THE CHINESE MARKET FOR DNA SEQUENCING

Transcription

1 THE CHINESE MARKET FOR DNA SEQUENCING BIO152A September 2016 Jason Chen Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 2 SCOPE OF REPORT 2 INTENDED AUDIENCE 3 METHODOLOGY 3 INFORMATION SOURCES 3 ANALYSTS' CREDENTIALS 3 RELATED BCC RESEARCH REPORTS 4 BCC RESEARCH WEBSITE 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 SUMMARY TABLE CHINESE SEQUENCING MARKET, BY PRODUCT TYPE, THROUGH SUMMARY FIGURE CHINESE SEQUENCING MARKET, BY PRODUCT TYPE, ($ LARGEST AND FASTEST-GROWING MARKETS 7 REGULATIONS AND TARGETS 8 PRECISION MEDICINE 8 END OF ONE-CHILD POLICY 8 NIPT APPROVAL CHAPTER 3 CHINESE SEQUENCING MARKET 10 TABLE 1 CHINESE SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH 2021 ($ FIGURE 1 CHINESE SEQUENCING MARKET, BY MAJOR SEGMENT, ($ GENERAL OVERVIEW 12 INDUSTRY DETAILS 12 BRIEF HISTORY 12 REGIONS 13 TABLE 2 CHINESE SEQUENCING MARKET, BY REGION, 13 TABLE 3 SEQUENCING COMPANIES IN CHINA, BY REGION, JULY 2016 (NUMBER) 14 DRIVING FORCES 14 BREAKDOWN OF THE CHINESE SEQUENCING MARKET 16 FIGURE 2 BREAKDOWN OF THE CHINESE SEQUENCING MARKET 16 PRE- AND POST-SEQUENCING PRODUCTS 17 TABLE 4 CHINESE PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, SEQUENCING SAMPLE PREP MARKET BY APPLICATION 17 TABLE 5 CHINESE SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, SEQUENCING INFORMATICS BY SOFTWARE FUNCTION 19 TABLE 6 CHINESE SEQUENCING INFORMATICS MARKET, BY FUNCTION, THROUGH SEQUENCING INSTRUMENTS AND CONSUMABLES

3 TABLE 7 NGS SEQUENCERS IN CHINA, BY REGION, JULY 2016 (NUMBER) 21 SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET BY PRODUCT TYPE TABLE 8 CHINESE SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, Sequencing Instruments 22 TABLE 9 NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES IN CHINA 24 TABLE 10 COMPARISON OF BGISEQ 500 AND NEXTSEQ Consumables 26 SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM 26 TABLE 11 CHINESE SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, SEQUENCING INSTRUMENTS AND CONSUMABLES BY INSTRUMENT CLASS 28 TABLE 12 CHINESE SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, SEQUENCING SERVICES MARKET 29 TABLE 13 CHINESE SEQUENCING SERVICES MARKET, BY END-USER MARKET, CLINICAL SEQUENCING SERVICE MARKET 31 TABLE 14 CLINICAL DIAGNOSIS CASES BY REGION, 2015 (MILLION CASES/%) 32 Clinical Sequencing Service Market by Indication 33 TABLE 15 CHINESE CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, Clinical Oncology Sequencing Service Market 34 Clinical Oncology Sequencing Service Market by Indication 34 TABLE 16 CHINESE CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 17 CANCER CASES IN CHINA, BY INDICATION, 2015 (THOUSANDS/%) 36 TABLE 18 CANCER CASES IN CHINA, BY REGION, 2015 (THOUSANDS/%) 38 Clinical Oncology Sequencing Service Market by Test Purpose TABLE 19 CHINESE CLINICAL NGS CANCER TEST MARKET, BY TEST PURPOSE, Clinical Oncology Sequencing Service Market by Test Complexity TABLE 20 CHINESE CLINICAL CANCER MARKET, BY TEST COMPLEXITY, THROUGH Clinical Reproductive Health Sequencing Service Market 41 Clinical Reproductive Health Sequencing Service Market by Indication TABLE 21 CHINESE CLINICAL REPRODUCTIVE HEALTH MARKET, BY APPLICATION, TABLE 22 NUMBER OF BIRTHS IN CHINA, BY REGION, 2015 (THOUSANDS) 42 NIPT 44 TABLE 23 CHINESE NGS NIPT INDUSTRY 45 TABLE 24 MEDICAL BODIES APPROVED FOR NIPT IN CHINA, 2015 AND 2016 (NO.) 46 TABLE 25 CHINESE NIPT MARKET, BY RISK TYPE, 47 IVF Market 47 TABLE 26 NUMBER OF ART CENTERS IN CHINA, BY REGION, 2015 (THOUSANDS) 48 Newborn Screening Market

