The National Institutes of Health ICs: mission and funding strategies

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1 The National Institutes of Health ICs: mission and funding strategies Perry Kirkham, Ph.D. Office of the Vice President for Research Phone: NIH Workshop topics and dates 9/9 STEW /4 STEW 310 1/20 STEW 310 NIH Overview/IC missions and funding strategies How to write an NIH proposal or resubmission: strategies, grantsmanship, and review process How to use NIH award data for your strategic advantage NIH Overview and IC Missions; Perry Kirkham; 1

2 Questions and topics to be addressed in this series: How do I break into the NIH funding pool? What is the NIH looking to fund? Why do I keep getting rejected? How do I choose the appropriate IC and study section for my submission? How do I strategize for my resubmission? What are innovation and "significance? What can I ask my program manager? What other types of grants are available other than the R01? Can I submit the same proposal to more than one agency at the same time? Differential Missions and Processes NIH USDA NIST DoE NSF AHRQ DoD DHS NIH Overview and IC Missions; Perry Kirkham; 2

3 27 NIH Institutes and Centers (ICs) Director budgeting, strategic planning, congressional mandates Program portfolio management, concept/rfa writing Review proposal review Advisory Council strategic planning, concept clearance, final proposal review NIH Overview and IC Missions; Perry Kirkham; 3

4 Funding Mechanisms Research Projects (R01, R03, R21) Solicited vs. Unsolicited Program Projects (P01) Cooperative Agreements (U01, U19) Resource Grants (U24, R24) Training and Fellowships (F and K) Center Proposals FY15 NIH Budget request increase of 0.7% over FY2014 to $30.362B Highlights: Increase research project grants by $280M over FY14 Big Data to Knowledge program ($24M annually over four years) Brain research through advancing innovative neurotechnologies (BRAIN) initiative ($100M) Accelerating Medicines Partnership (AMP) NIH Overview and IC Missions; Perry Kirkham; 4

5 DARPA-like program ($30M) to support rapid technology development (Common Fund) $566M for Alzheimer s Disease Increase Research Centers by $27M Increase the number of virtual review sessions to 15% Increase in T1 Diabetes money by $10.8M Proposed new Common Fund programs in 3D nucleome, bioelectronic medicines, citizen science, glycomics, and mechanisms underlying benefits from physical activity NIH Overview and IC Missions; Perry Kirkham; 5

6 Sources to understand each individual NIH IC scientific mission 1. website 2. strategic plan 3. program officer 4. trans-nih RFAs 5. award and application data NIH Overview and IC Missions; Perry Kirkham; 6

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9 NIH NIH Overview and IC Missions; Perry Kirkham; 9

10 Nanoscience and Nanotechnology in Biology and Medicine (R21) The National Cancer Institute (NCI) is interested in: 1. Early detection of the disease using imaging, 2. In vitro early diagnostics: multiplexed sensitive and specific sensors 3. Multi functional therapeutics and localized therapy delivery 4. Tools and approaches to interrogate, understand, and manipulate single cells, structures, and molecules. The National Institute on Aging (NIA) is interested in supporting research and development leading to: 1. Nanomaterials or nanoprobes for imaging, detecting and measuring biological processes that change in cells, tissues and organs with age and age related disease; 2. Development of nanomaterials for diagnosis or biomarkers of age related disease and associated loss of tissue function; 3. Design of nanoparticles or devices for novel drug delivery and/or for functional tissue repair and regeneration The National Institute of Biomedical Imaging and Bioengineering (NIBIB) is interested in: 1. The development of enabling nanotechnologies for drug and gene delivery systems and devices, sensors and micro/nanosystems, and tissue engineering 2. The development of new sets of design principles to generate biomaterials with nano level interfacial properties for tissue engineering, implants, and medical devices 3. The development of techniques to characterize the physical, chemical, structural, and biological properties of nanostructured assemblies/materials to advance biomedical technologies 4. The development of new materials processing methodologies for the synthesis, and/or optimization, of new or existing nanomaterials for biomedical applications 5. The research and development of nanomaterials and structures for novel biomedical imaging agents and molecular probes targeting preclinical and clinical applications 6. Research and development of nano scale technologies for biomedical imaging The National Institute of Environmental Health Sciences (NIEHS) is interested in supporting research projects for the: 1. Evaluation of individual exposure to toxicants both external and internalized dose, 2. Evaluation of the biological response to toxicants and the correlation of response to exposure with the etiology and progression of disease and dysfunction, and 3. Development of nanotherapeutic applications of nanotechnology to interfere in the influences of environmental factors on disease processes. NIH Overview and IC Missions; Perry Kirkham; 10

11 National Library of Medicine Basic informatics problem areas: Information and knowledge processing Natural language processing Information retrieval/discovery mining/ in-silico discovery Modeling and simulation Visualization and presentation of information Decision support Applied informatics domains: Health care EHR, including imaging and graphics Public health data integration for population research; disaster information Basic research informatics, knowledge organization; omics Complex models multilevel modeling Education innovative applications of simulation, VE or innovative integration to improve learning in health education NIH Overview and IC Missions; Perry Kirkham; 11

12 National Institute of General Medical Sciences Basic problem areas: Increase understanding of life processes Aspects of behavioral and medical areas that affect multiple organ systems Leadership in scientific training Increasing diversity of the scientific workforce Division of Biomedical Technology, Bioinformatics, and Computational Biology Division of Cell Biology and Biophysics Division of Extramural Activities Division of Genetics and Developmental Biology Division of Pharmacology, Physiology, and Biological Chemistry Division of Training, Workforce Development, and Diversity National Cancer Institute Basic problem areas: Cancer Statistics Cancer Depression Cancer Behavioral science Cancer NIH Overview and IC Missions; Perry Kirkham; 12

13 National Institute of Environmental Health Sciences Basic problem areas: Susceptibility across the life span to environmental factors Prevention of chronic disease Exposure science Epigenetics National Institute of Child Health and Human Development Basic problem areas: Pre- and post-natal child health (primarily wellbeing) Human growth and development (primarily biology) Reproductive health Medical rehabilitation NIH Overview and IC Missions; Perry Kirkham; 13

14 NIH Aging NIH Overview and IC Missions; Perry Kirkham; 14

15 Agricultural Mathematical Modeling NIH Overview and IC Missions; Perry Kirkham; 15

16 Engineering Neurodegeneration NIH Overview and IC Missions; Perry Kirkham; 16

17 Nanotechnology Differential Missions Differential Funding Strategies NIH Overview and IC Missions; Perry Kirkham; 17

18 Top 11 Categorical Rankings Category Biotechnology Prevention Cancer Genetics Neuroscience Brain disorder Women s Health Pediatric Behavioral/Social Science Infectious Diseases Top Categorical Rankings Category Biotechnology Prevention Cancer Genetics Neuroscience Brain disorder Women s Health Pediatric Behavioral/Soci al Science Infectious Diseases Clinical Research Rare Diseases NIH Overview and IC Missions; Perry Kirkham; 18

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20 R01-Equivalent grants, New (Type 1) Success rates, by career stage of investigator NIH Overview and IC Missions; Perry Kirkham; 20

21 Research Project Grants Competing applications, awards, and success rates NIH URLs of interest: Funded awards and investigators: Projectreporter.nih.gov/reporter.cfm Spending, success and funding data: Report.nih.gov Graphic representation of data by IC: report.nih.gov/retools/competing_research_ project.aspx IC strategic plans: Report.nih.gov/strategicplans/index.aspx NIH Overview and IC Missions; Perry Kirkham; 21