Section 1: Product and Company Identification

Transcription

1 Sectin 1: Prduct and Cmpany Identificatin Prduct Name: Human Cell-Expressed Cytkine Prducts Dcument Number: MSDS11600 Rev.00 Recmmended Use: Research Use Only Effective Date: 2/15/2014 Manufacturer: PBL Bimedical Labratries, Inc. 131 Ethel Rad West Suite 6 Piscataway, NJ USA Tel: ; Facsimile: This MSDS is applicable t the fllwing prducts in accrdance with OSHA CFR and includes prducts exempt frm requiring MSDS fr infrmatinal purpses. Prduct N. Prduct Name Descriptin Human Activin A, HCE Human Activin A, human cell-expressed Human beta NGF, HCE Human BMP-2, HCE Human BMP-4, HCE Human BMP-7, HCE Human beta NGF, human cell-expressed ; Human Nerve Grwth Factr beta Human BMP-2, human cell-expressed ; Human Bne Mrphgenic (Mrphgenetic) Prtein-2 Human BMP-4, human cell-expressed ; Human Bne Mrphgenic (Mrphgenetic) Prtein-4 Human BMP-7, human cell-expressed ; Human Bne Mrphgenic (Mrphgenetic) Prtein Human Cystatin C, HCE Human Cystatin C, human cell-expressed Human Erythrpietin, HCE Human Erythrpietin (EPO), human cell-expressed Human FGF-4, HCE Human FGF-7 (KGF), HCE Human FGF-8b, HCE Human FGF Basic, HCE Human FGF Basic-TS, HCE Human FLT3 Ligand, HCE Human G-CSF, HCE Human GM-CSF, HCE Human FGF-4, human cell-expressed ; Human Fibrblast Grwth Factr-4 Human FGF-7 (KGF), human cell-expressed ; Human Fibrblast Grwth Factr-7; Human Keratincyte Grwth Factr Human FGF-8b, human cell-expressed ; Human Fibrblast Grwth Factr-8b Human FGF Basic, human cell-expressed ; Human Fibrblast Grwth Factr Basic Human FGF Basic-TS, human cell-expressed ; Human Fibrblast Grwth Factr Basic, Thermstable (TS) Human FLT3 Ligand, human cell-expressed ; Human FMS-Like Tyrsine Kinase 3 Ligand Human G-CSF, human cell-expressed ; Human Granulcyte Clny Stimulating Factr Human GM-CSF, human cell-expressed ; Human Granulcyte-Macrphage Clny Stimulating Factr

2 11618 Human HGF, HCE Human Grwth Hrmne, HCE Human Hepatcyte Grwth Factr (HGF), human cellexpressed Human Grwth Hrmne (HGH), human cell-expressed Human Serum Albumin, HCE Human Serum Albumin (HSA), human cell-expressed Human IL-1 beta, HCE Human IL-2, HCE Human IL-3, HCE Human IL-4, HCE Human IL-6, HCE Human IL-7, HCE Human IL-9, HCE Human IL-10, HCE Human IL-12, HCE Human IL-17 (IL-17A), HCE Human IL-17F, HCE Human IL-23, HCE Human IL-27, HCE Human LEFTY-1, HCE Human LEFTY-2, HCE Human M-CSF, HCE Human IL-1 beta, human cell-expressed ; Human Interleukin 1 beta Human IL-2, human cell-expressed ; Human Interleukin 2 Human IL-3, human cell-expressed ; Human Interleukin 3 Human IL-4, human cell-expressed ; Human Interleukin 4 Human IL-6, human cell-expressed ; Human Interleukin 6 Human IL-7, human cell-expressed ; Human Interleukin 7 Human IL-9, human cell-expressed ; Human Interleukin 9 Human IL-10, human cell-expressed ; Human Interleukin 10 Human IL-12, human cell-expressed ; Human Interleukin 12 Human IL-17 (IL-17A), human cell-expressed ; Human Interleukin 17A Human IL-17F, human cell-expressed ; Human Interleukin 17F Human IL-23, human cell-expressed ; Human Interleukin 23 Human IL-27, human cell-expressed ; Human Interleukin 27 Human LEFTY-1, human cell-expressed ; Human Left-Right Determinatin Factr 1 Human LEFTY-2, human cell-expressed ; Human Left-Right Determinatin Factr 2 Human M-CSF, human cell-expressed ; Human Macrphage Clny Stimulating Factr Human Nggin, HCE Human Nggin, human cell-expressed Human Oncstatin M, HCE Human Oncstatin M (OSM), human cell-expressed