4 Carrier Screening Market 49 Clinical Reproductive Health Sequencing Service Market by Complexity TABLE 27 CHINESE REPRODUCTIVE HEALTH SEQUENCING MARKET, BY TEST COMPLEXITY, Clinical Transplant Sequencing Service Market 50 Clinical Transplant Sequencing Service Market by Analysis Purpose TABLE 28 CHINESE TRANSPLANT MARKET, BY ANALYSIS PURPOSE, THROUGH 2021 ($ TABLE 29 TRANSPLANT CASES IN CHINA, BY ORGAN TYPE, 2015 AND 2016 (NO.) 51 TABLE 30 CHINESE TRANSPLANT MONITORING MARKET, BY ORGAN TYPE, Clinical Sequencing Service Market by Test Complexity 52 TABLE 31 CHINESE CLINICAL SEQUENCING SERVICE MARKET, BY TEST COMPLEXITY, Clinical Sequencing Service Market by Test Purpose 53 TABLE 32 CHINESE CLINICAL SEQUENCING MARKET, BY TEST PURPOSE, THROUGH Applied Sequencing Services Market 54 TABLE 33 CHINESE APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, Agriculture Sequencing 54 Consumer Sequencing 55 Forensics Sequencing 55 Microbiology Sequencing 55 SEQUENCING SERVICE MARKET BY GENOME TYPE 55 TABLE 34 CHINESE SEQUENCING SERVICES MARKET, BY GENOME TYPE, THROUGH CHAPTER 4 GUANGDONG SEQUENCING MARKET 58 TABLE 35 GUANGDONG SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH FIGURE 3 GUANGDONG SEQUENCING MARKET, BY MAJOR SEGMENT, ($ GENERAL OVERVIEW 60 INDUSTRY DETAILS 60 DRIVING FORCES 60 TABLE 36 GUANGDONG SEQUENCING MARKET, BY CITY, THROUGH 2021 ($ PRE- AND POST-SEQUENCING PRODUCTS 62 TABLE 37 GUANGDONG PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, SEQUENCING SAMPLE PREP MARKET BY APPLICATION 63 TABLE 38 GUANGDONG SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, SEQUENCING INFORMATICS BY SOFTWARE FUNCTION 64 TABLE 39 GUANGDONG SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, SEQUENCING INSTRUMENTS AND CONSUMABLES

5 SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET BY PRODUCT TYPE TABLE 40 GUANGDONG SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM 66 TABLE 41 GUANGDONG SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, SEQUENCING INSTRUMENTS AND CONSUMABLES BY INSTRUMENT CLASS 67 TABLE 42 GUANGDONG SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, SEQUENCING SERVICES MARKET 68 TABLE 43 GUANGDONG SEQUENCING SERVICES MARKET, BY END-USER MARKET, CLINICAL SEQUENCING SERVICE MARKET 69 Clinical Sequencing Service Market by Indication 69 TABLE 44 GUANGDONG CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, Clinical Oncology Sequencing Service Market 70 TABLE 45 GUANGDONG CLINICAL CANCER MARKET, BY INDICATION, THROUGH TABLE 46 CANCER LIQUID BIOPSY SEQUENCING COMPANIES IN GUANGDONG, Clinical Reproductive Health Sequencing Service Market 71 Clinical Reproductive Health Sequencing Service Market by Indication TABLE 47 GUANGDONG REPRODUCTIVE HEALTH MARKET, BY APPLICATION, NIPT 72 TABLE 48 HOSPITALS AND COMPANIES APPROVED FOR NIPT IN GUANGDONG 73 TABLE 49 GUANGDONG NIPT MARKET, BY RISK TYPE, 74 IVF 74 Newborn Screening Market 74 Carrier Screening Market 75 APPLIED SEQUENCING SERVICES MARKET 75 TABLE 50 GUANGDONG APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, Agriculture Sequencing 76 Consumer Sequencing 76 Forensics Sequencing 76 Microbiology Sequencing CHAPTER 5 BEIJING SEQUENCING MARKET 79 TABLE 51 BEIJING SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH 2021 ($ FIGURE 4 BEIJING SEQUENCING MARKET, BY MAJOR SEGMENT, ($ GENERAL OVERVIEW 81 INDUSTRY DETAILS 81 DRIVING FORCES 81 PRE- AND POST-SEQUENCING PRODUCTS

