DIGITAL PATHOLOGY: TECHNOLOGIES AND GLOBAL MARKETS

Transcription

1 DIGITAL PATHOLOGY: TECHNOLOGIES AND GLOBAL MARKETS HLC161A February 2014 Bhavna Joshi Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY AND OBJECTIVE 2 STUDY BACKGROUND 2 SCOPE OF THE REPORT 3 INTENDED AUDIENCE 3 SOURCE OF INFORMATION AND METHODOLOGY 4 ANALYST CREDENTIALS 4 RELATED BCC RESEARCH REPORTS 4 BCC RESEARCH ONLINE SERVICES 5 DISCLAIMER 5 CHAPTER 2 EXECUTIVE SUMMARY 7 SUMMARY TABLE GLOBAL DIGITAL PATHOLOGY MARKET BY REGION, THROUGH 2018 ($ SUMMARY FIGURE GLOBAL DIGITAL PATHOLOGY MARKET BY REGION, ($ 7 7 CHAPTER 3 MARKET OVERVIEW 11 TELEPATHOLOGY AND DIGITAL PATHOLOGY: MARKET DEFINITION, EVOLUTION AND INTEGRATION FIGURE 1 TELEPATHOLOGY AND DIGITAL PATHOLOGY APPLICATIONS 12 CONVENTIONAL PROCESS VERSUS DIGITAL PATHOLOGY AND COST WORKS 13 FIGURE 2 COST ANALYSIS OF CONVENTIONAL LABS VERSUS DIGITAL PATHOLOGY SYSTEMS IMAGE ANALYSIS AND ITS IMPORTANCE IN KEY RESEARCH AREAS 16 DIGITAL PATHOLOGY IN CLINICAL TRIALS 17 DIGITAL PATHOLOGY: ELECTRONIC HEALTH RECORDS, ELECTRONIC MEDICAL RECORDS AND OTHER INFORMATION SYSTEMS REGULATORY ENVIRONMENT 19 U.S. FOOD AND DRUG ADMINISTRATION 19 HEALTH INSURANCE PORTABILITY AND ACCOUNTABILITY ACT 21 CLINICAL LABORATORY IMPROVEMENT AMENDMENTS 21 HEALTHCARE POLICIES: OBAMA MANDATORY 21 REIMBURSEMENT ISSUES 22 TECHNOLOGY TRENDS 22 SCANNING SPEEDS AND IMAGE RESOLUTIONS 24 VIEWING ADVANCEMENTS AND CLINICAL DECISION SUPPORT 25 ARCHIVAL STANDARDS 25 MULTI-SITE COLLABORATION APPLICATIONS 25 WHOLE-SLIDE DIGITAL IMAGING 25 CLOUD COMPUTING AND DIGITAL PATHOLOGY 26 DIGITAL PATHOLOGY: DEVELOPED VERSUS DEVELOPING ECONOMIES 27 MARKET INTELLIGENCE 28 TECHNOLOGY TRANSITION: DIGITAL PATHOLOGY COMPONENTS TO INTEGRATED SYSTEMS FIGURE 3 DIGITAL PATHOLOGY SYSTEM MARKET

3 AGREEMENTS AND COLLABORATIONS TO ENHANCE PRESENCE IN IMAGING APPLICATIONS FIGURE 4 KEY STRATEGIES, (%) 30 FIGURE 5 KEY COMPANIES, (%) 31 U.S. AS THE BASE FOR DIGITAL PATHOLOGY SYSTEM INNOVATION 31 FIGURE 6 GLOBAL PATENTS BY REGION, (%) 31 FIGURE 7 GLOBAL PATENTS BY TECHNOLOGY, (%) 32 STRATEGIC CONCLUSIONS 33 CASE STUDIES 35 CASE STUDY 1: DIGITAL PATHOLOGY ENABLING CRITICAL DIAGNOSIS 35 Background 35 Challenge 35 Solution 35 CASE STUDY 2: INITIATIVES AND EXAMPLES OF TELEPATHOLOGY DEPLOYMENT IN DEVELOPING ECONOMIES Cost-Related Issues 36 Hindrances for Telepathology in Developing Economies 36 Solutions for Developing Countries 37 CASE STUDY 3: DIGITAL PATHOLOGY'S