The prospective for the biodegradable microstructured optical fibers

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1 Reference for this presentation is: A. Dupuis, Y. Gao, N. Guo, E. Pone, N. Godbout, S. Lacroix, C. Dubois and M. Skorobogatiy "Biodegradable, double-core, porous optical fiber for sensing applications," 18th International Conference on Optical Fiber Sensors (OFS), Wa2, Cancun, Mexico, October The prospective for the biodegradable microstructured optical fibers Prof. Maksim Skorobogatiy Canada Research Chair in Photonic Crystals École Polytechnique de Montréal, Quebéc CANADA

2 Drawing of Microstructured Polymer Optical Fibers (MPOFs) for Applications in Sensing and Light Transmission Advantages of Polymer Material Combination Over Glasses: Low cost materials Ease of handling and preform prototyping, several polymers can be used in the same fiber Polymers are generally more bio-friendly (biocompatible) Polymer fibers can be environmentally friendly (biodegradable) Active polymer structures can be introduced by bio-functionalizing polymer matrix with complex materials (therapeuticals: anesthetics, anti-inflammatory drugs, etc.) École Polytechnique de Montréal, Dec Active materials (nanoparticles, low melting point metals, semiconductors, etc.) can be incorporated into preform to implement integrated sensor/power delivery fiber.

3 Advantages of Polymer Fiber Drawing over Glass Fiber Drawing In a melted state surface tension of polymers is typically significantly smaller than surface tension of glasses, thus it is easier to avoid surface tension induced collapse of microstructure during drawing (no core pressurization, single zone furnace, etc.) Composite polymer fibers incorporating two or more different polymer materials are relatively straightforward to fabricate by matching polymer thermo-mechanical properties via chemical manipulation of their structure and composition M. Skorobogatiy et al., Journal of Materials Research 21, 2246 (2006)

4 Bio-friendly ColorFull plastic fibers for advanced textiles M. Skorobogatiy et al., "Drawing of the hollow all-polymer Bragg fibers," Optics Express 14, 5838 (2006)

5 Biodegradable, Double Core, Porous Microstructured Fiber as a Smart Hypodermic Needle Efficient Light Transmission and Illumination Efficient Light Collection Microfluidics Release of Therapeuticals How to suspend inner core in the air? M. Skorobogatiy et al., Optics Letters, October (2006);

6 Fiber Preform Fabrication Low refractive index powder Inner Core Outer Core two cellulose butyrate cores (n=1.48) separated with hydroxypropyl cellulose powder (n=1.34)

7 Fiber Crossection and Structure

8 Optical Transmission Properties Transmission loss 1-2 db/cm Material loss at 630nm is 0.4dB/cm Outer Core Inner Core After 3cm of propagation Powder particles separating the cores

9 Material loss of cellulose butyrate Transmission window for medical applications. Fiber length of several meters.

10 Changes in the Fiber Transmission Properties when Submerged in Deionized Water

11 Changes in the Fiber Transmission Properties when Submerged in Deionized Water

12 Flow Through Fiber After ~ 24 Hours 2cm Evaporation When removed from a recipient after 24 hours of experiments, one observes unconstrained water evaporation along the whole fiber length with an evaporation rate of ~0.5mm/min

13 Conclusions While biocompatible/biodegradable materials are considered more suitable for a relatively gentle fiber spinning process, we have demonstrated that some bio-friendly materials can be suitable for industrially robust fiber drawing. It is possible to incorporate microstructure into biofriendly fibers. Fibers with dissolvable microstructure can be used to implement advanced functions such as drug release.

14 Acknowledgements Prof. C. Dubois Prof. S. Lacroux Prof. N. Godbout Res. Assoc. Y. Gao Post-Doc E. Pone PhD A. Dupuis MSc N. Guo Canada Research Chair Foundation Canadian Institute for Photonics Innovations