Patents List. FileRefNo / CSIRRefNo. Title Inventors Countries Filing Date Application No Grant Date Granted No. S.No PT-135

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1 S.No FileRefNo / CSIRRefNo Patents List Title Inventors Countries Filing Date Application No Grant Date Granted No 1 PT-135 NF-238/97 A Novel Biocatalytic process for the steroeselective synthesis of s-propanolol and their related analogues M Venkateswara Rao 24-Dec /DEL/98 26-Apr PT-165 NF-11/96 An efficient process for the synthesis of 4-aryl amino/alkylamino-4'-dimethyl podophyllo-toxins as potential anticancer agents N L Gayathri 27-Mar /DEL/96 3 PT-174 NF-155/96 A Novel biocatalytic process for the regio-selective preparation of 1,2-Azidoalchols and their related analogues Y Damayanthi M Venkateswara Rao 29-Nov /DEL/96 03-Feb PT NF1996 Synthesis of Epipodo phyllotoxin analogues with promissing anti-cancer activity N L Gayathri 24-Jun /DEL/97 25-Jan PT-185 NF An Improved process for the preparation of amines from azides Y Damayanthi B Lakshmi Narayana B Satyanarayana Reddy 16-Jan /DEL/98 11-Oct PT-198 NF-249/97 A New and Improved process for the preparation of 4'- dimethyl epipodo-phyllotoxin key precursor for the anti cancer drugs such as etoposide and temiposide N Venugopal Rao 24-Oct DEL Jun PT-253 NF-230/99 A Process for the preparation of 1,8-napthalimide linked pyrrolo02,1-c) (1,4) benxodiazepine-5-one, analogues as potential antitumour antibioties B Satyanarayana Reddy 09-Mar /DEL/ PT-253A NF-411/99 A Process for the preparation of 1,8-napthalimide linked pyrrolo(2,1-c) (1,4) benxodiazepine-5-one, analogues as potential antitumour antibioties B Satyanarayana Reddy 09-Mar /DEL/ Nov PT-263 NF-296/99 An Improved Process for the preparation of 4'-Dimethyl epipodo-phyllotoxin key precursor for the anti cancer drugs such as etoposide and teniposide N Laxman G Ramesh 03-Feb /DEL/ Sep PT-264 NF-329/99 Facile and efficient one-pot process for the preparation of 4 beta-substituted epipodophyllotoxins synthesis of DNA topoisomerase II inhibitors (NPF and w-68) N Laxman G Ramesh 03-Feb /DEL/ Nov PT-291 NF-263/2000 A Process for the preparation of new pyrrolo [2,1-C][1,4] benzodiazepines as potential antitumour agents N C Laxman G Ramesh P Ramulu O Srinivas 30-Jan /DEL/ Feb PT-291A NF-51/2001 A Process for the preparation of new pyrrolo [2,1-C][1,4] benzodiazepines as potential antitumour agents N C Laxman G Ramesh P Ramulu O Srinivas 30-Jan Mar /DEL/ Mar PT-296 NF-317/2000 A Process for the synthesis of new podophyllotoxin dimers as potential DNA-topoisomerase II inhibitors E Laxman Md Arifudin 29-Mar /DEL/ Oct

