Multidisciplinary Cardiovascular Research Centre Commercialisation

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1 Multidisciplinary

2 Multidisciplinary Founded in 2008, Leeds Multidisciplinary (MCRC) is an ambitious strategy for discovering causes and treatments of heart disease. It transcends traditional scientific and departmental boundaries to bring the full weight of the UK s second largest university and the city of Leeds teaching hospitals to bear on the primary reason for premature death and disability in westernized societies. MCRC s mission is to advance understanding of cardiovascular disease and thereby improve human life. It has particular focus on: (1) Revealing mechanisms of vascular disease and associated changes in the myocardium for the generation of therapeutics; (2) Using engineering and other fundamental disciplines to find innovative approaches for cardiovascular diagnosis and protection; and (3) Developing new investigators. Leeds is a city of about 750,000 people, sitting on the southern edge of the Yorkshire Dales countryside. Its oldest university, the University of Leeds, is amongst the largest of the UK s research-led universities, with its main campus in the city centre and joining the General Infirmary - one of the city s two major hospitals.

3 Multidisciplinary Facilities and services available: Human studies Vascular and cardiac disease models Drug discovery using small molecule libraries and in silico design Dedicated 1.5 Tesla large bore and 9.4 Tesla small bore MR scanners. Installation of 3 Tesla scanner anticipated in late Robotic multi-well patch-clamp and other electrophysiological techniques Confocal and electron microscopy Tissue bioreactors Computational simulations Training programmes: Clinical training programmes in vascular surgery and cardiovascular MR Yorkshire Enterprise Fellowship Training Programme CASE PhD Studentships Leeds Ion Channel Workshop Outputs: Patents (e.g. tissue engineering, biomarkers for peripheral arterial disease, novel targets for anticoagulants, novel targets for the prevention of diabetes and cardiovascular disease) Collaboration with industrial partners Sale of tools and reagents (e.g. antibodies and cell-lines) Publications

4 Research Area Details of Projects Researchers involved Cardiac and Vascular Tissue Engineering Ion channels, Ischaemia and Remodelling Patented technology, in collaboration with Tissue Regenix and NHS National Blood & Transplant Tissue services, for production of immunocompatible acellular cardiac valves and arterial conduits. Functional simulation systems (bioreactors) both for the growth/ conditioning of tissue-engineered constructs and for interrogating protein and cell function in health and disease. Magnetic resonance imaging of ischaemia and heart failure methodology development and application in clinical studies. Optical imaging technologies to investigate cardiac electrical activity. Chemical modulation of Transient Receptor Potential (TRP) calcium channels. Ion channel targets in vascular remodelling. Adverse cardiovascular tissue remodelling in disease or as a consequence of sustained systemic hypoxia. Development of protein and gene cardiovascular biomarkers. Professor Eileen Ingham, Dr Sotirios Korossis Dr Sotirios Korossis Dr Sven Plein, Dr John Greenwood, Professor David Buckley Dr Olivier Bernus, Professor Arun Holden Professor David Beech, Dr Lin-Hua Jiang, Professor Asipu Sivaprasadarao, Dr Colin Fishwick Professor David Beech, Dr Karen Porter, Professor Mark Kearney, Dr Ian Wood Professor Chris Peers Professor Alistair Hall Atherothrombosis and Diabetes Endothelial Function Understanding mechanisms of thrombosis to identify potential new targets for antithrombotic agents. Development of therapeutics against novel targets for anticoagulation. Understanding the mechanisms for increased thrombosis risk in diabetes individuals, in order to develop better preventative and treatment strategies. Investigating insulin-like growth factor binding proteins as targets to prevent diabetes and cardiovascular disease. Production of vascular endothelial growth factor, receptors and antibodies as vascular probes in research, diagnostics and therapeutics. Dr Helen Philippou, Dr Robert Ariens, Professor Peter Grant Dr Helen Philippou, Dr Robert Ariens, Professor Peter Grant, Dr Colin Fishwisk Dr Ramzi Ajjan, Dr Helen Philippou, Professor Peter Grant Dr Stephen Wheatcroft, Professor Peter Grant, Professor Mark Kearney Dr Vas Ponnambalam

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7 For further information please contact: Dr Helen Philippou Coordinator The LIGHT Building University of Leeds Leeds LS2 9JT t +44 (0) e cardiovascular@leeds.ac.uk w University of Leeds Leeds LS2 9JT