Curriculum Vitae. Education and Credentials

Transcription

1 Karim Muhammad Raafat 177 Abd El-Salam Aref St., Apt.18, Tharwat, Alexandria, Egypt (C) (C) Curriculum Vitae Education and Credentials Doctor of Philosophy in Pharmaceutical Biology (Magna Cum Laude), March 2010, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), (under the channel system and joint supervision scheme between The German University in Cairo and Johann Wolfgang Goethe-University Frankfurt, Germany). Thesis title: Natural Flavonoids as Inhibitors of Neuronal Glycine Receptors: Isolation, Mechanisms and Synergisms Identified by In Vitro Rapid Kinetic and In Vivo Animal Behavioral Studies. Master of Pharmaceutical Science, February 2008, Thesis Grade (A+), Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC). Thesis title: Marine Organisms as Source of Neuroactive Compounds. Bachelor of Pharmaceutical Science, June 2004, final year (Distinction) & cumulative (Very Good with Honor), Faculty of Pharmacy. Alexandria University.

2 Professional Development Assistant Professor of Pharmacognosy and Medicinal Plants, at the Faculty of Pharmacy, Beirut Arab University (BAU), (November, till now). Lecturer of Pharmacognosy and Medicinal Plants, at the Faculty of Pharmacy, Beirut Arab University (BAU), (September, 2011-November, 2011). Postdoctoral Associate at the Faculty of Pharmacy and Biotechnology, the German University in Cairo (GUC), (March 2010-till now). Assistant Lecturer and Senior Researcher at the German University in Cairo (GUC), (February 2008-March 2010). Visiting Scientist to Johann Wolfgang Goethe-University Frankfurt, Germany (July 2009-September 2009). Teaching Assistant at German University in Cairo (GUC), (September2005- March 2008). Medical Representative at Pfizer Pharma, (July2005-September2005). Medical Representative at AVENTIS Pharma, (April2005-July2005). Hospital Pharmacist (Pharm. D.) at International Cardiac Center (ICC), (February April2005). Teaching Assistant at Misr International University (M.I.U.), (September February 2005). Community Pharmacist at Nahdit Masr Pharmacy, Sidi Gaber, Alexandria. (May- August 2004). Research Accomplichments SCIENTIFIC PAPERS: 1. Karim Raafat, Ulrike Breitinger, Laila Mahran, Nahla Ayoub and Hans-Georg Breitinger Synergistic inhibition of glycinergic transmission in vitro and in vivo by flavonoids and strychnine" Toxicological Sciences, August (2010).

3 2. Karim Raafat, Ulrike Breitinger, Laila Mahran, Nazih Noureldin and Hans- Georg Breitinger Natural and Semisynthetic Marine Terpenoids Derived From Red Sea Sarcophyton glaucum As Modulators of In Vitro and In Vivo Glycinergic Receptors" Toxicological Sciences, under publish. 3. Karim Raafat, Hesham Saleh, Laila Mahran and Hans-Georg Breitinger Flavonoids and Strychnine Synergism to Inhibit Glycine Enhancement of the In Vivo Loss of the Righting Reflex by Alcohol", under publish. 4. Ulrike Breitinger, Karim Raafat and Hans-Georg Breitinger Extracellular glucose stabilizes a high-affinity state of the inhibitory glycine receptor, Journal of Biological Chemistry (JBC), submitted under publish. 5. Karim Raafat, Karim Abbara, Ulrike Breitinger, Mahmoud El-Olemy and Hans- Georg Breitinger Comparative Phytochemical Investigation on Ferula hermonis Root and Shoot: Isolation, Identification, and In Vitro and In Vivo Effects on the Inhibitory Glycine Receptors, Journal of Pharmaceutical Biology, under publish. 6. Karim Raafat, Hassan Jassar, Maha Aboul Ela and Abdalla El-Lakany Novel Glycine Receptor Modulators from a Plant Source: Fingerprinting, Isolation, Synergism and In vivo Behavioral Study" Journal of Phytomedicine, submitted PATENTS 7. Breitinger, H.-G., Raafat, K., Youssef, D., "DY# 77 marine extract as a novel modulator of ligand-gated ion channels under International Patent PUBLICATIONS AND PRESENTATIONS IN SCIENTIFIC CONFERENCES: 8. Ulrike Breitinger, Karim Raafat and Hans-Georg Breitinger. (2012) Ion channels as transmembrane signaling devices- structure, function and modulation Biomembrane Days International Conference, Potsdam-Golm, Germany, September (2012).

