Program SPECIFICATION FOR Ph.D Degree in Immunology δallergy. Code: A- Basic information. 2- Program type: B- Professional Information

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1 Department Of: Immunology δllergy Program SPEIFITION FOR Ph.D Degree in Immunology δallergy ode: University: leandria Faculty: Medical Research Institute Program Specification - asic information - Program title: Ph.D. Immunology and allergy - Program type: single Double multiple - Department(s): Immunology δ allergy - oordinator: Prof. Dr. Soheir Rizk Demian - Eternal evaluator(s): Prof.Dr. Mohamed bbas Elbarawy 6- Last date of program specification approval: 8//07 - Professional Information - Program aims: y the end of this program the students should:

2 Department Of: Immunology δllergy Provide the students with knowledge, skills and critical awareness to make has significant contribution to research and services provided by the department y the end of this program the student should:. Know and recognize the molecular cell biology with emphasis on genetic model, transcription, protein synthesis, structural cell biology and cell signaling.. cquire and add knowledge on various approaches of eperimental design including concepts like appropriate number of animals, proper control, applicable design types and good clinical practice.. Review molecular Immunology including molecular components of the immune response and contribution of molecular immunology to current developments in the field.. Discuss genome structure, mitochondrial DN, modes of inheritance as well as the genetics of MH as regards structure, function, variability and role in transplantation.. cquire a comprehensive view of modern immunology at the molecular and cellular level. disorders, bioinformatics, and the ethical, social and legal issues in genetic medicine. 6. cquire knowledge on the diagnosis and investigation of clinical cases which have underlying immunopathology. 7. Develop interactive abilities. 8. cquire and add knowledge on hypersensitivity reactions, Gell and oombs classification of hypersensitive reactions, the mechanism of action of the different types of allergens, the different types of hypersensitivity reactions and how to manage them. 9. Discuss immune response to tumors; oncogenesis and escape 0. Know the HL genetics, polymorphism and nomenclature, understand HL typing methods, b screening and cross matching as well as the procedures and work ups for solid organ and M transplantation.. Describe concepts of immunology to blood banking procedures. Integrate concepts and relate ideas covered in different parts of the degree programme.. Proficient in conducting research.. Use information technology to increase the immunology knowledge. - Intended learning outcomes (ILOs) a- knowledge and understanding: a- Discuss the development of cells and cellular functions at the molecular level. a- Understand research methodology and evidence based medical research. a- Eplain the mechanisms for the generation of antibody diversity

3 Department Of: Immunology δllergy a- Recall genome structure and function. a- omprehend how the immunological cells and molecules interact in defending the body against invading microorganisms a6- Recall immune mediated diseases a7- Review scientific information through different medical search engines. a8- Understand the build up of scientific paper. a9- Recall different molecules that share in immunological hypersensitivity reactions. a0- Understand immune response to tumors, the different mechanisms of oncogenesis, evasions of the different tumors to the immune response and the diagnosis and investigations of clinical cases which have underlying immunopathology. a- List the evidence for use, and limitations of, the common procedures used in the diagnosis and management of patients and donors a- Understand the different mechanisms of haemolytic diseases, haemolytic disease of newborn and drug induced haemolytic anaemia, microbiology, haematology and medical technology which underlie the practice of transplantation, the evidence for use, and limitations of, the common procedures used in the diagnosis and management of patients and donors. a- Describe characteristics of common blood group systems, the appropriate pre- and post-transfusion testing associated with components, the pathophysiology and laboratory investigation of transfusion reactions and hemolytic disease of the newborn. b- Intellectual skills: b- Interpret, analyze and evaluate basic immunologic information to solve problems b- Illustrate the basis of immune system and demonstrate the innate immune mechanisms. b- Relate immuonoglobulin structure with its function, illustrate the origin of antibody diversity and the role of adhesion molecules in immune response. b- Illustrate the types, structure and organization of MH genes, relate structure of HL to function and illustrate the concept of polymorphism with regards to genes encoding T cell receptors. b- Interpret immunodiagnostic tests in correlation with clinical data. b6- ompare different cellular immunological techniques, interpret data derived from laboratory techniques to understand underlying cellular functions of the immune system. b7- Illustrate the role of apoptosis in immune regulation. b8- Develop the ability to use scientific and systemic thinking in topics presented and improve interactive proficiency. b9- Illustrate thinking skills through demonstrating logical and critical thinking on reading scientific literature within the area of Immunology. b0- Distinguish between protective and hazards defense mechanisms. b- Illustrate inter-relation between allergic reactions and discuss differential diagnosis based on clinical signs.