6 TABLE 52 BEIJING PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, SEQUENCING SAMPLE PREP MARKET BY APPLICATION 83 TABLE 53 BEIJING SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, SEQUENCING INFORMATICS BY SOFTWARE FUNCTION 84 TABLE 54 BEIJING SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, SEQUENCING INSTRUMENTS AND CONSUMABLES 84 SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET BY PRODUCT TYPE TABLE 55 BEIJING SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM 86 TABLE 56 BEIJING SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, THROUGH SEQUENCING INSTRUMENTS AND CONSUMABLES BY INSTRUMENT CLASS 87 TABLE 57 BEIJING SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, SEQUENCING SERVICES MARKET 88 TABLE 58 BEIJING SEQUENCING SERVICES MARKET, BY END-USER MARKET, CLINICAL SEQUENCING SERVICE MARKET 88 Clinical Sequencing Service Market by Indication 89 TABLE 59 BEIJING CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, Clinical Oncology Sequencing Service Market 89 TABLE 60 BEIJING CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 61 BEIJING CANCER LIQUID BIOPSY SEQUENCING COMPANIES, Clinical Reproductive Health Sequencing Service Market 90 Clinical Reproductive Health Sequencing Service Market by Indication TABLE 62 BEIJING REPRODUCTIVE HEALTH MARKET, BY APPLICATION, THROUGH NIPT 91 TABLE 63 HOSPITALS APPROVED FOR NIPT IN BEIJING 92 TABLE 64 BEIJING NIPT MARKET, BY RISK TYPE, 92 IVF 93 Newborn Screening Market 93 Carrier Screening Market 93 APPLIED SEQUENCING SERVICES MARKET 93 TABLE 65 BEIJING APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, Agriculture Sequencing 94 Consumer Sequencing 94 Forensics Sequencing 94 Microbiology Sequencing CHAPTER 6 SHANGHAI SEQUENCING MARKET 97

7 TABLE 66 SHANGHAI SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH 2021 ($ FIGURE 5 SHANGHAI SEQUENCING MARKET, BY MAJOR SEGMENT, ($ GENERAL OVERVIEW 98 INDUSTRY DETAILS 99 DRIVING FORCES 99 PRE- AND POST-SEQUENCING PRODUCTS 100 TABLE 67 SHANGHAI PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, SEQUENCING SAMPLE PREP MARKET BY APPLICATION 100 TABLE 68 SHANGHAI SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, SEQUENCING INFORMATICS BY SOFTWARE FUNCTION 101 TABLE 69 SHANGHAI SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, SEQUENCING INSTRUMENTS AND CONSUMABLES 102 SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET BY PRODUCT TYPE TABLE 70 SHANGHAI SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM 102 TABLE 71 SHANGHAI SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, SEQUENCING INSTRUMENTS AND CONSUMABLES BY INSTRUMENT CLASS 103 TABLE 72 SHANGHAI SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, SEQUENCING SERVICES MARKET 104 TABLE 73 SHANGHAI SEQUENCING SERVICES MARKET, BY END-USER MARKET, CLINICAL SEQUENCING SERVICE MARKET 105 Clinical Sequencing Service Market by Indication 105 TABLE 74 SHANGHAI CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, Clinical Oncology Sequencing Service Market 106 TABLE 75 SHANGHAI CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 76 SHANGHAI CANCER LIQUID BIOPSY SEQUENCING COMPANIES, Clinical Reproductive Health Sequencing Service Market 107 Clinical Reproductive Health Sequencing Service Market by Indication TABLE 77 SHANGHAI REPRODUCTIVE HEALTH MARKET, BY APPLICATION, NIPT 108 TABLE 78 HOSPITALS APPROVED FOR NIPT IN SHANGHAI 108 TABLE 79 SHANGHAI NIPT MARKET, BY RISK TYPE, 109 IVF 109 Newborn Screening Market 109 Carrier Screening Market 109

