13 NIH Bioengineering Funding Opportunity Announcements Bioengineering Research Grants (BRG)(R01) Exploratory/Developmental Bioengineering Research Grants (EBRG) [R21] Bioengineering Research Partnerships (BRP)[R01]

14 NIH Biomedical Computing Funding Opportunity Announcements Search: NIH BISTI

15 Technical Challenges Goals Research Issues NIH Interests Assistive Medical Robotics Intelligent Homecare and long-term To achieve personalized Distributed, care robots robots Robotic that wellness/health functional promotion collective and robots respond maintenance to the independence in in the home and user s Robotic needs, behavioral and humans therapy long-term care to Robotic changing aids for mobility, manipulation, settings; human Timely environments. communication and cognition, vision & for effective nonsighted persons service; Assistive robotics to eliminate health disparities across populations Next Due Date: January 14, 2015 e-ducation.net Search: NSF NRI NATIONAL ROBOTICS INITIATIVE (NRI)

16 NIH and Biomedical Big Data

17 BD2K: Four Programmatic Areas I. Facilitating Broad Use of Biomedical Big Data II. Developing and Disseminating Analysis Methods and Software for Biomedical Big Data III. Enhancing Training for Biomedical Big Data IV. Establishing Centers of Excellence for Biomedical Big Data Search: NIH Big Data

18 NIH and the BRAIN Initiative Brain Research through Advancing Innovative Neurotechnologies Search: NIH Brain Initiative

19 Timeline Announced April 2, 2013 by President Obama, with an investment of $110 million, $40 million to NIH Advisory Committee to the NIH Director forms the BRAIN Working Group The BRAIN Working Group Issues its Interim Report, 9/16/13, with 9 High Priority Research Areas NIH issues 6 FOAs addressing these areas, 2/13/14 The BRAIN Working Group Issues its Final Report, 6/5/14 NIH announced $46 million in new grant awards, 9/30/14 NIH plans to reissue FOAs for FY2015, Fall 2014

20 BRAIN Initiative: 2025 Goals #1. Discovering diversity: Identify and provide experimental access to the different brain cell types to determine their roles in health and disease. #2. Maps at multiple scales: Generate circuit diagrams that vary in resolution from synapses to the whole brain. #3. The brain in action: Produce a dynamic picture of the functioning brain by developing and applying improved methods for large scale monitoring of neural activity. #4. Demonstrating causality: Link brain activity to behavior with precise interventional tools that change neural circuit dynamics.

21 #5. Identifying fundamental principles: Produce conceptual foundations for understanding the biological basis of mental processes through development of new theoretical and data analysis tools. #6. Advancing human neuroscience: Develop innovative technologies to understand the human brain and treat its disorders; create and support integrated human brain research networks. #7. From BRAIN Initiative to the brain: Integrate new technological and conceptual approaches produced in Goals #1 6 to discover how dynamic patterns of neural activity are transformed into cognition, emotion, perception, and action in health and disease. FY15 FOAs Coming Out Soon!

22 Stimulating Peripheral Activity to Relieve Conditions (SPARC) A New Common Fund Program Search: NIH SPARC

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25 The NIH electroceuticals project, tentatively called Stimulating Peripheral Activity to Relieve Conditions (SPARC), plans to bridge the knowledge gap by taking a step backwards and focusing on the mechanisms that underlie electrical control of organ systems. 18 NATURE VOL JULY 2014

26 Stimulating Peripheral Activity to Relieve Conditions (SPARC) Proposed Initiatives: FY $248 million investment over 6.5 years Biology: Anatomic and Functional Mapping: Deliver a detailed, integrated neural circuit map in five organ systems, $138.5M Next Generation Tools: Technology development for visceral nerves (optogenetics, stimulating/recording electrodes, cell-type specific tracing, etc.), $65.5M Off-label Use of Existing Market-Approved Technology for Small Market Indications: Partner with industry and FDA, $31.5 Data Coordination: Assemble data from all SPARC biology/technology projects into a coordinated data resource and incorporate new computer modeling methods, $12.5M Requests for Information (RFIs) Coming Out Soon!

27 Thank You! Grace C.Y. Peng