Trans-omics for a better life Decode Life, Explore the Future, Innovate Better Life

Transcription

1 Trans-omics for a better life Decode Life, Explore the Future, Innovate Better Life

2 History From 1% to World Leading Following HGP With a focus on scientific research in biotechnology, during this period BGI closely followed global genomics research in order to participate in the Human Genome Project. Electrophoresis Cost: $3 billion Data output: ~200 The First Stage BGI was established on September 9, Accompanied with the development of sequencing technology, BGI has formed the BT + IT model to achieve industrial scale output. Capillary sequencing Cost: $0.3 billion Data output: 10 3 The Second Stage Keeping up with the tide of new technological revolution, in 2007 BGI moved its headquarters to Shenzhen and since then have accomplished many milestones. Synthesis sequencing Cost: $3 million Data output: 10 9 ~ Outlook 2014 today BGI s contribution has grown from research collaboration and science technology services to health care services, with the ultimate goal of building a better future for everyone. CG sequencing Cost: $1000 Data output: ~ 10 18

3 Technology Platforms Sequencing Platforms BGI owns 230 sequencers, with a data output capability of ~16T/Day (as of Dec 2014). Platforms include BGI SEQ-100, BGI SEQ-1000, Complete Genomics, Illumina HiSeq 2500, Illumina HiSeq 2000, Illumina Miseq, Ion Proton, Bionano Irys system, ABI3730XL and Genotyping platform. Certifications: ISO9001, ISO14001, OHSAS18001, ISO27001, ISO17025, CAP Mass Spectrometry Platforms BGI has 13 mass spectrometry systems, including Triple Quadrupole Mass Spectrometer (QMS), MALDI mass spectrometer, Orbitrap and Q-TOF mass spectrometer (as of Dec 2014). These systems are used for industrial-scale proteomics, metabolomics research and targeted molecule detection. Certifications: OHSAS18001, ISO14001, ISO9001 Computing Platform BGI s total peak performance of computing is up to 248 Tflop, the total memory capacity is 46.3 TB and the total storage capacity is 22.7 PB (as of May 2014). BGI has several supercomputing centers, located in Shenzhen, Hong Kong, Beijing, Wuhan, and Hangzhou. It has established the TH-BGI Bioinformatics Union Lab with the National Supercomputing Center in Tianjin.

4 Global Presence Headquartered in Shenzhen, BGI has branches and affiliates in over 50 countries. In China, BGI comprises 5 regions (BGI North China, BGI East China, BGI South China, BGI Central China and BGI Northwest China). BGI has three international regions, including BGI Asia, BGI Europe & Africa, and BGI Americas.

5 Organizations BGI Research BGI College China National Genebank GigaScience BGI Tech BGI Dx BGI Agriculture BGI Manufacturing Complete Genomics

6 BGI Research 1007 Published Papers BGI Average Citation: 89/Paper Asia Ranking China Ranking 5 Top 200 Research Institutes in the World 17 Science Nature Cell New Engl J Med Total: 175 papers SCI Collection: 950 papers Citation: 55,299 Global Average Citation: 9.8/Paper China Average Citation: 6.51/Paper 87 updated by December, 2014 Pioneer in Omics Science & Technology NPI index 2013 Develop the high-throughput, low-cost transomics platform Lead technology development Achieve breakthroughs in fundamental research Support the applications of health care and breeding Drive biotech s application growth Assist in the setting up of industrial standard in genomics sequencing. Four areas of research focus: personal genomics, cancer, reproductive health and molecular breeding. Ten Key Laboratories:

7 BGI College >100 Ph.D. Students >140 MSc Students >160 Undergraduate Students Innovative Education and Training Set up the innovative education system for life science, bio-industry and bioeconomy Educate outstanding innovative talents in the field of life science To be a pioneering institution integrated with academic education, professional training and certification Programs include: Joint education in collaboration with many domestic and international universities External training bioinformatics training, medical related training & genetic counselor training Public education popular science education & summer internships BGI South University of Science and Technology of China (SUSTC) and University of Copenhagen (UCPH) collaborate on establishing a specialized college, focus on cultivating talents for the life sciences and bio-industry.

