Haley Shelley (née Porter) 501 Webster Rd. Lot 315 Auburn, AL (256)

Transcription

1 (née Porter) 501 Webster Rd. Lot 315 Auburn, AL (256) Education Auburn University Auburn, AL Bachelor of Chemical Engineerin g: Specialization in Biomedical Engineering May 2014 Ph.D. of Pharmaceutical Sciences/Pharmaceutics August 2018 Cumulative GPA: 3.91/4.00 Summary Formulation scientist with an engineering background equipped with strong critical thinking and problem-solving expertise. Specialization in topical ophthalmic/transdermal formulations and biodegradable synthetic/natural polymers for sustained drug delivery. Strong leadership and intrapersonal skills for successful collaboration with colleagues and companies. Organized, energized and ready to thrive in a fast-paced company. Research Experience Graduate Research Assistant May 2014 Present Optimization and characterization of nanoemulsions for topical drug delivery; characterization using particle size/ zeta potential analyzer and viscometer; formulation assay using HPLC; analytical HPLC method development; development of stability indicating assay methods; accelerated stability studies; preparation of SOPs, presentations, protocols and reports PhD Research Projects May 2014-Present Solubility enhancement of nepafenac by complexation with Hydroxypropyl-β-Cyclodextrin May May 2015 o Developed successful complexation between nepafenac and hydroxypropyl-β-cyclodextrin to improve water solubility of nepafenac, confirmed using differential scanning calorimetry, x-ray diffraction, and nuclear magnetic resonance spectroscopy o Formulated nepafenac complex into a solution which achieved 11-times higher corneal permeation compared to, Nevanac Increased ocular retention of nepafenac using in-situ gel former: sodium alginate May 2015-May 2016 o Design of in-situ gel for nepafenac/hydroxypropyl-β-cyclodextrin complex using optimum amount of sodium alginate that yields appropriate clarity and gelation o Rheology studies revealed that the viscosity increased 30-fold when exposed to the simulated tear fluid at 35 o Accomplished improved permeation to posterior ocular tissues in porcine perfusion studies Improved difluprednate delivery to the posterior segment of the eye using Hydroxypropyl-β- Cyclodextrin and PLGA microneedles May 2016-Present o Preparation of liquid and solid-state complexation of hydroxypropyl-beta-cyclodextrin and difluprednate achieved enhanced permeation to the posterior segment compared to the commercial, Durezol o PLGA-based microneedles with dissolving PAA provided sustained drug release over a 7-day period; PAA dissolved within 30 minutes o Texture Analyzer and SEM revealed sharp uniform microneedles with a high failure force o Permeation studies through porcine sclera yielded steady permeation over 24-hours, without the presence a burst effect

2 Awards 1 st place overall at Harrison School of Pharmacy Annual Research Symposium, st place Podium Presentation at GRASP Regional Conference, 2016 Top 10 Most Viewed & 7 th Most Shared Poster at American Association of Pharmaceutical Scientists (AAPS) Conference; 2016 Drug Discovery and Development Graduate Teaching Assistant of the Year, AAPS Blog Post: Eye-opening research: finding solutions to problems experienced by patients using Nepafenac, Published on January 17, 2017 Travelship for Annual American Association of Pharmaceutical Scientists (AAPS) Conference; 2016 Don Tillery Travel Award by Harrison School of Pharmacy, Awarded three times: November 2014, October 2015, and November 2016 Auburn University Graduate Research and Travel Fellowship, November 2017 Outstanding Graduate Student Council Member, Who s Who In American Colleges and Universities, Professional Societies/Organizations Phi Sigma Pi National Honor Fraternity American Association of Pharmaceutical Scientists Golden Key International Honor Society Auburn Alumni Association Life Member Graduate Women in Science Kappa Psi Pharmacy Fraternity, Inc. American Association of Colleges of Pharmacy Rho Chi Academic Honor Society in Pharmacy American Institute of Chemical Engineers Society of Women Engineers 100 Women Strong Involvement Auburn University-American Association of Pharmaceutical Scientists: o Founder & Chair-Elect, September 2016-April 2017 o Founder & Chair, April 2017-May 2018 Graduate Student Council: o Senator for the Department of Drug Discovery and Development, September 2014-May 2018 o Events Committee, November 2014-September 2016 o Concessions Board Member, May 2015-Present o Hiring Committee, November 2015 March 2016 o Communications Committee, September May 2018 o International Student Committee, August 2017-May 2018 Department of Drug Discovery and Development Ambassador: August 2015-May 2018 Teaching Experience Graduate Teaching Assistant May 2014 Present Contemporary Aspects of Pharmacy Practice (CAPP) Lab, August 2014-Present Directly assists, supervises, grades and teaches basic pharmaceutic compounding experiments to PharmD students Pharmacokinetics, January 2015-May 2016 Conducted weekly review sessions on pharmacokinetics for PharmD students Undergraduate Student Research Mentor, July 2016-Present Guides and assists undergraduate student in conceptualization and execution of research projects