2 G B Ramesh Khanna 22-Dec / Aug PT-297 NF-318/2000 A One-pot Process for the synthesis of new podophyllotoxin dimers as potential anticancer agents E Laxman P S Murali Mohan Reddy 10-Nov /DEL/ Sep Feb /DEL/ Jan PT-300 NF-329/2000 A chemoenzymatic process for the selective preparation of both R & S enantiomers of 3-hydroxy-3-phenyl propane nitrile G B Ramesh Khanna M Venkateswara Rao K V Raghavan 19-Sep Jul Jan /IN01/ Nov-2004 GB Jul /DELNP/04 31-Mar / Aug Mar Aug-2005 GB Mar Nov Aug-2005 EP PT-369 NF-233/2002 New 4 Beta-1"-[2,-(Substituted Benzoyl)Anilino] podophyllotoxin analogues useful as anti cancer agents P S Murali Mohan Reddy Switzerland 28-Mar Feb Nov-2005 /IN02/ Spain 10-Nov Nov Nov Italy 10-Nov PT-370 NF-234/2002 One-Pot Chemoenzymatic process for the preparation of chiral secondary alcohols from carbonyl compounds by in -situ transesterification M S Sandbhor M Venkateswara Rao K Venkata Ramana 28-Mar /DEL/02 12-Jan Sep /DELNP/04 05-Mar Mar / Mar PT NF2002 New Pyrrolo[2,1-c][1,4] benzodiazepines useful as antitumour agents P S Murali Mohan Reddy D Rajasekhar Reddy Russia 28-Oct Mar /Ib03/ Nov Nov Australia Jun Canada Aug

3 Nov Nov Nov Oct /DELNP/04 02-Jul Mar / Apr Jan PT NF2002 New Non-Cross-Linking pyrrollo [2,1-c][1,4] Benzodiazepines useful as potential anti cancer agents G Ramesh O Srinivas P Ramulu Australia Canada Russia 31-Oct Apr Oct Jan-2008 AU CA RU Jan Jan Jan Mar /DEL/03 31-Mar Mar / May Dec-2002 /IB02/ PT NF2002 A Chemoenzymatic process for the stereoselective preparation of both R and S enantiomenrs of 3-Hydroxyx(2-theienyl) propanenitrile G B Ramesh Khanna R Ramu M Venkateswara Rao 16-Jun Jun Jun Apr Apr Jun Apr Jun Apr May /DEL/03 18-Aug PT-418 NF-152/03 New Pyrimidine linked pyrrolo[2,1-c][1,4] benzodiazepines as potential antitumour agents K Laxma Reddy 25-Mar Mar / /IN03/ Jan PT NF2003 Pyrene-Linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids as anti-cancer agents G Ramesh P Ramulu O Srinivas 27-Mar Mar Oct /DEL/03 10/ Mar Oct Jun

4 Canada Sep-2009 CA Mar-2003 /IN03/ Oct Jun Oct Jun Oct Jun Mar DELNP PT-427 NF-333/03 C8-Linked pyrrolo[2,1-c][1,4] Benzodiazepine- Acridone/Acridine Hybrids as anti -tumour agents O Srinivas P Ramulu G Ramesh P Praveen Kumar 30-Mar Jul Jun Dec / /IN03/ Jun Jun Apr GB Mar DELNP Dec / Mar PT-431 NF-435/03 Novel C2-fluoropyrrolo[2,1-c][1,4] benzo diazepine dimers useful as anticancer agents P S Murali Mohan Reddy D Rajasekhar Reddy 31-Dec Jul-2006 /IN03/ Jul-2008 GB Jun Sep Aug /DELNP/05 30-Mar / Oct PT-432 NF-437/03 Subsituted benzimidazoles linked to pyrrolo [2,1-C][1,4] benzodiazepines as anticancer agents P Ramulu O Srinivas 31-Dec Jul-2006 /IN03/ Oct-2008 GB Jun May Jul DEL Feb Jul / Feb PT-456 NF-245/04 New Pyrrolo[2,1-C][1,4] benzodiazepine -anthraquinone conjugates useful as antitumour agents R Ramu G B Ramesh Khanna 30-Jul May-2007 /IN04/ Jun PT-457 New Pyrrlo[2,1-C][1,4] benzodiazepine-nepthalimide conjugates linked through piperazine moiety useful as R Ramu 30-Jun /DEL/04 19-Nov

