Eleventh Annual Chapel Hill Pharmaceutical Sciences Conference. Pharmacy in the Era of Precision Medicine: From Discovery to Implementation

Transcription

1 Eleventh Annual Chapel Hill Pharmaceutical Sciences Conference Pharmacy in the Era of Precision Medicine: From Discovery to Implementation May 18 19, 2017 The Carolina Inn, Chapel Hill, NC Co-Chairs: Daniel Gonzalez, PharmD, PhD and Tim Wiltshire, PhD Thursday May 18, :30 8:15 AM Registration and Breakfast 8:15 8:30 AM Welcome from Dean Bob Blouin and Associate Dean Kim Brouwer ACPE# L04-P (2.75 hours) Session 1: Pharmacogenomics in Precision Medicine 8:30 9:00 AM Regulatory Perspective on Precision Medicine Provide a general overview of the regulatory aspects related to use of biomarkers to achieve precision medicine. Discuss more specifically the regulatory landscape of genetic biomarkers of drug response. Page 1 Lawrence Lesko, PhD, FCP Clinical Professor and Director, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida 9:00 9:45 AM How to Interpret Patient Genotyping Data (Part 1) Provide meeting participants genotyping data for the actionable pharmacogenome. Discuss case studies to illustrate the process of how to interpret pharmacogenetics testing for pharmacists and its clinical impact. Provide a panel discussion of the application of pharmacogenetics testing for cancer, pain management, and cardiovascular disease today. 9:45 10:00 AM Break Tim Wiltshire, PhD Director, Center for Pharmacogenomics and Individualized Therapy; Associate Professor, Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy 10:00 10:30 AM How to Interpret Patient Genotyping Data (Part 2: Case Studies)

2 Daniel Crona, PharmD, PhD Assistant Professor, DPET, UNC Eshelman School of Pharmacy Craig Lee, PharmD, PhD Associate Professor, DPET, UNC Eshelman School of Pharmacy DPET Division of Pharmacotherapy and Experimental Therapeutics PACE Division of Practice Advancement and Clinical Education 10:30 11:00 AM How to Interpret Patient Genotyping Data (Part 3: Panel Discussion) Daniel Crona, PharmD, PhD Craig Lee, PharmD, PhD John Valgus, PharmD, MHA, BCOP Jon Easter, BSPharm Amber Proctor, PharmD 11:00 11:30 AM Implementation of Genetic Information within an Institutional Setting Describe practical implementation at the institutional level (example of best practices). 11:30 AM 12:30 PM Lunch Page 2 Alan Shuldiner, MD Vice President of Translational Genetics, Regeneron Pharmaceuticals, Inc. ACPE# L04-P (4.0 hours) Session 2: Novel Pharmacologic and Phenotypic Approaches to Precision Medicine 12:30 1:00 PM T-Cell Engineering for the Treatment of Cancer Provide an introduction to the use of Individualized T cell engineering as a novel therapeutic strategy for the treatment of malignancies. Barbara Savoldo, MD, PhD Professor, Immunology, Virology, Pediatrics Hematology-Oncology, UNC-Chapel Hill 1:00 1:30 PM The Role of the Gastrointestinal Microbiome in Precision Medicine Describe the influence of the gut microbiome on individual drug response, and highlight new technologies in this emerging field of study. Lawrence David, PhD Assistant Professor, Center for Genomic and Computational Biology, Duke University 1:30 2:00 PM Integration of Pharmacometabolomics into Precision Medicine Describe recent advances in pharmacometabolomics, and discuss how it s being used to complement pharmacogenomics for individualized drug therapy.

