Systems Science Developments. Health Systems Science at NIH

Transcription

1 Systems Science Developments at the Funding National Opportunities Institutes of for Health Systems Science at NIH Patty Mabry, Ph.D. Office of Behavioral and Social Sciences Research (OBSSR) National Institutes of Health

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3 vacancy Francis Collins

4 About NIH & OBSSR The National Institutes of Health (NIH) is an agency of the U.S. federal government within the Department of Health and Human Services. With a near $30 billion budget, it is the the steward of medical and behavioral research for the Nation. ( NIH is made up of 27 Institutes and Centers (ICs) - each covering a specific domain of research, which is conducted both at NIH (intramural) and at grantee universities (extramural). See a directory of the ICs at The Office of Behavioral and Social Sciences Research (OBSSR) stimulates behavioral and social sciences research across the ICs. (

5 The Complex Problem Space of Human Health Outside the skin Under the skin zz

6 Systems Science terminology at NIH Systems Science approaches appreciate the complexity, context, dynamic nature, and emergent phenomena associated with the problem under study SS methodologies include Computational/mathematical modeling Agent-based modeling Dynamic modeling Network Analysis Related Terms: Complexity science Complex adaptive systems Non-linear dynamics

7 What are the benefits of systems science to NIH? Heuristic: to better understand problems (e.g., underlying dynamics) Hypothesis Generation: new hypotheses and/or narrow the list of existing hypotheses prior to empirical studies Knowledge Synthesis: synthesize existing knowledge for meaningful interpretation Expose Gaps in Knowledge about a problem Forecasting to aid in preparing for the future Intervention Testing in a virtual environment: saves time and money; can do things that are impossible or unethical in the real world; and exposes unintended consequences.

8 Current SS at NIH Interest in systems science (SS) is growing rapidly at NIH Systems biology is further along than SS in the behavioral and social sciences. SS is being used to study infectious disease transmission (e.g., HIV, flu, smallpox, SARS). Less SS is being done in chronic disease/behavioral and social determinants of health these areas are ripe for SS Any area of health and disease is applicable for NIH funding

9 Potential Areas of Modeling for NIH Pandemic flu Tobacco use/substance abuse/addiction Obesity Health disparities/inequalities Social determinants of health Chronic disease cardiovascular, cancer, diabetes Health care delivery Stress, mental illness Demography and population health

10 Grant Funded Systems Science and BSSR at NIH Joshua Epstein, Director s Pioneer Award, NIGMS, OBSSR, Project Title: Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Disease. David Lounsbury, R03, NIDA, Project Title: Dynamics Modeling as a Tool for Disseminating the PHS Tobacco Treatment Guideline David T. Levy, U01, NCI, CISNET. Project Title: A Simulation of Tobacco Policy, Smoking and Lung Cancer. Linda Collins & Daniel Rivera, R21, NIH Roadmap. Dynamical System /Related Engineering Approach /Improving Behavioral Intervention Daniel Rivera, K25, NIDA, OBSSR. Control Engineering Approaches to Adaptive Interventions in Drug Abuse Prevention.

11 Grant Funded Systems Science and BSSR at NIH Joe Eisenberg, Jim Trostle, R01 NIAID/NSF. Project 1Title: Environmental change and diarrheal disease. Project 2 Title: Ecology of Infectious Disease. Yasmin Said, F32, NIAAA. A Social Network Model of Ecological Alcohol Systems PAR Awards pending. RFA-HD (R01), Innovative Computational and Statistical Methodologies for the Design and Analysis of Multilevel Studies on Childhood Obesity (R01). Awards pending.

12 Funding Mechanisms at NIH NIH has a variety of mechanisms to address most any stage of the scientific development cycle: R03 small grant, in general $100K for two years R21 - $275K Direct cost for a two year period R01 up to $500K per year for up to 5 years Training and career development awards are also encouraged. Institutional and individual awards. Refer to for detailed funding info I can also send a resource page to you

13 Open Funding Opportunity Announcements at NIH in Systems Science PAR Using Systems Science Methodologies to Protect and Improve Population Health (R21). PAR , -213, -214 Methodology and Measurement in the Behavioral and Social Sciences (R01, R21, R03). RFA , -080 Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01, R21) PAR Predictive Multiscale Models of the Physiome in Health and Disease (R01). RFA-NR Incorporating Cost-Effectiveness Analysis Into Factors Affecting Quality-of-Life Health Related Research (R01) PA (R01) ; PA (R21) ; PA (R03) Research on Alcohol-Related Public Policies such as Those Detailed in the Alcohol Policy Information System

14 NIH Roadmap for Medical Research The NIH Roadmap is a trans-nih initiative funded through the Common Fund ALL Institutes and Centers (ICs) participate. Initiatives funded through the Roadmap/Common Fund fit into one or more of these major themes and address specific roadblocks or gaps to: Foster high-risk/high-reward research Enable the development of transformative tools and methodologies Fill fundamental knowledge gaps Change academic culture to foster collaboration Director s Pioneer Award - 1 receipt date per year - apply in fall New Innovator Award 1 receipt date per year - apply in fall

15 Advice for Getting NIH Funding Identify a research question or area for which your skills are needed. Identify collaborators with the content expertise, NIH track record of success Identify pertinent FOAs Identify one or more IC s who might be interested Develop a concept paper Talk to Program Staff (Scientific Contacts) Prepare application well before deadline send draft out for feedback.

16 Poster Opportunity Society for the Study of Human Development October 18-20, 2009 Panel Presentation and Poster Session featuring systems science Call for poster submissions Extended to Aug 3 (see me) Travel scholarships available

17 Future Activities Comparative modeling network in obesity Society for the Study of Human Development (Ann Arbor, MI; Oct 18-20, 2009). Travel scholarships avail. Social Computing, Behavioral Modeling and Prediction (SBP10) Washington, DC March 30-April 2. Society for Prevention Research (June 2010)

18 Nkl; Nko; Seeking: Participants Faculty Speakers

19 September 24, in Lister Hill, on the NIH main campus. The Obesity Research Task Force Seminar Series is open to all NIH staff. 8:30am-2:30pm. SEMINAR TOPIC - Non-traditional Risk Factors for Obesity SPEAKERS * Dr. Jeff Gordon (Washington University, St. Louis) -- microbiome * Dr. Nikhil Dhurandhar (Pennington Biomedical Research Center, Baton Rouge) -- adenoviruses * Dr. Dr. Elissa Epel (U.C. San Francisco) -- psychological stress * Dr. Jerry Heindel (NIEHS) -- environmental toxins

20 OFFICE HOURS As arranged JOIN THE LISTSERV!!!

21 END Patty Mabry, Ph.D. OBSSR