ROLE IN COST SAVINGS AMONG BIG PHARMA COMPANIES CASE STUDY 4: DIGITAL PATHOLOGY IN RESOURCE POOR SETTINGS 38 MARKET DYNAMICS 38 DRIVERS 38 Cost-Effectiveness Drives Expansion 38 Case Transport 38 Better Image Analysis and Analytics 39 Increasing Adoption 39 Workflow Efficiency 40 System Benefits 41 Remote Diagnosis 41 Greater Efficiency 41 RESTRAINTS 42 CHALLENGES AND OPPORTUNITIES CHAPTER 4 DIGITAL PATHOLOGY SYSTEM MARKET 44 TABLE 1 GLOBAL DIGITAL PATHOLOGY SYSTEM MARKET, THROUGH 2018 ($ DEVICES MARKET 44 TABLE 2 GLOBAL DIGITAL PATHOLOGY DEVICE MARKET, THROUGH 2018 ($ TABLE 3 GLOBAL DIGITAL PATHOLOGY DEVICE MARKET BY REGION, THROUGH 2018 ($ VIRTUAL MICROSCOPY AND VIRTUAL SLIDES 45 Legal Status 46 Advantages 46 Disadvantages 47 Challenges 47 DIGITAL CAMERAS 47 Advantages

4 TABLE 4 GLOBAL DIGITAL CAMERAS IN THE DIGITAL PATHOLOGY MARKET BY REGION, ROBOTIC MICROSCOPES 48 ADVANTAGES OF ROBOTIC MICROSCOPY 48 DISADVANTAGES OF ROBOTIC MICROSCOPY 48 HINDRANCES 48 IMAGE SENSORS 49 TABLE 5 GLOBAL ROBOTIC MICROSCOPES IN DIGITAL PATHOLOGY MARKET BY REGION, SCANNERS 49 TABLE 6 GLOBAL SCANNERS IN DIGITAL PATHOLOGY MARKET BY REGION, DIGITAL PATHOLOGY ANALYTIC MARKET 51 TABLE 7 GLOBAL DIGITAL PATHOLOGY ANALYTIC MARKET BY PLATFORM, TABLE 8 GLOBAL DIGITAL PATHOLOGY ANALYTIC MARKET BY REGION, THROUGH 2018 ($ VISUALIZATION AND IMAGE ANALYSIS PLATFORMS 52 Applications for Image Analysis in Pathology 53 Drivers for Automated Image Analysis Market 54 Images Required by Analyzer 54 Correlation of Image Data with Different Data Sources 54 Quantification of More Complex Tissue Features and Morphology Analysis TABLE 9 GLOBAL DIGITAL PATHOLOGY VISUALIZATION AND IMAGE ANALYSIS PLATFORM MARKET BY REGION, DIGITAL PATHOLOGY INFORMATION MANAGEMENT SYSTEMS 55 Digital Image Management in Pathology 55 TABLE 10 GLOBAL DIGITAL PATHOLOGY INFORMATION SYSTEM MARKET BY REGION, DIGITAL PATHOLOGY STORAGE AND COMMUNICATION PLATFORM MARKET 56 TABLE 11 GLOBAL DIGITAL PATHOLOGY STORAGE PLATFORM MARKET BY REGION, TABLE 12 GLOBAL DIGITAL PATHOLOGY COMMUNICATION PLATFORM MARKET, COMMUNICATION PLATFORM 59 WEB-BASED OR CLOUD-BASED COMMUNICATION PLATFORMS IN DIGITAL PATHOLOGY TABLE 13 GLOBAL DIGITAL PATHOLOGY COMMUNICATION PLATFORM MARKET BY REGION, TELEPATHOLOGY SYSTEMS 60 TABLE 14 GLOBAL TELEPATHOLOGY SYSTEM MARKET, THROUGH 2018 ($ TABLE 15 GLOBAL TELEPATHOLOGY SYSTEM MARKET BY REGION, THROUGH 2018 ($ KEY ADVANTAGES OF TELEPATHOLOGY SYSTEMS 61 STATIC IMAGE-BASED SYSTEMS 62 TABLE 16 GLOBAL STATIC TELEPATHOLOGY SYSTEM MARKET BY REGION, HYBRID TELEPATHOLOGY SYSTEMS