5 NF-269/04 potential antitumour agents G B Ramesh Khanna 30-Jun / Dec Jun-2004 /IN04/ Sep Aug Oct Dec Sep Aug Aug Sep Aug Aug Sep Aug Aug Apr /DEL/05 15-Oct / Oct PT-458 NF-322/04 A Chemoenzymatic process for the stereoselective preparation of (R)-gama-amino-beta-hydroxybutyric acid [(R)-GABOB] and (R) carnitine G B Ramesh Khanna T Krishnaji R Ramu 29-Nov Nov Nov-2005 /IN05/ Jan Jan Nov Jan Nov Jan Mar /DEL/ Jun Dec / May Dec-2005 /IN05/ PT-471 NF-469/04 An Enantioconvergent chemoenzymatic synthesis of (R)- gamma-amino-beta-hydroxybutyric acid((r)-gabob) G B Ramesh Khanna T Krishnaji R Ramu Switzerland 11-Oct Oct Oct May Apr Apr EP Oct Apr Oct Apr Oct Apr Dec /DEL/05 30-Dec-2005 /IN05/ WO/2007/ PT-481 NF-205/05 Process for production of Brassylic acid from tridecane microbial oxidation G Sheelu N W Fadnavis Canada China 12-Jun Jun Nov-2011 ZL Dec May

6 30-Dec / Feb Nov /DEL/05 21-Sep Mar / Dec PT-483 NF-334/05 Coumarin linked pyrrolo[2,1-c]1[1,4] benzodiazepine hybrids as potential anticancer agents A Hari Babu A Venkata Ramana E Vijaya Bharathi 27-Dec Apr May-2008 /IN05/ May-2009 GB May Dec Feb /DEL/06 09-Oct Feb / Dec PT-484 NF-361/05 New Bis-pyrrolo[2,1-c][1,4] benzodiazepine anthraquinone conjugates useful as potential antitumour agents R Ramu G B Ramesh Khanna 12-Feb Sep Jul-2008 /IB07/ Feb Dec Mar /DEL/06 26-Feb-2007 /IB07/ Mar / Jan PT NF2006 C2-Difluoro pyrrolo[2,1-c][1,4] benzodiazepine dimers D Rajasekhar Reddy Rajender Canada 10-Sep Feb Feb Dec Dec Feb Dec Feb Dec Aug /DEL/06 24-Aug PT-496 NF-141/06 Quinazolinone linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents A V Ramana A Hari Babu 10-Aug Aug Mar-2009 /IN07/ / Oct Oct GB PT-497 NF-143/06 Synthesis and biological evaluation of benzophenone linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anti cancer agents B Rajendra Prasad 08-Aug Aug /DEL/06 11/ May

7 10-Aug-2007 /IN07/00336 Canada 13-Feb Mar Mar Mar Mar Mar May /DEL/07 30-Apr / Jun PT NF2006 New - 4 beta-[4"-(1"-3"-subsituted benzothiazole-2"-yl) anilino podophyllotoxin analogues as antitumour agents B Ashwini Kumar 23-Apr Nov-2009 /IN08/ Sep Apr Nov-2011 GB Mar /DEL/07 13-Mar-2008 /IN08/00143 WO/2008/ Jan / Nov PT-505 NF-227/06 Synthesis and biological evaluation of anthranilic acid hybrids as potential anti cancer agents B Rajendra Prasad 27-Jan Mar Mar Jun Jan Jan Mar Jan Mar Jan Mar /DEL/07 26-Mar-2008 /IN08/00192 WO/2008/ Sep May PT NF2006 Synthesis and biological evaluation of benzophenone hybrids as potential anticancer agents B Rajendra Prasad 30-Sep Oct / Mar Oct Canada 29-Sep Oct Oct Oct Oct

