Stago Newsletter. Volume 6 Issue 1 May 2016

Transcription

1 1 Stago Newsletter Volume 6 Issue 1 May 2016

2 Haemostasis Catalogue INSIDE THIS ISSUE: 2016 Haemostasis Catalogue 2 VWF Collagen Binding 3 Customer Corner 4 ihemostasis and Haemoscore 5 Continuing Education 6 STart Max 7 Stago Prize 2015 RMIT 8 Dates to Remember 9 Our new 2016 Stago and Tcoag Haemostasis Catalogues are now available in hardcopy or softcopy. If you would like to receive a copy of either or both please let us know which version you would prefer and where you are from.

3 3 VWF: Collagen Binding Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Clinically, it is often characterised by mucocutaneous haemorrhages. Three principal types of VWD have been defined: Type 1 corresponds to a quantitative deficiency of VWF; classically, type 1 is the most frequently encountered (70 to 80% of VWD); however, this notion is under discussion; Type 2 refers to a qualitative deficiency of VWF; the defect is often located in the multimeric structure; Type 3 is characterized by virtually a total absence of VWF in both the plasma and cellular compartments. Furthermore, VWF deficiencies may be associated with several clinical states such as myeloma, lymphoma, systemic lupus ery- thematosus, hypothyroidism, etc. These cases may be referred to as acquired von Willebrand diseases. Von Willebrand Factor Collagen-Binding Ability Only the VWF functional multimers of high molecular weight can bind to collagen. A decrease VWF:CB level reflects a quantitative or qualitative disorder of the VWF multimers. The ratio value of [VWF:CB]/[VWF:Ag] is useful to differentiate type 2 subtypes of VWD in which a loss of HMWM occurs. This assay allows one to distinguish the subtype 2A (very decreased [VWF:CB]/[VWF:Ag] ratio) from the subtype 2M (normal or slightly decreased [VWF:CB]/[VWF:Ag] ratio) Asserachrom VWF:CB TEST PRINCIPLE The VWF to be measured is captured through the HMWM by hu- man collagen (Reagent 1) coated on the internal walls of a plastic microplate well. Next rabbit anti-vwf antibodies coupled with peroxidase (Reagent 2) bind to the remaining free antigenic determinants of the bound VWF. The bound enzyme peroxidase is revealed by its action on the TMB substrate (Reagent 3). After stopping the reaction with a strong acid, the intensity of the colour is directly proportional to the concentration of the VWF:CB initially present in the plasma sample. The Stago Asserachrom VWF:CB kit is an assay for the quantitative determination of the capacity of von Willebrand factor to bind to collagen (VWF:CB) by enzyme-linked immunosorbent assay (ELISA). If you would like a quotation or more information please contact us at: * Informaon source Stago Asserachrom VWF:CB Package Insert

4 4 Stago Customer Corner Stago Customer Corner is available via our new-look website You simply log-in (clicking the Login button top right) and you will get access to all your data and available services. The information available includes: your laboratory analysers, orders and IDcard; Material Safety Data Sheets, Package Inserts, Barcode Sheets, Instrument Documents, and Standard Operating Procedures If you would like access to Customer Corner please contact us for your log-in and password - it s free!

5 ihemostasis and Haemoscore - Stago Apps for ipad and Android 5 Stago are pleased to announce the release of our block buster applications ihemostasis and Haemoscore. These applications are available free of charge from the Apple App Store and Google play worldwide. The ihemostasis tablet application serves as a haemostasis primer for anyone looking to increase knowledge in the area. The uncomplicated user interface offers four areas of interest: Coagulation Cascade: Major coagulation mechanisms are animated along with detailed explanations of each phase, including intracellular and extracellular components. Quick Guide: Detailed descriptions of the most current assays used to examine hemostasis in a global fashion along with various therapies, disease state classifications and decision trees. Special Focus: Product literature supporting Stago s anticoagulant, thrombin generation and flow cytometry products is housed, along with reference ranges for hemostasis tests in childhood and pregnancy. Clinical Cases: Three case studies are presented, along with quizzes to test the viewer s knowledge. The Haemoscore App is available for tablet and smartphone from the Apple Store and Google play. Clinical scores and algorithms play a central role in modern patient care derived from evidence-based medicine. Evidence based medicine provides guidelines to physicians aimed at improving efficacy and safety of patient management. An international expert panel has developed this application that compiles, in a clear and simples way, most recognised and useful clinical scores and diagnosis algorithms in the field of Thrombosis and Haemostasis. Each algorithm includes the indication and a brief interpretation emphasising the most relevant aspects of each one followed by some representative references. We hope this application may guide the clinician in the most appropriate diagnostic strategy, answering some of the questions that may arise when treating thrombotic and bleeding problems.