5 Hybrid Telepathology System Applications 64 TABLE 17 GLOBAL HYBRID TELEPATHOLOGY SYSTEM MARKET BY REGION, REAL-TIME TELEPATHOLOGY IMAGING SYSTEM 65 Applications 66 TABLE 18 GLOBAL REAL-TIME TELEPATHOLOGY SYSTEM MARKET BY REGION, CHAPTER 5 IN VITRO DIAGNOSTIC AND OTHER DIAGNOSTIC DEVICES IN DIGITAL PATHOLOGY MARKET TABLE 19 GLOBAL DIGITAL IN VITRO AND OTHER DIAGNOSTIC DEVICE MARKET, TABLE 20 GLOBAL DIGITAL IN VITRO AND OTHER DIAGNOSTIC DEVICES MARKET BY REGION, AUTOMATED HEMATOLOGY ANALYZERS AND BLOOD CELL COUNTERS 69 HEMATOLOGY ANALYZER COMPONENTS AND MECHANICS 70 HEMATOLOGY INSTRUMENT SOFTWARE 71 HEMATOLOGY INSTRUMENTATION FROM THE MANUFACTURER'S PERSPECTIVE ADVANCED HEMATOLOGY ANALYZER MODEL MARKET 72 STANDARD HEMATOLOGY ANALYZER MODEL MARKET 73 DIGITAL CELL COUNTER FEATURES 74 CURRENT PRODUCTS AND FEATURES 74 TABLE 21 GLOBAL AUTOMATED HEMATOLOGY ANALYZER AND BLOOD CELL COUNTER MARKET BY REGION, DIGITAL CHROMOSOME ANALYZERS 75 TABLE 22 GLOBAL DIGITAL CHROMOSOME ANALYZER MARKET BY REGION, FLUORESCENCE IN SITU HYBRIDIZATION ENUMERATION SYSTEMS 76 TABLE 23 GLOBAL FLUORESCENCE IN SITU HYBRIDIZATION ENUMERATION SYSTEM MARKET BY REGION, DIGITAL URINE SEDIMENT ANALYZERS 77 TABLE 24 GLOBAL DIGITAL URINE SEDIMENT ANALYZER MARKET BY REGION, IMMUNOHISTOCHEMISTRY IMAGE ANALYSIS APPLICATIONS 79 TABLE 25 GLOBAL IMMUNOHISTOCHEMISTRY IMAGE ANALYSIS APPLICATION MARKET BY REGION, DIGITAL CYTOPATHOLOGY 79 TABLE 26 GLOBAL DIGITAL CYTOPATHOLOGY MARKET BY REGION, THROUGH 2018 ($ DIGITAL POLYMERASE CHAIN REACTION 81 DIGITAL POLYMERASE CHAIN REACTION APPLICATIONS 81 DIGITAL POLYMERASE CHAIN REACTION ADVANTAGES 81 REAL-TIME VERUS TRADITIONAL VERSUS DIGITAL POLYMERASE CHAIN REACTION TABLE 27 GLOBAL DIGITAL POLYMERASE CHAIN REACTION MARKET BY REGION, SIGNET CELL DETECTION 83 TABLE 28 GLOBAL SIGNET CELL DETECTION MARKET BY REGION, THROUGH 2018 ($

6 DIGITAL HOLOGRAPHIC MICROSCOPY 84 TABLE 29 GLOBAL DIGITAL HOLOGRAPHIC MICROSCOPY MARKET BY REGION, 85 CHAPTER 6 PATHOLOGY MARKET TYPES 87 TABLE 30 GLOBAL DIGITAL PATHOLOGY MARKET BY TYPE, THROUGH 2018 ($ ANATOMICAL PATHOLOGY 87 KEY CONSIDERATION FOR INTEGRATING DIGITAL PATHOLOGY SYSTEMS WITH ANATOMY PATHOLOGY LABORATORY INFORMATION SYSTEMS TABLE 31 GLOBAL DIGITAL PATHOLOGY IN THE ANATOMIC PATHOLOGY MARKET BY REGION, GENETIC PATHOLOGY 89 TABLE 32 GLOBAL DIGITAL PATHOLOGY IN GENETIC PATHOLOGY