3 11645 Human PDGF-AA, HCE Human pr-igf-ii, HCE Human PDGF-AA, human cell-expressed ; Human Platelet-Derived Grwth Factr-AA Human pr-igf-ii, human cell-expressed ; Human pr-insulin-like Grwth Factr II Human Pleitrphin, HCE Human Pleitrphin (PTN), human cell-expressed Human Stem Cell Factr, HCE Human TGF beta 1, HCE Human TGF beta 2, HCE Human TGF beta 3, HCE Human TNF alpha, HCE Human Thrmbpietin, HCE Human VEGF121, HCE Human VEGF165, HCE Human Stem Cell Factr (SCF), human cell-expressed Human TGF beta 1, human cell-expressed ; Human Transfrming Grwth Factr beta 1 Human TGF beta 2, human cell-expressed ; Human Transfrming Grwth Factr beta 2 Human TGF beta 3, human cell-expressed ; Human Transfrming Grwth Factr beta 3 Human TNF alpha, human cell-expressed ; Human Tumr Necrsis Factr alpha Human Thrmbpietin (TPO), human cell-expressed Human VEGF121, human cell-expressed ; Human Vascular Endthelial Grwth Factr 121 Human VEGF165, human cell-expressed ; Human Vascular Endthelial Grwth Factr 165 Sectin 2: Hazards Identificatin Ptential Health Effects: Eye cntact: May cause eye irritatin. Skin cntact: May cause skin irritatin. Inhalatin: N recgnized inhalatin hazard. Ingestin: N recgnized ingestin hazard. HMIS CODE (Health: 0) (Flammability: 0) (Reactivity: 0) NFPA CODE (Health: 0) (Flammability: 0) (Reactivity: 0) Sectin 3: Cmpsitin / Infrmatin n Ingredient This prduct des nt cntain hazardus chemicals at cncentratins f 1% r greater. Additinally, this prduct is nt knwn t cntain carcingens at cncentratins f 0.1% r greater. Symptms: Inhalatin: Lung irritatin r breathing difficulty. Sectin 4: Symptms and First Aid Measures

4 Skin Cntact: Skin irritatin r sensitizatin. Skin inflammatin is characterized by itching, reddening, and ccasinal blistering. Eye Cntact: Eye irritatin. Ingestin: Can cause nausea r vmiting. First Aid Measures: Inhalatin: If inhaled, remve t fresh air. If nt breathing, give artificial respiratin. If breathing is difficult, give xygen and call a physician. Get medical attentin if symptms persist r reappear. Skin Cntact: Immediately wash skin with ample amunts f sap and water. Cver the skin with an emllient. Get medical attentin if irritatin develps. Cld water may be used. Eye Cntact: Check fr and remve any cntact lenses. Immediately flush pen eyes with ample amunts f water fr at least 15 minutes. Cld water may be used. Get immediate medical attentin. Ingestin / Oral expsure: If the persn is cnscius wash muth with water. If swallwed, drink plenty f water. Get immediate medical attentin. Lsen any tight clthing. Sectin 5: Fire Fighting Measures Flammability f Prduct: Nnflammable material. Flash Pints: Nne established. Fire Hazards in presence f Varius Substances: Nt available Fire Fighting Media: Nt applicable nnflammable material. Prtective Clthing (Fire): Nt applicable-nnflammable material Special Remarks n Fire Hazards: Nne Hazardus cmbustin prducts: Nn-determined Autignitin temperature: Nne established Sectin 6: Accidental Release Measures Prcedures f Persnal Precautins: Wear safety glasses, lab cat and glves. Implement apprpriate precautins t minimize direct cntact with skin r eyes and prevent inhalatin f dust. Small Spill and Leak: Use apprpriate tls t put the spilled slid in a waste dispsal cntainer. Ventilate area, finish cleaning the cntaminated surface, and dispse f material accrding t lcal and reginal authrity requirements. Envirnmental Precautins and Clean-up Methds: Put the material int a waste dispsal cntainer. Finish cleaning by spreading water n the cntaminated surface and allw the water t evacuate thrugh the sanitary system. Sectin 7: Handling and Strage Handling: Avid cntact with skin, eyes, and clthing. Avid inhalatin r ingestin. Strage: Keep tightly clsed and refer t the strage temperatures indicated in the prtcl. It is recmmended t use riginal cntainers fr strage. Intended Use: Refer t the prduct data sheet r prtcl supplied fr prper use. If questins arise please cntact inf@pblassaysci.cm Packaging materials: Use riginal cntainers. Expsure Guidelines: Sectin 8: Expsure Cntrls/Persnal Prtectin