3 Rima Kaddurah-Daouk, PhD Director, Pharmacometabolomics Research Center, Duke University Professor, Psychiatry and Behavioral Sciences, Medicine, Duke University 2:00 2:30 PM Speaker Panel Discussion 2:30 2:45 PM Break Session 3: Role of Quantitative Clinical Pharmacology in Delivering Precision Medicine 2:45 3:00 PM Role of Adaptive Feedback Control in Precision Medicine Discuss the roles of adaptive feedback control in delivering precision medicine. Alan Forrest, PharmD Clinical Professor, DPET, UNC Eshelman School of Pharmacy 3:00 3:30 PM Innovative Tools and Applications to Adaptive Feedback Control Provide examples of innovative tools and applications to adaptive feedback control. David D Argenio, PhD Professor, Biomedical Engineering, USC Viterbi School of Engineering 3:30 4:00 PM Applications of Adaptive Feedback Control in the Pediatric Population Present an overview of the applications of adaptive feedback control in the pediatric population. Michael Neely, MD, MSc, FCP Director, Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute 4:00 4:30 PM Regulatory Perspective on Implementing Adaptive Feedback Control in Drug Development Provide a regulatory perspective of the challenges and opportunities to implementing adaptive feedback control in drug development. 4:30 4:50 PM Panel Discussion Philip Colangelo, PharmD, PhD Clinical Pharmacology Team Leader, Office of Translational Sciences, U.S. Food and Drug Administration Evening Session: Cocktails, Hors d oeuvres, and Science 5:30 7:30 PM Poster Session and Evening Cocktails/Hors d oeuvres Page 3

4 6:00 6:30 PM Guided poster tour, two posters within each grouping (six total) 10-minute presentation with 5 minutes for questions. Learning 1. Disseminate ongoing research across therapeutic areas 2. Stimulate opportunities for future collaboration within and beyond The School of Pharmacy 3. Advance professional development of trainees in methods of scientific presentation. Friday May 19, :15 8:00 AM Registration and Breakfast ACPE# L04-P (4.25 hours) Session 4: Implementing Precision Therapy Main Content: Precision medicine is an innovative medical model that takes into account individual variability in genes, environment, and lifestyle for each person. This customization of healthcare is one of the biggest of the big data problems. 1. Assess and understand broadly the current state of precision therapy. 2. Describe the developing opportunities/strategies for precision therapy to leverage collaborations with academic and the non-academic partners. 3. Discuss new opportunities/strategies that should be pursued in Precision Therapy at UNC, and in North Carolina. Questions to Address: o What is the current state of precision therapy? o What are the immediate opportunities for precision therapy? o What is the future of precision medicine? o Where should precision medicine be headed at UNC? 8:15 8:30 AM Welcome and Introduction Summarize events from Day 1. Daniel Gonzalez PharmD, PhD, and/or, Tim Wiltshire PhD (Conference Co-Chairs) 8:30 9:15 AM Plenary Lecture: Imprecision Medicine Define what we are and aren t doing right in precision medicine. Nick Schork, PhD Director of Bioinformatics and Biostatistics; Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute 9:15 10:15 AM Presentations: The Future of Precision Therapy from three perspectives Page 4

5 Presenters (3 areas for 20 minute presentations) 10:30 11:30 AM Panel Discussion Pharmaceutical Industry Arlene Hughes Genomic Medicine Senior Director, PAREXEL International Technology Industry Fah Sathirapongsasuti, PhD Computational Biologist, 23andMe Health Care Payers Jon Easter, BSPharm Director, Center for Medication Optimization through Practice and Policy (CMOPP) UNC Eshelman School of Pharmacy Panel presenters, plenary speakers and closing speaker will discuss the following in a panel format. 1. What are the strategies and barriers? 2. What technology should we be using? 3. What can we transfer from other disciplines (disciplines/stakeholders as well as Academia, Clinical, Industry (Pharmaceutical and Technology), Payers, and Regulatory)? 11:30 AM 12:00 PM Closing Plenary: Vision for Precision Medicine at UNC Discuss the current state and vision for precision medicine initiatives at UNC-Chapel Hill. Terry Magnuson, PhD Vice Chancellor for Research, UNC-Chapel Hill 12:00 12:15 PM Closing of Conference: Associate Dean Kim Brouwer The University Of North Carolina Eshelman School Of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. The program ACPE# L04-P, L04-P L04-P provides contact hours of continuing pharmacy education credit. To receive CE credit, you must complete the CE attendance form and the online evaluation of the program. Statements of credit can be viewed and printed in CPE Monitor in approximately 2 to 3 weeks. Page 5