MARKET BY REGION, HEMATOLOGY AND CLINICAL PATHOLOGY 91 TABLE 33 GLOBAL DIGITAL PATHOLOGY IN HEMATOLOGY AND CLINICAL PATHOLOGY MARKET BY REGION, IMMUNOPATHOLOGY 92 TABLE 34 GLOBAL DIGITAL PATHOLOGY IN IMMUNOPATHOLOGY MARKET BY REGION, CHEMICAL PATHOLOGY 93 TABLE 35 GLOBAL DIGITAL PATHOLOGY IN CHEMICAL PATHOLOGY MARKET BY REGION, FORENSIC PATHOLOGY 94 TABLE 36 GLOBAL DIGITAL PATHOLOGY IN FORENSIC PATHOLOGY MARKET BY REGION, MICROBIOLOGY 95 TABLE 37 GLOBAL DIGITAL PATHOLOGY IN MICROBIOLOGY MARKET BY REGION, CHAPTER 7 DIGITAL PATHOLOGY APPLICATION MARKET 97 TABLE 38 GLOBAL DIGITAL PATHOLOGY MARKET BY APPLICATION, THROUGH 2018 ($ DISEASE DIAGNOSIS 97 TABLE 39 GLOBAL DIGITAL PATHOLOGY IN DISEASE DIAGNOSIS MARKET BY REGION, DRUG DISCOVERY AND DRUG DEVELOPMENT 98 DIGITAL IMAGE USES 99 TABLE 40 GLOBAL DIGITAL PATHOLOGY IN DRUG DISCOVERY AND DRUG DEVELOPMENT MARKET BY REGION, RESEARCH AND DEVELOPMENT 101 TABLE 41 GLOBAL DIGITAL PATHOLOGY IN RESEARCH AND DEVELOPMENT BY REGION, CHAPTER 8 END-USER MARKET 104 TABLE 42 GLOBAL DIGITAL PATHOLOGY MARKET BY END USER, THROUGH 2018 ($ BIOTECH AND PHARMA COMPANIES

7 TABLE 43 GLOBAL DIGITAL PATHOLOGY IN BIOTECH AND PHARMACEUTICAL COMPANIES MARKET BY REGION, HOSPITALS AND DIAGNOSTIC CENTERS 107 TABLE 44 GLOBAL DIGITAL PATHOLOGY IN HOSPITALS AND DIAGNOSTIC CENTERS MARKET BY REGION, ACADEMIC CENTERS: CONSULTING AND TRAINING 109 TABLE 45 GLOBAL DIGITAL PATHOLOGY IN ACADEMIC CENTERS, CONSULTING AND TRAINING MARKET BY REGION, CHAPTER 9 COMPETITIVE LANDSCAPE 113 NEW PRODUCT DEVELOPMENT 113 TABLE 46 NEW PRODUCTS BY COMPANY, FIGURE 8 NEW PRODUCT DEVELOPMENT BY COMPANY, (%) 115 AGREEMENTS AND COLLABORATIONS 116 FIGURE 9 AGREEMENTS AND COLLABORATIONS BY COMPANY, (%) 117 TABLE 47 AGREEMENTS AND COLLABORATIONS BY COMPANY, PRODUCT APPROVALS 122 FIGURE 10 PRODUCT APPROVALS BY COMPANY, (%) 122 TABLE 48 PRODUCT APPROVALS BY COMPANY, MERGERS AND ACQUISITIONS 124 TABLE 49 MERGERS AND ACQUISITIONS BY COMPANY, OTHER STRATEGIES 124 TABLE 50 OTHER STRATEGIES BY COMPANY, CHAPTER 10 GEOGRAPHIC ANALYSIS 127 NORTH AMERICA 127 TABLE 51 NORTH AMERICAN DIGITAL PATHOLOGY MARKET, THROUGH 2018 ($ EUROPE 128 CASE STUDY: IMPLEMENTATION ISSUES FOR VIRTUAL MICROSCOPY IN EUROPE TABLE 52 EUROPEAN DIGITAL PATHOLOGY MARKET, 129 ASIA 130 CHINA 130 INDIA 130 TABLE 53 ASIAN DIGITAL PATHOLOGY MARKET, 131 REST OF THE WORLD 132 TABLE 54 REST OF WORLD DIGITAL PATHOLOGY MARKET, THROUGH 2018 ($ CHAPTER 11 PATENT ANALYSIS 134 U.S. PATENT ANALYSIS 134 FIGURE 11 U.S. PATENTS BY TECHNOLOGY, FIGURE 12 U.S. PATENTS BY COMPANY, (%) 135 EUROPEAN PATENT ANALYSIS 136 FIGURE 13 EUROPEAN PATENTS BY TECHNOLOGY, (%) 136 FIGURE 14 EUROPEAN PATENTS BY COMPANIES, (%) 136 JAPAN PATENT ANALYSIS 137 FIGURE 15 JAPAN PATENTS BY TECHNOLOGY, (%) 138

