2. For what indications Probiotics are generally prescribed?

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1 Zeebon FAQs 1. What are probiotics? Probiotics are the live micro-organisms when administered in adequate quantity confer health benefits to patients. (Pre-biotics are the indigestible fibrous compound when administered helps the intestinal flora to flourish and act as a substratum for their growth. Syn-biotics are mixture of Pre and Pro biotic) 2. For what indications Probiotics are generally prescribed? Probiotics are widely prescribed as an anti-diarrheal and to improve digestion and immunity. Probiotics also Produce Digestive enzymes and help in the digestion of food Increase ability to assimilate the nutrients from food Produce B complex Vitamins and help in Calcium absorption Maintain Water an Electrolyte balance Reduce the growth of harmful pathogenic bacteria in Gut 3. What is/are key ingredient of Zeebon? Zeebon contains 4 billion Bacillus clausii CFUs {CFU : Colony Forming Units 1 Billion = 100 Crore} 4. What is therapeutic dosage and duration of Zeebon Zeebon contains 4 billion Bacillus clausii spores and needs to be given as OD dosage.

2 Dr can also give it in 2 divided dosages in a day. (5 ml in the morning and remaining 5mL in the evening) When giving divided dosage it is recommended to keep the remaining 5mL in the refrigerator. Duration:- Acute Diarrhea:- 5 days Chronic Indigestion:- 4 to 8 weeks 5. Can Zeebon be given to adult patients Zeebon can be given to patients from Paediatrics to Geriatrics class. 6. Is it safe to prescribe Zeebon in pregnancy and lactation? Zeebon has no contraindication in pregnancy and lactation hence can be prescribed. 7. Is there any adverse undue drug interaction of Zeebon? No interactions with consecutive concomitant use with other medicines or food. 8. Is there any adverse clinical manifestation of over dosage? There have not been any reported clinical manifestations caused by an overuse. 9. What is the shelf life of Zeebon? Under proper storage condition and undamaged Zeebon has shelf life of 18 months. 10. What is Smart Cap Advantage in Zeebon? Zeebon offers Smart Cap Technology which holds the Bacillus claussi spores in the Cap until administration which keeps the Bacillus clausii in the Spore form and keeps its Efficacy Intact as Bacillus clausii do not undergo vegetation. When Cap is turned clockwise direction, spore repository seal breaks and the Bacillus clausii spores falls into water. Shaking the bottle ensures homogeneous mixing and Zeebon gets ready for administration.

3 11. What are the 3 easy steps of Activating the Smart Cap of Zeebon. 1) Turn the cap in clockwise direction to break the seal 2) Shake well 3) Open the bottle in anticlockwise direction and drink. 12. What are the 3 USP s of Zeebon 1) Zeebon is the only probiotic which offers Smart Cap Technology which keeps the Efficacy of the Bacillus clausii intact 2) Zeebon is the only probiotic offers 4 billions Bacillus clausii spores for effective relief in Diarrhea 3) Zeebon comes with Very Delicious Berry flavour which improves acceptability amongst paediatric patients. 13. What are the indications for Zeebon? GI tract disturbance Antibiotic associated diarrhea Chronic Indigestion 14. To which target audience Zeebon needs to be promoted? Zeebon needs to be promoted only to Paediatricians at P Is there any side effect for Zeebon? Bacillus clausii is considered as one of the safest amongst probiotics in paediatrics hence widely used with no recorded side effects. 16. Who are the competitors over Zeebon will win over? Enterogermina (Sanofi) Tufpro ( Sun) Ecobion BC (Merck)

4 17. Do we need to refrigerate Zeebon. Zeebon do not require any cold chain storage or refrigeration as the Bacillus clausii spores are stored in the smart cap in anhydrous form keeping its efficacy intact. 18. What is the MRP of Zeebon? Zeebon is available for Rs 80 per unit. 19. Zeebon is costly, Isnt it? Zeebon offers 4 Billion Bacillus clausii spores unlike other competitor which offering 2 billion spores. Enterogermina costs 42 Rs per unit. Which offers 2 billion spores and often prescribed as BID Per day therapy cost with Enterogermina = 2 X 42 = 84 Per day therapy cost with Zeebon = 1X 80 = 80 Hence Zeebon is cost effective compared to Enterogermina and also offers Novel Smart Cap technology which keeps the efficacy of Bacillus claussi Intact!!! Zeebon palatability can also be leveraged to drive an extra mileage as other competitors are tasteless. 20. Give 1 relevant prelude to sell Zeebon s smart cap well Dr you would agree that now its an era of technology everyone is using Smart phone, Smart TVs and Smart watches to stay ahead of time. We at Wockhardt believe that diarrhea management also need to be Smart. So Dr Presenting 1st time in India Zeebon- 4 billion Bacillus Clausii spores with Novel Smart Cap Technology which keeps Probiotics Efficacy Intact. 21. How we can counter competitor in Probiotic- Powder form. Leading pharma companies have Bacillus clausii in liq form only and not in granules.eg. Sanofi, Abbott,Sun,Merck