8 APPLIED SEQUENCING SERVICES MARKET 109 TABLE 80 SHANGHAI APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, Agriculture Sequencing 110 Consumer Sequencing 110 Forensics Sequencing 110 Microbiology Sequencing CHAPTER 7 SEQUENCING MARKET IN OTHER REGIONS 113 TABLE 81 OTHER REGIONS SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH FIGURE 6 OTHER REGIONS SEQUENCING MARKET, BY MAJOR SEGMENT, ($ GENERAL OVERVIEW 114 INDUSTRY DETAILS 115 DRIVING FORCES 115 PRE- AND POST-SEQUENCING PRODUCTS 116 TABLE 82 OTHER REGIONS PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, SEQUENCING SAMPLE PREP MARKET BY APPLICATION 116 TABLE 83 OTHER REGIONS SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, SEQUENCING INFORMATICS BY SOFTWARE FUNCTION 117 TABLE 84 OTHER REGIONS SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, SEQUENCING INSTRUMENTS AND CONSUMABLES 118 SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET BY PRODUCT TYPE TABLE 85 OTHER REGIONS SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM 119 TABLE 86 OTHER REGIONS SEQUENCING INSTRUMENTS, BY PLATFORM, THROUGH SEQUENCING INSTRUMENTS AND CONSUMABLES BY INSTRUMENT CLASS 120 TABLE 87 OTHER REGIONS SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, SEQUENCING SERVICES MARKET 120 TABLE 88 OTHER REGIONS SEQUENCING SERVICES MARKET, BY END-USER MARKET, CLINICAL SEQUENCING SERVICE MARKET 121 Clinical Sequencing Service Market by Indication 121 TABLE 89 OTHER REGIONS CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, Clinical Oncology Sequencing Service Market 122 TABLE 90 OTHER REGIONS CLINICAL CANCER MARKET, BY INDICATION, THROUGH TABLE 91 CANCER LIQUID BIOPSY SEQUENCING COMPANIES IN OTHER REGIONS, Clinical Reproductive Health Sequencing Service Market

9 Clinical Reproductive Health Sequencing Service Market by Indication TABLE 92 OTHER REGIONS REPRODUCTIVE HEALTH MARKET, BY APPLICATION, NIPT 124 TABLE 93 OTHER REGIONS NIPT MARKET, BY RISK TYPE, THROUGH 2021 ($ 125 IVF 125 Newborn Screening Market 126 Carrier Screening Market 126 APPLIED SEQUENCING SERVICES MARKET 126 TABLE 94 OTHER REGIONS APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, Agriculture Sequencing 127 Consumer Sequencing 127 Forensics Sequencing 127 Microbiology Sequencing CHAPTER 8 INDUSTRY STRUCTURE AND MARKET STRATEGIES 129 INDUSTRY STRUCTURE 129 BGI MODEL 130 MAIN CHARACTERISTICS 130 Government Loans and Subsidies 130 Connections to Government-sponsored Academic Institutions and State-owned Companies Low Labor Cost 131 Work with Profit-oriented Hospitals 131 DISADVANTAGES 132 STRATEGIES 132 MARKET CHANNELS 132 INSTRUMENTS AND CONSUMABLES 132 SEQUENCING SERVICES 133 BIOINFORMATICS CHAPTER 9 COMPANY PROFILES 136 GUANGDONG 136 GUANGZHOU 136 AIC 136 AnchorDx 136 Burning Rock 137 Daan Gene 137 Darui Biotechnology Co. Ltd. 137 EZlife 138 Forever Gen 138 Gene Denovo 138 IGE 139 Kingmed Diagnostics Center Co. Ltd. 139 Linked-Biotech 139

10 Magigen Bio-Technology Ltd. 140 RiboBio 140 SCGene 140 Top Gene 141 SHENZHEN 141 BGI 141 Direct Genomics 142 Haplox 142 HYK Gene Technology Co. Ltd. 143 Imuno Biotech Co Ltd 143 Macrogen 143 Microbiota 144 TGS 144 YuceBio Co. Ltd. 144 DONGGUAN CITY 144 CapitalGenomics 145 BEIJING 145 ALLWEGENE 145 ANNOROAD GENE TECHNOLOGY 145 BERRY GENOMICS CO. LTD. 146 BIOLOGICAL COMPUTING DIVISION, BEIJING COMPUTING CENTER 146 BIOMARKER 147 BIOMARRY 147 BOHENG 147 CAPITALBIO TECHNOLOGY 148 EMEI TONGDE 148 GENEDOCK 148 GENEKANG 149 GENETRON 149 GENEWAY 149 GENNLIFE 149 HIKEWELL 150 HKGI 150 HONOR TECH 150 HUANIU BIOTECHNOLOGY 151 HUASHENG HENGYE 151 HUAYI 151 IGENETECH 152 IMH-BIO 152 IPE 152 JABREHOO 153 LUCIDUS 153 MICROHELIX GENE 153 MYGENOSTICS 154 NOVOGENE BIOINFORMATICS TECHNOLOGY CO. LTD. 154 ORI-GENE 154 QUANTI HEALTH 155

