CURRICULUM VITAE REFAAT E. GABR, PHD. Department of Diagnostic and Interventional Imaging

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1 CURRICULUM VITAE REFAAT E. GABR, PHD Feb 21, 2018 PRESENT TITLE: WORK ADDRESS: Assistant Professor Department of Diagnostic and Interventional Imaging The University of Texas Science Center at Houston 6431 Fannin Street, MSE R102D Houston, Texas UNDERGRADUATE EDUCATION: B.Sc. Biomedical Engineering, 2000 Cairo University Cairo, Egypt GRADUATE EDUCATION: Ph.D. Electrical and Computer Engineering, 2009 The Johns Hopkins University Baltimore, Maryland M.S.E. Electrical and Computer Engineering, 2006 The Johns Hopkins University Baltimore, Maryland M.Sc. Biomedical Engineering, 2003 Cairo University POSTGRADUATE TRAINING: Post-doctoral Fellow ( ) The Johns Hopkins University Baltimore, Maryland ACADEMIC APPOINTMENTS: Assistant Professor (2013-present), Department of Diagnostic and Interventional Radiology, University of Texas Medical School at Houston, Houston, TX. Research in MRI and MR spectroscopy and their application in the study of neurological diseases. Core Director, 3T MRI Center 2016-present. Post-doctoral Fellow ( ), Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD. I conducted research to study metabolism in the cardiac muscle using MRI/MRS methods. Research Assistant ( ), Department of Electrical and Computer Engineering and the Department of Radiology, Johns Hopkins University, Baltimore, MD. My research focused on improved method for saturation transfer MRS to quantify energy metabolism in the heart.

2 Class Assistant (2007), Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD. Participated in teaching the "Medical image analysis" course. Teaching Assistant ( ), Systems and Biomedical Engineering Dept., Cairo University, Giza, Egypt. Research in MRI image reconstruction from arbitrary trajectories. I also participated in teaching multiple undergraduate courses like computer systems, data structures, statistics and stochastic processes, and microprocessors systems. OTHER PROFSSIONAL APPOINTS: Design Engineer (April 2002-July 2004) Engineering Office for Integrated Projects (EOIP), Cairo, Egypt. Research and development in the field of embedded control and communication systems. CERTIFICATIONS: Passed American Board of Medical Physics (ABMP) MRI Scientist Exams Part I and Part II, 2015 PROFESIONAL ORGINIZATIONS: International Society of Magnetic Resonance in Medicine (ISMRM), 2006-present Institute of Electrical and Electronics Engineers (IEEE), 2008-present The international society for optics and photonics (SPIE), 2015 American Association of Physicists in Medicine (AAPM), 2017-present HONORS AND AWARDS: Junior Fellow Award, ISMRM, 2013 ISMRM Travel Award (2006, 2009, 2011) Dean Excellence Award, Cairo University Faculty of Engineering (1995,1996,1997,1998,1999) EDITORIAL POSITIONS: Reviewer, Magnetic Resonance in Medicine Reviewer, Journal of Magnetic Resonance Imaging Reviewer, IEEE Transaction on Biomedical Engineering Reviewer, International Journal of Biomedical Imaging Reviewer, International Journal of Cardiovascular Imaging Reviewer, International Society of Magnetic Resonance in Medicine, Reviewer, Cairo International Biomedical Engineering Conference (CIBEC), 2012 Technical Program Chair, CIBEC, 2014 Medical Imaging Technologies Track Chair, CIBEC, 2016 COMMITTEES: SERVICE ON THE UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON COMMITTEES: Member, Graduate Student Education Committee SERVICE ON PROFESSIONAL COMMITTEES: Member, ISMRM Ad Hoc Committee on Historical Archives, 2017-present