3 Service University Service : Team Leader for Hargreave s Day 2017: Nanodays Volunteer 2017: Auburn University Annual Research Symposium Judge : Judge for GEARSEF (Greater East Alabama Regional Science and Engineering Fair) Junior & (Grades 6-8) Senior Division (Grades 9-12) American Association of Pharmaceutical Scientist (AAPS) 2016: Abstract Screener 2016: AAPS Annual Meeting Co-moderator: Getting Oral Peptides to the Market: To Conjugate and/or Disperse the Peptide? Secondary Ad-Hoc Reviews AAPS PharmSciTech SciTechnol Drug Development and Industrial Pharmacy International Journal of Pharmaceutics Journal of Pharmaceutical Sciences Certifications/ Training Dust Explosion Control Certification Inherently Safer Design Certification Runaway Reactions Certification Process Safety Certification Scanning Electron Microscopy Training Animal Resources Core Training The Humane Care and Use of the Laboratory Rabbit Training Post- Approval Monitoring Using Hazardous and Toxic Agents in Animals Working with Rabbits in Research Settings Working with IACUC Publications 1. H. Shelley, R. Jayachandra Babu; (2018) Role of Cyclodextrins in Nanoparticle Based Drug Delivery Systems. Journal of Pharmaceutical Sciences, In Press (Epub ahead of print) 2. H. Shelley, R. Jayachandra Babu, Forrest T. Smith, Eva M. Abarca; Characterization of nepafenac/hydroxypropyl-β-cyclodextrin complex for improved ocular delivery. (Submitted to AAPS PharmSciTech). 3. H. Shelley, R. Jayachandra Babu; In-situ gel of nepafenac/hydroxypropyl-β-cyclodextrin complex for the sustained release to the cornea. (Under Preparation) 4. H. Shelley, R. Jayachandra Babu; Sustained delivery of difluprednate to the posterior segment of the eye using biodegradable microneedles. (Under Preparation) Patents 1. Application Number: 62/322,075 (Provisional) Title: Nepafenac Solution Formulation File Date: 04/13/2016

4 Presentations Podiums 1. H. Shelley Delivery to the Posterior Segment of the Eye Using Biodegradable Microneedles. Auburn University s This is Research: Student Symposium, Auburn, AL, March 26, H. Shelley Microneedles for Delivery to the Posterior Segment of the Eye. American Association of Pharmaceutical Scientist at Auburn University s Rapid Research Review, Auburn, AL, February 06, H. Shelley Research Update. Auburn University: Department of Drug Discovery and Development, Auburn, AL, February 06, H. Porter Improved Retention of nepafenac on the ocular surface for sustained drug delivery. Auburn University s This is Research: Student Symposium, Auburn, AL, April 13, H. Porter Cyclodextrins in Ophthalmic Drug Delivery. Graduate Research Association of Students in Pharmacy (GRASP) Conference, Florida A&M University, Tallahassee, FL, July 23, *Received first place award for podium 6. H. Porter Improving Bioavailability of Nepafenac Using Hydroxypropyl-Beta-Cyclodextrin Complexes. Three Minute Thesis Competition, Auburn University, Auburn, AL, October 26, H. Porter The Application of Cyclodextrin Derivatives in Drug Delivery. Auburn University s This is Research: Student Symposium, Auburn, AL, April 8, H. Porter Research Update. Auburn University: Department of Drug Discovery and Development, Auburn, AL, February 23, Posters 1. H. Shelley, R. Jayachandra Babu; Comparison of Nepafenac Drug Delivery Between Nevanac and In Situ Gel in Perfused Porcine Eye Model; International American Association of Pharmaceutical Scientists Annual Meeting,San Diego, CA, November 12-16, H. Shelley, R. Jayachandra Babu; Ion-activated in-situ gel for prolonged release and enhanced retention in the porcine cornea; Annual NanoBio Summit, Mobile, Al, November 9-10, Poster# T H. Porter, R. Jayachandra Babu, Forrest T. Smith; Physicochemical Characterization of Nepafenac by Hydroxypropyl-Beta-Cyclodextrin Complex for Ocular Delivery; Annual Harrison School of Pharmacy Research Symposium in Auburn, Al, April 8, *Received first place award overall 4. H. Porter, R. Jayachandra Babu, Forrest T. Smith; Physicochemical Characterization of Nepafenac by Hydroxypropyl-Beta-Cyclodextrin Complex for Ocular Delivery; International American Association of Pharmaceutical Scientists Annual Meeting, Denver, CO, November 13-17, *Top 10 Most Viewed, 7 th Most Shared (out of 2000 posters) 5. H. Porter, R. Jayachandra Babu, Forrest T. Smith; Evaluation of Nepafenac In-Situ Gel Formulation for Ocular Delivery; International American Association of Pharmaceutical Scientist Annual Meeting, Denver, Colorado, November 13-17, 2016.

5 6. H. Porter, R. Jayachandra Babu, Forrest T. Smith; Perfusion Studies of Ophthalmic In-Situ Nepafenac Gel on Porcine Eyes; Annual NanoBio Summit, Auburn, Al, October 13-14, H. Porter, Forrest T. Smith, R. Jayachandra Babu; Ion-Activated Ocular In-situ Gel for Improved Residence Time in the Eye; Graduate Research Association of Students in Pharmacy (GRASP) Conference, Florida A&M University, Tallahassee, FL, July 23, H. Porter, Forrest T. Smith, R. Jayachandra Babu; Solubilization of Lipophilic Drug Molecules via Complexation with Cyclodextrins; Auburn University Golden Eagles Reunion in Auburn, Al, May 19, H. Porter, Forrest T. Smith, R. Jayachandra Babu; Ex-Vivo Permeation Studies of Cyclodextrin- Complexed NSAID using Porcine Corneas; Annual NanoBio Summit, Birmingham, Al, October15-16, H. Porter, Li Chen, S. Kurapati, V. Mulabagal, R. Jayachandra Babu; Stability and Degradation Profiles of Betamethasone Dipropionate in Topical Nanoparticle Formulation; International American Association of Pharmaceutical Scientists Annual Meeting,San Diego, CA, November 2-6, 2014.