8 15-Oct Oct Feb /DEL/07 39 PT-509 NF-303/06 Novel Benzothiazole and benzoxazole linked pyrrolo [2,1- c][1,4] benzodiazepine hybrids as potential antitumour agents and process for the K Srinivasa Reddy M Naseer Ahmed Khan Rajesh V C R N C Shetti 31-Dec Aug Sep-2009 /IN07/ / Nov Sep GB Aug /DEL/07 16-Jan / Jul Oct-2007 /IN07/ PT NF2007 Pyrrolo [2,1-C][1,4] Benzodiazepine glycoside prodrugs with potential for selective cancer therapy J Venkatesh 01-Feb Feb Nov Feb Feb Feb Feb Feb Mar /DEL/08 03-Mar-2009 /IN2009/ WO/2009/ PT-518 NF-172/07 Novel Napthalimide-benzimidazole hybrids as potential anticancer agents and process for the P Praveen Kumar 31-Jul Sep / Oct Sep Feb-2012 GB Mar /DEL/08 /IN08/ WO/2009/ Sep / Apr PT NF2008 Quinazoline linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the B Rajendra Prasad 03-Sep Jul Jul Jul Jul PT NF2008 Benzophenone-piperazine linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the preparation there of B Rajendra Prasad 26-Mar /DEL/08 /IN08/000714

9 09-Sep Sep Mar /DEL/08 /IN08/ PT NF2008 Chalcone linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the B Rajendra Prasad 01-Oct Sep Oct / Jun Oct Mar /DEL/08 /IN08/ WO/2009/ PT NF2008 Novel benzimidazole linked pyrrolo [2,1-C][1,4] benzodiazepine hybrids as potential anticancer agents and process for the P Praveen Kumar B N Seshadri K Sreekanth 09-Sep Sep Sep / Sep Sep Mar /DEL/08 12-Mar-2009 /IN2009/ WO/2009/ PT NF2008 Novel phenanthrylphenol linked pyrrole [2,1-C][1,4] benzodiazepine hybrids as potential antitumour agents and process for the preparation there of K Sreekanth P Praveen Kumar G Balakishan 10-Sep Oct Oct / Jul Oct Oct Oct Oct Oct Oct Mar /DEL/08 47 PT NF2008 C2-Fluoro subsituted piperazine linked pyrrolo [2,1- C][1,4] benzodiazepine dimers and a process for the Rajender M Kashi Reddy G Balakishan 10-Sep-2010 /IN08/ / Feb Dec-2012 WO/2009/ Dec

10 Dec Dec Mar /DEL/08 /IN08/ WO/2009/ PT NF2008 Isoxazoline linked pyrrolo[2,1-c][1,4] bezodiazepine hybrids as potential anticancer agents and the process for the J Surendranadha Reddy D Dastagiri E Vijaya Bharathi 24-Sep Sep Sep / Feb Feb Feb Sep Feb Sep Feb Nov /DEL/08 13-Jul-2009 /IN2009/ PT NF2008 Quinazolinone linked pyrrolo [2,1-C][1,4] benzodiazepine hybrids as potential anticancer agents and process for the E Vijaya Bharathi D Dastagiri J Surendranadha Reddy A Viswanath 18-May May May May / Jun Jun Jun May Jun Nov /DEL/08 50 PT NF2008 Cinnamide-pyrrolo [2,1-C][1,4] benzodiazepines as potential anticancer agents and process for the G Balakishan G Rama Krishna K Sreekanth Rajender 27-Feb May May-2011 /IN2009/ / WO/2010/ Nov /DEL/08 51 PT NF2008 Synthesis and in vitro anticancer activity of new pyrrolo[2,1-c][1,4] benzodiazepine derivatives with dithiocarbomate side chains and process for the K Sreekanth P Praveen Kumar G Balakishan 24-Mar May May-2011 /IN2009/ / Nov-2013 WO/2010/ PT-533 NF-68/08 Novel 4 beta-polyarylamine podophyllotoxin analogues as potential anticancer agents B Ashwini Kumar P Suresh 07-Nov Mar /DEL/08 /IN2009/ WO/2010/052733