8 FIGURE 16 JAPAN PATENTS BY COMPANY, (%) 138 CHAPTER 12 COMPANY PROFILES 141 3DHISTECH LTD. 141 TABLE 55 3DHISTECH LTD. PRODUCT PORTFOLIO 141 TABLE 56 3DHISTECH LTD. RECENT DEVELOPMENTS 141 APERIO TECHNOLOGIES INC. 142 TABLE 57 APERIO TECHNOLOGIES INC. PRODUCT PORTFOLIO 142 TABLE 58 APERIO TECHNOLOGIES INC RECENT DEVELOPMENTS 142 APOLLO PACS INC. 143 TABLE 59 APOLLO PACS INC. PRODUCT PORTFOLIO 143 TABLE 60 APOLLO PACS INC. RECENT DEVELOPMENTS 143 AURORA INTERACTIVE LTD. 144 TABLE 61 AURORA INTERACTIVE LTD. PRODUCT PORTFOLIO 144 TABLE 62 AURORA INTERACTIVE LTD. RECENT DEVELOPMENTS 144 CORISTA LLC 145 TABLE 63 CORISTA LLC PRODUCT PORTFOLIO 145 TABLE 64 CORISTA LLC RECENT DEVELOPMENTS 145 DEFINIENS AG 146 TABLE 65 DEFINIENS AG PRODUCT PORTFOLIO 146 TABLE 66 DEFINIENS AG RECENT DEVELOPMENTS 147 DIGIPATH INC. 148 TABLE 67 DIGIPATH INC. PRODUCT PORTFOLIO 148 TABLE 68 DIGIPATH INC. FINANCIALS ($ 148 TABLE 69 DIGIPATH INC. RECENT DEVELOPMENTS 149 HURON TECHNOLOGIES INTERNATIONAL INC. 149 TABLE 70 HURON TECHNOLOGIES INTERNATIONAL INC. PRODUCT PORTFOLIO 149 TABLE 71 HURON TECHNOLOGIES INTERNATIONAL INC. RECENT DEVELOPMENTS 150 INDICA LABS INC. 150 TABLE 72 INDICA LABS INC. PRODUCT PORTFOLIO 150 TABLE 73 INDICA LABS INC. RECENT DEVELOPMENTS 151 LEICA MICROSYSTEMS GMBH 152 TABLE 74 LEICA MICROSYSTEMS GMBH PRODUCT PORTFOLIO 152 TABLE 75 LEICA MICROSYSTEMS GMBH RECENT DEVELOPMENTS 153 LIGOLAB LLC 154 TABLE 76 LIGOLAB LLC PRODUCT PORTFOLIO 154 MIKROSCAN TECHNOLOGIES INC. 154 TABLE 77 MIKROSCAN TECHNOLOGIES INC. PRODUCT PORTFOLIO 154 TABLE 78 MIKROSCAN TECHNOLOGIES INC. RECENT DEVELOPMENTS, 2011 AND 2012 NIKON INSTRUMENTS INC. 155 TABLE 79 NIKON INSTRUMENTS INC. PRODUCT PORTFOLIO 156 TABLE 80 NIKON INSTRUMENTS INC. FINANCIALS, ($ 156 TABLE 81 NIKON INSTRUMENTS INC. RECENT DEVELOPMENTS, OMNYX LLC 157 TABLE 82 OMNYX LLC PRODUCT PORTFOLIO 157 TABLE 83 OMNYX LLC RECENT DEVELOPMENTS, PATHCENTRAL INC