3 MENTORING ACTIVITIES: Sheeba J. Sujit, Postdoctoral Fellow. July present Cameron Williams, Physics undergraduate student, summer research. May-July 2017 Atsushi Hayashi, international medical student summer research (Japan). June-Aug 2015 Alden Bahr, GSBS student summer research, 2015 Adarsh Nednur, University of Texas at Austin, summer research, May-Aug 2016 Getaneh Tefera, Postdoctoral Fellow, Xiaojun Sun, Medical Imaging Programmer, 2014-present PATENTS: System and method of performing magnetic resonance spectroscopic imaging, Application Filed System and method for adaptive and patient-specific magnetic resonance imaging, Application Filed CURRENT GRANT SUPPORT: UL1 TR McPherson, D (PI) 06/01/16 5/31/ calendar months Center for Clinical and Translational Sciences NIH/NCATS Major goals: To develop translational research infrastructure. Direct cost: $2,759,336 Role: 3T MRI Core COMPLETED GRANT: UL1 TR Gabr, R (PI) 01/01/15 08/31/ calendar months Center for Clinical and Translational Sciences/CTSA Patient Adaptive Scanning and Optimization of Magnetic Resonance Imaging. Major goals: Develop patient-adaptive scanning and optimization of MRI. Direct cost $29,000 Role: PI PUBLICATIONS: Refereed Original Articles in Journals 1. Gabr RE, Pednekar AS, Kamali A, Lincoln JA, Nelson FM, Wolinsky JS, et al. Interleaved susceptibility-weighted and FLAIR MRI for imaging lesion-penetrating veins in multiple sclerosis. Magn Reson Med In press. 2. Haque ME, Gabr RE, Zhao X, Hasan KM, Valenzuela A, Narayana PA, et al. Serial quantitative neuroimaging of iron in the intracerebral hemorrhage pig model. J Cereb Blood Flow Metab.2018; In press. 3. Allen WJ, Gabr RERE, Tefera GBGB, Pednekar ASAS, Vaughn MWMW, Narayana PAPA. Platform for Automated Real-Time High Performance Analytics on Medical Image Data. J Biomed Heal Informatics. 2017; In press. 4. Gabr RE, Pednekar AS, Govindarajan KA, Sun X, Riascos RF, Ramirez MG, et al. Patient-specific 3D FLAIR for enhanced visualization of brain white matter lesions in multiple sclerosis. J Magn Reson Imaging. Wiley Online Library; 2017;46(2):

4 5. Keser Z, Hasan KM, Mwangi B, E Gabr R, M Nelson F. Diffusion Tensor Imaging- Defined Sulcal Enlargement Is Related to Cognitive Impairment in Multiple Sclerosis. J Neuroimaging. Wiley Online Library; 2017;27(3): Gabr RERE, Tefera GBGB, Allen WJWJ, Pednekar AAS, Narayana PAPA. GRAPE: a graphical pipeline environment for image analysis in adaptive magnetic resonance imaging. Int J Comput Assist Radiol Surg. 2017;12(3): Keser Z, Hasan KM, Mwangi B, Gabr RE, Steinberg JL, Wilken J, et al. Limbic Pathway Correlates of Cognitive Impairment in Multiple Sclerosis. J Neuroimaging. Wiley Online Library; 2017;27(1): Gabr RE, Hasan KM, Haque ME, Nelson FM, Wolinsky JS, Narayana PA. Optimal combination of FLAIR and T2-weighted MRI for improved lesion contrast in multiple sclerosis. J Magn Reson Imaging Apr;44(5): Gabr RE, Sun X, Pednekar A, Narayana PA. Automated patient-specific optimization of three-dimensional double inversion recovery magnetic resonance imaging. Magn Reson Med. 2016;75(2): Shetty AN, Gabr RE, Rendon DA, Cassady CI, Mehollin-Ray AR, Lee W. Improving spectral quality in fetal brain magnetic resonance spectroscopy using constructive averaging. Prenat Diagn. Wiley Online Library; 2015;35(13): Schär M, Gabr RE, El-Sharkawy A-MM, Steinberg A, Bottomley PA, Weiss RG. Two repetition time saturation transfer (TwiST) with spill-over correction to measure creatine kinase reaction rates in human hearts. J Cardiovasc Magn Reson. Springer; 2015;17(1): Zhang Y, Gabr RE, Zhou J, Weiss RG, Bottomley P a. Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. J Magn Reson [Internet]. 2013;237C: Available from: El-Sharkawy A-MM, Gabr RE, Schär M, Weiss RG, Bottomley PA. Quantification of human high-energy phosphate metabolite concentrations at 3 T with partial volume and sensitivity corrections. NMR Biomed. 2013;26: Zhang Y, Gabr RE, Schär M, Weiss RG, Bottomley PA. Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity. Vol. 218, Journal of Magnetic Resonance p Gabr RE, El-Sharkawy A-MM, Schär M, Weiss RG, Bottomley PA. High-energy phosphate transfer in human muscle: diffusion of phosphocreatine. Am J Physiol Cell Physiol. 