Program. Innate Immunity of Crop, Livestock and Fish update: 9 September Monday 19 September Tuesday 20 September 2016

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1 Innate Immunity of Crop, Livestock and Fish update: 9 September 2016 Program Monday 19 September :00-10:35 Arrival, registration and coffee/tea 10:35-10:50 Welcome & Introduction to Lorentz Center 10:50-11:05 Opening Comments: Masaaki Toyomizu (CFAI, Japan) 11:05-11:20 Opening Comments: Corné Pieterse (Utrecht, the Netherlands) 11:20-11:35 Opening Comments: Ton Bisseling (Wageningen, the Netherlands) 11:35-12:00 Keynote Address (Overview of the whole week): Hideki Takahashi (CFAI, Japan) Dawn of Agricultural Immunology 13:15-14:00 Guest lecture (Plant scientist of Food industry) Marcel Prins (Vice president of vegetable crops, Keygene N.V. and Prof. of Plant Pathology at the University of Amsterdam) Harnessing the innate immunity of plants for improved crop resistance 14:00-14:45 Guest lecture (Animal scientist of Food industry) Coen Smits (Ingredients research manager at Nutreco) 14:45-15:15 Coffee/tea break 15:15-16:00 Keynote Address (Session I): Geert Wiegertjes (Wageningen, the Netherlands) How the innate immune system unites biologists and improves memory 16:00-16:45 Keynote Address (Session II): Masahiko Harata (CFAI, Japan) Modulating gene functions for immunity and susceptibility to diseases: Towards epigenetic control of innate immunity 16:45-17:00 Arrangement of agenda and discussion group: Geert Wiegertjes 17:30 - Wine and Cheese room Tuesday 20 September 2016 Session I. Innate immunity in livestock, fish and crop: difference and similarity 09:40-10:15 Marca Wauben (Utrecht, the Netherlands) Milk-derived extracellular vesicles are a distinct functional milk component that influence immunity and epithelial barrier function 10:15-10:50 Shuhei Miyashita (CFAI, Japan) Understanding the surviving strategies of plant viruses by mathematical modeling 11:25-12:00 Tomonori Nochi (CFAI, Japan) Challenge to the activation of the mammary gland immune system by modulating the intestinal environment 13:15-13:50 Sylvia Brugman (Wageningen, the Netherlands) Using zebrafish to understand fish gut health 13:50-14:25 Maria Forlenza (Wageningen, the Netherlands) Oral vaccination of fish: successes, challenges and future perspectives

2 14:55-15:25 Group discussion I-A 15:25-15:55 Special Lecture: Kinya Toriyama (Tohoku University, Graduate School of Agricultural Science, Japan) Arms race between mitochondria and nuclei exemplified by cytoplasmic male sterility in rice 17:00 - JAPAN NIGHT at "Japanese Garden in Leiden University" (17:00 18:00: tour in the lovely Hortus Botanicus garden, Von Siebold). (18:00 20:00: Japanese Dinner and drinks in the Hortus Botanicus house) Wednesday 21 September :40-10:15 Richard Kormelink (Wageningen, the Netherlands) Cross-kingdom perspectives on host defence and counter defence by a plantinfecting bunyavirus 10:15-10:50 Annemarie Rebel (Wageningen, the Netherlands) Maternal and early life programming of immune competence and microbiota composition 10:50-11:05 Coffee/tea break 11:05-11:35 Group discussion I-B with "Coffee/tea" 11:35-12:00 Moderated discussion (Session I) Moderator: Huub Savelkoul (Wageningen, the Netherlands) Session II. Preventive strategy to diseases in livestock, fish, shellfish and crop 13:15-13:50 Ad P Koets (Utrecht, the Netherlands) Chronic bacterial infections: still haven t found what you re looking for? 13:50-14:25 Mayuko Saito (Tohoku University, Medical School, Japan) Epidemiological evidences for antigenic diversity of norovirus and sapovirus in community studies 14:55-15:30 Special Lecture: Masaaki Toyomizu (CFAI, Japan) Mitochondrial function and animal production 15:30-16:00 Free discussion / collaborations 17:00 Departure bus to harbour 17:30 21:30 Boat trip & workshop dinner 21:30 Bus will bring you back to Station, Lorentz Center and Hotel van der Valk Thursday 22 September :40-10:15 Willem van Eden (Utrecht, the Netherlands) Nutritional manipulation of stress protein expression as a disease preventive strategy in mammals 10:15-10:50 Toshiki Nakano (CFAI, Japan) Can we use a good stress for cultured fish? 11:25-12:00 Huub Savelkoul (Wageningen, the Netherlands) Immunomodulation by processed feed

