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2 Join AAAS. Get instant access to Science. Support all of the sciences. When you subscribe to Science, you become part of the American Association for the Advancement of Science (AAAS), a nonprofit community of more than 100,000 members worldwide who believe in the power of science to make the world a better place. AAAS is hard at work promoting science in government, schools, and in the public commons around the globe. AAAS s award-winning journal Science offers the top peer-reviewed research across multiple disciplines. With your subscription, you'll get: ß 51 weeks of home delivery of Science ß Instant online retrieval of every Science article ever published, dating back to 1880 ß Full access to the Science mobile site and apps ß Career advice, webinars, blogs and fascinating features exclusively for AAAS members ß Members-only newsletters, and much more With increasing public skepticism about science and public funding for research more uncertain than ever our work has never been more important. Join hands with us today! Visit promo.aaas.org/joinaaas. Together, we can make a difference.

3 LIFE SCIENCE TECHNOLOGIES NEW PRODUCTS: GENERAL LAB EQUIPMENT Produced by the Science/AAAS Custom Publishing Office Table Top Centrifuges Blue Line table top centrifuges can accommodate sample volumes from ml up to ml. They have a maximum speed of 18,000 rpm/ maximum relative centrifugal force (RCF) of 30,065 x g. The MicroCen and the UniCen can be instantly recognized by their blue covers, and both series can be supplied as refrigerated versions. A range of rotors are available for all models. Customer safety is very important to Herolab, so all models come with a range of standard safety features. For example, the stainless steel chamber has an additional inner guard ring. The Automatic Positive Rotor the rotor itself and checks for the speed setting. If the speed is selected too high for a particular rotor, the machine will automatically reduce the speed setting to the maximum speed possible for that rotor. If any imbalance is detected, an Herolab For info: +44-(0) Tube Racks Hamilton introduces the RackWare HD138 and HD60 high-density Society for Biomolecular Screening (SBS)- footprint racks for microtube and cryovial storage. Designed for use with Hamiltonís BiOS, Sample Access Manager (SAM), and Verso sample management and storage systems, the new RackWare increases the storage capacity in a given space by increasing the number of tubes that can be placed in an SBS-footprint rack. These new racks can also be used to maximize storage in manual freezers. RackWare HD138 supports most major 96-format labware and increases storage capacity in a comparable SBS footprint from 96 to 138 tubes. RackWare HD60 increases the storage from 48 to 60 larger cryovials. A common problem in todayís labs is ever-growing sample collections coupled with less and less available space. Our new automationfriendly, high-density storage format can deliver space savings of more than 25%, combined with similar savings in both investment and operating costs per sample. Hamilton Storage For info: High-Voltage Power Supply The high-voltage power supply series now 10-kV model joins the already popular 1-, 2-, and 5-kV versions, all of which are used for many purposes in the laboratory. They power photomultiplier tubes, channel and electron multipliers, microchannel plates, adjustable high-voltage supply. Like existing models, the 10-kV Model 7645 is highly regulated and very stable. Voltage is set at the front panel by a precise 10-turn potentiometer. The easy to read 4.5-digit liquid crystal display (LCD) allows users to con- with 0.001% peak-to-peak regulation. The instrument rear panel features a scaled analog input for remote control and a current monitor output. The new Model kV power supply operates sensitive photomultiplier tubes and related devices for critical photometric and spectroscopy applications. McPherson For info: Sample Cooling Block The ChilliBlock is designed for precise, controlled cooling and heating of biological samples in microplates, vials, and Eppendorf tubes. ChilliBlocks can be used directly in conjunction with an ice bath to keep your samples cool and dry. For precise temperature-controlled experiments, ChilliBlocks should be used with our cooling/heating base unit. The ChilliBlock base unit attaches to most laboratory cooling/heating circulators, enabling precise, stable, and even temperature control of biological samples from ñ30 C to +160 C. Insulated to prevent ice formation at lower temperatures and ensure homogeneity, the ChilliBlock enables stable, consistent temperature control (+/ñ0.1 C) of biological samples, for a wide range of standard and custom container formats. Manufactured from clear, resistant, anodized aluminum, tance and homogeneous sample tem- makes it fully compatible with robotic sample-handling systems. Asynt For info: +44-(0) Horizontal Clean Benches The new horizontal clean benches combine Class 100 (ISO 5) process protection with rugged, easy-toclean polypropylene construction and microprocessor-based controls. from AirClean Systems are the ideal solution for Class 100 (ISO 5) applications where process protection is needed. Constructed from allwhite, seamless polypropylene, these workstations are easy to clean and can be used for many applications, including electronic assembly, intravenous (IV) admixture preparation, tissue culture, optic repair, and media preparation. The horizontal clean benches are available in several sizes and can be placed on a benchtop or a cart/stand. Standard on all horizontal clean benches, the UVTect controller constantly are made in the United States and are shipped fully assembled. AirClean Systems For info: Electronically submit your new product description or product literature information! Go to for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier JANUARY 2016 VOL 351 ISSUE 6271 sciencemag.org/products SCIENCE

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5 want new technologies? antibodies apoptosis biomarkers cancer cytometry data diseases DNA epigenetics genomics immunotherapies medicine microbiomics microfuidics microscopy neuroscience proteomics sequencing toxicology transcriptomics watch our webinars Learn about the latest breakthroughs, new technologies, and ground-breaking research in a variety of felds. Our expert speakers explain their quality research to you and answer questions submitted by live viewers. VIEW NOW! webinar.sciencemag.org Brought to you by the Science/AAAS Custom Publishing

6 DRUG DISCOVERY AND DEVELOPMENT Finding cures starts with research tools that actually work... Proteomic products and services Focused product portfolio Products tested for specificity and sensitivity Antibodies rigorously tested across a wide range of research applications Custom formulations GMP-grade recombinant rabbit monoclonal antibodies* Bulk orders and lot reservations * Custom formulations of certain monoclonal antibodies can be produced by CST in compliance with FDA regulations governing ASRs. Such products would be classified as Analyte Specific Reagents. Analytical and performance characteristics are not established. All other products are for Research Use Only. Not For Use In Diagnostic Procedures. Learn more at: Cell Signaling Technology, Inc. Cell Signaling Technology, and CST are trademarks of Cell Signaling Technology, Inc. 15PADINDUPHAR0001ENG_01