8 China National Genebank Big Resource Big Data The China National Genebank (CNGB) was initiated in 2011 and is the first national genebank in China integrating a largescale bio-repository and an omics database. The mission is to collect, preserve and utilize genomics resources, and to build a network fostering global communication and collaboration on biodiversity conservation and genetic resources utilization. Biological Bank Human samples 1.15 million Plant, Animal and Microbe samples 150,000 Bioinformatics Bank 40+ reference genome database 20PB data storage Peak performance 212T 60+ organization in consortia 40+ collaborative institutions Consortium Network CNGB has preserved thousands of genomes, representing 80% of the finished large genome projects in the world. The total storage capacity is 20 PB and peak computing performance is 212 Tflops. By the end of 2015: Store 30 million copies of traceable biospecimens; Build 1EB accessible genetic information database.

9 GIGA Science Revolutionize Data Publishing GigaScience is a open-access online journal launched on 12 July With a novel scheme integrating normalized full-text articles, information databases and informatics analysis tools. Allows readers to evaluate and verify the results with the data and the analysis tools provided by the literatures. GigaGalaxy offers a novel method for sharing the computing tools and procedures and better supports the repeatability of data analysis. GigaDB supplies Aspera data transmission 100 times faster than FTP. 133 datasets 35TB data

10 BGI Tech Premier Scientific Partner BGI-Tech was founded in Its mission is to facilitate ground-breaking research, foster productive collaboration; and accelerate scientific progress. The service network covers more than 100 countries and regions, including 18 of the top 20 global pharmaceutical companies. 200 bioinformaticians 20 branches and offices 10,000 organizations 30,000 partners Tens of thousands of research projects

11 BGI Tech BGI-Tech offers high quality and state-of-the-art services, expertise and technologies including: Service Solutions Next-generation sequencing Genotyping Proteomics Sanger sequencing Oligo synthesis Bio-cloud computing Customized services Applications Basic Research: Plan and animal Human diseases Evolution Application Research: Drug discovery Agricultural Breeding Microbiology

12 BGI Dx Genetic Diagnostics Excellence BGI Diagnostics aims to apply high genetic research capacity and a well-developed global network to solving current health issues worldwide. Preconception Genetic Testing Newborn Genetic Testing Cancer Genetic Testing It is committed to raising genetic health awareness and reducing the rate of major disease by offering a broad array of accurate, reliable and affordable genetic tests and molecular diagnostics services. Prenatal Genetic Testing Blood Diseases Genetic Testing Pathogenic Microorganism Genetic Testing

13 BGI Dx BGI Laboratories Total area:32,033 m 2 Total running time:67 years and 6 months updated June 2014 BGI owns 28 laboratories around the world, with extensive distribution in Asia, Europe and America. BGI has been certificated by ISO9000, ISO14001, OHSAS18001, ISO/IEC17025, ISO27001, CAP/CLIA, GMP, IVD etc. As of Sep 2014, BGI Diagnostics has formed collaborations with over one thousand hospitals in over fifty countries, and completed testing of 1.72 million samples with an accuracy rate of >99.9%. Clinical laboratories International joint core labs hospitals On June 30, 2014, CFDA approved the registrations of BGI s sequencers BGISEQ-1000, BGISEQ-100 and its diagnostic kits for fetal chromosomal aneuploidy (Trisomy 21, Trisomy 18 and Trisomy 13). These are the first next generation sequencing diagnostic products approved by CFDA.

14 BGI Agro Leader of Genomics Assisted Breeding BGI Agro aims to accelerate the development of a new agricultural industry. It is well equipped with facilities applicable for various molecular breeding needs. Areas of focus include plants, animals, microbes and marine organisms. It has a national key laboratory, a ministerial key laboratory, a provincial key laboratory and four municipal key laboratories. High throughput technical platforms: transgenic platform whole-genome molecular breeding platform animal handmade cloning platform marine organism platform