11 QY NODE 155 READER BIOINFORMATIC 155 SANVALLEY 155 SINOGENOMAX 156 SINOMDGENE 156 SINOPATH 156 SOLOMENBROTHERS 157 VISHUO 157 YINHEHONGRI 157 YIKON GENOMICS CO. LTD. 157 SHANGHAI 158 ACCURAGEN INC 158 ADICON CLINICAL LABORATORIES 158 BASETRA LTD. 159 BENEGENE 159 BIOGENIUS 159 BIOREFER 160 BIOTECAN 160 BIOTECHNOLOGY SHANGHAI 160 BIOTREE 160 CLOUDHEALTH MEDICAL GROUP LTD. 161 FENGHE TECH 161 FIND BIO-TECH 161 GENERGY SHANGHAI 162 GENOMEPILOT 162 GMINIX 162 HANYU 163 HONGSHUN 163 JEAYEA 163 JIAYIN 164 KANGCHEN BIO-TECH 164 LOGIC INFORMATICS CO. LTD. 164 MAJORBIO 164 NOVELBIO 165 OEBIOTECH 165 OFFO 165 PAIHANG 165 QUANMAI 166 REALGENE 166 SANGON BIOTECH 166 SENSICHIP 167 SHANGHAI BIOASIA GENE CO. LTD. 167 SHANGHAI PERSONAL BIOTECHNOLOGY CO. LTD. 167 SHANGHAI YUNYING MEDICAL TECHNOLOGY CO. LTD. 168 SOUTH GENE 168 TINYGENE 168 TRI-I 169

12 UNIMED DIAGNOSTIC TECHNOLOGY LTD. 169 WUXI APPTEC 169 XINPEIJING 170 XYBIOTECH 170 YINGBIO 170 ZJ BIO-TECH 170 ZHEJIANG 171 ADICON CLINICAL LABORATORIES INC. 171 DIAN DIAGNOSTICS 171 GENERUI 172 HANGZHOU BIOSAN BIO-TECHNOLOGY CO. LTD. 172 HANGZHOU G-BIO BIOTECH CO. LTD. 172 HANGZHOU GUHE INFORMATION TECHNOLOGY CO. LTD. 173 HANGZHOU HEYI GENE TECHNOLOGY CO. LTD. 173 HANGZHOU LIANCHUAN BIO TECHNOLOGIES CO. LTD. 173 HANGZHOU MITIAN GENE TECHNOLOGY CO. LTD. 174 HANGZHOU OTO BIOLOGICAL TECHNOLOGY CO. LTD. 174 HANGZHOU PTM BIOLABS CO INC 174 HANGZHOU RUICHUANG BIOTECHNOLOGY CO. LTD. 175 HANGZHOU SHENGTING BIOTECH CO. LTD. 175 ZHEJIANG TIANKE HI-TECHNOLOGY DEVELOPMENT CO. LTD. 175 JIANGSU 176 BIONOVOGENE 176 CYAGEN 176 GENESEEQ 176 GENESKY 177 GENEWIZ 177 PUSHI 177 SUZHOU BIOMEDICAL RESEARCH & DEVELOPMENT CENTER 178 HUBEI 178 ABLIFE INC. 178 BENAGEN 178 DATABRIDGE 179 FRASERGEN 179 KINDSTAR 179 NEXTOMICS 180 OTHER PROVINCES 180 RHONIN 180 ZIXIN PHARMACEUTICAL INDUSTRIAL CO. LTD. 180 CHAPTER 10 APPENDIX GLOSSARY 183

