A FULLY INTEGRATED COMPANY

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2 A FULLY INTEGRATED COMPANY RESEARCH Copan laboratories and technical team work in close relation with key opinion leaders and reference laboratories in order to continually improve the currect products performance and standards as well as stimulate the development of novel solutions according to the actual needs of the market. DEVELOPMENT Copan designs and develops anatomic and ergonomic geometries for the realization of new collection tools necessary to optimize the sample recovery both from the human body and from the crime scene environment. TECHNOLOGY Copan team of engineers optimizes the manufacturing process to ensure efficient, reliable, consistent and standardized manufacturing, through automations and custom designed production solutions. DNA-FREE Copan 4N6FLOQSwabs line is certified DNase, RNase-Free and Human DNA-Free, as well as free of any PCR inhibitors. QUALITY Copan is fully dedicated to ensure the compliance with the highest quality standards; in addition to internal QC, external evaluations of the products are done and results published. GMP manufacturing standards and ISO 9001 certification are garantee of Copan quality policy. COPAN S MISSION IS TO CONTINUALLY IMPROVE THE QUALITY OF THE PRE-ANALYTICAL PHASE WITH A QUANTITATIVE APPROACH. Copan, the acronym for COllection and Preservation for ANalysis, is a worldwide leading manufacturer of collection and preservation systems for microbiology and forensic applications. Its innovations in pre-analytics include patented FLOQSwabs, which have been proven to advance the quality and sensitivity of traditional and contemporary analytical assays through improved fluid-dynamics. Commitment to innovation in sample processing led to the development of a dedicated product line for Forensic and Human Identity Applications. Copan is a fully integrated company. All functions - product R&D, design, prototyping, manufacturing, assembling, validation and quality control - are all done in-house. Copan s competence with its internal laboratories: bacteriology, virology and molecular biology and a team of scientists fully dedicated to run extensive quality controls, e.g. DNA-free certification, to verify Copan products compatibility with various analytical methods and directly involved in the development of innovative solutions, provides the guarantee to have an expert and competent partner. Copan QA and R&D laboratories participate yearly to the GEDNAP Proficiency Tests for DNA typing.

3 FLOQ SWABS [ HOW IT WORKS] Patented* FLOQSwabs comprise of a solid molded plastic applicator shaft with a tip that can vary in size and shape, coated with short Nylon fibers that are arranged in perpendicular fashion. FLOQSwabs have no internal absorbent core to disperse and entrap the specimen - as traditional fiber swabs - but the entire sample stays close to the surface for fast and complete elution. Copan FLOQSwabs represent a breakthrough to guarantee that even minute amounts of DNA can be collected and are available for testing. BETTER SAMPLE COLLECTION By simple contact with the swab tip, liquid samples are rapidly absorbed between the the perpendicular fibers thanks to the active absorption capacity and hydraulic capillary properties of the device. Cellular Material is collected easily and efficiently because the brush-like texture of 4N6FLOQSwabs is more effective at dislodging and removing cells. Cells are easily collected between the fibers [ ] Traditional fiber swabs: the sample stays entrapped in the fiber wad FLOQSwabs have no inside: the sample is instantly and entirely released. THE BREAKPOINT A convenient and safe breakpoint is pre-moulded on the swab shaft and allows an easy and smooth breaking of the swab. The breakpoint is designed to be compatible with standard cuvettes (i.e. Eppendorf and other brands). Different and customized breaking points can also be designed on request. DNASE, RNASE-FREE AND HUMAN DNA FREE 4N6FLOQSwabs are free of PCR inhibitors and interference. They are certified DNase, RNase-Free as well as Human DNA-Free. 4N6FLOQSwabs TM PLUS FEATURES Stringent controls and automated manufacturing process Use of only selected and inhibitory-free components Validation of a dedicated EtO treatment Profiling of Copan workers involved in production and quality control ENTIRE SAMPLE RELEASE The entire sample is instantaneously and automatically released when 4N6FLOQSwabs are mixed with assays reagents, placed in buffer solutions or onto solid absorbant substrates, e.g. Copan NUCLEICard. Copan flocked swabs demonstrated a sample release capacity of more than 90% of the collected sample. ng/ul DNA collected and released by each swab type 4N6FLOQSwabs rayon swabs polyester swab HUMAN DNA-FREE DNASE AND RNASE-FREE FREE OF INHIBITORS TO MOLECULAR AMPLIFICATION AND STR ANALYSIS * Worldwide Patent No. WO 2004/086979, European Patent N , Canadian Patent N , Australian Patent N , New Zealand Patent N , Japanese Patent N and Chinese Patent. US Patent Pending. IMPROVED ASSAYS SENSITIVITY, CONSISTENCY, ROBUSTNESS Samples collected using 4N6FLOQSwabs have been shown to improve the sensitivity of various analytical tests. SCIENTIFIC STUDIES Published scientific studies show that Copan FLOQSwabs significantly improve the quantity and quality of samples collected and released into various assay systems.