11 04-May / Jan May Jan May Jan May Jan May Jan Nov /DEL/08 53 PT NF2008 Isoxazole/isoxazoline / combretastatin linked dihydroquinazolinone hybrids a potential anticancer agents and process for the E Vijaya Bharathi J Surendranadha Reddy D Dastagiri A Viswanath 08-Aug May May-2011 /IN2009/ / WO/2010/ PT-544 NF-218/08 Microbial process preparation of Acrylic acid from Acrylonitrile G Sheelu M A Azhar M Shivakumar T B Shaik C Ganesh Kumar R K Jain D Prakash 24-Mar /DEL/ Oct /DEL/09 55 PT NF2009 Imidazothiazole-chalcone hybrids as potential anticancer agents and process for the D Dastagiri J Surendranadha Reddy E Vijaya Bharathi A 07-Oct Apr May-2012 /IB2010/ / WO/2011/ PT-555 NF-46/09 Chalcone linked imidazolones as potential anticancer agents and process for the G Rama Krishna G Balakishan P Raju A Viswanath M Bala Krishna 12-Jan Dec Jun Jun /DEL/2010 /IB2010/ / WO/2011/ PT-557 NF-73/09 Synthesis of 4Â -sulphonamido podophyllotoxin congeners as antitumour antibiotics and the process for P Suresh B Ashwini Kumar N Shankaraiah Country2 58 PT NF2009 Carbazole linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the Rajesh V C R N C Shetti K Srinivasa Reddy 22-Mar Dec May /Del/2010 /IB2010/ / WO/2011/117668

12 05-Oct May Oct May Oct May Oct May Mar /Del/ PT NF2009 Pyrrolo[2,1-c][1,4] benzodiazepine conjugates linked through piperazine moiety as potential antitumour agent and process for the Rajesh V C R N C Shetti K Srinivasa Reddy P Swapna 18-Mar Jul Jun-2012 /IN2011/ / WO/2011/ Mar /DEL/82 13-Nov Spain 04-Jan Nov PT NF0000 A PROCESS FOR THE PREPARATION OF O-CARBAMOYL SALICYLATES P B Sattur G Thyagarajan Russia 18-Aug May / Jan Mar PT NF2010 Novel Thiolactomycin based congeners as potential antitubercular agents. Shaik Azeeza Ahmed Ali Shaik M Shaheer Malik Inshad Ali Khan S T Abdullah Sandeep Sharma Anshu Benlah 06-May May Jan Oct /Del/2010 /IB2011/ / WO/2011/ Nov /DEL/ PT NF2010 Synthesis of new 4beeta-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for P Suresh B Ashwini Kumar P Venkat Reddy 09-Mar May Mar-2013 /IN2011/ / PT NF2010 Biological evaluation of 4-aza-2,3- didehydropodophyllotoxin analogues possessing potent antitumour activity P Suresh B Ashwini Kumar P. Venkat Reddy Jaki Rasheed Tamboli 13-Dec Mar Jun Jul /DEL/2010 /IB2011/ / PT Anilino nicotinyl linked 2-amino benzothiazole conjugates as potential anticancer agents, apoptosis Y V V Srikanth 14-Feb /DEL/2011

13 0145NF2010 inducers and the process thereof M N Ahmed Khan M Ashraf I Sehar G Chashoo P R Sharma A Hamid Dar Shashi Bhushan S K Singh D M Mondhe A K Saxena 30-Mar Aug Aug-2013 /IN2011/ / PT-079 A process for the preparation of 1-arylony/1-alfanapthylony -3- (Substituted -2- benzyoylanilino)-2- propanols as analgesic anti-inflammatory & antispasmodic agents. A V Narender Reddy A Bhaskar Rao P V Diwan P B Sattur 06-Dec /DEL/ PT NF2010 Pyrrolo[2,1-c][1,4] benzodiazepine linked imidazo[1,5- a]pyridine conjugates as potential antitumour agents and process for the G Rama Krishna P Raju A V Subba Rao A Viswanath G Balakishan UK 23-Mar Nov Nov-2011 /IB2011/ Jun / Aug PT NF2010 Benzylidineanthracenone linked pyrrolobenzodiazepine hybrids useful as anti cancer agents and the process for P Suresh Rajesh V C R N C Shetti 06-Dec Mar /DEL/ / Nov PT NF2010 Synthesis of new benzothiazole derivatives as potential anti-tubercular agents Rajesh V C R N C Shetti P Swapna Shaik Azeeza Inshad Ali Khan Sheikh Tasduq Abdullah Sandeep Sharma Nitin Pal Kalia A 14-Sep Sep /DEL/ / Feb /DEL/ Mar-2011 /IN2011/ PT NF2010 Amidobenzothiazole analogues useful as potential anticancer agents and process for the P Suresh N Sankara Rao Rajesh V C R N C Shetti 28-Aug Aug / Great Britian