9 TABLE 84 PATHCENTRAL PRODUCT PORTFOLIO 158 TABLE 85 PATHCENTRAL RECENT DEVELOPMENTS, PATHXL 159 TABLE 86 PATHXL PRODUCT PORTFOLIO 160 TABLE 87 PATHXL RECENT DEVELOPMENTS, PIXCELLDATA LTD. 160 TABLE 88 PIXCELLDATA LTD PRODUCT PORTFOLIO 161 TABLE 89 PIXCELLDATA LTD. RECENT DEVELOPMENTS, SUNQUEST INFORMATION SYSTEMS 162 TABLE 90 SUNQUEST INFORMATION SYSTEMS PRODUCT PORTFOLIO 162 TABLE 91 SUNQUEST INFORMATION SYSTEMS RECENT DEVELOPMENTS, VENTANA MEDICAL SYSTEMS INC. 163 TABLE 92 VENTANA MEDICAL SYSTEMS INC.: PRODUCT PORTFOLIO 163 TABLE 93 VENTANA MEDICAL SYSTEMS INC. RECENT DEVELOPMENTS 164 VISIOPHARM 165 TABLE 94 VISIOPHARM PRODUCT PORTFOLIO 166 TABLE 95 VISIOPHARM RECENT DEVELOPMENTS, CHAPTER 13 APPENDIX 169 PATENT LIST 169 TABLE 96 PATENT LIST,

10 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL DIGITAL PATHOLOGY MARKET BY REGION, THROUGH 2018 ($ TABLE 1 GLOBAL DIGITAL PATHOLOGY SYSTEM MARKET, THROUGH 2018 ($ TABLE 2 GLOBAL DIGITAL PATHOLOGY DEVICE MARKET, THROUGH 2018 ($ TABLE 3 GLOBAL DIGITAL PATHOLOGY DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 4 GLOBAL DIGITAL CAMERAS IN THE DIGITAL PATHOLOGY MARKET BY REGION, TABLE 5 GLOBAL ROBOTIC MICROSCOPES IN DIGITAL PATHOLOGY MARKET BY REGION, TABLE 6 GLOBAL SCANNERS IN DIGITAL PATHOLOGY MARKET BY REGION, TABLE 7 GLOBAL DIGITAL PATHOLOGY ANALYTIC MARKET BY PLATFORM, THROUGH 2018 ($ TABLE 8 GLOBAL DIGITAL PATHOLOGY ANALYTIC MARKET BY REGION, THROUGH 2018 ($ TABLE 9 GLOBAL DIGITAL PATHOLOGY VISUALIZATION AND IMAGE ANALYSIS PLATFORM MARKET BY REGION, TABLE 10 GLOBAL DIGITAL PATHOLOGY INFORMATION SYSTEM MARKET BY REGION, TABLE 11 GLOBAL DIGITAL PATHOLOGY STORAGE PLATFORM MARKET BY REGION, TABLE 12 GLOBAL DIGITAL PATHOLOGY COMMUNICATION PLATFORM MARKET, TABLE 13 GLOBAL DIGITAL PATHOLOGY COMMUNICATION PLATFORM MARKET BY REGION, TABLE 14 GLOBAL TELEPATHOLOGY SYSTEM MARKET, 61 TABLE 15 GLOBAL TELEPATHOLOGY SYSTEM MARKET BY REGION, THROUGH 2018 ($ TABLE 16 GLOBAL STATIC TELEPATHOLOGY SYSTEM MARKET BY REGION, THROUGH 2018 ($ TABLE 17 GLOBAL HYBRID TELEPATHOLOGY SYSTEM MARKET BY REGION, TABLE 18 GLOBAL REAL-TIME TELEPATHOLOGY SYSTEM MARKET BY REGION, TABLE 19 GLOBAL DIGITAL IN VITRO AND OTHER DIAGNOSTIC DEVICE MARKET, TABLE 20 GLOBAL DIGITAL IN VITRO AND OTHER DIAGNOSTIC DEVICES MARKET BY REGION, TABLE 21 GLOBAL AUTOMATED HEMATOLOGY ANALYZER AND BLOOD CELL COUNTER MARKET BY REGION, TABLE 22 GLOBAL DIGITAL CHROMOSOME ANALYZER MARKET BY REGION, TABLE 23 GLOBAL FLUORESCENCE IN SITU HYBRIDIZATION ENUMERATION SYSTEM MARKET BY REGION, TABLE 24 GLOBAL DIGITAL URINE SEDIMENT ANALYZER MARKET BY REGION, TABLE 25 GLOBAL IMMUNOHISTOCHEMISTRY IMAGE ANALYSIS APPLICATION MARKET BY REGION,