4 GENETICS TARGETED SAMPLES APPLICATIONS Buccal cells Epithelial cells Saliva Skin Semen Blood Stains Others STR Analysis Human Identity Forensics Genetic DNA-based tests DNA-Paternity Tests DOA (Drugs of Abuse) Others [ HOW TO COLLECT BUCCAL CELLS] Rinse your mouth with water and do not drink coffee or tea for at least 30 minutes before sample collection Insert the swab tip in the mouth and firmly rub the swab 10 times against the cheeks close to the gingival wall. Repeat the same steps on the other side of the mouth. Remove the swab from the mouth and process immediately as per laboratory standard procedures or use transport kit provided. DNASE, RNASE-FREE AND HUMAN DNA FREE RAPID ABSORPTION Sprayed-on Nylon fibers arranged in a uniform perpendicular fashion results in tremendous hydraulics to rapidly absorb the sample and optimize the collection of epithelial cells. SUPERIOR SAMPLE RELEASE Open fiber structure means no sample entrapment as it occurs with traditional fiber swabs, thus leading to Increased Assay Sensitivity. 4N6FLOQSwabs line is proven to elute more than 90% of the original sample rapidly and easily resulting in improved assay sensitivity. [ FORMATS] IN PEEL POUCH 4N6FLOQSwabs with moulded breakpoint is available in a convenient peelpouch format. IN DRY TUBE After collection, the regular size 4N6 FLOQSwabs can be inserted back into the transport tube and sent to the testing laboratory. The plastic tube guarantees the swab integrity and avoids risks of sample contamination during transport. WITH EPPENDORF CUVETTE A regular size 4N6FLOQSwab is packed and sterilized in a peel pouch with a 2ml LoBind Eppendorf cuvette. Product reference: 3520CS01 Product reference: 3508C After collection, insert swab into the cuvette and snap the swab shaft at the moulded breakpoint position Swab Break Point at 20mm, compatible with 2ml LoBind Eppendorf cuvette Discard the applicator shaft and close the cuvette cap Product reference: 3520CA, 3520CF WITH ACTIVE DRYING SYSTEM Copan 4N6FLOQSwabs are available also in a special plain tube with an integrated active drying system: molecular sieve particles contained in the tube stopper actively absorb water molecules and dry out the collected sample. Active Drying System: Ensures the sample drying in the tube and therefore prevents microbial growth. Aluminum Foil Barrier Packaging to ensure molecular sieve drying action is activated upon peel pouch opening only. Product reference: 3500C, 3504C

