Take Your Microwell Plate Pipetting Back to the Comfort Zone

Size: px
Start display at page:

Download "Take Your Microwell Plate Pipetting Back to the Comfort Zone"

Transcription

1 Take Your Microwell Plate Pipetting Back to the Comfort Zone Looking for ways to speed up Microwell plate pipetting without errors? Experience the Picus with the unique Plate Tracker feature that keeps track of where you need to pipette next. In combination with the multi-dispensing mode, plate work has never been easier and faster! To find out more, visit:

2 First-class PCR results served with every run Applied Biosystems thermal cyclers Trustedforreliabilityandprecisionforover30years Verifiedforsuperiortemperatureaccuracyanduniformity Comprehensive portfolio of instruments delivering first-class PCR results for every application Press the call button at thermofisher.com/thermalcyclerdemo FindoutmoreaboutInvitrogen PCR reagents at thermofisher.com/amplifly ForResearchUseOnly.Notforuseindiagnosticprocedures Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. COL

3 HK REKLAMEBYRÅ CHALLENGE POSSIBILITIES NTNU is Norway s leading science and technology university. Here, equality, stability and long-term government research funding create freedom to innovate, collaborate and explore new ideas. Together, we challenge challenge established truths, naysayers and ourselves. We create knowledge for a better world.

4 Tahiti Total Solar Eclipse June 25-July 4, 2019 with optional Bora Bora Extension to July 7, 2019 French Polynesia is one of the most beautiful places on earth. Discover the magic of these islands and see the Total Solar Eclipse July 2nd from our chartered aircraft near the remote Gambier Islands. Enjoy this marine wonderland of coral reefs, exquisite islands, and a hardy Polynesian people who have learned to exist in this ruggedly beautiful environment For a detailed brochure, call (800) All prices are per person twin share + air BETCHART EXPEDITIONS Inc Montebello Rd, Cupertino, CA AAASInfo@betchartexpeditions.com NATIONAL GEOGRAPHIC ADVENTURES Space is available on these departures Galapagos Islands (With free air from Miami) Dec 7-16, 2018 ï Feb 8-17, 2019 Costa Rica & the Panama Canal Dec 15-22, 2018 ï Mar 29 - Apr 5, 2019 Baja California Whales Jan 28 - Feb 6, 2019 Belize & Tikal Feb 13-21, 2019 French Polynesia May 9-18, 2019 Alaska s Coastal Wilderness June 1-8, 2019 For a detailed brochure, call (800) All prices are per person twin share + air BETCHART EXPEDITIONS Inc Montebello Rd, Cupertino, CA Info@betchartexpeditions.com With its amazing and entertaining photographs and precise text, this book brings readers close up to the wonders of the living creatures that evolve in the Galápagos. Arturo Izurieta, executive director of the Charles Darwin Foundation for the Galápagos Islands Cloth $35.00

