Research Centre for Natural Sciences Hungarian Academy of Sciences Institute of Enzymology

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1 Research Centre for Natural Sciences Hungarian Academy of Sciences Institute of Enzymology Director: László Buday Dávid Szüts Genome Stability Research Group

2 University Campus of Lágymányos BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

3 Goals and objectives for RCNS Doing multi-disciplinary research on natural sciences including biology, chemistry, physics, physiology, psychology and neuroscience Combining basic and applied research Involvement in undergraduate, graduate and postgraduate education Participation in social programs as a knowledge base

4 The Institute of Enzymology within the RCNS 4 institutes Institute of Materials and Environmental Chemistry Institute of Enzymology Institute of Cognitive Neuroscience and Psychology Institute of Organic Chemistry 2 centres of competences (Common Equipment and Technical Core Facility Brain Imaging Centre, e.g. fmri) Staff number: app. 420/140 Number of researchers: app. 290/110 Number of research groups: 45/15 Annual budget : ~7 bn HUF (~22 million EUR)

5 Major topics in the Institute of Enzymology Signaling pathways DNA repair, genome stability Multidrug transporters Bioinformatics Systems biology Structure and function of proteins Cell, stem cell and animal models Genome editing

6 Major topics in the Institute of Enzymology Signaling pathways DNA repair, genome stability Protein structure Multidrug transporters Bioinformatics Membrane biology Systems biology Structure and function of proteins Cell, stem cell and animal models Biology of cancer Genome editing

7 RESEARCH GROUPS IN THE INSTITUTE OF ENZYMOLOGY Lab Head SIGNAL TRANSDUCTION AND FUNCTIONAL GENOMICS RESEARCH GROUP László Buday MG CELL ARCHITECTURE RESEARCH GROUP Ferenc Orosz MEMBRANE PROTEINS RESEARCH GROUP Gergely Szakács MG GENOME STABILITY RESEARCH GROUP Dávid Szüts MG RESEARCH GROUP OF INTRINSICALLY DISORDERED PROTEINS ACTIVE TRANSPORT PROTEINS RESEARCH GROUP Péter Tompa András Váradi LABORATORY OF GENOME METABOLISM AND REPAIR Beáta Vértessy LABORATORY OF STRUCTURAL BIOPHYSICS Péter Gál MEMBRANE PROTEIN BIOINFORMATICS RESEARCH GROUP Gábor Tusnády MG LABORATORY OF MOLECULAR CELL BIOLOGY László Homolya MG BIOMEMBRANE RESEARCH GROUP METABOLIC DRUG-INTERACTIONS RESEARCH GROUP Balázs Sarkadi Katalin Monostory PROTEIN INTERACTION GROUP Attila Reményi MG SYSTEMS BIOLOGY OF REPRODUCTION RESEARCH GROUP Gábor Than MG MG = momentum grant holder ONCOLOGY BIOMARKER RESEARCH GROUP Balázs Győrffy MG

8 Institute of Enzymology in numbers Staff number Researcher number Young scientists below 35 PhD degrees obtained Number of SCI publications Sum of impact factors ,8 318,2 268,0 210,1 241,4 202, Citations Independent citations

9 Genome Stability Research Group (Dávid Szüts) Main research themes Mechanisms of mutagenesis The mutagenic effect of drugs and environmental agents The role of mutagenesis and DNA repair in cancer Bioinformatic tools for mutation detection in whole genome sequences

10 The mutagenic effect of drugs: a survey of common chemotherapeutics A novel mutagenesis assay: whole genome sequencing of cultured cell clones Treatment-dependent mutagenesis Szikriszt al., 2016 Genome Biology

11 The role of mutagenesis and DNA repair in cancer Modelling cancer in cell culture using genetically modified cell lines Increased mutagenesis in BRCA deficient cells Wild type or BRCA mutant Genotype-dependent mutagenesis Zámborszky et al., 2017 Oncogene

12 Bioinformatic tools for mutation detection Primary tumour and several metastases lung primary tumour liver metastasis lymph node metastasis bone metastasis (Collaboration with the Korányi Institute)

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14 Our strategy: extending boundaries Independent and committed research groups Active cooperation in-house, national and international levels Strategic alliances with innovation players Rational and effective development of research infrastructure Identify, attract and integrate research excellence