5 CRIME SCENE FORENSIC FLOQSWABS [ WITH ANTIMICROBIAL ACTION ] [ ANATOMIC AND ERGONOMIC DESIGN ] pg/ul The ability of a sample collection device to prevent or neutralize microbial contamination while preserving nucleic acids integrity is essential: contaminations can affect the genetic analysis and compromise the reliability of the results. Copan has developed a unique and revolutionary product line 4N6FLOQSwabs crime scene, specifically designed for sample procurement of evidence such as: sweat, semen, blood stains, skin and any environmental trace found at the crime scene. ABILITY TO NEUTRALIZE MICROBIAL CONTAMINATION 4N6FLOQSwabs crime scene are specially treated with agents that exert an antimicrobial effect on a wide spectrum of microbes deriving from the environmental contamination of the sample. NO MORE NEED TO DRY OUT THE SAMPLE Thanks to 4N6FLOQSwabs crime scene strong antimicrobial action, the sample can be transferred into a transport tube or vial, without any need to dry out the sample. DNA collected will be maintained stable also in humid conditions. COMPATIBILITY WITH DIFFERENT DNA EXTRACTION METHODS 4N6FLOQSwabs crime scene have been validated with numerous DNA extraction methods and complete profiles were obtained by sequencing the DNA extracted. OPTIMIZATION OF DNA PRESERVATION IN CRITICAL ENVIRONMENTAL CONDITIONS 4N6FLOQSwabs crime scene, preserve DNA integrity also after 7 days storage at 37 C in heavily contaminated environment. PROFILED WORKERS ONLY ARE INVOLVED IN 4N6FLOQSWABS CRIME SCENE PRODUCTION 600,00 500,00 400,00 300,00 200,00 100,00 0,00 HUMAN DNA PRESERVATION AT 37 C T=0 time 36 h time 3 days time 7 days 4N6FLOQSwabs crime scene rayon swab 4N6FLOQSwabs with Active Drying System REGULAR, ANATOMICALLY AND ERGONOMICALLY SHAPED COLLECTION DEVICES ALLOW TO COLLECT SAMPLES FROM CHALLENGING SURFACES AND IN SITUATIONS WITH LCN (LOW COPY NUMBER) DNA. 4N6FLOQSwabs crime scene are available with anatomic and ergonomic geometries in order to ensure the maximum amount of sample can be collected also from the most challenging surfaces. A complete range of special geometries is available for collection from: subungual (under nails),bottle or cap borders, dip corners, flat surfaces or regular size swabs for multi-use. 100% SAMPLE COLLECTION [ AND RELEASE ] 4N6FLOQSwabs crime scene rapidly absorbs traces even where the amount of sample is limited. The superior release of the 4N6 line compared to traditional fiber swabs becomes critical when the sample is limited (LCN). By recovering over 90% of the evidence using Copan unique 4N6FLOQSwabs, assay sensitivity increases and DNA recovery is maximized. DNASE, RNASE-FREE AND HUMAN DNA FREE FORENSICS FORENSICS FORENSICS FORENSICS FORENSICS

6 NAO BASKET [ NUCLEIC ACID OPTIMIZER] The Nucleic Acid Optimizer is a special plastic filter basket that allows fast and complete recovery of nucleic acids from swab samples, card punches or other specimens into the sample tube. NAO basket is designed with a grid bottom that allows passage of all eluted DNA sample from the collection device (i.e. swab) during the high speed centrifugation step, while guaranteeing the perfect tightness of the system during vortexing. NAO TM PLUS FEATURES DNASE, RNASE-FREE AND HUMAN DNA FREE 60% increased recovery of DNA from the specimen Ability to release all DNA from the swab after high speed centrifugation Perfect tightness of the system during vortexing: demonstrated ability to retain different types of liquid after several vortexing times and storage conditions. Significantly reduced manipulation of the sample: less labor intensive processing and risks of contamination. Compatibility and performance with commercial nucleic extraction platforms NAO basket in conjunction with 4N6FLOQSwabs is a fast and highly efficient system for recovering LCN of DNA from samples for crime scene investigation. + 60% DNA RECOVERY Laboratory tests show that a 60% increased recovery of nucleic acids can be achieved by processing the sample with NAO basket in comparison with standard procedures. DNA recovered (pg/ul) test n.1 with NAO 469,68 with NAO 337,31 without NAO 257,92 without NAO 279,09 test n.2 with NAO 283,27 with NAO 260,6 without NAO 175,32 without NAO 155,05 test n.3 with NAO 934,16 with NAO 794,38 without NAO 578,63 without NAO 382,48 Average (pg/ul) 403,5 268,51 271,94 165,19 864,27 480,56 [ HOW IT WORKS] [ 1] [ 2] NAO basket is placed inside the microtube. After collection, break the 4N6FLOQSwab at breakpoint into the NAO basket. [ 1] NAO basket grid bottom allows passage of all eluted DNA during centrifugation. 2 [ ] [ 3] [ 4] Fill the basket with lysis buffer. Close the cap of the cuvette, vortex and incubate as per kit instructions. Once the incubation step is completed, centrifuge at high speed for at least 1 minute. Note: Centrifugation must be used. Vortexing does not allow the specimen elution from the basket. Remove the swab and NAO basket from the microtube and proceed with the extraction. [ 3] [ 4] Watch a demonstration video by linking at:

