Advances in Neuromonitoring. Don M. Tucker. Electrical Geodesics, Inc. University of Oregon

Transcription

1 Advances in Neuromonitoring Don M. Tucker Electrical Geodesics, Inc. University of Oregon

2 Advances in Neuromonitoring Don M. Tucker Electrical Geodesics, Inc. University of Oregon

3 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

4 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

5 A geodesic is the shortest distance between 2 points on the surface of a sphere.

6 The geodesic sensor net partitions the head surface with geodesic tessellation.

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11 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

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14 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

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16 UO NeuroInformatics Center Allen D. Malony, Director Don M. Tucker, Associate Director Sergei Turovets, Computational Physicist Bob Frank, Senior Data Analyst Kai Li, Computer Scientist Chris Hoge, Computational Software Engineer Matt Sottile, Computer Scientist, CIS Department Dejing Dou, Computer Scientist, CIS Department Gwen Frishkoff, Neuro Scientist, Wisconsin Medical C. Brad Davidson, Systems administrator Adnan Salman, Ph.D. student, Computer Science Jason Sydes, Ph.D. student, Computer Science

17 UO NeuroInformatics Center

18 Automated Segmentation & Cortical Surface Extraction Kai Li: UO NeuroInformatics Center workflow segmentation result cortical surface visualization parameters

19 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

20 beit: Head Conductivity Scanning Geodesic sensor net integration Scanning current injection hardware EEG and bounded EIT data acquisition Geodesic photogrammetry system

21 Head Conductivity Scanning

22 Los Alamos USC Skull Phantom John Mosher, Bob Kraus Jeff Eriksen

23 Skull Warping Skull warping

24 ICCS 2007 Best Paper

25 GeoSource: Cortex from MNI average MRI 2400 voxels: x,y,z dipoles linear inverse: LORETA, LAURA - Pascual-Marqui, Grave de Peralta RMS of xyz for color intensity source orientation vectors (+) => nchan vs nsource => FDM!

26 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

27 12 year-old girl with daily partial complex seizures 24-hr monitoring with 128 GSN Seizure localization with GeoSource photo of normal child Journal of Pediatric Neurosurgery, 2008

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34 Comparing Dense-Array and Intracranial EEG for Source Localization of Seizures Mark D. Holmes, MD (1,2) Don M. Tucker, PhD (3,4,5) Jason M. Quiring, PhD (3,4,5) Micah Brown (3) John W. Miller, MD, PhD (1,2,6) Shahin Hakimian, MD (1,2) Jeffrey G. Ojemann, MD (1,6) Regional Epilepsy Center, University of Washington (1), Department of Neurology, University of Washington (2), Electrical Geodesics, Inc. (3), Department of Psychology, University of Oregon (4), University of Oregon Institute of Cognitive and Decision Sciences (5), Department of Neurological Surgery, University of Washington (6)

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36 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

37 Dipoles Oriented to the Cortical Surface Performed after brain tissue segmentation Use the marching cube isosurface algorithm Guarantee topology correctness Application to surface tessellation and dipole creation

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39 Overview Dense Array EEG (deeg): - head surface potentials - sensor registration Electrical Source Analysis - accurate head model EIT of the Volume Conductor - skull conductivity modeling Current Protocol for Neurosurgical Planning Next Generation: Individual MRI Head Model Tractography and Functional Connections

40 Hagmann et al: PLoS Biology 2008

41 Mind From Body EXPERIENCE FROM NEURAL STRUCTURE D O N M. T U C K E R

42 Thanks for your attention.

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