Quest Diagnostics and QIAGEN Relationship. Michael A. Lewinski, Ph.D., D(ABMM) Director, Infectious Diseases Quest Diagnostics Nichols Institute

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1 QIAGEN Presents: An Investor/Analyst Event Quest Diagnostics and QIAGEN Relationship Michael A. Lewinski, Ph.D., D(ABMM) Director, Infectious Diseases Quest Diagnostics Nichols Institute Objectives Who is Quest Diagnostics? Mission, Vision, Values Laboratories Industry Trends (Challenges) Why QIAGEN? Questions? 2

2 Who is Quest Diagnostics? Mission: We will be the undisputed world leader in diagnostic testing, information and services Vision: Dedicated people improving the health of patients through unsurpassed diagnostic insights and innovation Values: Quality, Integrity, Innovation, Accountability, Collaboration, Leadership 3 Quest Diagnostics Leader in Providing Healthcare Insights and Solutions Comprehensive Diagnostic Testing Routine» Esoteric Diagnose Monitor Predict Prevent Advanced Information Technology Solutions Improve Care and Efficiency Facilitate Introduction of New Therapeutics Clinical Trials Testing Touching 145 Million Patients Annually 4

3 Quest Diagnostics: The Leader US Diagnostic Testing Market: >$40 B Source: Washington G-2 Reports and company estimates 5 Quest Diagnostics 35 Regional Laboratories 150 Rapid Response Laboratories 2000 Patient Service Centers 2 Esoteric Testing (Reference) Laboratories Nichols Institute, San Juan Capistrano, California Nichols Institute, Chantilly, Virginia* Announced agreement to acquire Focus Diagnostics *HLA and Donor Screening Laboratories in Chantilly, VA 6

4 Quest Diagnostics Nichols Institute San Juan Capistrano, CA Quest Diagnostics Nichols Institute San Juan Capistrano, CA One of two Reference Laboratories for Quest Diagnostics ISO 9001 Certified (International Organization for Standards) Six Sigma Quality Center of Research and Development activities for various subspecialties Subspecialties Endocrinology/Toxicology Genetics Hematology/Oncology Immunology/Coagulation Infectious Diseases 8

5 INFECTIOUS DISEASES Nichols Institute, SJC Microbiology Bacteriology Mycobacteriology Mycology Parasitology Virology Molecular Microbiology Infectious Disease Serology Research and Development 9 MOLECULAR INFECTIOUS DISEASES Nichols Institute, SJC One of the largest commercial molecular infectious disease labs in country Automated molecular diagnostic laboratory Nucleic acid extraction Nucleic acid amplification/detection Gene sequencing Qualitative and Quantitative assays Gene sequencing for identification, drug resistance, and strain typing. Strain typing by PFGE Employ various nucleic acid amplification/detection methods Oligonucleotide synthesis laboratory 10

6 Key Industry Trends Lab tests influence >70% of healthcare decisions Molecular diagnostics expanding >20%/year versus <5% for most other laboratory methods [G-2 Industry Outlook] Molecular diagnostics becoming standard-of-care Molecular methods are supplanting traditional methods in Microbiology NAAT s rapidly replacing culture-based methods (eg, Bordetella pertussis and HSV) Only way to confirm diagnosis in some settings (eg, detection of noncultivable microorganisms) 11 Keys to Success (Challenges) Be the early provider of esoteric testing services (Industry Leader) Intellectual property to promote and sustain leadership position Relationships that provide access to innovative technology Be a rapid responder to industry demands (Rapid Follower) Better, Faster, Cheaper Automate, standardize, and regionalize SOC molecular diagnostic testing services to improve quality and deliver rapid results Champion information technology services to rapidly deliver complex patient information in a secure manner 12

7 Why QIAGEN? Quality- Established provider of quality reagents for nucleic acid extraction. Innovation and Leadership- One of the first to provide Quest Diagnostics with an automated solution for nucleic acid extraction (BioRobot in 1999) Collaboration- Under an NDA, our companies worked together to adapt BioRobots to fit the Quest Diagnostics paradigm Accountability- Rapidly resolved unexpected issues 13 Why Automation? Improved quality Increased throughput capacity Reduced anxiety time Reduce repetitive motion injuries associated with manual procedures 14

8 QIAGEN BioRobots used by Quest Diagnostics EZ M48 M MDx 15 Principal Uses of BioRobots within Quest Diagnostics Total nucleic acid extraction (DNA and RNA) from whole blood, plasma or cells. DNA extraction from whole blood, plasma or cells. RNA extraction from whole blood, plasma or cells. Qualitative and quantitative assays Infectious diseases HIV HCV HBV 16

9 Select Abstracts 1. Baumann, R.E., and M.A. Lewinski. Evaluation of a COBAS TaqMan Hepatitis B quantitative assay. Clinical Virology Symposium (19 th ), Clearwater Beach, Florida. April 27 April 30, S Baumann, R.E. and M.A. Lewinski. Performance evaluation of a semiautomated HIV-1 RNA assay using QIAGEN BioRobot RNA isolation and AMPLICOR HIV-1 MONITOR, version 1.5 detection. 102 nd General Meeting, American Society for Microbiology, Salt Lake City, Utah. May 19 23, C Baumann, R.E., H. Hamdan, and M.A. Lewinski. Evaluation of a COBAS TaqMan Hepatitis C quantitative assay. Clinical Virology Symposium (18 th ), Clearwater Beach, Florida. April 28 May 1, S Baumann, R.E. and M.A. Lewinski. Evaluation of semi-automated Hepatitis C RNA quantitative assays using QIAGEN BioRobot RNA isolation and COBAS AMPLICOR HCV MONITOR detection. 15 th Annual Meeting of AACC, San Diego, California. November