3 13:15-13:50 Haruki Kitazawa (CFAI, Japan) Immunobiotic evolution in livestock healthy growth strategy 13:50-14:25 Keisuke Takahashi (CFAI, Japan) Memory in innate immune system of aquatic invertebrates 14:55-15:25 Group discussion II-A 15:25-15:55 Special Lecture: Craig Hamilton Warden (UC Davis, USA) Finding genes for bacterial resistance in rodents Friday 23 September :40-10:15 Saskia van Wees (Utrecht, the Netherlands) Adaptivity of the plant innate immune system 10:15-10:50 Bart Thomma (Wageningen, the Netherlands) How fungal pathogens deal with plant immune systems 11:25-12:00 Peter Bakker (Utrecht, the Netherlands) The rhizosphere microbiome to the rescue 13:15-13:50 Wakako Ikeda-Ohtsubo (CFAI, Japan) Understanding "native" microbial ecosystem to improve biological control technologies 13:50-14:25 Free discussion / collaborations 14:55-15:25 Moderated discussion (Session II) Moderater: Hitoshi Shirakawa (CFAI, Japan) 15:25-15:55 Closing Remarks: Corné Pieterse (Utrecht, the Netherlands) (Including draft idea for position paper)

4 Group discussion I-A (Tuesday) Group 1 : Willem van Eden (A) (Discussion leader), Saskia van Wees (P), Maria Forlenza (M), Craig Hamilton Warden (A), Keisuke Takahashi (M), Masahiko Harata (A), Kinya Toriyama (P), Wakako Ikeda-Ohtsubo (A) Group 2 : Bart Thomma (P) (Discussion leader), Corné Pieterse (P), Huub Savelkoul (A), Sylvia Brugman (M), Tomonori Nochi (A), Toshiki Nakano (M), Mayuko Saito (A), Masaaki Toyomizu (A), Shuhei Miyashita (P) Group 3 : Geert Wiegertjes (M) (Discussion leader), Peter Bakker (P), Hideki Takahashi (P), Hitoshi Shirakawa (A), Marca Wauben (A), Richard Kormelink (P), Ad P Koets (A), Haruki Kitazawa (A), (P: Plant Immunology, A: Animal Immunology, M: Marine Immunology) Group discussion I-B (Wednesday) Group 1 : Annemarie Rebel (A) (Discussion leader), Craig Hamilton Warden (A), Masaaki Toyomizu (A), Tomonori Nochi (A), Keisuke Takahashi (M), Masahiko Harata (A), Haruki Kitazawa (A), Geert Wiegertjes (M) Group 2 : Huub Savelkoul (A) (Discussion leader), Toshiki Nakano (M), Mayuko Saito (A), Willem van Eden (A), Wakako Ikeda-Ohtsubo (A), Marca Wauben (A), Hitoshi Shirakawa (A), Ad P Koets (A) Group 3 : Peter Bakker (P) (Discussion leader), Hideki Takahashi (P), Richard Kormelink (P), Saskia van Wees (P), Kinya Toriyama (P), Bart Thomma (P), Corné Pieterse (P), Shuhei Miyashita (P) Group discussion II-A (Thursday) Group 1 : Saskia van Wees (P) (Discussion leader), Willem van Eden (A), Craig Hamilton Warden (A), Toshiki Nakano (M), Kinya Toriyama (P), Hitoshi Shirakawa (A), Keisuke Takahashi (M) Group 2 : Tomonori Nochi (A) (Discussion leader), Marca Wauben (A), Ad P Koets (A), Annemarie Rebel (A), Huub Savelkoul (A), Bart Thomma (P), Masahiko Harata (A), Shuhei Miyashita (P) Group 3 : Wakako Ikeda-Ohtsubo (A) (Discussion leader), Hideki Takahashi (P), Corné Pieterse (P), Masaaki Toyomizu (A), Haruki Kitazawa (A), Geert Wiegertjes (M), Peter Bakker (P)

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