6 6 Continuing Education Diagnostica Stago has a number of websites to assist in the continuing education of your staff. On a regular basis Stago hosts live webinars at a range of times, to suit us in Australia and New Zealand, presented by Key Note Speakers from laboratories from around the world. These webinars are also available for viewing on demand a few weeks after the live presentation. The topics covered so far include: 1. D-Dimers Its use in the Strategy for VTE exclusion and as a predicator for the risk of VTE recurrence 2. How to diagnose and manage Heparin Induced Thrombocytopenia (HIT)? 3. Laboratory measurement of New oral Anticoagulants 4. New insights in Lupus Anticoagulant Testing 5. Quality Control in the Haemostasis Laboratory. How Quality Control contributes to result reliability. 6. Thrombin Generation: a universal laboratory tool emerging from research to clinical practice 7. How I interpret an APTT result? 8. The laboratory diagnosis of inherited and acquired Haemophilia 9. Disseminated Intravascular Coagulation: pathophysiology and diagnosis, contribution of the clinical lab and importance of Fibrin-related markers 10. Heparin monitoring Here to stay! (Which screened May 24, 2016) The above webinars are currently all available to view on demand. All you need to do is go to the Stago ANZ website and press the icon Stago Webinars (see below). This link will take you to the webinars website where you register for access and future webinar notifications. The webinars are best viewed using Google Chrome and SD (standard definition) depending on your connection speed. Another link on our Stago website Ed-Vantage Continuing Education provides access to a huge amount of resources covering topics such as Lab Management, General Coagulation Testing, Case Studies in Hemostasis, Primary Hemostasis, Anticoagulation, Hypercoagulability, Hypocoagulability, and Screening Tests. Some of these talks also attract PACE points.

7 7 STart Max Would you like to know more? Contact us:

8 RMIT Science and Health Student Prizes Jaelyne Birrell receives The Stago Prize at RMIT Awards Ceremony from Vicki Guppy Scien$fic and Training Manager Stago ANZ Congratula ons to Jaelyne Birrell for winning the Stago Prize awarded to the best Bachelor of Biomedical Science (Laboratory Medicine) student in their final year of study at RMIT in Not only did Jaelyne win the Stago Prize she also won the School of Medical Sciences Prize awarded to the best student from an undergraduate program in the School of Medical Sciences in 2015 as well as the Pro Vice-Chancellor Health Prize awarded to the best student in their final year of a Health program, selected on academic achievement and contribu ons to School and University ac vi es. And that is not all for awards. At the RMIT Uni School of Medical Sciences and AIMS Lab Medicine Student Awards Night (May 24, 2016) Jaelyne received Top Student in Microbology, Top Student in Pathology, Top Graduate in BBiomedSci in Lab Medicine, Top 10% of Graduates, Top Fourth Year Student, and the IBMS President s Prize awards. Jaelyne is a Microbiologist with Microgene x, a molecular microbiology company in Melbourne, where she performs DNA sequencing to iden fy microorganisms to species level.

9 Dates to Remember 9 Diagnostica Stago Pty. Ltd. 651 Doncaster Road Doncaster, VIC, 3108 Australia Phone (AUS): STAGO Phone (NZ): STAGO Fax: AUSTRALIA - NEW ZEALAND At the Heart of Haemostasis