5 Produced by the Science/AAAS Custom Publishing Office Ultra-High Mass Range Mass Spectrometer The Q Exactive UHMR Hybrid QuadrupoleñOrbitrap Mass Spectrometer from Thermo substantially increased sensitivity and mass resolution at high m/z with MS 2 and pseudo- MS 3 capabilitiesócreating a unique and powerful analytical solution for investigating the structure and heterogeneity of protein complexes. With its superior ability to perform native intact mass and top-down analyses, Q Exactive UHMR (ultra-high mass range) MS provides unprecedented structural detail not visible with other methods, enabling deeper understanding of protein function, disease mechanisms, potential drug targets, and biotherapeutic compounds. It can analyze intact megadalton assemblies and resolve small interactions for better understanding of biological processes. With orders-of-magnitude enhanced sensitivity at high m/z For info: Fluorescent Secondary Antibodies StarBright Blue 520 Fluorescent Secondary Antibodies from Bio-Rad exposure times, and easy multiplexing. These plug-and-play antibodies allow simultaneous detection of up to three proteins (two targets of 520 antibodies can detect low-abundance protein targets in exposure times that are two to four times shorter than those of traditional Bio-Rad For info: Protein Tagging System need for molecular cloning prior to insertion and simplifying detection and bioluminescence enables antibody-free detection with the sensitivity to detect endogenous expression. The HiBiT detection method also eliminates the need for antibody-based techniques for receptor internalization studies. With HiBiT, multiple antibody-binding steps and associated washes are eliminated from detection protocolsósimply add LIFE SCIENCE TECHNOLOGIES new products:protein analysis tagging methods are limited in throughput and sensitivity, require highquality antibodies, and may only yield semiquantitative results. HiBiT tagging brings the simplicity and sensitivity of bioluminescence to protein abundance studies, quantifying proteins down to endogenous levels, even those maintained at low expression levels. Promega For info: Complex Charged Molecule Separator fractionation (EAF4) system designed to enhance molecular separation applied simultaneously across the FFF channel, enabling separations by particle size and particle charge based on electrophoretic mobility. opens the door to characterizing complex proteins, antibodies, and viruses as well as environmental and charged nanoparticles or polymers that have proven resistant to other techniques. Postnova Analytics For info: +44-(0) Aerosol Inlet System for PTR-TOFMS characterization of sub-µm particulate organic matter as well as particulate ammonium and nitrate at single-digit ng/m³ mass volatility organic compounds, semivolatile organic compounds, and low- IONICON For info: +43-(0) LC/MS/MS Sample Prep Kit for Monoclonal Antibodies antibodies from blood or other biological samples using immunoglobulin collection resin, followed by selective proteolysis of the antigen-binding (Fab) region of these antibodies via trypsin-immobilized nanoparticles. sample preparation and analysis. With the nsmol (nano-surface and to analysis (Fab region) is selectively fragmented, resulting in a sample and ion suppression, and leads to improved response and quantitative repeatability. In addition, the selective collection of Fab peptides limits contamination from excessive peptides or trypsin. For info: Electronically submit your new product description or product literature information! Go to for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier. SCIENCE sciencemag.org/custom-publishing 19 OCTOBER 2018 VOL 362 ISSUE

6 AAAS ISTHE FORCE FOR SCIENCE According to the 2017 Member Survey, you joinedaaas... to subscribe to Science magazine to support formal advocacy for STEM to be part of a larger community that supports STEM to show public support for STEM in oursociety to support STEM learning in ourschools TELL US WHAT S IMPORTANTTO YOU! The 2018 Member Survey is launching in September. Look in your inbox for a link. Yourresponses help us to better serve science, scientists, and the global community. Don t miss your chance to tell us what s most importantto you!

7 BIOLOGY EARTH ENVIRONMENT LIFE INTERDISCIPLINARY PHYSICAL MATERIAL SOCIAL SCIENCES OPEN ACCESS, DIGITAL, AND FREE TO ALL READERS Pushing the Boundaries of Knowledge As AAAS s frst multidisciplinary, open access journal, Science Advances publishes research that refects the selectivity of high impact, innovative research you expect from the Science family of journals, published in an open access format to serve a vast and growing global audience. Check out the latest fndings or learn how to submit your research: ScienceAdvances.org

8

9 be INSPIRED drive DISCOVERY stay GENUINE How low can you go? NEBNext Single Cell/ Low Input Library Prep Kit With this unique streamlined method, highquality, full-length transcript sequencing libraries are made directly from single cells, or from as little as 2 pg 200 ng of total RNA. Detect more transcripts, including low-abundance transcripts Obtain uniform, full-length transcript coverage, regardless of input amount or sample type Save time with a streamlined workflow, minimal handling steps and hands-on time Visit NEBNext.com to request your sample today. Superior transcript detection with the NEBNext Single Cell/Low Input RNA Library Prep Kit Number of Transcripts 1 5 TPM TPM : NEBNext Kit 2: SMART-Seq v4/nextera XT TPM Sequencing libraries were generated from Jurkat single cells (6 replicates) using the NEBNext Single Cell/Low Input RNA Library Prep Kit, or the SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing plus the Nextera XT DNA Library Prep Kit. Libraries were sequenced on an Illumina NextSeq 500. Each dot represents the number of transcripts identified at the given Transcripts Per Kilobase Million (TPM) range, and each box represents the median, first and third quartiles per replicate and method. Salmon 0.6 was used for read mapping and quantification of all GENCODE v25 transcripts. Increased identification of low abundance transcripts is observed with the NEBNext libraries. One or more of these products are covered by patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc. For more information, please us at gbd@neb.com. The use of these products may require you to obtain additional third party intellectual property rights for certain applications. ILLUMINA, NEXT-SEQ and NEXTERA are registered trademarks of Illumina, Inc. SMART-SEQ and ULTRA are registered trademarks of Takara Bio, Inc Copyright 2018, New England Biolabs, Inc.; all rights reserved >50 TPM