11 TABLE HEADING TABLE 26 GLOBAL DIGITAL CYTOPATHOLOGY MARKET BY REGION, THROUGH 2018 ($ TABLE 27 GLOBAL DIGITAL POLYMERASE CHAIN REACTION MARKET BY REGION, TABLE 28 GLOBAL SIGNET CELL DETECTION MARKET BY REGION, THROUGH 2018 ($ TABLE 29 GLOBAL DIGITAL HOLOGRAPHIC MICROSCOPY MARKET BY REGION, TABLE 30 GLOBAL DIGITAL PATHOLOGY MARKET BY TYPE, THROUGH 2018 ($ TABLE 31 GLOBAL DIGITAL PATHOLOGY IN THE ANATOMIC PATHOLOGY MARKET BY REGION, TABLE 32 GLOBAL DIGITAL PATHOLOGY IN GENETIC PATHOLOGY MARKET BY REGION, TABLE 33 GLOBAL DIGITAL PATHOLOGY IN HEMATOLOGY AND CLINICAL PATHOLOGY MARKET BY REGION, TABLE 34 GLOBAL DIGITAL PATHOLOGY IN IMMUNOPATHOLOGY MARKET BY REGION, TABLE 35 GLOBAL DIGITAL PATHOLOGY IN CHEMICAL PATHOLOGY MARKET BY REGION, TABLE 36 GLOBAL DIGITAL PATHOLOGY IN FORENSIC PATHOLOGY MARKET BY REGION, TABLE 37 GLOBAL DIGITAL PATHOLOGY IN MICROBIOLOGY MARKET BY REGION, TABLE 38 GLOBAL DIGITAL PATHOLOGY MARKET BY APPLICATION, THROUGH 2018 ($ TABLE 39 GLOBAL DIGITAL PATHOLOGY IN DISEASE DIAGNOSIS MARKET BY REGION, TABLE 40 GLOBAL DIGITAL PATHOLOGY IN DRUG DISCOVERY AND DRUG DEVELOPMENT MARKET BY REGION, TABLE 41 GLOBAL DIGITAL PATHOLOGY IN RESEARCH AND DEVELOPMENT BY REGION, TABLE 42 GLOBAL DIGITAL PATHOLOGY MARKET BY END USER, THROUGH 2018 ($ TABLE 43 GLOBAL DIGITAL PATHOLOGY IN BIOTECH AND PHARMACEUTICAL COMPANIES MARKET BY REGION, TABLE 44 GLOBAL DIGITAL PATHOLOGY IN HOSPITALS AND DIAGNOSTIC CENTERS MARKET BY REGION, TABLE 45 GLOBAL DIGITAL PATHOLOGY IN ACADEMIC CENTERS, CONSULTING AND TRAINING MARKET BY REGION, TABLE 46 NEW PRODUCTS BY COMPANY, TABLE 47 AGREEMENTS AND COLLABORATIONS BY COMPANY, TABLE 48 PRODUCT APPROVALS BY COMPANY, TABLE 49 MERGERS AND ACQUISITIONS BY COMPANY, TABLE 50 OTHER STRATEGIES BY COMPANY, TABLE 51 NORTH AMERICAN DIGITAL PATHOLOGY MARKET, THROUGH 2018 ($ TABLE 52 EUROPEAN DIGITAL PATHOLOGY MARKET, 129 TABLE 53 ASIAN DIGITAL PATHOLOGY MARKET, 131 TABLE 54 REST OF WORLD DIGITAL PATHOLOGY MARKET, THROUGH 2018 ($ TABLE 55 3DHISTECH LTD. PRODUCT PORTFOLIO

12 TABLE HEADING TABLE 56 3DHISTECH LTD. RECENT DEVELOPMENTS 141 TABLE 57 APERIO TECHNOLOGIES INC. PRODUCT PORTFOLIO 142 TABLE 58 APERIO TECHNOLOGIES INC RECENT DEVELOPMENTS 142 TABLE 59 APOLLO PACS INC. PRODUCT PORTFOLIO 143 TABLE 60 APOLLO PACS INC. RECENT DEVELOPMENTS 143 TABLE 61 AURORA INTERACTIVE LTD. PRODUCT PORTFOLIO 144 TABLE 62 AURORA INTERACTIVE LTD. RECENT DEVELOPMENTS 144 TABLE 63 CORISTA LLC PRODUCT PORTFOLIO 145 TABLE 64 CORISTA LLC RECENT