Regenerative and Immune Engineering Focus Area Upper-Level Engineering Courses updated October, 2018 For BME Class of 2021 and beyond

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1 Regenerative and Immune Engineering Focus Area Upper-Level Engineering Courses updated October, 2018 For BME Class of 2021 and beyond EN Structure of Materials 3 EN Thermodynamics/Materials 3 EN Mechanical Properties of Materials 3 EN Electronic Properties of Materials 3 EN Physical Chemistry of Materials II 3 EN Biomaterials I 3 EN Materials Characterization 3 EN Biomaterials II: Host response and biomaterials applications 3 EN The Chemistry of Materials Synthesis 3 EN Nanoparticles 3 EN Micro and Nano Structured Materials & Devices 3 EN Biomolecular Materials I - Soluble Proteins and Amphiphiles 3 EN Biomaterials Lab 3 EN Mechanical Properties of Biomaterials 3 EN Nanomaterials Lab 3 EN Polymer Chemistry & Biology 3 EN Biomechanics of the Cell 3 EN Biofluid Mechanics 3 EN Bioinspired Science and Technology 3 EN Experimental Methods in Biomechanics 3 EN Biosolid Mechanics 3 EN Kinetic Processes 4 EN Transport Phenomena I 3 EN Transport Phenomena II 4 EN Chemical & Biomolecular Separations 3 EN Project in Design: Pharmacokinetics 3 EN Metabolic Systems Biotechnology 3 EN Colloids and Nanoparticles 3 EN The Design of Biomolecular Systems 3 EN Computational Protein Structure Prediction and Design 3 EN Project in Design: Pharmacodynamics 3 EN Introduction to Polymeric Materials 3 EN Supramolecular Materials and Nanomedicine 3 EN Application of Molecular Evolution to Biotechnology 3 EN Micro/Nanotechnology: The Science and Eng. of Small Structures 3 EN Engineering Principles of Drug Delivery 3 EN Metabolic Systems Biotechnology 3 EN Dynamical Systems 4 EN Pulmonary Physiology 3

2 EN Systems Pharmacology and Personalized Medicine 3 EN Bioelectricity 3 EN Applied Bioelectrical Engineering I 1.5 EN Applied Bioelectrical Engineering II 1.5 EN Cellular Engineering 3 EN Tissue Engineering 3 EN Biomedical Applications of Glycoengineering 3 EN Physical Epigenetics 3 EN Biomechanics of the Cell 3 EN /2 Cell and Tissue Engineering Lab 3 EN Introduction to Rehabilitation Engineering 3 EN Rehabilitation Engineering Design Laboratory 3 EN Build-a-Genome Mentor 4 EN Microfabrication Lab 4 EN Advanced Orthopaedic Tissue Engineering 3 EN Molecular Immunoengineering 3 EN Fundamentals of Physics and Chemistry in Nanomaterials 3 Contact the BME Department advising office for course additions. Non Upper-Level Focus Area Courses (maximum of 3 credits from this list may count in focus area) AS Genetics 3 AS Stem Cells & the Biology of Aging & Disease 2 AS Developmental Biology 3 AS Developmental Biology Lab 2 EN BME Design Group 3 EN BME Design Group 3 EN BME Design Group 3 EN BME Design Group 3 EN BME Design Group 3 EN BME Design Group 3 EN BME Design Group 3 EN Design-Team, Team Leader 4 EN Design Team/Team Leader 4 EN Senior Design Project 3 EN Senior Design Project 3 Students may use a maximum of 3 research credits as a non-upper-level engineering course.

3 Cell and Tissue Engineering (CTE) is an interdisciplinary field that covers research areas ranging from materials science, stem cell engineering to regenerative tissue engineering and immunology. There are several subjects that all CTE students should master, which can be accomplished by taking courses that include Biomaterials I and II and both the Cell Engineering and Tissue Engineering courses. When selecting your CTE courses beyond these platform classes, the following specialization areas may provide guidance. While designed only to serve as a guide, the areas of specialization represent important subfields within CTE where cutting edge research that promises to transform the practice of medicine and patient care over the next generation are now taking place. BIOMATERIALS AREA SPECIALIZATION. This area of specialization is for students who desire a strong foundation in designing, synthesizing, processing, and characterizing biomaterials; in addition to creating these materials students will gain an understanding they interact with living cells and tissues in biological systems. Students can select a set of upper level electives from the following list that covers a variety of topics ranging from biomaterials synthesis and characterization, to biocompatibility of materials, and to various applications of biomaterials. ULE Focus Area Courses: Biomaterials Lab (3) Structure of Materials (3) Mechanical Properties of Materials (3) Electronic Properties of Materials (3) Materials Characterization (3) The Chemistry of Materials Synthesis (3) Biomolecular Materials (3) Polymer Chemistry and Biology (3) Advanced Topics in Biomaterials (3) Colloids and Nanoparticles (3) Microfabrication Laboratory (4) Fundamentals of Physics and Chemistry in Nanomaterials (3) BIOMECHANICS AREA SPECIALIZATION. This area incorporates traditional engineering approaches into understanding tissue structure and function. Students who plan to build a strong foundation on cell and tissue biomechanics and mechanobiology may select from these upper electives. These courses cover topics that range from the mechanical characterization of cells and tissues, cellular responses to mechanical cues, the general properties of materials, and orthopaedic biomechanics. This area complements the Biomaterials specialty.