7 ORDERING INFORMATION SAMPLE PRODUCT DESCRIPTION BREAK POINT DISTANCE* (from tip end) PRODUCT CODE PACKAGING Buccal cells Saliva Blood Stains Semen Skin Environmental Samples Others In peelpouch In plain tube plus 2ml Eppendorf Cuvette in peelpouch plus 2ml Eppendorf Cuvette with evaporation duct In peelpouch 4N6FLOQSwabs Buccal shape tip In plastic tube with Active Drying System 20mm 3520CS01 10x100pcs 20mm 3508C 10x100pcs 20mm 3520CA 6x100 pcs 20mm 3520CF 6x100pcs N/A 3500C 6x50pcs DNASE, RNASEFREE AND HUMAN DNA-FREE CERTIFIED In plastic tube with Active Drying System 20mm 3504C 6x50pcs crime scene 4N6FLOQSwabs Regular mini head tip in plain tube 20mm 3507C 10x100pcs Evidence samples i.g.: sweat, semen, blood, blood stains, skin, etc Environmental trace evidence Not for Use on Living Humans 4N6FLOQSwabs Scalpel Shape tip In plain tube 4N6FLOQSwabs Mini Shape tip in tube with Active Drying System 4N6FLOQSwabs Flat Surfaces in tube with Active Drying System 20mm 3506C 10x100pcs 20mm 3501C 6x50 pcs 20mm 3502C 6x50pcs Undernails/ Subungual collection 4N6FLOQSwabs Subungual Shape in tube with Active Drying System 20mm 3503C 6x100pcs Bottle Collar / Steering Wheel Collection 4N6FLOQSwabs Round Shape in tube with Active Drying System 20mm 3505C 6x100pcs NAO BASKET Nucleic Acid Optimizer Basket N/A NAO Basket N/A 3002C 5x50pcs N/A Buccal cells, Saliva Blood Stains, Environmental, Others * Additional breakpoint distances may be available. NAO Basket + 2ml Eppendorf Cuvette In peelpouch NAO Basket + 2ml Eppendorf Cuvette + 4N6FLOQSwabs Regular Size, in peelpouch N/A 3002CS01 6x100pcs 20mm 3003CS01 6x100pcs Besides the general product listing, Copan offers a variety of customization [ CUSTOMIZED SOLUTION ] and engineering services in order to manage identification, chain-of-custody, traceability and packaging specific requirements. CUSTOMIZED COLLECTION KITS Upon request and according to the customer requirements, sample collection kits can be customised and assembled to include all components required for sample collection, preservation, transport, identification and traceability. Collection kits for buccal DNA collection and crime scene sample procurement can be designed, projected and realized with a choice of multiple configurations in terms of: Packaging solutions Components to be included in the kit, such as: 4N6FLOQSwabs, gloves, mask, envelope, tamper proof evidence tape, barcode labels, sterile water vials, instructions for use, etc Labelling Barcoding CHAIN-OF CUSTODY AND TRACEABILITY 4N6FLOQSwabs and/or collection kits can be univocally identified with customized labelling and barcoding that guarantee the most secure and effective way to trace the product and ensure chain-ofcustody control. Copan can implement different technologies for products identification and tracking with uniquely assigned sequential barcodes, bi-dimensional barcodes or RFID tags.

8 COPAN FLOCK TECHNOLOGIES Via Perotti 16/ Brescia, Italy Tel: Fax: KC07A R