4 Department Of: Immunology δllergy b-distinguished between oncogene and protooncogenes and hazards defense mechanisms and iillustrate the diagnostic procedures which utilize the immune response to reach the final diagnoses of different types of tumours. b- onstruct the algorithm to diagnose and evaluate autoimmune diseases. b- Illustrate evidence based medical approach to issues related to donor-recipient matching and demonstrate when a process or test is out of control, suggest possible reasons for this and select an appropriate solution from a range of alternatives. b- Relate immunologic theory to performance of procedures in the blood bank and serology laboratory. c- professional and practical skills: c- Initiate the use of safety procedures and personal protective equipment in the laboratory, outline the procedure for labeling, handling and disposing of potentially infectious material. c- Gain skills to perform different tests in immunodiagnosis and apply quality control standards in immunodiagnostic tests. c- Develop skills to perform and interpret results of different cellular immunological techniques. c- Gain skills to diagnose and investigate clinical cases which have underlying immunopathology. c- Gain skills to differentiate between different allergic reactions. c6- Outline the procedure for labeling, handling tumor specimens. Initiate the use of safety procedures and personal protective equipment in the laboratory to make stained slides from tumor specimen c7- cquire skills for performing tests of autoimmunity c8- Plan and eecute safely a series of transplantation eperiments and analyze eperimental transplantation results and determine their strength and validity c9- Perform and interpret O blood grouping and Rh typing and resolve O discrepancies and promoting ecellence in diagnosing immunohematological disease. d- General and transferable skills: d- ommunicate through group discussion d- Work as a part of team d- Develop skills in information technology d- Develop skills for oral presentation d- Develop skills in reading and research d6-develop skills to work safely in a laboratory environment

5 - cademic standards Department Of: Immunology δllergy a Eternal references for standards (enchmarks) Generic cademic Reference Standards if the National uthority for Quality ssurance and ccreditation of Education (NQE) Date of cademic Reference standards (RS) approval by Institute ouncil: /6/0 b omparison of provision to selected eternal references Generic cademic Standards -asic facts, theories, of the specialty and related subjects/ fields - Mutual relation between professional practice and effects on environment - Recent advances in the field of practice PhD of Immunology a- Recognize the development of cells and cellular functions at the molecular level. a- Eplain the mechanisms for the generation of antibody diversity a- Recall genome structure and function. a- omprehend how the immunological cells and molecules interact in defending the body against invading microorganisms a6- Recognize immune mediated diseases a9- Recall different molecules that share in immunological hypersensitivity reactions. a- Understand research methodology and evidence based medical research a0- Understand immune response to tumors, the different mechanisms of oncogenesis, evasions of the different tumors to the immune response and the diagnosis and investigations of clinical cases which have underlying immunopathology. a- Understand the different mechanisms of haemolytic diseases, haemolytic disease of newborn and drug induced haemolytic anaemia. a7- Review scientific information through different medical search engines.

6 -Details of ethical & legal practice -Quality standards of the practice 6- Design, conduction & publishing of scientific research 7- Ethical considerations in different types of scientific research - nalyze, deduce, etrapolate & evaluation of information - Solve the majority of problems in the specialty according to the available data ( complete or incomplete) - onduct research studies that add to the eisting specialty knowledge a- List the evidence for use, and limitations of, the common procedures used in the diagnosis and management of patients and donors a8- Understand the build up of scientific paper. Design, conduction & publishing of scientific research through thesis a8- Understand the build up of scientific paper. Recognize Ethical considerations in different types of scientific research through thesis b- Interpret, analyze and evaluate basic immunologic information to solve problems b- Illustrate the basis of molecular cell biology b- Illustrate the basics of the use of new technologies in the area of immunology b Illustrate the isotyping switching and its importance in immune system b- Differentiate the various modes of inheritance b6- Differentiate between specific and non specific response b7- Illustrate the immunopathology of the different diseases. b0- Illustrate the basis of hypersensitivity. b- Interpret, analyze and evaluate basic immunologic information to solve problems b8- Illustrate the use scientific and systemic thinking in topics presented. onduct research studies that add to the eisting specialty knowledge through thesis and assignments Department Of: Immunology δllergy