4 Biomechanical Specialty Courses: Mechanical Properties of Materials (3) Materials Characterization (3) Biomechanics: Cells and Organisms (3) Introductory Biomechanics (3) Experimental Methods in Biomechanics (3) Biosolid Mechanics (3) Microfabrication Laboratory (4) /2 Cellular and Tissue Engineering Laboratory (2) Biomechanics of Cells and Organisms (3) Advanced Orthopaedic Tissue Engineering (3) CELL ENGINEERING AREA SPECIALIZATION. This area of specialization is for students who wish to incorporate a strong foundation of cell level and smaller scale (e.g., biochemical and molecular) knowledge into the systems and organism-level knowledge gained from other parts of the BME undergraduate curriculum. To pursue this option, students can select electives that primarily focus on the biochemistry of molecules found within a cell or molecular scale phenomenon (e.g., kinetic processes or transport phenomenon courses). Another cell-based option is to focus on stem cells and complementary coursework (e.g., developmental biology). Cell Engineering Specialty Courses: Biomechanics: Cells and Organisms (3) Kinetic Processes (4) Transport Phenomena I (3) Transport Phenomena II (4) Metabolic Systems Biotechnology (3) Biomacromolecules at the Nanoscale (3) Computational and Experimental Design of Biomolecules (3) Dynamical Systems (4) Build-A-Genome (4) Biomedical Engineering Applications of Glycoengineering (3) Physical Epigentics Biomechanics of Cells and Organisms (3) /2 Cellular and Tissue Engineering Laboratory (3) Build-A-Genome Mentor (4)

5 Other Specialty Area Courses (non-ule) : Stem Cell Biology in Development & Disease (3) Developmental Biology (3) Developmental Biology Laboratory (2) Biological Macromolecules: Structure and Function (3) Proteins and Nucleic Acids (3) TISSUE ENGINEERING AREA SPECIALIZATION. This specialty area is closely related to cell engineering --- e.g., stem cells are germaine to both areas --- but has more of a focus on larger systems such as building tissues, immunoengineering, and regenerative medicine. Students can select from a number of courses related to stem cells, cell and tissue organization, metabolic systems, and cell biology in addition to the platform courses suggested for all focus area students. Tissue Engineering Specialty Courses: Metabolic Systems Biotechnology (3) Bioengineering in Regenerative Medicine (3) /2 Cellular and Tissue Engineering Laboratory (3) 580.xxx Advanced Topics in Regenerative Medicine Other Specialty Area Courses (non-ule): Stem Cell Biology in Development & Disease (3) Developmental Biology (3) Developmental Biology Laboratory (2) NANOBIOTECHNOLOGY AREA SPECIALIZATION. This area of specialization is for students who are interested in complementing the fundamental scientific knowledge obtained in the standard BME undergraduate curriculum with a focus on the technological aspects of cell and tissue engineering, with particular emphasis on the nanoscale. Students can select from a variety of upper level courses that cover the design, fabrication, and characterization of particles, surfaces, devices, and delivery systems and how they interact with biological systems. Topics include designing nanomaterials (including those used as growth substrates or those intended as drug delivery vehicles) to interact with cells, using cells for regenerative medicine applications, and manipulating various sub-cellular components and classes of biomacromolecules.

6 Nanobiotechnology Specialty Area Courses: The Chemistry of Materials Synthesis (3) Biomaterials Lab (3) Chemical and Biological Separations (3) Metabolic Systems Biotechnology (3) Colloids and Nanoparticles (3) Micro/Nanotechnology (3) Bioengineering in Regenerative Medicine (3) Computational and Experimental Design of Biomolecules (3) Build-A-Genome (4) /2 Cellular and Tissue Engineering Laboratory (3) Build-A-Genome Mentor (4) Microfabrication Laboratory (4) Fundamentals of Physics and Chemistry in Nanomaterials (3) Other Specialty Area Courses (non-ule): Stem Cell Biology in Development & Disease (3) COMBINED UNDERGRADUATE-MSE PROGRAM. BME undergraduates who are interested in Department s Master of Science in Engineering (MSE) program have the opportunity to double count up to 6 credits of graduate level classwork, which generally means that the courses are designated with a 600 (and sometime 700 or 800) level number. In some cases this requirement can be met by taking the graduate level course Cellular Engineering (i.e., instead of ), Tissue Engineering (i.e., instead of ), or Biomedical Applications of Glycoengineering (i.e., instead of ). In other cases, undergraduate students may be provide permission (upon approval of the course instructor) to take graduate level courses, such as Advanced Orthopaedic Tissue Engineering ( ), Molecular Immunoengineering ( ), or other 600- or higher level courses listed above.