Asterand Bioscience Strategic Alliances

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1 Asterand Bioscience Strategic Alliances Excellence through partnership

2 WHY ASTERAND BIOSCIENCE Asterand Bioscience has a well-established human tissue heritage, having been formed in 2006 through the merger of Asterand (founded 2000), a human tissue biorepository, and Pharmagene (founded 1996), a human tissue-based drug discovery company. With our capability in human tissue sample procurement, characterization and service, Asterand Bioscience is uniquely positioned to provide a comprehensive approach to meet the research needs of pharmaceutical, biotechnology and diagnostic companies, and academia. From our offices in Detroit, MI and Royston, U.K., our employees are focused on providing services and products to accelerate drug discovery research from target identification through to compound evaluation and preclinical drug and diagnosis development. ESTABLISHED AND PROSPECTIVE SOLUTIONS Asterand Bioscience offers unparalleled access to human biosamples through its worldwide network of active collaborating donor institutions. Our XpressBANK contains specimens across a broad range of therapeutic areas and with diverse ethnic representation. Our renowned quality control procedures provide stringent oversight on specimen collection and characterization and on the corresponding associated clinical data. We independently confirm pathology with our in-house board certified pathologists and assess RNA integrity of our tissues. Our quality control results are provided to researchers before they purchase so they can choose samples that will best meet their scientific requirements. Through our ProCURE service, human tissues and clinical data can also be custom collected to meet special requirements. This may include the collection of follow-up data related to patient treatment and outcome. DRUG DISCOVERY SERVICES Asterand Bioscience s services division offers exemplary scientific expertise in human tissue research, with experience in providing top multinational pharmaceutical companies with human tissuebased services since Through our PhaseZERO drug discovery services platform, we provide a collaborative scientific approach to deliver human tissue-based data on target & biomarker validation as well as compound potency, effect and safety. Our studies can be custom designed and are conducted on a fee-for-service basis where our clients own and retain all resulting IP and data.

3 WHO WE ARE? Asterand Bioscience is the leading global provider of high quality, well characterized human tissue and biofluid samples and human tissue-based research solutions to drug discovery scientists. Our mission is to provide human-based solutions to accelerate the identification and validation of drug targets and enhance the selection of drug candidates with an increased likelihood of clinical success. Asterand Bio Human Tissue Products (XpressBANK, BioSPOKE ) and Services (PhaseZERO ) Phase 1 Phase 2 Phase 3 Approval 5,000-10,000 Compounds Target Identification Biomarker Discovery Target Validation Lead Identification Lead Optimization ADME Preclinical Clinical 1 Approved Drug Preclinical discovery and development 3-6 years Clinical development 7-9 years STRATEGIC ALLIANCE PARTNERS Asterand Bioscience, in conjunction with our Strategic Alliance Partners, is the leading provider of high quality human biosamples and associated clinical information. Our Strategic Alliance Partners follow rigorous criteria for the procurement and quality control of samples. Biosamples are acquired through different procurement means to best meet the research requirements of our customers through an IRB approved process.

4 WHY BECOME A STRATEGIC ALLIANCE PARTNER WITH ASTERAND BIOSCIENCE? Asterand Bioscience s research partners are the leading scientists in drug discovery for a wide range of diseases, including cancer, heart disease, autoimmune disorders, CNS diseases and more. Their progress is dependent on donated human diseased and normal tissues and biofluids that are used to accelerate and move their research from the bench to the clinic. Our tissue samples are consented for use in research and are excess to diagnostic and therapeutic needs and are not suitable for transplant. This provides individuals and families the option to participate in the advancement of drug discovery, contributing to the understanding of these diseases and to the development of new treatments, cures and diagnoses. THE ASTERAND BIOSCIENCE PROCESS Asterand Bioscience, a CAP accredited organization, has the experience and dedication to provide researchers the best quality specimens required for their research needs. Many facilities, including hospitals, tissue banks and organ procurement organizations, work with Asterand Bioscience to ensure the best outcomes for tissues donated from individuals and families wishing to help advance the understanding of disease and the development of new drugs and diagnostics. You can help further research, which will benefit the lives of millions.

5 Asterand Bioscience has a highly trained staff of scientists and technicians, who work with partner organizations to facilitate the best use of donated biospecimens. Asterand Bioscience has provided over 200,000 human biospecimens to an extensive group of long standing partners located world wide. CURRENT RESEARCH NEEDS Organs and tissues routinely discarded during standard treatment processes are critical for researchers working to understand biological mechanisms and drug discovery. Surgical discards Tumor, adjacent normal tissue and matched blood Explanted organs from transplant recipients and non-transplanted organs from organ donors Skin, fat and cartilage removed during surgery Autopsy tissues Normal and diseased tissues with short post-mortem recovery times Archived specimens Paraffin blocks, slides, and other archived specimens

6 ETHICAL LEADERSHIP AND REGULATORY CONTROL All human tissue samples are obtained with informed donor consent and are de-identified prior to banking and distribution. Asterand Bio acts in strict compliance with the US Health Insurance Portability and Accountability Act (HIPAA) and the United Kingdom Human Tissue Authority (HTA) and is accredited by the College of American Please contact our Strategic Alliance Directors in the following regions to discuss your requirements: United States Tech One, Suite Burroughs Detroit, MI USA T: F: International 2A Orchard Rd. Royston, Hertfordshire, SG8 5HD UK T: +44 (0) F: +44 (0) Pathologists (CAP) and ISO DRUG DISCOVERY SERVICES: Immunohistochemistry In situ Hybridization Tissue MicroArrays Digital Pathology Fluorescent In situ Hybridization Histopathology Western Blotting Laser Capture Microdissection qrt-pcr Autoradiography Primary Cell Isolation and Culture Cell Based Assays Cell Based Assay Development OrganDOT sirna Target Knockdown Mutation Analysis THERAPEUTIC AREAS: Oncology Cardiovascular Disease Metabolic Disorders CNS Disorders Respiratory Diseases Inflammatory & Allergy Genitourinary System Diseases Normal Tissues BIOMATERIALS AVAILABLE: Flash-Frozen Tissues Fixed & Embedded Tissues Serum, Plasma, Blood Synovial Fluid RNA & DNA biomaterials Tissue MicroArrays Primary Cells and Cell Lines Unless otherwise noted, all trademarks are the property of Asterand Bioscience, Inc Asterand Bioscience, Inc. All rights reserved. Issue Code: AB-SA-Partnership