7 - Publish scientific articles/papers ( in indeed journals) Publish scientific through thesis articles/papers ( in indeed journals) Department Of: Immunology δllergy - Plan and implement ( or supervise implementation of) enhancement & Improvement approaches to practice 6- Take decisions in various professional situations ( including dilemmas & controversial issues) 7- dd to the specialty field through creativity & innovation 8- Manage discussions on basis of evidence and proofs - ompetent in all basic and all required advanced professional skills ( to be determined according to the specialty board/ department) b9- Identify scientific problems within the area of immunology and design strategies for investigating the problems. lso through student questionnaire b9- Identify scientific problems within the area of immunology and design strategies for investigating the problems b- Distinguished between oncogene and protooncogenes and hazards defense mechanisms and illustrate the diagnostic procedures which utilize the immune response to reach the final diagnoses of different types of tumours. b- Evaluate disciplines related to transfusion and transplantation science in order to be able to integrate information into a wider contet b9- Identify scientific problems within the area of immunology and design strategies for investigating the problems. dd to the specialty field through creativity & innovation through thesis b- Differentiate the various modes of inheritance b- Demonstrate knowledge of immune-hematological principles and procedures c- Gain skills to perform different techniques for protein separation, PR and fractionation of cell etraction. c- onduct the correct handling procedure for various laboratory specimens. c- Gain eperience in conducting eperiments to isolates the different types of cells c- Perform and understand the principle of tests specific for different

8 - Write and appraise reports - Evaluate and improve methods and tools used in specialty - Use technology to advance practice - Plan professional development courses to improve practice and enhance performance of juniors D- ommunicate effectively using all methods D- Use information technology to improve his/her professional practice diseases c6- Gain skills in setting a research eperimental model to study the role of the immune response in oncogenesis c7- Gain skills to differentiate self-tolerance and autoimmunity c6- Gain skills in setting a research eperimental model to study the role of the immune response in oncogenesis c9- Perform and supervise the tests and procedures necessary to provide diagnosis of haemolytic disease of newborn c8- - Plan and eecute safely a series of eperiments on transplantation lso through student questionnaire c- Gain skills to perform different techniques for protein separation, PR and fractionation of cell etraction. c- Gain skills to perform different immunological techniques in separation, detection and purification of allergens c8- Plan and eecute safely a series of eperiments on transplantation d- ommunicate through group discussion d- Develop skills in information technology Department Of: Immunology δllergy D- Teach and evaluate others d- Develop skills for oral presentation D- Perform self appraisal & seek continuous learning d- Develop skills in reading and research

9 D- Use different sources of information to obtain data D6- Work in teams as well as a member in larger teams D7- Manage scientific meetings and appropriately utilize time d- Develop skills in information technology d- Develop skills in reading and research d- Work as a part of team d- Develop skills for oral presentation Department Of: Immunology δllergy - curriculum structure and contents.a program duration: years).b program structure :.b.i- No. of hours per week in each year/semester: Semester First semester 7 ore ourses No. of hours Elective ourses No. of hours

10 Second semester Department Of: Immunology δllergy Third semester Fourth semester.b.ii- No. of credit hours Lectures 6 Practical 6 Total ompulsory Elective 9 Optional 0.b.iii- No. of credit hours of basic science courses (elective from other departments ecept for computer and statistics) No. %..b.iv- No. of credit hours of courses of social sciences and humanities. No. 0 % 0.b.v- No. of credit hours of specialized courses No. % 87..b.vi- No. of credit hours of other courses (e.g. statistics, computer) No. %..b.vii- Field Training No. 0 % 0

11 Department Of: Immunology δllergy.b.viii- Program levels (in credit-hours system) Student is required to pass at least credit hours with GP not less than + before submitting a thesis proposal. - Program ourses.- ompulsory (H) ode No ourse Title Molecular ell iology Research Topics in iomedical Science Molecular Immunology II Immunogenetics ellular & Molecular Immunology General linical Immunology II Interactive Immunology Journal lub No. of credit hours No. of hours /week Lecture Practical Elective I (6H) ode No ourse Title Hypersensitivity reactions II Tumor Immunology II Specific utoimmunity II No. of credit hours No. of hours /week Lecture Practical

12 Department Of: Immunology δllergy Medical Research Institute Transplantation II Immuno-haematology II.- Elective II (H) ode No ourse Title iochemistry Haematology acteriology Medical iophysics omputer hemical Pathology Genetics Medical Statistics No. of credit hours No. of hours /week Lecture Practical.- Optional (none) 6- Program admission requirements 7- Regulations for progression and program completion

