EuroGenomics: A successful European Partnership

Transcription

1 3ème Congrès de France Génétique Elevage, 16 Janvier 2013 EuroGenomics: A successful European Partnership for Genomic Selection Egbert FEDDERSEN German Holstein Association (DHV) Content 1. What happens before the era of Genomic Selection? 2. Key factors of Genomic Selection 3. EuroGenomics and other International cooperation 4. Some main results and Success 5. Advantage and Conclusion

2 Animal Breeding before the era of genomic selection ect Traditional domestic breeding programs Cooperation between breeding organisations and AI companies (mainly domestically) Key factors Quality of performance recording and phenotypic data the size of the test population and number of test bulls Results of at least progenies European AI companies were strong competitors Research based on national partnerships between industry and scientific groups with common funding Scientific Research Start in 90s: Fundamental research: Genome analysis: Marker selection and QTL detection National partnerships between Industry and scientific groups with common funding AARHUS UNIVERSITY

3 Key factors in genomic selection Quality of performance recording and phenotypic data phenotypic data In the era of genomics phenotype is the king! Coffey, WCGALP Leipzig 2010 Efficient use of the know how and methodology Size of the reference population Key factors Necessity of International cooperation

4 European contact and cooperation In the 90s: Common scientific research between FRA and DEU January 2009: First discussion about a Genomic airbus (Maurice Barbezant) March 2009: Sept. 2009: First meeting with European group Signature of the contract of EuroGenomics EuroGenomics (The Founders) «5E European breeding partners (competitors) )have joined forces in EuroGenomics to further improve results from genomic selection in the Holstein breed.» The need to increase the reference population The will to share scientific collaboration The strategy to be more efficient To concentrate of back office tasks

5 Today: Seven parties nine countries Sept.2009 Full Partner Research partner Netherlands/ Flanders University of Liège Germany and France INRA France DEN - SWE - FIN University it of Aarhus and Nordic Cattle Evaluation (NAV) Sept Spain Oct Poland Genomika Polska INIA Spain Animal Breeding Institute, Balice Holstein testing potential of EuroGenomics - Number of proven bulls and test daughters - Number of proven bulls and test daughters Reents, EAAP Meeting Stavanger 2011

6 Milk recorded Cows Meanwhile highest number of Milk-Recorded Cow in Europe International co-operations North America consortium: USA, CDN, ITA, UKE (Transatlantic-) (HOL, JER) Intergenomics (BSW) AUT, CHE, DEU, FRA, ITA, SLO, USA EuroGenomics (HOL) DEU, DFS, FRA, NLD, ESP, POL IGenoP: (International Genomic Partnership) Several smaller countries under Irish Leadership

7 Reference Populaionof EuroGenomics Exchanges Pedigree Genotypes Performances (via Interbull) 16,000 then 18,300 and now 25,000 Size of the reference population The increase of reliability Goddard & Hayes, Domestic Holsteins

8 Main results obtained since September 2009 (I) Reference population: First exchange with 16,000 bulls (Data from 19.4 Mio cows included): d) DEU / FRA mainly younger bulls ( ) DFS / NLD many older bulls Complete European and all important North American bulls included jointly an excellent structure of the reference population Main results obtained since September 2009 (II) Reference population: Today 25,000 Holstein bulls with progeny daughters => increase today of >12% in reliability Expected and realised gain in reliability

9 Main results obtained since September 2009 (III) Development of imputation know-how : 2009: between two 54K chips (accuracy of 99%) 2010: between 3K and 54K (accuracy of 96-99%) 2011: between 54K and 800K (accuracy of 92-96%) Know-how of the handling of genotype exchanges => routine exchanges Competitive genomic service offer: Through a combined purchase of chips Savings: >3 millions since 2010 Main results obtained since September 2009 (IV) Participation in the development of the new LD - chip (6K) of Illumina Development of a new EuroG10K - chip (February 2012) Strong collaboration within the 1000 bulls genome project

10 gebv validation in Germany (S. Rensing, vit 2012) P r o g e n y RZG - Holstein p r o o f gebv 962 validation bulls: December 2010: no daughter information August 2012: at least a second daughter based proof 4 Years into Genomic Era Is there value in progeny data? Young Bulls Proven Bulls 560 Net Me erit, $ April 2010 August 2012 Genomic Evaluation, mo yr NM$ results for top 100 young and proven bulls from April 2010 Evaluation No change in NM$ formula over this time period For high ranking young bulls, PA & gpa overestimated daughter performance Progeny and performance data continue to add necessary information Source: Marjorie Faust, World Holstein Conference, Nov 2012, Toronto Kanada

11 Strong points and advantage of EuroGenomics Breeders-owned enterprises: Cooperatives => from and for the breeders Providing reliable breeding values => long term breeding vision Joining forces in R&D for innovative solutions in GS and further development => efficiency Cost degression and common technical developments To setup the Golden Standard in Genomic Selection Thank you for your attention! ti Egbert Feddersen, DHV/ Germany: 22

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