ZW800-1, Carboxylic Acid

Transcription

1 ZW800-1, Carboxylic Acid Product Finder Information: Category I want to. Checkbox (Select One of the following choices) X Label an antibody, protein, or hydrophilic molecule Perform immunofluorescence or single cell imaging Highlight normal tissues/organs in vivo Highlight tumors in vivo Track cells in vivo, including stem cells Perform 3-D histological reconstruction My emission wavelength of interest is: X 700 nm 800 nm My desired chemistry is: NHS Ester Maleimide Donkey anti-rabbit IgG Donkey anti-mouse IgG Goat anti-mouse IgG Donkey anti-rabbit IgG Donkey anti-mouse IgG Goat anti-mouse IgG My desired biomedical imaging application is: X NIR angiography X Thoracic duct imaging X Ureter mapping Neuroendocrine tumors Breast cancer Primary and metastatic tumors of liver Pricing Information: Package Pricing ($ USD) Price/mg : 1 x 1 mg : 1 mg x : 1 x 10 mg : 10 mg x Curadel Document Number: MKT Page 1 of 7

2 Description: ZW800-1 is the world s first zwitterionic NIR fluorophore, having geometrically-balanced and net-neutral polyionicity. It is engineered with peak emission 800 nm for use with Channel #2 of the FLARE imaging system. Because of this unique chemical structure, ZW800-1 exhibits extremely low non-specific binding and uptake both in vitro and in vivo, and also exhibits 100% renal clearance and elimination from the body into urine after a single intravenous injection. During the elimination process, ZW800-1 highlights the ureters with an extremely high signal-to-background ratio for at least minutes, making image-guided identification or avoidance of the ureters possible. After bolus intravenous injection, ZW800-1, in conjunction with the FLARE imaging system, permits extremely high resolution NIR fluorescence angiography of arteries, capillaries, and veins. Because of its single carboxylic acid and no other reactive groups, ZW800-1 can also be used as a generalpurpose labeling reagent, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation. ZW800-1 is a member of the Ligand-Match family of labeling reagents and can help solubilize poorly soluble molecules. FLARE IMAGING APPLICATIONS NIR angiography, ureter mapping, thoracic duct imaging GENERAL INFORMATION Form Provided Storage Packaging Shelf Life Shipping Disclaimer Lyophilized dry powder Sealed foil package can be stored at room temperature. Opened vials should be stored in a desiccator at RT or lower. 1 x 1 mg, 1 x 10 mg Lyophlized powder is stable for up to 1 year Normal shipping conditions Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use. SELECTED REFERENCES Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Angew Chem Int Ed Engl. 2011; 50: PMID: < Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy. Ashitate Y, Stockdale A, Choi HS, Laurence RG, Frangioni JV. J Surg Res. 2012; 176: PMID: < Curadel Document Number: MKT Page 2 of 7

3 cgmp-compatible preparative scale synthesis of near-infrared fluorophores. Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. Contrast Media Mol Imaging. 2012; 7: PMID: < Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Nat Biotechnol. 2013; 31: PMID: < RELATED PRODUCTS ZW800-1-NHS ZW700-1 Forte ZW700-1 Forte-NHS Ligand Match Sample Kit R1 Chemical CHEMICAL PROPERTIES Chemical Name CAS Number [(E)-2-[(3E)-2-[4-(2-carboxyethyl)phenoxy]-3-{2-[(2E)-3,3- dimethyl-5-sulfonato-1-[3-(trimethylazaniumyl)propyl]-2,3-dihydro- 1H-indol-2-ylidene]ethylidene}cyclohex-1-en-1-yl]ethenyl]-3,3- dimethyl-1-[3-(trimethylazaniumyl)propyl]-3h-indol-1-ium-5- sulfonate trifluoroacetate Chemical Structure (2D/3D) Molecular Weight Log D, ph 7.4 Typical purity absorbance) as trifluoroacetic salt (JChem Calculation) 95% Curadel Document Number: MKT Page 3 of 7

4 PHYSICOCHEMICAL PROPERTIES Ligand-Match Compatibility N/A SOLVENT SOLUBILITY (Saturation Method) PBS, ph mg/ml (31 mm) 100% Serum, ph mg/ml (25.5 mm) DMSO 2.9 mg/ml (2.7 mm) Optical FLARE CHANNEL COMPABILITY Channel #2 ( 800 nm NIR fluorescence) OPTICAL PROPERTIES PBS, PH % SERUM, PH 7.4 DMSO Excitation Max (nm) Emission Max (nm) Stokes Shift (nm) Extinction Coefficient (@ Ex max) 235, , ,000 Quantum Yield (%) Curadel Document Number: MKT Page 4 of 7

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