2011;301:C Gabr RE, Schär M, Edelstein AD, Kraitchman DL, Bottomley PA, Edelstein WA. MRI dynamic range and its compatibility with signal transmission media. J Magn Reson. 2009;198: Gabr RE, Weiss RG, Bottomley PA. Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy. J Magn Reson. 2008;191: Gabr RE, Ouwerkerk R, Bottomley PA. Quantifying in vivo MR spectra with circles. J Magn Reson. 2006;179: Gabr RE, Aksit P, Bottomley PA, Youssef A-BBM, Kadah YM. Deconvolutioninterpolation gridding (DING): Accurate reconstruction for arbitrary k-space trajectories. Magn Reson Med. 2006;56: Gabr RE, Sathyanarayana S, Schär M, Weiss RG, Bottomley PA. On restoring motion-induced signal loss in single-voxel magnetic resonance spectra. Magn Reson Med. 2006;56:

5 21. Kadah YM, Fahmy AS, Gabr RE, Heberlein K, Hu XP. Progressive magnetic resonance image reconstruction based on iterative solution of a sparse linear system. Int J Biomed Imaging. 2006;2006(ID 49378). Refereed Conference Papers and Abstracts 1. Haque ME, Gabr RE, Zhao X, Hasan KM, Narayana PA, Savitz SI, et al. Quantitative Serial Neuroimaging of Iron in the Intracerebral Hemorrhage Pig Model. In: 17th International Stroke Conference. Houston, TX, USA; Hasan K, Gabr R, Lincoln J, Narayana P. Toward Real Time Estimation and Quality Assurance for Myelin Water Mapping in the Human Central Nervous System. In: International Society of Magnetic Resonance in Medicine (ISMRM). Honolulu, Hawaii, USA; p Haque M, Gabr R, Hasan K, Jeevarajan J, Izygon J, Nghiem D, et al. Serial MRI of Lateral Ventricular Enlargement to Measure Rate of Brain Atrophy in Patients with Ischemic Stroke. In: International Society of Magnetic Resonance in Medicine (ISMRM). Honolulu, HI, USA; p Gabr R, Pednekar A, Govindarajan K, Sun X, Riascos R, Ramírez M, et al. Improving White Matter Lesion Conspicuity in Multiple Sclerosis Using Patient- Specific Optimization of 3D FLAIR. In: International Society of Magnetic Resonance in Medicine (ISMRM). Honolulu, HI, USA; p Allen W, Gabr R, Tefera G, Pednekar A, Liu S, Liu H, et al. Automated Real-Time Quantitative Magnetic Resonance Imaging. In: International Conference on Biomedical and Health Informatics (BHI). Orlando, FL, USA; Gabr R, Tefera G, Allen W, Pednekar A, Narayana P. A Graphical Programming Environment for Creating and Executing Adaptive MRI Protocols. In: International Society of Magnetic Resonance in Medicine (ISMRM). Honolulu, HI, USA; p Gabr RE, Narayana PA. Patient Distraction and Entertainment System for Magnetic Resonance Imaging using Visual Effects Synchronized to the Scanner Acoustic Noise. In: The 13th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications (VISIGRAPP). Rome, Italy; p Gabr RE, Pednekar AS, Narayana PA. Interleaved acquisition of high resolution 3D susceptibility-weighted and FLAIR MRI. In: International Society of Magnetic Resonance in Medicine (ISMRM). Singapoer, Signapore; p Gabr RE, Pednekar AS, Sun X, Narayana PA. A Framework for Precision Magnetic Resonance Imaging: Initial Results. In: IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI). Las Vegas, NV, USA; p Rister B, Reiter D, Zhang H, Volz D, Horowitz M, Gabr RE, et al. Scale- and orientation-invariant keypoints in higher-dimensional data. In: 2015 IEEE International Conference on Image Processing (ICIP) [Internet] p Available from: Shetty AN, Gabr RE, Rendon D, Cassady C, Mehollin Ray A, Lee W. Constructive averaging improves motion-induced signal loss in fetal brain magnetic resonance spectroscopy (MRS). In: Ultrasound in Obstetrics & Gynecology. Montréal, Canada; Gabr RE, Sun X, Pednekar AS, Narayana PA. Optimizing gray-matter white-matter contrast on three-dimensional double inversion recovery MRI using patient-specific inversion times. In: International Society of Magnetic Resonance in Medicine (ISMRM). Toronto, Canada; p

