Research Projects funded by the World Class University Project, University of Sri Jayewardenepura

Transcription

1 Research Projects funded by the World Class University Project, University of Sri Jayewardenepura Project Title Ph.D/19/ th August 2013 Investigation into possible natural products /herbal based therapeutics intervention with special reference to extract of Ceylon green tea on the functional status of patients with Duchene Muscular Dystrophy and Spinal Muscular Atrophy in relation to their genetic mutations Name Of Principal Investigator Prof. Ranil de Silva (1) Number of Publications* Local (2) Number of Presentations** In Sri Lanka Outside Sri Lanka (3) Number of published Abstracts*** Local Name of Training Institution Mcgill University- Montreal, Canada (World Ranking 35) Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India Institute of Genomics and Integrative Biology (IGIB), New Delhi, India Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER) (4) Hands-on Training of PhD Student Training Period 02 weeks 01 Week 01 Week Type of Training**** Hands on training Training on Functional Imaging Techniques- Multiple Ligation Dependant Probe Amplification [MLPA], Polymerase Chain reaction techniques, DNA sequencing, DNA Fingerprinting) Techniques- Polymerase Chain Reaction techniques, DNA sequencing, DNA isolation by salting out technique 03 Days Techniques- Multiple Ligation Dependant Probe Amplification [MLPA]) Internation al Local

2 (1) Details of each Publication* / Local Title Author Details and Affiliations Name of Journal Impact Factor Genotype-phenotype analysis of Duchenne and Becker muscular dystrophy in two South Asian populations: A study protocol Nalaka Wijekoon 1, Pyara Ratnayake 2, Vindika Suriyakumara 1, Lakmal Gonawala 1, Ashwin Dalal 3, Akshay Anand 4, Dhammika Amarathunga 5, Sebahattin Cirak 6,Javad Nazarian 6,7, Eric Hoffman 6,7, Ranil de Silva 1 Affiliations- 1 Genetic Diagnostic & Research Lanka. 2 Lady Ridgway Children's Hospital, Colombo 08, Sri Lanka. 3 Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda Complex, , Hyderabad, Andhra Pradesh, India. 4 Department of Neurology, Post

3 Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. 5 Department of Nonclinical Statistics, Johnson & Johnson Pharmaceutical Research & Development, Raritan, USA 6 Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, USA. 7 Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA

4 (2) Details of each Presentation** Country of Presentation Nature of Presentation (Abstract Poster, Oral, Invited Lecture, Oration, etc.) Poster Duchenne Muscular Dystrophy in Probable Monozygotic Twins: Seventh Report Worldwide. Title Author Details (Name, Designation, Institute) 1Nalaka Wijekoon, Pyara Ratnayake2, Vindika Suriyakumara1, Beneeta Hettiarachchi1, Lakmal Gonawala1, Ashwin Dalal3, Sebahattin Cirak4, Javad Nazarian4,5, Eric Hoffman4,5, Ranil de Silva1. Affiliation- 1Genetic Diagnostic & Research Laboratory, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka, 2Lady Ridgeway Hospital, Sri Lanka, 3Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Hyderabad, India, 4Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, USA. 5Department of Integrative Systems Biology, George Presented At: (Place, Name of Conference/Symposia/Meeting) 8th Annual Canadian Neuroscience Meeting, Montreal, Canada

5 Poster Performance in activities of daily living in children with Duchenne Muscular Dystrophy: A Sri Lankan perspective Oral Statistical analysis of the relationship between consanguineous marriages and the incidence of Spinal Muscular Atrophy (SMA). Washington University School of Medicine and Health Sciences, Washington, DC, USA 1 Wijekoon DNB, Gamage R 2, Ratnayake PD 3, Gonawala BL 1, Jayasinghe MC 1, Nazarian J 4, Hoffman E 4, De Silva KRD 1 Affiliation - 1 Genetic Diagnostic & Research Laboratory, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka, 2 National Hospital of Sri Lanka, 3 Lady Ridgeway Hospital, Sri Lanka, 4 Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, USA 1Wijekoon, D.N.B., 2Amarathunga, D, 1De Silva, K.R.D. Affiliation- 1Genetic Diagnostic & Research Laboratory, XXX Annual Conference of Indian Academy of Neurosciences(IAN), Amritsar, India. Presented at Visiting Lecture Team Programme, Brain Research Organization, organized by the Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka.

6 (3) Details of each Abstract*** / Local Title Duchenne Muscular Dystrophy in Probable Monozygotic Twins: Seventh Report Worldwide Performance in activities of daily living in children with Duchenne Muscular Dystrophy: A Sri Lankan perspective. Territorial localization and familial genetic transmission of Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA): A Sri Lankan outlook towards genetic analysis. First Author Details (Name, Designation, Institute) 1Nalaka Wijekoon 1Genetic Diagnostic & Research Lanka, 1Wijekoon DNB 1Genetic Diagnostic & Research Lanka, 1Gonawala BL 1Genetic Diagnostic & Research Lanka, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka, 2Department of Nonclinical Statistics, Johnson & Johnson Pharmaceutical Research & Development, Raritan, USA Published in: (Name of published journal/ site of published) 8th Annual Canadian Neuroscience Meeting, Montreal, Canada XXX Annual Conference of Indian Academy of Neurosciences(IAN), Amritsar, India. XXX Annual Conference of Indian Academy of Neurosciences(IAN), Amritsar, India.

7 (4) Nature of Training Opportunity**** - Details of skills that were developed (eg: training in novel techniques [techniques should be mentioned], etc.,) (1) Mcgill University- Montreal, Canada (World Ranking 35)- Basic Sciences of Development and Plasticity of the Nervous System. (Techniques- Training on Functional Imaging) (2) Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India- Genetic Analysis of Neurogenetic Diseases (Techniques- Multiple Ligation Dependant Probe Amplification [MLPA], Polymerase Chain reaction techniques, DNA sequencing, DNA Fingerprinting) (3) Institute of Genomics and Integrative Biology (IGIB), New Delhi, India- Genetic Analysis of Trinucleotide Repeat Disorders (TRDs) (Techniques- Polymerase Chain Reaction techniques, DNA sequencing, DNA isolation by salting out technique) (4) Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER)- (Techniques- Multiple Ligation Dependant Probe Amplification [MLPA])