FluidFM INSPIRED BY PRECISION. Subject to change without notice. Revision: 1.3 Copyright 2016 Cytosurge AG, Switzerland

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1 WELCOME TO

2 FluidFM INSPIRED BY PRECISION. 4 Subject to change without notice. Revision: 1.3

3 CYTOSURGE AG IS BASED IN ZURICH SWITZERLAND. The company is active in the field of single cell isolation and manipulation and employs specialists from various fields in business development, engineering, biology and computer science. POWERFUL TOOLS FOR THOSE READY TO GO FURTHER. With FluidFM Cytosurge AG is reinventing the micropipette with the goal to make single cell applications more powerful, more automated, and more cost effective. The company s vision is to provide a new generation of tools to stimulate novel applications at the forefront of nanotechnology, life sciences and single cell biology in particular. FluidFM technology utilizes microfabricated microand nanopipettes with direct force control capabilities. The technology can be integrated with standard inverted optical microscopes. The unique features of FluidFM allows it to carry out many applications with respect to single cell isolation and manipulation. Cytosurge AG was founded in 2009 as a spinoff of ETH Zurich. The company is active in the field of single cell isolation and manipulation, develops the patented FluidFM technology and has recently started its commercial operations in several markets within Europe, Asia and the United States. The company is based in Zurich Switzerland and employs specialists from various fields in business development, engineering, biology and computer science. In 2012 the company was awarded with the ZKB Pionierpreis Technopark. The price is one of the most important national startup awards in Switzerland. Thanks to the highly precise force control, FluidFM micro- and nanopipettes can be controlled with utmost precision and without damaging the manipulated cells. The unmatched ability of FluidFM to dispense and sample liquid at the femtoliter scale (10 15 l) are prone to redefine the capabilities of state of the art micropipetting instrumentation. FluidFM technology has proven to be highly versatile with an impressive portfolio of validated applications in life sciences and beyond. The possibility to carry out all operations even when fully immersed in liquid render the technology ideal for biological applications at the single cell level.

4 REINVENTING THE MICROPIPETTE. FluidFM TECHNOLOGY The truly unique combination of force microscopy and microfluidics elevates your applications to a higher level, from single cell biology to surface analysis and beyond. FluidFM technology gives you maximum experimental flexibility for your most demanding nanomanipulation tasks. Benefit from simplified workflows and higher productivity. FluidFM probes have an aperture 500 times smaller than the diameter of a human hair. This allows flow rates as small as femtliters per second; a million times smaller than what the best flow sensor can detect. The patented technology that makes this possible is FluidFM. PRE-ASSEMBLED FluidFM PROBE HOLDER OPTICAL FORCE FEEDBACK TUBING RESERVOIR MICROCHANNELED FluidFM PROBE BUFFER SOLUTION GLASS SLIDE OPTICAL MICROSCOPE THE UNIQUE FluidFM TECHNOLOGY. Symbiosis of nanofluidics and force microscopy. SENSITIVE pn FORCE CONTROL ACCURATE pm PRECISION PRECISE fl LIQUID VOLUMES VERSATILE APPLICATIONS FluidFM IN A NUTSHELL. TECHNICAL DESCRIPTION. FluidFM technology unites the best features of microfluidics and force microscopy by introducing closed microscopic channels into force sensitive probes. This unique combination enables the handling of liquid volumes at the femtoliter scale, as well as force controlled manipulations of microscopic objects. FluidFM technology elevates the application scope of traditional glass micropipettes to new levels. Thanks to the nanofluidic channel inside FluidFM probes, soluble molecules can be dispensed through a sub-micrometer aperture at the tip. At the same time, the sensitive force feedback system allows surfaces in liquid environments to be modified in a controlled fashion. It also provides a reliable distinction between gentle contact with cell membranes and perforation.

5 MULTIPLY YOUR POSSIBILITIES. FluidFM A WORLD OF APPLICATIONS FluidFM technology is both universal and versatile. It opens the door to a new world of experiments at the sub-micrometer scale for research in life sciences, physics and beyond. Our simple and intuitive operator software, in combination with functional instrument design, ensures that FluidFM technology is easy to use and ready for your application. COLLOIDAL SPECTOSCROPY FluidFM OUR VIEW ON DIMENSION.

