Sectra s view on AI. Knowledge & Passion

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1 Sectra s view on AI Knowledge & Passion

2 Sectra Swedish listed company Market leader in Northern Europé Best in KLAS US PACS 5 years in a row Profitable every year since 1983 Market leader for Radiology PACS in the Netherlands. First company to do both Radiology PACS and Pathology PACS in the same system Sweden is rapidly becoming fully digital in pathology PIE provider in the Netherlands NOW 1993

3 Also world leading in data security One of Europes most renown IT-security companies: NATO and EU TOP SECRET mobile and stationary encryption systems Contract with EU for all European union countries top ministers with secure desktop and mobile phones.

4 Main business areas IT for Cybersecurity IT for medical imaging

5 Cybersecurity customers EU in Brussels and around the world Swedish Security Police and Secret Service NATO Governments Swedish Defence Forces EU Battlegroups Cybersecurity for Critical Infrastructure Missions

6 Synergies

7 Company Profile & Philosophy (if you want to understand a company, begin with the culture)

8 Philosophies 8 Patient outcomes / cost Staff: Knowledge & Passion Integrated diagnostics Sharing & Integration Diagnostics is a part of the hospital Hospitals are part of a country or region Research centric Quality is a good idea! Long term stability

9 Philosophy: The Outcome/Cost equation

10 Population pyramid of Sweden

11 Population pyramid of Italy

12 Population pyramid of Germany

13 Population pyramid of the Netherlands

14 Cost for healthcare per capita

15 What to do? Evolution will not be enough, Revolution is needed! Focus on age related diseases Artificial Intelligence will be key in increasing the productivity of health care

16 Medical imaging Medical systems Growth areas Age related diseases: Neurological Cardiac Cancer Skeletal

17 Leading to Sectra s mission statement in medical Our mission is to increase effectiveness of healthcare, while maintaining or increasing quality in patient care

18 Philosophy: Customers

19 Philosophy Customers Quality is profitable Customer satisfaction is the best marketing you can have, and it has the highest return on investment In addition, it boosts morale and creates flow!

20 Philosophy: Integrated diagnostics

21 Cancer imaging diagnostics Sectra can do all imaging diagnostics in one single system.

22 Sectra pathology users Västernorrland Case Western Reserve Univ. City of Hope cancer center Hartford N. Ireland Cancer Vanguard TMC Remote Värmland Furst Sahlgrenska Umeå Gävle Kuopio Linköping Copenhagen Univ hospital Utrecht MC PIE, national telepathology Pathology North Sydney RCPAQAP

23 Machine Learning

24 AI as business idea 24

25 Gartner hype cycle 2017 Machine Learning/ Deep Learning Artificial General Intelligence

26 AI A new toolbox!

27 Humans and Machines are tighter better than either alone A new toolbox, not a substitute Man + machine = increased efficiency and precision!! Server side for workflow support Client side for decision support

28 There will be many new companies and good solutions: What Sectra does! A vendor-neutral integration interface for Machine Learning In-house research and development!!!

29 Sectra projects Breast CAD integration from icad and ScreenPoint Lung CAD from Aidence Sectra Ki67, Her-2 and PDL-1 for pathology Sectra ML hanging protocols for Radiology Workflow 2016: Automatic vertebra labelling Automatic Nipple detection

30 State of the art radiology LUNA16 challenge ~1,000 CT exams (LIDC) Gold standard: >=3 mm nodules, at least 3 of 4 radiologists Best result: ~90% sensitivity at 1 FP/image CAD has improved a lot with deep learning.

31 State of the art pathology Camelyon challenge 2016 Histology breast cancer lymph nodes Best result: ~85% sensitivity at 1 FP/slide Pathologist with no time constraints: 73% sensitivity

32 High impact publications

33 What it cannot do. What s in the picture vs what s wrong with this picture

34 Medical AI tasks Hard : Find diagnosis/replace physician A lot of but misguided attention Unrealistic for a foreseeable future Soft : Revolutionize partial tasks Automate time-consuming actions Compare outcomes for relevant patient group Detect rare diseases Simplify case flows (stratification, triage)

35 35 Customer satisfaction Outcomes/Cost Enterprise integration Machine learning Cybersecurity

36 The vision going forward Multiscale Diagnostics; Phenotype to Genotype Quality registers MRI analytics Light microscopy DNA sequencing Underlying slide from: University of Tennesee, Biomedical Engineering

37 Thank You

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