4 9. Ulrike Breitinger, Karim Raafat and Hans-Georg Breitinger. (2011) Glucose and related sugars are allosteric potentiators of glycine receptor-mediated signaling Molecular Life Sciences 2011.International Fall Meeting of the German Society for Biochemistry and Molecular Biology, Frankfurt, Germany, September (2011). 10. Breitinger, H.-G., Raafat, K., Abd El Galil, R., Mahran, L., Youssef, D., Breitinger, U. (2010) Novel modulators of ligand-gated ion channels: mechanism-based in vitro and in vivo approaches to identify new drugs targeting the inhibitory glycine receptor. The 7th Forum of European Neuroscience Societies (FENS), Amsterdam, Netherlands, July (2010). 11. Breitinger, H.-G., Raafat, K., Abd El Galil, R., Mahran, L., Youssef, D., Breitinger, U. (2010) Novel modulators of ligand-gated ion channels mechanism-based in vitro and in vivo approaches to identify new drugs targeting the inhibitory glycine receptor. International Conference of Frontiers in Medicinal Chemistry (GDCh), Münster, Germany, March (2010). 12. Karim Raafat, Laila Mahran, Ulrike Breitinger, Nahla Ayoub, Hans-Georg Breitinger (2009) A kinetic approach identifies target sites and synergistic effects of drugs potentiated inhibition of glycine receptor channels by flavonoids and strychnine". International Conference SignaL transmission in health and disease, Aachen, Sept. (2009). 13. Hans-Georg Breitinger, Karim Raafat, Nahla Ayoub, (2009) From function to structure mechanism based approaches for the identification of drug target sites on the inhibitory glycine receptor". Journal of Neurochemistry (2009). 14. Breitinger, H.-G., *, Raafat, K., Abd El Galil, R., Mahran, L., Youssef, D., Breitinger, U. New Agonists and Antagonists for the Inhibitory Glycine Receptor Identified From Marine Extracts and Combinatorial Approaches

5 The 1 st Euro-Mediterranean Conference on Marine Natural Products (EMCMNP-I), 2008, Sharm El-Sheikh, Egypt. (2008). 15. Breitinger, H.-G., *, Raafat, K., Abd El Galil, R., Mahran, L., Becker, C.-M., Youssef, D., Breitinger, U. Combinatorial searches reveal new modulators and suggest a novel mechanism of activation for the inhibitory glycine receptor 6 th Forum of European Neuroscience 2008, Geneva, Switzerland. (2008). 16. Breitinger, H.-G.,*, Raafat, K., Breitinger, U., Youssef, D., Hess, G. P. Mechanism-based characterization of multiple drug-receptor interactions and search of new ion channel modulators. The German Society for Biochemistry and Molecular Biology (GBM), International conference, Hamburg, Germany. (2007). 17. Breitinger, H.-G.,*, Raafat, K., Breitinger, U., Youssef, D., Hess, G. P. Mechanism-based characterization of multiple drug-receptor interactions and search of new ion channel modulators Neuronal signalling mechanisms in health and disease - Annual meeting of the Study group Neurochemistry, Hamburg, Germany (2007). PROFESSIONAL, ORGANIZATIONAL AND EXTRA-CURRICULAR ACTIVITIES: A) Consultant: "BAU Research Centre in Bekaa" in establishment and analysis of medicinal and aromatic plants garden. Beirut, Lebanon. November, B) Attended: "Ethics and Medical Reliability" International Conference and Workshop. The American University in Beirut (AUB). Beirut, Lebanon. October, C) Attended: "The 19 th Congress of Pharmacy". Lebanese Syndicate of Pharmacists. Beirut, Lebanon. October, 2011.

6 D) Organizing: Liquid Chromatography and Pharmaceutical Quality Control (LC- P.QC) Project. This Project aims to bridge the science and practice of Pharmaceutical quality control. Proposal submitted pending approval. E) Organizing: Professional Pharmacist Qualification Project (PPQ Project). This project aims to give pharmacists either freshly graduates or undergraduates an orientation training, through highly professional calibers in the profession of pharmacy. Proposal submitted pending approval. F) Attended: "Professional Teaching, Presentation and Communication Skills" Workshop. The German University in Cairo (GUC). May, G) Attended: "International Conference on Molecular and Clinical Oncology". The German University in Cairo (GUC). February, H) Attended: "Biosafety Laboratory Training" Workshop. The German University in Cairo (GUC). May I) Attended: "BioVision Alexandria 2006" Conference. Bibliotheca Alexandrina. April, J) Attended: "Professional Assessment" Workshop. The German University in Cairo (GUC). October, RESEARCH INTEREST AND EXPERIENCE: Ligand gated ion channelopathies (wild and mutants). Hereditary neuronal diseases. Drug discovery: Following bioactivity directed fractionation of medicinal plants. Isolation and structural elucidation of new natural compounds of promising biological activity applying the conventional method of chromatographic analysis and new techniques of spectroscopy.