6 FULLY INTEGRATED SYSTEM SOLUTION. FluidFM BOT INVERTED OPTICAL MICROSCOPE WITH CAMERA FluidFM BOT XY - STAGE FluidFM BOT Z - STAGE WITH BOT HEAD FluidFM ARYA OPERATOR SOFTWARE BLISTER PACK BARCODE READER FluidFM MICROFLUIDICS CONTROL SYSTEM ANTI-VIBRATION TABLE RECOMMENDED FluidFM BOT CONTROLLER The FluidFM BOT system by Cytosurge provides the most comprehensive FluidFM experience available today. Go beyond imaging with the FluidFM BOT. The FluidFM BOT supports the complete range of Fluid- FM applications, unified in a stand-alone system. From single cell biology to material sciences give your research applications the edge with our flagship product. Redesigned from the ground up, the FluidFM BOT system takes FluidFM technology to the next level. Extended automation capabilities and a revolutionary sample positioning system enable unmatched levels of experimental versatility, speed, and precision for FluidFM applications. The FluidFM BOT gives you the best FluidFM experience available today. Unleash the true power of FluidFM with our unified system solution. 1 nm XY-SENSOR RESOLUTION 240x74 mm SAMPLE AREA 0.1 nm Z-SENSOR RESOLUTION 60 mm Z-RANGE PRECISION AT YOUR FINGERTIPS. FluidFM ARYA OPERATOR SOFTWARE Meet ARYA, the patented and award winning FluidFM operator software. ARYA combines simplicity and unified integration into a single interface, making it easy for beginners and experts alike to carry out FluidFM experiments. ARYA puts simple and intuitive control of all optical, mechanical, and positional parameters of your experiment at your fingertips. Take control of your FluidFM experiment with the FluidFM ARYA operator software. ARYA provides a single, comprehensive interface for all your FluidFM. applications. ARYA IN ACTION. Fully integrated, intuitive and powerful. INTUITIVE TOUCH & CLICK OPERATION SMART CONTEXT AWARE TOOLS SIMPLE WORKFLOW DRIVEN INTERFACE PREMIUM FluidFM EXPERIENCE

7 EASY UPGRADE SOLUTION. FluidFM ADD-ON FOR NANOSURF FLEX-AFM FlexAFM SCAN HEAD INVERTED OPTICAL MICROSCOPE WITH CAMERA FluidFM ARYA OPERATOR SOFTWARE BLISTER PACK BARCODE READER ANTI-VIBRATION TABLE RECOMMENDED FluidFM MICROFLUIDICS CONTROL SYSTEM The FluidFM add-on for Nanosurf FlexAFM allows you to enter the world of FluidFM using your existing atomic force microscope from Nanosurf. The innovative add-on option opens the door to a wide range of new applications made possible by FluidFM. From single cell biology to material sciences harness the possibilities provided by FluidFM using your existing Nanosurf instrument. FluidFM technology greatly extends the application scope of classical AFM. Applications ranging from single cell isolation to colloidal spectroscopy measurements become readily possible with this easy upgrade solution. FluidFM technology enables your research at the nanoscale to become faster, more powerful and economical. Go beyond imaging and unleash the true power of your Nanosurf FlexAFM with the FluidFM add-on. pm XYZ-RESOLUTION pn FORCE CONTROL 100% AFM CAPABILITIES 100% FluidFM APPLICATIONS QUALITY FOR MAXIMUM RELIABILITY. MICROFABRICATED FluidFM PROBES At the heart of FluidFM lies the patented production process for our microfluidic probes. The high precision microfabrication technology ensures constant probe quality for maximum reliability. We take pride in our Swiss precision and craftsmanship; our know-how goes into every single probe we deliver. Each specimen is individually tested to comply with all quality requirements of our customers. FluidFM probes are delivered preassembled and individually wrapped in a convenient blister pack. A complete range of different probe designs is available to meet your application requirements. We can also create customized probe designs for your experiments thanks to our innovative, rapid prototyping platform. PRECISION THROUGH TECHNOLOGY. FluidFM nanopipette with pyramidal tip and nanometer sized aperture. HIGH QUALITY MICROFABRICATION PRECISE > 50 NM APERTURES INTEGRATED MICROFLUIDIC SYSTEM VERSATILE APPLICATIONS

8 CONTACT US. VISIT OUR WEBSITE CYTOSURGE AG, SÄGEREISTRASSE 25, 8152 GLATTBRUGG, SWITZERLAND PHONE , FAX ,