14 02-Feb /DEL/ Aug / PT NF2010 Benzothiazole hybrids useful as potential anticancer agents and process for the P Suresh Rajesh V C R N C Shetti Harish Chandra Pal Ajit Kumar Saxena Great Britian WO 03-Feb-2012 /IN2012/ Aug Feb /DEL/ Aug / PT NF2011 Pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates as potential antitumour agents and process for the J N S C Murty A Viswanath UK 12-Aug May WO 10-Jan-2012 /IN12/ Feb /DEL/ PT NF2011 Diaryl ether linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and process for the A Viswanath J N S C Murty E Vijaya Bharathi G Rama Krishna Farheen Sultana UK 30-Mar Sep Sep Sep-2011 /IB2011/ / Feb /DEL/ Nov / PT NF Phenyl benzothiazole linked imidazole compounds as potential anticancer agents C Ratna Reddy S Prabhakar UK 15-Feb-2012 /IB2012/ Feb PT NF Arylethynyl substituted quinazolinone compounds useful as potential anticancer agents Farheen Sultana E Vijaya Bharathi Y V V Srikanth A Viswanath P Swapna UK 15-Feb Mar Aug May /DEL/2011 /IN2011/ /

15 09-Aug May PT NF2011 A highly enantioselective epoxide hydrolase from achromobacter Rohini Khanna C Ganesh Kumar Anver Basha Shaik M Shivakumar 26-Aug Aug Aug DEL2011 /IN2012/ / Dec DEL PT NF2011 Phenyl nitrofurfuryl linked piperidino-oxadiazolone conjugates as antitubercular agents and process for the preparation there of A Viswanath J N S Chandra Murthy Farheen Sultana G Rama Krishna Inshad Ali Khan Nitin Pal Kalia A UK 18-Dec-2012 /IN2012/ PT-577A 0148NF2011 Benzothiazole compounds and process for the preparation thereof Rajesh V C R N C Shetti Swapna Ponnampalli Shaik Azeeza Malla Reddy A Inshad Ali Khan Sheikh Tasduq Abdullah Sandeep Sharma Nitin Pal Kalia 06-Jan DEL Aug DEL PT NF2013 Synthesis and biological evaluation of pyrazolochalcone derivatives as potential anticancer agents Shaik Anver Basha Bharath Kumar G Santhosh Reddy V C Ganesh Kumar A U K 16-Dec-2013 /IN2013/ Aug DEL2013 A 79 PT NF2013 Synthesis and biological evaluation of 3-(4-ethynyl phenyl) pyrido-pyrimidinone compounds as potential anticancer agents Ranjita Nayak Farheen Sultana Canada U K 15-Oct-2013 /IN2013/ PT NF2013 N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide derivatives as potential anticancer agents and process for the preparation there of N Venkata Subba Reddy B Prasad

16 V Lakshma Nayak V Saida Reddy 81 PT NF Anilinonicotinyl based chalcone and pyrazoline derivatives useful as potential anti cancer agents and process for the preparation there of M Ashraf Shaik Faazil Bagwan Y V V Srikanth S M A Hussaini 04-Oct DEL PT-628 Synthesis and biological evaluation of 3,4,5-trimethoxy styrylarylamino Propenone as potential anticancer agents. Bharath Kumar G Shaik Anver Basha Santhosh Reddy V R Mahesh 83 PT NF2013 Pyrazole linked benzimidazole conjugates as potential cancer agents Shaik Anver Basha Bharath Kumar G Santhosh Reddy V