6 13. Gabr RE, Pednekar A, Sun X, Narayana PA. Online brain tissue classification in multiple sclerosis using a scanner-integrated image analysis pipeline. In: International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications. Lisbon; Kalamangalam GP, Gabr RE, Narayana PA. Field Potential Imaging: A New Paradigm for Focal Epilepsy. In: 68th Annual Meeting of the American Epilepsy Society. Society, Seattle, WA, USA; Gabr RE, Narayana PA. Enhanced detection of cortical lesions in multiple sclerosis using magnetization transfer and double inversion recovery. In: International Society of Magnetic Resonance in Medicine (ISMRM). Milan Italy; p Gabr RE, Pednekar AS, Sun X, Narayana PA. Advancing the clinical utility of MRI with online quantitative analysis: application to brain tissue classification in multiple sclerosis. In: International Society of Magnetic Resonance in Medicine (ISMRM). Milan, Italy; p Zhang Y, Gabr RE, Zhou J, Weiss RG, Bottomley PA. Spectroscopy with linear algebraic modeling (SLAM): speed and quantification in brain tumor studies. In: Proceedings of the International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition p Gabr RE, El-Sharkawy AM, Schär M, Weiss RG, Bottomley PA. Noninvasive assessment of cardiac work and CK energy supply in healthy and failing human hearts. In: International Society of Magnetic Resonance in Medicine (ISMRM). Salt Lake City, UT, USA; p Panjrath GS, Schär M, El-Sharkawy A-M, Gabr R, Schulman SP, Gerstenblith G, et al. Skeletal muscle ATP kinetics during exercise in patients with systolic heart failure. Age. 2013;41(11.1): El-Sharkawy A-MM, Gabr RE, Schär M, Weiss RG, Bottomley PA. Human Cardiac 31P Metabolite Concentrations at 3T. In: International Society of Magnetic Resonance in Medicine (ISMRM). Melbourne, Australia; p Zhang Y, Gabr RE, Schär M, Zhu H, Barker P, Weiss RG, et al. Dramatic speedup in 1D-, 2D-and 3D-MRS scan times with linear algebraic modeling (SLAM). In: Proceedings of the International Society for Magnetic Resonance in Medicine Zhang Y, Gabr RE, Schär M, Weiss RG, Bottomley PA. Encoding of pre-selected compartments produces large SNR and speed advantages for 31P MRS. In: Proceedings of the International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition p Gabr RE, El-Sharkawy AM, Schär M, Weiss RG, Bottomley PA. Measuring energy diffusion: phosphocreatine in human skeletal muscle. In: Proceedings of the International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition p Ahmed HM, Gabr RE, Youssef AM, Kadah YM. Optimizing kernel size in generalized auto-calibrating partially parallel acquisition in parallel magnetic resonance imaging. In: Physics [Internet] p Available from: Mohamed H, Gabr RE, Youssef AM, Kadah YM. New Approach for Data Acquisition and Image Reconstruction in Parallel Magnetic Resonance Imaging. In: 26th NATIONAL RADIO SCIENCE CONFERENCE (NRSC2009) p Gabr RE, Ahmed HM, Youssef AM, Kadah YM. A New Method for Data Acquisition and Image Reconstruction in Parallel Magnetic Resonance Imaging. In: International

7 Society of Magnetic Resonance in Medicine (ISMRM). Honolulu, Hawaii, USA; p Ahmed HM, Gabr RE, Kadah YM, Youssef AM. A New Method for Data Acquisition and Image Reconstruction in Parallel Magnetic Resonance Imaging. In: Biomedical Engineering Conference, 2008 CIBEC 2008 Cairo International p Gabr RE, Schar M, Edelstein AD, Bottomley PA, Edelstein WA. MRI Dynamic Range: Theory and Measurement. In: Proceedings of the International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition p Gabr RE, Bottomley PA. Improving the Circle Fitting (CFIT) Performance for MRS Data Quantification. In: ISMRM Workshop on Data Processing for MR Spectroscopy and Imaging. Warrenton, VA, USA; Gabr RE, Ouwerkerk R, Bottomley PA. CFIT: A novel circle-fitting approach to spectral analysis. In: International Society of Magnetic Resonance in Medicine (ISMRM). Seattle, WA, USA; p Gabr RE, Aksit P, Bottomley PA, Youssef AM, Kadak YM. Iterative Deconvolution- Interpolation Gridding. In: International Society of Magnetic Resonance in Medicine (ISMRM). Seattle, WA, USA; p Gabr RE, Schär M, Sathyanarayana S, Weiss RG, Bottomley PA. Predicting SNR gains from constructive averaging of proton spectra: theory and practice. In: International Society of Magnetic Resonance in Medicine (ISMRM). Seattle, WA, USA; p Ahmed H, Gabr R, Heberlein K, Hu X, Kadah Y. New strategy for simultaneous suppression of intra- and inter-slice motion. In: International Society of Magnetic Resonance in Medicine (ISMRM) p Ahmed HM, Gabr RE, Youssef A-BM, Heberlein K, Hu X, Kadah YM. Combined intra-and inter-slice motion artifact suppression in magnetic resonance imaging. In: Medical Imaging p ElSayed R, Youssef T, Badawi A. Localization of Facial Features Using Pulse- Coupled Neural Network and Active Contour. In: IEEE, International Conference on Industrial Electronics, Technology and Automation (IETA) Book Chapters 1. El-Sayed H. Ibrahim, Refaat E. Gabr, MRI Basics In Heart Mechanics: Magnetic Resonance Imaging Mathematical Modeling, Pulse Sequences, and Image Analysis (Volume 1) 1st Edition El-Sayed H. Ibrahim, Refaat E. Gabr, Michael Salerno. Image Acquisition Sequences in Myocardial Tagging In Heart Mechanics Magnetic Resonance Imaging: Advanced Techniques, Clinical Applications, and Future Trends. Other Professional Communications 1. Improving White Matter Lesion Conspicuity in Multiple Sclerosis Using Patient- Specific Optimization of 3D FLAIR,.ISMRM, Honolulu, HI, USA; (Oral Presentation). 2. A Graphical Programming Environment for Creating and Executing Adaptive MRI Protocols, ISMRM, Honolulu, HI, USA; (Poster Presentation) 3. Patient-specific MRI Faculty meeting, Department of Diagnostic and Interventional Imaging, UTHealth, March 24th, 2016 (Oral Presentation). 4. A Framework for Precision Magnetic Resonance Imaging: Initial Results, IEEE Biomedical and Health Informatics (BHI), Las Vegas, NV, 2016 (Oral Presentation).

8 5. "Optimizing gray-matter white-matter contrast on three-dimensional double inversion recovery MRI using patient-specific inversion times", ISMRM 23rd Annual Meeting, Toronto, Canada, (Poster Presentation) 6. "Enhanced detection of cortical lesions in multiple sclerosis using magnetization transfer and double inversion recovery", ISMRM 22nd Annual Meeting, Milan Italy, (Oral Presentation) 7. "Advancing the clinical utility of MRI with online quantitative analysis: application to brain tissue classification in multiple sclerosis", ISMRM 22nd Annual Meeting, Milan, Italy, (Oral Presentation) 8. Noninvasive Assessment of Cardiac Work and CK Energy Supply in Healthy and Failing Human Hearts, ISMRM 21st Annual Meeting, Salt Lake City, UT, USA, (Oral Presentation) 9. Measuring energy diffusion: phosphocreatine in human skeletal muscle, ISMRM 19th Annual Meeting, Montreal, Canada, (Poster Presentation) 10. A New Method for Data Acquisition and Image Reconstruction in Parallel Magnetic Resonance Imaging, ISMRM 17th Annual Meeting, Hawaii, USA, (Poster Presentation) 11. MRI dynamic range: theory and measurement, ISMRM 16th Annual Meeting, Toronto, Canada, (Poster Presentation) 12. Improving the Circle Fitting (CFIT) Performance for MRS Data Quantification, ISMRM Workshop on Data Processing for MR Spectroscopy and Imaging, Warrenton VA, (Poster Presentation) 13. CFIT: A novel circle-fitting approach to spectral analysis, ISMRM 14th Annual Meeting, Seattle, WA, (Poster Presentation) 14. Iterative Deconvolution-Interpolation Gridding, ISMRM 14th Annual Meeting, Seattle, WA, (Poster Presentation) 15. Predicting SNR gains from constructive averaging of proton spectra: theory and practice, ISMRM 14th Annual Meeting, Seattle, WA, (Poster Presentation)