th Course on Epigenetics. Institut Curie - Paris March 12-19

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1 2008-4th Course on Epigenetics SCIENTIFIC ORGANIZERS G. Almouzni - P-A. Defossez - N. Dostatni - E. Heard - A. Taddei Keynote Speakers P. Jones (Los Angeles, USA) R. Martienssen (Cold Spring Harbor, USA) S. Bateman (Paris) P. Becker (Munich) W. Bickmore (Edinburg) C. Bowler (Paris) M-L. Caparros (London) V. Colot (Paris) C. Collet (London) J. Cooper (London) L. Dandolo (Paris) O. Delattre (Paris) K. Dubrana (Paris) A. Ferguson-Smith (Cambridge) P-H. Gaillard (Marseille) A. Lamond (Edinburg) P. Le Baccon (Paris) B. McVittie (London) J-P. Quivy (Paris) P. Pasero (Montpellier) D. Schuebeler (Basel)) L. Ringrose (Vienna) S. Tajkbash (Paris) M. Van Lohuizen (Amsterdam) A.Verdel (Grenoble) - Paris March Topics: - Epigenetics and Chromatin Dynamics - Imaging the Nucleus and its functions - Silencing, transcriptional landscapes and genomics - Memory of transcriptional states - Stem cells and reprogramming - maintenance of (Epi)genome integrity - Epigenetics and Cancer Workshops: - Ethical issues - Career development - Art & Science Image from Wikipedia with permission from Sam Fentress On-line Registration : NoE Epigenome

2 2008 Fourth Course on Epigenetics Eligibility This course (3 ECTS) is open: - to students (up to 10) from the Master (M2) mention "Biologie Moléculaire et Cellulaire" of the University Paris VI, the Master (M2) mention "Européen de Génétique" of the University Paris VII and the graduate schools "Logique du vivant", "Gène, Génome, Cellule" and "Biologie et Biotechnologie" and Cancérologie and other Parisian universities. - to Master or Ph. D students from France at large and European universities (up to 10). There are no registration fees for this course. Travel and accommodation are not covered, but foreign students or French students living outside the Parisian area can apply for fellowships at the time of registration. Selected students will be reimbursed. All presentations and discussions will be in English for this European Course. Application deadline: November 1st, Dates: March 12 to March 19, Distribution of the articles: February 12, Venue:, Paris. Objectives: to provide an overview of the epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on the technological limits and the new experimental approaches developed today. Links between the disruption of nuclear function and the development of human pathologies will be presented. Topics: The module is organized in sessions containing two lectures of 50 mn on the following themes: Epigenetics and Chromatin Dynamics Imaging the Nucleus and its functions Silencing, transcriptional landscapes and genomics Memory of transcriptional states Stem cells and reprogramming maintenance of (Epi)genome integrity Epigenetics and Cancer In addition, during each session two students will present scientific articles related to the topics discussed. Students and lecturers will have the opportunity to meet during an informal lunch every day. Workshops: Ethical issues and Art & Science Round table dedicated to career development after a Ph. D in Biology will be organized on Saturday morning (15/03/2008).

3 05/09/2008 PROVISIONAL PROGRAM Epigenetics, Chromatin and Nuclear Organization Wednesday 12th of March 2008 Chairman : Geneviève Almouzni Epigenetics and Chromatin Dynamics 09:00 F. Berger, D. Chardonnieras, M. Martin (, Paris) G. Almouzni, PA Defossez, N. Dostatni, E. Heard, A. Taddei (UMR 218, /CNRS, Paris) Welcome & practical aspects Presentation of the module and the organizers 09:15 The participants Short presentation of background and research interest (2-3 mn each) 10:45- Pierre-Antoine Defossez (UMR218, /CNRS, Paris) DNA Methylation and gene expression 11:45-12:30 Nathalie Dostatni (UMR218, /CNRS, Paris) Position effect variegation in Drosophila LUNCH "Chez Marie" 14:45 Marie-Laure Caparros (Freelance project manager, London, UK) Peter Becker (Ludwig Maximilians University, Munich, Germany) Grant application, work and project presentation Chromatin dynamics and gene regulation Lacassagne Amphitheatre 16:00 and PICTURE "Chez Marie" or garden 16:30-17:30 Opening Lecture: Rob Martienssen (Cold Spring Harbor Lab, USA) Epigenetics in Arabidopsis Lacassagne Amphitheatre 18:00 Welcome reception Salle de la Montagne Sainte Geneviève