15 BGI Agro BGI Agro carries out genomics guided plant germplasms development and application, plant variety improvement and modern agriculture industrialization promotion. It has a lab area of over 8000 square meters, over 1200 mu breeding field, well equipped with advanced experimental instruments. BGI-Agro has 4 production bases: Baguang base in Shenzhen, Yangling base in Shanxi province, Huidong base in Guangdong province and Laos base. Baguang Aquatic Base Huidong Experimental Base Laos Agroforestry Demonstration Base Yangling Breeding Base

16 BGI Mfg BGI Manufacturing is focused on the development, production and sales of in vitro diagnostic reagents, medical devices, research reagents and equipment. BGI Manufacturing has set up manufacturing bases in Shenzhen and Wuhan. On 30 June 2014, China Food and Drug Administration (CFDA) approved the registrations of BGI Manufacturing s sequencers BGISEQ-1000 and BGISEQ- 100 and its diagnostic kits for fetal chromosomal aneuploidy.

17 Complete Genomics Accurate Whole Human Genome Sequencing & Analysis Complete Genomics was established in 2006 and is based in Mountain View, California. It is a leader in whole human genome sequencing. Using its proprietary sequencing instruments, chemistry, and software, the company has sequenced more than 20,000 whole human genomes over the past three years. The company s mission is to improve human health by providing researchers and clinicians with the core technology and commercial systems to understand, prevent, diagnose, and treat diseases and conditions. In 2013, Complete Genomics was purchased by BGI.

18 Social Responsibility Public Health Fighting Against SARS Combat Against E.coli Epidemic H7N9 outbreak Disaster Relief DNA identification of Indian Ocean Tsunami Victims Epidemic Surveillance after Wenchuan Earthquake Ya an Earthquake Public Welfare HPV screening for cervical cancer Genetic Birth Defects Project

19 Recognitions 2012 Nature BGI was established in 1999 to support the Human Genome Project. It went from accounting for about 1% of the genomics community s sequencing capacity at that time, to more like 50% today, says George Church, a geneticist at Harvard University in Cambridge, Massachusetts. BGI-Shenzhen has emerged as a genomics superpower. Since its inception in 1999, BGI has focused on developing its sequencing and bioinformatics capabilities while turning to outside teams in crop science, human disease, and microbiology to help define its research objectives. As a result, BGI has become the go-to organization for groups in need of sequencing Science: China's Sequencing Powerhouse Comes of Age 2014 New Yorker: The Gene Factory As the world s scientists focus with increasing intensity on transforming the genetic codes of every living creature into information that can be used to treat and ultimately prevent disease, Shenzhen is home to a different kind of factory: B.G.I., the world s largest genetic-research center...b.g.i. produces at least a quarter of the world s genomic data more than Harvard University, the National Institutes of Health, or any other scientific institution. I m impressed by the achievements BGI made in genetic sequencing, genomics and bioinformatics since its founding I knew a lot of people who dropped out of the university and did technical and business work. But it s my first time to see, in BGI, people dropped out of the university to do basic research and could achieve remarkable success Bill Gates 2013 Boao Forum for Asia Dialogue with Bill Gates: Investment for the poor There are so many examples of great innovative works have been done here. One becoming a partner of our Foundation recently is BGI, the biotechnology institute headquartered in Shenzhen. It s very interesting how they ve gone after very young people and talented people, reminds me of the early days of Microsoft - the great energy, the minds thinking in the new ways all committed to solve the top problems in science.

20 Leadership Founder, Chairman Prof Huanming Yang Founder, President Prof Jian Wang Director, CEO Prof Jun Wang 2012 Elected as a member of the German National Academy of Sciences Listed as Thomson Reuters Highly Cited Researchers Elected as the foreign associates of the National Academy of Science Received the City s Technology Innovation Award Won the innovative prize for the People of the year award Listed as Thomson Reuters Highly Cited Researchers Awarded Nature s 10 of the year in Science by Nature Awarded The Hottest Scientific Researchers of 2012 by Thomson Reuters Ranked No. 8 on Fortune s 40 Under 40 list of the hottest young stars in business Listed as Thomson Reuters Highly Cited Researchers Awarded Cell s 40 under 40 by Cell Listed on CNBC NEXT LIST for the next 25 years.

21 BGI (Headquarters) Tel / Fax Address: Building 11, Beishan Industrial Zone, Yantian District, Shenzhen (518083) Website