DEVELOPMENTS 145 TABLE 65 DEFINIENS AG PRODUCT PORTFOLIO 146 TABLE 66 DEFINIENS AG RECENT DEVELOPMENTS 147 TABLE 67 DIGIPATH INC. PRODUCT PORTFOLIO 148 TABLE 68 DIGIPATH INC. FINANCIALS ($ 148 TABLE 69 DIGIPATH INC. RECENT DEVELOPMENTS 149 TABLE 70 HURON TECHNOLOGIES INTERNATIONAL INC. PRODUCT PORTFOLIO 149 TABLE 71 HURON TECHNOLOGIES INTERNATIONAL INC. RECENT DEVELOPMENTS 150 TABLE 72 INDICA LABS INC. PRODUCT PORTFOLIO 150 TABLE 73 INDICA LABS INC. RECENT DEVELOPMENTS 151 TABLE 74 LEICA MICROSYSTEMS GMBH PRODUCT PORTFOLIO 152 TABLE 75 LEICA MICROSYSTEMS GMBH RECENT DEVELOPMENTS 153 TABLE 76 LIGOLAB LLC PRODUCT PORTFOLIO 154 TABLE 77 MIKROSCAN TECHNOLOGIES INC. PRODUCT PORTFOLIO 154 TABLE 78 MIKROSCAN TECHNOLOGIES INC. RECENT DEVELOPMENTS, 2011 AND 2012 TABLE 79 NIKON INSTRUMENTS INC. PRODUCT PORTFOLIO 156 TABLE 80 NIKON INSTRUMENTS INC. FINANCIALS, ($ 156 TABLE 81 NIKON INSTRUMENTS INC. RECENT DEVELOPMENTS, TABLE 82 OMNYX LLC PRODUCT PORTFOLIO 157 TABLE 83 OMNYX LLC RECENT DEVELOPMENTS, TABLE 84 PATHCENTRAL PRODUCT PORTFOLIO 158 TABLE 85 PATHCENTRAL RECENT DEVELOPMENTS, TABLE 86 PATHXL PRODUCT PORTFOLIO 160 TABLE 87 PATHXL RECENT DEVELOPMENTS, TABLE 88 PIXCELLDATA LTD PRODUCT PORTFOLIO 161 TABLE 89 PIXCELLDATA LTD. RECENT DEVELOPMENTS, TABLE 90 SUNQUEST INFORMATION SYSTEMS PRODUCT PORTFOLIO 162 TABLE 91 SUNQUEST INFORMATION SYSTEMS RECENT DEVELOPMENTS, TABLE 92 VENTANA MEDICAL SYSTEMS INC.: PRODUCT PORTFOLIO 163 TABLE 93 VENTANA MEDICAL SYSTEMS INC. RECENT DEVELOPMENTS 164 TABLE 94 VISIOPHARM PRODUCT PORTFOLIO 166 TABLE 95 VISIOPHARM RECENT DEVELOPMENTS, TABLE 96 PATENT LIST,

13 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL DIGITAL PATHOLOGY MARKET BY REGION, ($ FIGURE 1 TELEPATHOLOGY AND DIGITAL PATHOLOGY APPLICATIONS 12 FIGURE 2 COST ANALYSIS OF CONVENTIONAL LABS VERSUS DIGITAL PATHOLOGY SYSTEMS FIGURE 3 DIGITAL PATHOLOGY SYSTEM MARKET 29 FIGURE 4 KEY STRATEGIES, (%) 30 FIGURE 5 KEY COMPANIES, (%) 31 FIGURE 6 GLOBAL PATENTS BY REGION, (%) 31 FIGURE 7 GLOBAL PATENTS BY TECHNOLOGY, (%) 32 FIGURE 8 NEW PRODUCT DEVELOPMENT BY COMPANY, (%) 115 FIGURE 9 AGREEMENTS AND COLLABORATIONS BY COMPANY, (%) 117 FIGURE 10 PRODUCT APPROVALS BY COMPANY, (%) 122 FIGURE 11 U.S. PATENTS BY TECHNOLOGY, FIGURE 12 U.S. PATENTS BY COMPANY, (%) 135 FIGURE 13 EUROPEAN PATENTS BY TECHNOLOGY, (%) 136 FIGURE 14 EUROPEAN PATENTS BY COMPANIES, (%) 136 FIGURE 15 JAPAN PATENTS BY TECHNOLOGY, (%) 138 FIGURE 16 JAPAN PATENTS BY COMPANY, (%)