4 Thursday 13th of March Chairman : Angela Taddei Imaging the nucleus and its functions 09:30-10:30-11:15 Patricia Le Baccon (UMR218, /CNRS, Paris) Angus Lamond (School of Life Sciences Research Biocenter, Dundee, UK) Live cell imaging: diving in the nucleus Nuclear structure and RNA processing 12:00 Selected paper presented by a student 12:30 Selected paper presented by a student 14:45 LUNCH "Chez Marie" Nuclear organization and genome activity Wendy Bickmore (MRC, Edinburgh) Integrating chromosome structure and function 16:00 16:30 Angela Taddei (, Paris) CURIE MUSEUM: guided tour Nuclear organisation and transcription in budding yeast 17:30 Selected paper presented by a student 18:00 Selected paper presented by a student

5 Friday 14th of March Chairman : Pierre-Antoine Defossez Silencing, transcriptional landscapes and epigenomics 09:30- André Verdel (Institut Albert Bonniot, La Tronche) RNA interference 10:30-11:15 Vincent Colot (INRA, Evry) Epigenomics in Arabidopsis 12:00 Selected paper presented by a student 12:30 Selected paper presented by a student 14:45 LUNCH "Chez Marie" Chris Bowler (ENS, Paris) Molecular signalling and functional genomics in marine diatoms Dirk Schübeler (Friedrich-Miescher Institute for Biomedical Research, Basel) Propagation and dynamics of epigenetic states 16:00 16:30 Selected paper presented by a student 17:00 Selected paper presented by a student 17:30 Brona McVittie (Public Science Officer Epigenome, London) and Carole Collet (Art advisor, London) Art and Science workshop

6 Saturday 15th of March 11:00 - BRUNCH DEVOTED TO CAREER DEVELOPMENT (sponsored by ) Organized by: PhD students (UMR218, Institut Curie/CNRS, Paris) Naill Murphy, Tomislav Horvat, Armelle Corpet Invited participants :

7 Monday 17th of March Chairman : Luisa Dandolo Epigenetic memory of transcriptional states 09:30- Leonie Ringrose (IMBA, Vienna) Polycomb/Trithorax 10:30-11:15 Edith Heard (UMR218, ) X-inactivation in mice 12:00 Selected paper presented by a student 12:30 Selected paper presented by a student LUNCH "Chez Marie" Stem cells and reprogramming 14:15 Anne Ferguson-Smith (University of Cambridge, Cambridge) Genomic imprinting and reprogramming Sharaghim Tajkbash (Institut Pasteur, Paris) Adult stem cells 16:00 16:30 Selected paper presented by a student 17:00 Selected paper presented by a student 17:30-18:15 Simone Bateman (Centre de recherche sens, éthique, société, Paris) "EpigenEthics" : Ethical issues in stem cell biology

8 Tuesday 18th of March Chairman : Nathalie Dostatni Chromatin and maintenance of genome integrity 09:30- Philippe Pasero (Institut de Génétique Humaine, Montpellier) Maintenance of genome integrity during DNA replication 10:30-11:15 Geneviève Almouzni, Jean-Pierre Quivy (UMR218, /CNRS, Paris) Chromatin assembly factors, histone H3 variants and cell cycle 12:00 Selected paper presented by a student 12:30 Selected paper presented by a student 14:45 LUNCH "Chez Marie" Karine Dubrana (CEA, Fontenay-aux-Roses) Chromatin and repair in yeast 16:00 PH Gaillard (CNRS Centre J. Aiguier, Marseille) Control of structure specific endonucleases and implications in the biology of cancer 16:30 Selected paper presented by a student 17:00 Selected paper presented by a student 17:30-18:30 Julie Cooper (Cancer Research UK, London, UK)) Telomeres function throughout the cell cycle 19:30 Farewell Cocktail & Buffet Dinner (sponsored by Nikon) Salle de la Montagne Sainte Geneviève

9 Wednesday 19th of March Chairman : Edith Heard Chromatin and Cancer 09:30 10:30 Olivier Delattre (U830, ) Martin Van Lohuizen (The Netherlands Cancer Institute, Amsterdam) Genetics and biology of pediatric tumours Biology and epigenetic regulation of normal and cancer stem cells 12:00 Closing lecture: Peter Jones (University of Southern California, Los Angeles) DNA Methylation and Cancer Curie Amphitheatre