13 Department Of: Immunology δllergy For the progression and completion of the program to obtain the degree of Ph.D. in Immunology and allergy, the student must complete credit hours with GP of at least + and submit a thesis validity report. For the progression and completion of the program to obtain the degree of Msc the student must: - omplete credit hours with GP of at least +. - Submit a thesis validity report by an eamination committee approved by the department council and their members include at least two eternal eaminers. 8- Evaluation of Students enrolled in the program. Tool evaluation Intended learning outcomes being assessed Written a- Recall the general description of immune system and describe different molecules that share in immunological cellular interaction. a- Recognize the basic structure of immuonoglobulin molecule, describe the complement system, the organization and epression of immunoglobulin genes. a- Recall the MH genes regarding their types, structure, and organization, the structure and functions of HL types, the genes generating polymorphism and the genes

14 encoding T cell receptors. a- Discuss the different modalities of immunodiagnosis, types of immunodiagnostic techniques e.g. ELIS, RI, immunoflourescence, etc. and tests for molecular immunology. b- Interpret, analyze and evaluate basic immunologic information to solve problems b- Illustrate the basis of immune system and demonstrate the innate immune mechanisms. b- Relate immuonoglobulin structure with its function, illustrate the origin of antibody diversity and the role of adhesion molecules in immune response. b- Illustrate the types, structure and organization of MH genes, relate structure of HL to function and illustrate the concept of polymorphism with regards to genes encoding T cell receptors. Department Of: Immunology δllergy Practical c-initiate the use of safety procedures and personal protective equipment in the laboratory, outline the procedure for labeling, handling and disposing of potentially infectious material. c- Gain skills to perform different tests in immunodiagnosis and apply quality control standards in immunodiagnostic tests. c- Develop skills to perform and interpret results of different cellular immunological techniques. c- Gain skills to diagnose and investigate clinical cases which have underlying immunopathology. c- Gain skills to differentiate between different allergic reactions.

15 c6- Outline the procedure for labeling, handling tumor specimens. Initiate the use of safety procedures and personal protective equipment in the laboratory to make stained slides from tumor specimen c7- cquire skills for performing tests of autoimmunity c8- Plan and eecute safely a series of transplantation eperiments and analyze eperimental transplantation results and determine their strength and validity c9- Perform and interpret O blood grouping and Rh typing and resolve O discrepancies and promoting ecellence in diagnosing immunohematological disease. Department Of: Immunology δllergy Oral a-recall proper understanding of functions of different immune cells in relation to primary and secondary immune response and immunological memory and the relationship between mucosal immune system and different immune cells. a6- Understand the difference between the peripheral and central apoptosis, pathways of apoptosis and how the immunological cells and molecules interact in defending the body against invading microorganisms & role of apoptosis in this. b-interpret immunodiagnostic tests in correlation with clinical data. b6- ompare different cellular immunological techniques, interpret data derived from laboratory techniques to understand underlying cellular functions of the immune system. b7- Illustrate the role of apoptosis in immune regulation. d-ommunicate through group discussion

16 d- Work as a part of team Department Of: Immunology δllergy d- Develop skills in information technology Semester Work b8- Develop the ability to use scientific and systemic thinking in topics presented and improve interactive proficiency. b9- Illustrate thinking skills through demonstrating logical and critical thinking on reading scientific literature within the area of Immunology. b0- Distinguish between protective and hazards defense mechanisms. b- Illustrate inter-relation between allergic reactions and discuss differential diagnosis based on clinical signs. b-distinguished between oncogene and protooncogenes and hazards defense mechanisms and iillustrate the diagnostic procedures which utilize the immune response to reach the final diagnoses of different types of tumours. b- onstruct the algorithm to diagnose and evaluate autoimmune diseases. b- Illustrate evidence based medical approach to issues related to donor-recipient matching and demonstrate when a process or test is out of control, suggest possible reasons for this and select an appropriate solution from a range of alternatives. b- Relate immunologic theory to performance of procedures in the blood bank and serology laboratory. d- ommunicate through group discussion d- Work as a part of team d- Develop skills in information technology d- Develop skills for oral presentation