5 Hence 85% market contribution comes from liq form only but for remaining 15% combat points are as below Granule form is low on compliance as mother need to do a tedious job of cutting the sachet taking a bowl full of water and then mixing and stirring the Bacillus clausii granules. Purity of the water used and the utensil hygiene is also questionable In Zeebon only 3 simple steps of administration and 4 billion OD dose offer patients compliance Solid form B.clausii are available in 2 billion strength only. In some of the sachet due to moist condition, crumples can get formed or it can get sticky. If that happens during mixing with the water Bacillus clausii CFUs will be less than 2 billion. But In Zeebon as water and spores are part of the same system hence CFUs will be sufficient. 22. Is the bacillus clausii in Zeebon is the safest probiotic. Bacillus clausii is the safest and the effective strain of probiotics hence most preferred in the paediatric patients. Other stains like clostridium and some Streptomyces may lead to side effect. 23. Can fluctuation in the temperature leads to decreased efficacy of the probiotics in the already reconstituted form. (Entero******a, Tu***o)? Fluctuation in the Optimum storage conditions such as temperature may lead to decreased efficacy in the probiotics in the reconstituted form. Zeebon safeguard the bacillus clausii spores in the smart cap and keeps its efficacy intact and hence do not needs refrigeration for storage. 24. In case of divided dosage of 5 ml do I need to refrigerate the remaining 5 ml? Why? If Yes isn t it contradictory with the claim that Zeebon needs No refrigeration? In case of divided dosage it is recommended to keep the remaining 5mL in the refrigeration to prevent any kind of contamination and also to prevent any chances of germination after reconstitution. The Basic reason of communicating NO REFRIGERATION for Zeebon at retailer level is to highlight the chances of Loss of efficacy in the Premix probiotics like Tuf**O and Entero******a, as not all the retailers maintain the optimum temperature conditions during storage. During summers as the temperature goes high the chances of loss of potency is very high in the pre-mix probiotics. 25. How to sell 4 Billion CFU concept of bacillus clausii? Zeebon with revolutionary Smart Cap Technology is India s 1st Bacillus clausii probiotic brand which offers 4 Billion CFUs bacterial spores. Other pre-mixed liquid suspension form Bacillus clausii brands

6 are available only in 2 Billion CFUs in 5ml due to sedimentation issues as well as feasibility issues of packaging higher Spore CFUs in suspension. 3 compromises made by other B clausii suspension preparations which are not made by Zeebon and are its USPs: a) Other pre-mixed liquid suspension form Bacillus clausii brands are available only in 2 Billion CFUs in 5ml due to sedimentation issues as well as feasibility issues of packaging higher Spore CFUs in suspension. Due to Therefore they have to be taken as 2 mini-bottles daily. Since Zeebon has anhydrous spores of B clausii, a larger amount 4 billion CFU can be packaged, and this is reconstituted as suspension only just before intake. Therefore only one bottle per day needs to be taken which gives a definite compliance advantage in Pedia. b) B clausii in the form of Dry spores maintain better stability and viability. Spore activation happens only at the time of intake whereas in suspension form, spore activation and germination can occur with increased temperatures and mechanical agitation thereby reducing spore viability and amounts reaching past gastric acid to the lower GI tract. c) Taste is of utmost importance in pediatric formulations. In suspension, adding small amounts of sugar to improve taste is not possible as the sugar will function as a nutrient to activate and germinate spores. Zeebon has the advantage of a pedia friendly taste with blueberry flavour increasing acceptability in children. Zeebon with 4 billion bacillus clausii spores which reconstitutes only at the time of administration and keeps spore Efficacy Intact offers OD dosage advantage and better palatability considering paediatric patient requirement. So doctor why go for tasteless BID dosage liquid form of Bacillus clausii - Choose Smart-Cap technology- choose Zeebon. 26. Comparison between Saccharomyces boulardii.and Bacillus clausii. Bacillus clausii is gram positive bacteria and antibiotic resistant hence can be given in Antibiotic associated diarrhea. B. clausii do not transfer antibiotic resistant properties to other malefic (Infectious) bacteria. Bacillus clausii is also safe even in patient less than a year old ( Can also be given in less than 6 month old baby) and it do not any major side effects such as septicemia. S. boulardii is a fungal strain and generally available as granules. It is been widely used in elderly patients as a probiotic supplement compared to pedia counterparts. Some cases fungal infections have been recorded in some of the patients with S.boulardi.

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