5 D nt get in eyes Wash thrughly after handling Engineering Cntrls Safety Shwer and Eye Wash Mechanical exhaust required Persnal Prtective Equipment Bdy: Lab Cat Hands: Glves that cannt be penetrated by chemicals r il Eyes: Safety Glasses (recmmended) Expsure Limits: OSHA PEL- Nt Established ACGIH TLV- Nt Established Sectin 9: Physical and Chemical Prperties Physical State and Appearance: Slid freeze dried pwder. Vapr pressure: N data available Vapr density: N data available Biling pint: N data available Melting pint: N data available Slubility: N data available Specific Gravity (Water=1): N data available Vlatile%: N data available Decmpsitin Temperature: N data available VOC cntent: N data available Viscsity: N data available Dispersin prperties: N data available Odr: N data available Taste: N data available Clr: N data available Sectin 10: Stability and Reactivity Stability and Reactivity: Nn-flammable. Nn-explsive. Cnditins t Avid: Strng xidizing agents. Materials t Avid: Strng xidizing agents. Hazardus Decmpsitin Prducts: Nne determined. Hazardus Plymerizatin: Des nt spntaneusly plymerize. Sectin 11: Txiclgical Infrmatin Eye cntact: May cause eye irritatin. Skin cntact: May cause skin irritatin. Inhalatin: May be harmful if inhaled. May be irritating t mucus membranes. Ingestin: May be harmful if swallwed.

6 T the best f ur knwledge, the chemical, physical and txiclgical prperties have nt been thrughly investigated. Sectin 12: Eclgical Infrmatin Eclgical testing has nt been cnducted n this prduct. Sectin 13: Dispsal Cnsideratins Observe all federal, state, and lcal envirnmental regulatins. service t dispse f this material. Cntact a licensed prfessinal waste dispsal Fr all materials, waste must be dispsed f accrding t federal, state and lcal envirnment cntrl regulatins. Sectin 14: Transprt Infrmatin DOT Prper Shipping Name: Nne The kit is transprted as Nn-Hazardus. IATA Air Transprt: Nn-hazardus fr air transprt. Sectin 15: Regulatry Infrmatin CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR Part 302.4): This prduct is nt reprtable under 40 CFR Part SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR Part 355): This prduct is nt regulated under Sectin 302 f SARA and 40 CFR Part 355. SARA TITLE III SECTIONS 311/312 HAZARDOUS CATEGORIZATION (40 CFR Part 370): This prduct is nt defined as hazardus by OSHA under 29 CFR Part (d). SARA TITLE III SECTION 313 (40 CFR Part 372): This prduct des nt cntain any f the substances n the Txic Chemicals List in 40 CFR Part 372. U.S. INVENTORY (TSCA): Nt listed n inventry. OSHA HAZARD COMMUNICATION STANDARD: nn hazardus WHMIS Cntrlled Prduct Classificatin: this prduct has been classified in accrdance with the hazard criteria f the CPR, and the MSDS cntains all the infrmatin required by the CPR. EC INVENTORY (EINECS/ELINCS): Nt determined. JAPAN INVENTORY (MITI): Nt determined. AUSTRALIA INVENTORY (AICS): Nt determined. KOREA INVENTORY (ECL): Nt determined. CANADA INVENTORY (DSL): Nt determined. PHILIPPINE INVENTORY (PICCS): Nt determined. Regulatry infrmatin n the cmpnents at their supplied cncentratins is nt available. Risk phrases at supplied cncentratins are nt available. Please refer belw fr definitins f applicable risk phrases t pure frm f hazardus cmpnents. Risk Phrases:

7 20 Harmful by inhalatin 21 Harmful in cntact with skin 22 Harmful if swallwed 28 Very txic if swallwed 32 Cntact with acids liberates very txic gas 34 Causes burns 37 Irritating t the respiratry system 43 May cause sensitizatin by skin cntact 50 Very txic t aquatic rganisms 53 May cause lng-term adverse effects in the aquatic envirnment Internatinal regulatins: Japan: Chemical Substances Cntrl Law: Kathn CG/ICP (classificatin: Existing), Sdium Acetate (classificatin: Existing); Bidegradatin and Bicncentratin f Existing Chemical Substances under the Chemical Substances Cntrl Law: Sdium Acetate (listed); Sdium Azide (Chemical Substances Law classificatin: Existing type III mnitring, Industrial Safety and Health Act: MSDS required) Nte: Prduct nt classified accrding t EU regulatins. Fr infrmatin n Hazard Symbl and EC number f pure frm f hazardus cnstituents, refer t sectin 2. Japanese regulatins pertain t pure frms f cmpnents, and nt fr frms at the cncentratins used in the prduct(s). Sectin 16: Other Infrmatin Disclaimer: Fr research use nly. Nt fr drug, husehld r ther uses. Warranty: The abve infrmatin is crrect t the best f ur knwledge. This infrmatin is nt guaranteed t be all inclusive. The user shuld handle all materials with care using the MSDS as a guideline nly. PBL Bimedical Labratries shall nt be held respnsible fr any damage resulting frm handling r frm cntact with the abve prduct.