7 Isolation and structural elucidation of biologically active polyphenolics and Saponins. Quality control of herbal drugs (HPLC, LC-MS, MS and NMR). Plant and Marine Biotechnology affecting Proliferation and Differentiation of Stem Cells. STATEMENT OF TEACHING Teaching Pharmacognosy, Isolation of Natural Products, Quality control of Phytopharmaceuticals courses for undergraduates of faculty of Pharmacy, Beirut Arab University (BAU) (essential oils, glycosides, tannins, bitter principles, alkaloids, carbohydrates and all naturally occurring products). Teaching Phytochemistry courses for undergraduates of faculty of Pharmacy and Biotechnology, The German University in Cairo (GUC) (essential oils, glycosides, tannins, bitter principles, alkaloids, carbohydrates and all naturally occurring products). Pharmacognosy. Spectroscopy and structural elucidation of naturally occurring compounds. Tissue culture. Quality control. Establishment the practical courses of the following courses at faculty of Pharmacy, Beirut Arab University (BAU): Pharmacognosy I, Pharmacognosy II, Isolation of Natural Products and Quality control of Phytopharmaceuticals. Establishment the practical courses of the following courses at German University in Cairo (GUC): Pharmacognosy II, Phytochemistry I and Phytochemistry II. Teaching Biochemistry courses for undergraduates of faculty of Pharmacy and Biotechnology, The German University in Cairo (GUC). Teaching Introduction to Biotechnology and Biology courses for undergraduates of faculty of Pharmacy, Misr International University (MIU).

8 CO- SUPERVISION Comparative Phytochemical Investigation on Ferula hermonis Root and Shoot: Isolation, Identification and In Vitro and In Vivo Effects on the Inhibitory Glycine Receptors. Karim Abbara, M.Sc. Thesis, Pharmaceutical Biology Department- Pharmacognosy Unit, Faculty of Pharmacy and Biotechnology, The German university in Cairo (GUC). Phytochemical Investigation on Nigella sativa seeds: Isolation, Identification and Effects on the Glycine Receptors. Mayar El-Ganzory, M.Sc. Thesis, Pharmaceutical Biology Department-Pharmacognosy Unit, Faculty of Pharmacy and Biotechnology, The German university in Cairo (GUC). Egyptian Herbal Drugs as Anti-HCV Drug Leads. Mary Soliman, M.Sc. Thesis, Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, The German university in Cairo (GUC). Natural Drugs as HCV-Receptors Inhibitors. Marian William, M.Sc. Thesis, Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, the German university in Cairo (GUC). HCV-Receptors Modulators as Novel HSV Intervention. Michael Raouf, M.Sc. Thesis, Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, the German university in Cairo (GUC). Plant and Marine Biotechnology affecting Proliferation and Differentiation of Stem Cells. Hend Saraya, M.Sc. Thesis, Biotechnology Department, Faculty of Pharmacy and Biotechnology, the German university in Cairo (GUC). Natural and Semisynthetic Anticancer Marine Terpenoids Derived from Red Sea Sarcophyton glaucum controlled drug release system. Mina Youssef, M.Sc. Thesis, Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, the German university in Cairo (GUC). Comparative Phytochemical and Neuropharmacological Investigation of Egyptian and Lebanese Marjoram. Hassan Jassar, M.Sc. Thesis, Pharmacognosy and Medicinal Plants Department, Beirut Arab University (BAU). Isoflavones as a novel lead compound for treatment of osteoporosis. Sara Mohamed M.Sc. Thesis, Pharmaceutical Sciences Department, Beirut Arab University (BAU).

9 Skills COMPUTER SKILLS: MS Office (Word, Excel, PowerPoint), ORIGIN, Chemoffice, Endnote and others. Professional Memberships Executive Supervisor of the Junior Research Team (JRT), Faculty of Pharmacy, Beirut Arab University (BAU). Member of the Students Affair Committee, Faculty of Pharmacy, Beirut Arab University (BAU). Member of the Ethics Committee, Faculty of Pharmacy, Beirut Arab University (BAU). Member of the Graduation Committee, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC). Member of the Professional Development Committee, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC). Member of the Alexandria Scientific Pharmaceutical Students` Association (A.S.P.S.A.), Faculty of Pharmacy, Alexandria University. Member of the Egyptian General Syndicate of Pharmacists. HONORS, AWARDS AND GRANTS Postdoctoral Researcher, Research Grant to Prof. Dr. Hans-Georg Breitinger (HGB) and Dr. Ahmed Ihab, , Science and Technology Development Fund (STDF), Egypt. Awarded GUC/DAAD (German Academic Exchange Service) Ph.D. Channel Scholarship to Johann Wolfgang Goethe-University Frankfurt, Germany (July, 2009). Investigator research grant to HGB, , Deutsche Forschungsgemeinschaft (DFG), Germany. REFERENCES WOULD BE FURNISHED UPON REQUEST