13 LIST OF TABLES TABLE HEADING SUMMARY TABLE CHINESE SEQUENCING MARKET, BY PRODUCT TYPE, THROUGH TABLE 1 CHINESE SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH 2021 ($ TABLE 2 CHINESE SEQUENCING MARKET, BY REGION, 13 TABLE 3 SEQUENCING COMPANIES IN CHINA, BY REGION, JULY 2016 (NUMBER) 14 TABLE 4 CHINESE PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, TABLE 5 CHINESE SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, THROUGH TABLE 6 CHINESE SEQUENCING INFORMATICS MARKET, BY FUNCTION, THROUGH TABLE 7 NGS SEQUENCERS IN CHINA, BY REGION, JULY 2016 (NUMBER) 21 TABLE 8 CHINESE SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, TABLE 9 NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES IN CHINA 24 TABLE 10 COMPARISON OF BGISEQ 500 AND NEXTSEQ TABLE 11 CHINESE SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, THROUGH TABLE 12 CHINESE SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, TABLE 13 CHINESE SEQUENCING SERVICES MARKET, BY END-USER MARKET, TABLE 14 CLINICAL DIAGNOSIS CASES BY REGION, 2015 (MILLION CASES/%) 32 TABLE 15 CHINESE CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, TABLE 16 CHINESE CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 17 CANCER CASES IN CHINA, BY INDICATION, 2015 (THOUSANDS/%) 36 TABLE 18 CANCER CASES IN CHINA, BY REGION, 2015 (THOUSANDS/%) 38 TABLE 19 CHINESE CLINICAL NGS CANCER TEST MARKET, BY TEST PURPOSE, TABLE 20 CHINESE CLINICAL CANCER MARKET, BY TEST COMPLEXITY, THROUGH TABLE 21 CHINESE CLINICAL REPRODUCTIVE HEALTH MARKET, BY APPLICATION, TABLE 22 NUMBER OF BIRTHS IN CHINA, BY REGION, 2015 (THOUSANDS) 42 TABLE 23 CHINESE NGS NIPT INDUSTRY 45 TABLE 24 MEDICAL BODIES APPROVED FOR NIPT IN CHINA, 2015 AND 2016 (NO.) 46 TABLE 25 CHINESE NIPT MARKET, BY RISK TYPE, 47 TABLE 26 NUMBER OF ART CENTERS IN CHINA, BY REGION, 2015 (THOUSANDS) 48 TABLE 27 CHINESE REPRODUCTIVE HEALTH SEQUENCING MARKET, BY TEST COMPLEXITY, TABLE 28 CHINESE TRANSPLANT MARKET, BY ANALYSIS PURPOSE, THROUGH 2021 ($ TABLE 29 TRANSPLANT CASES IN CHINA, BY ORGAN TYPE, 2015 AND 2016 (NO.) 51 TABLE 30 CHINESE TRANSPLANT MONITORING MARKET, BY ORGAN TYPE, THROUGH TABLE 31 CHINESE CLINICAL SEQUENCING SERVICE MARKET, BY TEST COMPLEXITY,

14 TABLE HEADING TABLE 32 CHINESE CLINICAL SEQUENCING MARKET, BY TEST PURPOSE, THROUGH TABLE 33 CHINESE APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, TABLE 34 CHINESE SEQUENCING SERVICES MARKET, BY GENOME TYPE, THROUGH TABLE 35 GUANGDONG SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH TABLE 36 GUANGDONG SEQUENCING MARKET, BY CITY, THROUGH 2021 ($ TABLE 37 GUANGDONG PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, TABLE 38 GUANGDONG SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, TABLE 39 GUANGDONG SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, TABLE 40 GUANGDONG SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, TABLE 41 GUANGDONG SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, TABLE 42 GUANGDONG SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, TABLE 43 GUANGDONG SEQUENCING SERVICES MARKET, BY END-USER MARKET, TABLE 44 GUANGDONG CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, TABLE 45 GUANGDONG CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 46 CANCER LIQUID BIOPSY SEQUENCING COMPANIES IN GUANGDONG, TABLE 47 GUANGDONG REPRODUCTIVE HEALTH MARKET, BY APPLICATION, TABLE 48 HOSPITALS AND COMPANIES APPROVED FOR NIPT IN GUANGDONG 73 TABLE 49 GUANGDONG NIPT MARKET, BY RISK TYPE, 74 TABLE 50 GUANGDONG APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, TABLE 51 BEIJING SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH 2021 ($ TABLE 52 BEIJING PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, TABLE 53 BEIJING SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, THROUGH TABLE 54 BEIJING SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, TABLE 55 BEIJING SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, TABLE 56 BEIJING SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, THROUGH TABLE 57 BEIJING SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, TABLE 58 BEIJING SEQUENCING SERVICES MARKET, BY END-USER MARKET,

