QUIBIM PRECISION Powering AI and Imaging Biomarkers

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1 Quantitative Imaging Biomarkers in Medicine QUIBIM PRECISION Powering AI and Imaging

2 1896. William Morton First radiology report: Abdomen X-Ray there is no stone of appreciable size in the kidney

3 2018 Today radiology report: CT renal stones no adenopathy is seen.

4 ISEASE vs. THE EYE

5 THE NEED: MEASUREMENTS

6 When you can measure what you are speaking about, and express it in numbers, you know something about it Lord Kelvin

7 Imaging Biomarkers It is a measurement obtained objectively from medical images which represents and quantifies a tissue property (structural, functional or biological) extracted after applying computational models to images and specific signal processing, resolved in space and time. to measure is to know

8 QUIBIM PRECISION platform

9 ONCOLOGY BONE LUNG Solid tumours, hematology Osteoporosis COPD Diffusion (IVIM, DKI), Pharmacokinetics, Bone Marrow Infiltration, Multi- Parametric Analysis Trabecular morphology, fractal irregularity, anisotropy, mechanical resistance & elasticity Lung & lobes volumes, emphysema percentage, bronchia wall, trachea wall NEURO Alzheimer, ALS, MS, Stroke LIVER Steatohepatitis, fibrosis, hemochromatosis Volumetry, cortical thickness, lesions segmentation, iron quantification, tractography Fat fraction quantification, iron concentration, Diffusion- IVIM

10 IMAGING BIOMARKERS DEVELOPMENT Idea Proof of concept Proof of mechanism Image acquisition Image processing Image analysis Value Measurements Proof of principle Proof of efficacy and effectiveness Structured report Martí-Bonmati L, Alberich-Bayarri A, et al. Imaging biomarkers, quantitative imaging, and bioengineering. Radiologia. 2012;54:

11 IMAGING BIOMARKERS DEVELOPMENT Our stepwise methodology was adopted in 2013 by the European Society of Radiology guidelines ESR statement on the stepwise development of imaging biomarkers. Insights Imaging (2013) 4:

12 SCIENTIFIC EXCELLENCE 1ST IMAGING BIOMARKERS Book Editors: QUIBIM Founders Examines all aspects of the development of imaging biomarkers and their integration into clinical practice

13 TARGET MARKETS QUIBIM Care QUIBIM Pharma Innovative Medical Doctors and Researchers Boost your imaging workflows! CRO s and Biotech Companies Step-up your clinical trials! We act in the full process of imaging biomarkers integration, from the optimization of the images acquisition in the equipments up to the biomarkers report integration into the PACS. We can safely detect and monitor early biological changes in the organs and tissues as a consequence of a given therapy.

14 BUSINESS MODELS Local Cloud Basic license + modules 1 st year yearly manteinance Pay per analysis Customized versions

15 QUIBIM Precision Platform From Images to Data Our Advanced Cloud Platform for centralized image management, storage and quantitative analysis.

16 QUIBIM Precision platform Web application/noninstallation required. Accesible from any computer with internet. Includes Quantitative Analysis Plugins.

17 QUIBIM Precision platform Upload your image studies just with a Drag&Drop action on your DICOM files! Pre-visualization DICOM viewer

18 QUIBIM Precision platform The Platform includes a Cloud DICOM Viewer with ROI & Segmentation tools.

19 QUIBIM Precision platform The platform includes automatic imaging biomarkers tools for different pathologies in: Brain, Musculoskeletal, Oncology, Liver and Lung. DataMiner Module All the raw data and variables are downloadable by the customer in a wide range of formats: XLS, SPSS, CSV, MATLAB

20 STRUCTURED REPORTS Designed in collaboration with K.O.L. s in each specialty Patient data compared to normative data

21 METRICS Analysis Revenue Reached 1000 analysis/month in NOV Analysis Analysis

22 METRICS Analysis per disease area BONE 10% ONCO 5% CUSTOM 2% NEURO 15% Analysis distribution per Business Un it PHARMA 39% CARE 61% Analysis distribution per Platform technol ogy LOCAL 23% LUNG 42% LIVER 25% CLOUD 77%

23 OUR TIMELINE An exciting track record QUIBIM is founded by Angel Alberich- Bayarri and Luis Martí-Bonmatí, K.O.L. s in image processing and radiology First customers 2014 First international customer (US) Development of new algorithms Patent application (lung emphysema) Development of the business model Spin-off company of IIS La Fe LANZADERA acceleration program by Juan Roig 180k Development of the new QUIBIM platforms (MINION & MASTER) Customers retention Marketing & sales strategy QUIBIM Precision platform v1.0 released Booth at ECR New customers Seed round 550k 2017 Growth and consolidation 1.25M SME Instrument ECR & RSNA booth Filed v2.3 CE mark certification Filed v2.3 FDA 510k certification 2018 Partnerships with big players ECR & RSNA booth (Machine Learning SC) Medical Device certified Series A for product improvement and sales

24 QUIBIM Care CUSTOMERS QUIBIM Pharma

25 Ángel Alberich-Bayarri Pedro de Álava Founder & CEO Chief Financial Officer Management OUR TEAM Marketing Encarna Sánchez Bernabé Mª Carmen Rodríguez Katherine Wilisch Ramírez COO Team Coordinator Marketing Manager Rafael Hernández Navarro Development CTO Alfredo Torregrosa Lloret Image Analysis Scientist Alejandro Mañas García Fabio García Castro Full Stack Senior Developer Image Analysis Scientist Belén Fos Guarinos Image Analysis Image Analysis Scientist Irene Mayorga Ruiz Pharma Core Lab services Clinical Trials Coordinator Ana Jiménez Pastor Raúl Yébana Huertas Image Analysis Scientist Image Analysis Technician

26 SCIENTIFIC ADVISORY BOARD

27 QUIBIM SL Polytechnics and University Hospital La Fe Av. Fernando Abril Martorell 106, Torre A, Biopolo La Fe (Valencia, Spain) Headquarters

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