Uma rede global sobre a resistência de Aedes aegypti a inseticidas. Ademir J Martins FIOCRUZ

Transcription

1 Uma rede global sobre a resistência de Aedes aegypti a inseticidas Ademir J Martins FIOCRUZ Gramado, 04 de Setembro de 2018

2 Combat insecticide resistance With the support of WHO-TDR and WHO NTD since March 2016 The Worldwide Insecticide resistance Network aims at tracking and combating insecticide resistance in mosquito vectors of arboviruses by: Establishing a global resistance surveillance system for arbovirus vectors, Filling knowledge gaps and identify research priorities on insecticide resistance, Assisting WHO and national authorities in decision-making on insecticide resistance management and deployment of resistancebreaking tools.

3 Pillars of action Foundation WIN positioning within the GVCR GLOBAL VECTOR CONTROL RESPONSE ( ) «Reduce the burden and threat of vector-borne diseases through effective locally adapted sustainable vector control» WIN support the GVCR by putting Insecticide Resistance on the Vector Control agenda. Build/strengthen capacities for vector resistance monitoring & management Conduct/support basic & applied research on vector resistance and resistance breaking tools Develop a global surveillance & warning systems for resistance to guide decisionmaking

4 The WIN members

5 Strategic pillars - 4 key pillar activities: Networking; Expertise; Research; Education & Training - 3 levels of engagement: Lead, Contribute or Support

6 Core activities RESEARCH 1. Contemporary status of insecticide resistance in the major vectors of arboviruses infecting humans 2. Insecticide Resistance Management strategies applicable to mosquito vectors of arboviruses 3. Integrated Aedes Management for the control of Aedes-borne diseases 4. Alternative Strategies for Arbovirus Control

7 Global distribution of Insecticide Resistance Kdr markers Metabolic markers

8 Insecticide Resistance Management Insecticide Resistance Management strategies applicable to mosquito vectors of arboviruses, Chandre, Dusfour, et al - Submitted

9 Insecticide Resistance Management Insecticide Resistance Management strategies applicable to mosquito vectors of arboviruses, Chandre, Dusfour, et al - Submitted

10 Insecticide Resistance Management Insecticide Resistance Management strategies applicable to mosquito vectors of arboviruses, Chandre, Dusfour, et al - Submitted

11 Integrated Aedes Management (IAM) Integrated Aedes Management for the control of Aedes-borne diseases, Roiz, Corbel et al - Submitted

12 Alternative tools for Aedes vector control Alternative Strategies for Arbovirus Control, Achee, Vontas, et al - Submitted

13 Core activities RESEARCH EXPERTISE

14 WIN expertise Inter-lab validation for determination of discriminatory concentrations 24 centers (including 10 WIN partners) Costing assessment of insecticide resistance monitoring at national level Objective Establish and validate DCs for existing and new molecules against mosquito vectors through a multi centre study. Duration August 2017 December 2018 Objective Provide an estimation of costs to fulfil the needs in terms of insecticide resistance testing on mosquitoes at national level. Duration July March 2018 Lab investigation of molecules synergist effects for combating resistance Objective Investigate the synergist effects of new molecules developed by Evergreen Land for combating PYTs resistance in mosquitoes. Duration December 2017 May 2018

15 Core activities RESEARCH NETWORKING EXPERTISE

16 WIN biennial conference WIN international conference The workshop served as a forum: - to identify priorities in vector research; - to provide national authorities with recommendations for the improvement of insecticide resistance management and deployment of alternative vector control tools Save the date! Next WIN conference: Oct 2018 in Singapore -Universities -Research centers -Agencies (Int. & national) -Private companies

17 WIN biennial conference II WIN international conference

18 Core activities RESEARCH NETWORKING EXPERTISE EDUCATION & TRAINING

19 WIN governance Founding members (college A) Academic & public organizations (college B) Not-for Profit associations (college C) International organizations (college D) Commercial companies (college E) General Assembly (GA) Project Office (PO) President (A) Executive secretary Vice president (A) Executive committee (EC) External Advisory Board (EAB) 2 Representatives of college A 2 Representatives of college B 1 Representative of college C 1 observer from college D 1 observer from college E Funding Bodies (FB) Working Groups Working Groups Working Groups Working Groups

20 Key members role & benefits Founding members (college A) Academic & public organizations (college B) Not-for profit organizations (college C) International organizations (college D) Commercial companies (college E) $500 $500 $1000 $1000 $1500 Attends to GA Full voting power at GA Voting power at EC A B C D E A B C A B C Observer at EC D E Eligible to pump prime funding for collaborative research project Contribute to working groups (Research, Expertise, Networking, Training & Education) Fees % reduction for registration and premium access to oral/poster presentation at the WIN biennial conference Receive & contribute to WIN newsletter (view point/news ) Access to WIN annual report and database A B A B C D E A B C D E A B C D E A B C D E

21 USD $ Who has supported the WIN since its creation? WHO-TDR WHO-NTD US CDC Academic partners Industries EU Ministries Others academia Total

22 From a selective network to an expansive network... The WIN is welcoming new partnerships and financial support. Countries willing to contribute WIN current members

23 Thank you for your attention!

24 A política de asuteridade econômica destruiu o nosso Museu Nacional, um dos mais grandiosos templos da Entomologia do Brasil

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26 WIN predictive budget (USD / year) for 2018 This table describes the annual budget requires for WIN through SPONSORSHIP TASKS Activities USD/Year Minimum budget to exist $70,000 Project management Salary Project manager Networking & communication Website Research activities Research activities (pump-prime funding) Minimum budget to conduct activities and ensure leadership $230,000 Conference & meetings Education & Training WIN international Conference Annual executive committee meeting Building countries capacity (training course) Expertise Database depository & management TOTAL

27 Current IRM in Brazil 5,570 municipalities 656 priority DR pyriproxyphen - DD malathion (bottle) - kdr genotyping sentinel municipalities municipalities, covering the whole country/ year