15 TABLE HEADING TABLE 59 BEIJING CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, TABLE 60 BEIJING CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 61 BEIJING CANCER LIQUID BIOPSY SEQUENCING COMPANIES, TABLE 62 BEIJING REPRODUCTIVE HEALTH MARKET, BY APPLICATION, THROUGH TABLE 63 HOSPITALS APPROVED FOR NIPT IN BEIJING 92 TABLE 64 BEIJING NIPT MARKET, BY RISK TYPE, 92 TABLE 65 BEIJING APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, TABLE 66 SHANGHAI SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH 2021 ($ TABLE 67 SHANGHAI PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, TABLE 68 SHANGHAI SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, TABLE 69 SHANGHAI SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, TABLE 70 SHANGHAI SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, TABLE 71 SHANGHAI SEQUENCING INSTRUMENTS MARKET, BY PLATFORM, TABLE 72 SHANGHAI SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS, TABLE 73 SHANGHAI SEQUENCING SERVICES MARKET, BY END-USER MARKET, TABLE 74 SHANGHAI CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, TABLE 75 SHANGHAI CLINICAL CANCER MARKET, BY INDICATION, THROUGH 2021 ($ TABLE 76 SHANGHAI CANCER LIQUID BIOPSY SEQUENCING COMPANIES, TABLE 77 SHANGHAI REPRODUCTIVE HEALTH MARKET, BY APPLICATION, THROUGH TABLE 78 HOSPITALS APPROVED FOR NIPT IN SHANGHAI 108 TABLE 79 SHANGHAI NIPT MARKET, BY RISK TYPE, 109 TABLE 80 SHANGHAI APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION, TABLE 81 OTHER REGIONS SEQUENCING MARKET, BY MAJOR SEGMENT, THROUGH TABLE 82 OTHER REGIONS PRE- AND POST-SEQUENCING PRODUCT MARKET, BY MAJOR TYPE, TABLE 83 OTHER REGIONS SEQUENCING SAMPLE PREP MARKET, BY APPLICATION, TABLE 84 OTHER REGIONS SEQUENCING INFORMATICS MARKET, BY SOFTWARE FUNCTION, TABLE 85 OTHER REGIONS SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY PRODUCT TYPE, TABLE 86 OTHER REGIONS SEQUENCING INSTRUMENTS, BY PLATFORM, THROUGH TABLE 87 OTHER REGIONS SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY INSTRUMENT CLASS,

16 TABLE HEADING TABLE 88 OTHER REGIONS SEQUENCING SERVICES MARKET, BY END-USER MARKET, TABLE 89 OTHER REGIONS CLINICAL SEQUENCING SERVICE MARKET, BY INDICATION, TABLE 90 OTHER REGIONS CLINICAL CANCER MARKET, BY INDICATION, THROUGH TABLE 91 CANCER LIQUID BIOPSY SEQUENCING COMPANIES IN OTHER REGIONS, TABLE 92 OTHER REGIONS REPRODUCTIVE HEALTH MARKET, BY APPLICATION, TABLE 93 OTHER REGIONS NIPT MARKET, BY RISK TYPE, THROUGH 2021 ($ TABLE 94 OTHER REGIONS APPLIED SEQUENCING SERVICES MARKET, BY APPLICATION,

17 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE CHINESE SEQUENCING MARKET, BY PRODUCT TYPE, ($ FIGURE 1 CHINESE SEQUENCING MARKET, BY MAJOR SEGMENT, ($ FIGURE 2 BREAKDOWN OF THE CHINESE SEQUENCING MARKET 16 FIGURE 3 GUANGDONG SEQUENCING MARKET, BY MAJOR SEGMENT, ($ FIGURE 4 BEIJING SEQUENCING MARKET, BY MAJOR SEGMENT, ($ FIGURE 5 SHANGHAI SEQUENCING MARKET, BY MAJOR SEGMENT, ($ FIGURE 6 OTHER REGIONS SEQUENCING MARKET, BY MAJOR SEGMENT, ($