17 Department Of: Immunology δllergy Medical Research Institute d- Develop skills in reading and research d6-develop skills to work safely in a laboratory environment Evaluation of the Program Evaluator Tool Sample - Senior students Interview t least 0 % - lumni Interview Representative sample - Stakeholders (Employers) Interview Representative sample - Eternal Evaluator(S) or Eternal Eaminer (s) - Other Reports Dr /Mohamed bbas Elbarawy Dates of Previous editions/revisions: Editions/Revisions Number Edition no. 009 Date Edition no. 0 Edition no. /6/0 Edition no., revision no. /0 Edition no., revision no. 0/06

18 Program coordinator: Name: Prof. Dr. Soheir Rizk Demian Signature:. Department Of: Immunology δllergy Department Head: Name: Prof. Dr Eman ly Rashwan Date of Department ouncil pproval: 6/9/07 Signature:.

19 Department Of: Immunology δllergy ourses vs program ILO Matri d6 d d d d d c 6 c c c c 0 9 b 8 b 7 b 6 b b b b b 0 a 9 a 8 a 7 a 6 a a a a a ourse Title Molecular ell iology (70880) X Research Topics in iomedical Science (70880) X Molecular Immunology II (70880) X X Immunogenetics (70880) ellular & Molecular Immunology (70880) X X General linical Immunology II (708806) X X Interactive Immunology (708807) X X Journal lub (708808) Hypersensitivity reactions II (708809) Tumor Immunology II (70880) Specific utoimmunity II (7088) Transplantation II (7088) Immuno-haematology II (7088)

20 Department Of: Immunology δllergy Medical Research Institute Program ims vs ILOs matri IMS PROGRMME ILOS D D D D D D 6. Know and recognize the molecular cell biology with emphasis on genetic model, transcription, protein synthesis, structural cell biology and cell signaling.. cquire and add knowledge on various approaches of eperimental design including concepts like appropriate number of animals, proper control, applicable design types and good clinical practice.. Review molecular Immunology including molecular components of the immune response & contribution of molecular immunology to current developments in the field.. Discuss genome structure, mitochondrial DN, modes of inheritance as well as the genetics of MH as regards structure, function, variability&role in transplantation.. cquire a comprehensive view of modern immunology at molecular& cellular level.

21 disorders, bioinformatics, and the ethical, social & legal issues in genetic medicine. 6. cquire knowledge on the diagnosis and investigation of clinical cases which have underlying immunopathology. Department Of: Immunology δllergy 7. Develop interactive abilities. 8. cquire & add knowledge on hypersensitivity reactions, Gell and oombs classification of hypersensitive reactions, the mechanism of action of the different types of allergens, the different types of hypersensitivity reactions and how to manage them. 9. Discuss immune response to tumors; oncogenesis and escape 0. Know the HL genetics, polymorphism and nomenclature, understand HL typing methods, b screening and cross matching as well as the procedures and work ups for solid organ and M transplantation.. Describe concepts of immunology to blood banking procedures. Integrate concepts and relate ideas covered in different parts of the degree programme.. Proficient in conducting research.. Use information technology to increase the immunology knowledge.

22 Department Of: Immunology δllergy Medical Research Institute RS vs ILOs matri RS ILOs D D D D D D 6 -asic facts, theories, of the specialty and related subjects/ fields - Mutual relation between professional practice and effects on environment - Recent advances in the field of practice -Details of ethical & legal practice -Quality standards of the practice 6- Design, conduction & publishing of scientific research 7- Ethical considerations in different types of scientific research - nalyze, deduce, etrapolate & evaluation of information - Solve the majority of problems in the specialty according to the available data ( complete or incomplete)

23 Department Of: Immunology δllergy Medical Research Institute - onduct research studies that add to the eisting specialty knowledge - Publish scientific articles/papers ( in indeed journals) - Plan and implement ( or supervise implementation of) enhancement & Improvement approaches to practice 6- Take decisions in various professional situations ( including dilemmas & controversial issues) 7- dd to the specialty field through creativity & innovation 8- Manage discussions on basis of evidence and proofs - ompetent in all basic and all required advanced professional skills ( to be determined according to the specialty board/ department) - Write and appraise reports - Evaluate and improve methods and tools used in specialty

24 Department Of: Immunology δllergy - Use technology to advance practice - Plan professional development courses to improve practice and enhance performance of juniors D- ommunicate effectively using all methods D- Use information technology to improve his/her professional practice D- Teach and evaluate others D- Perform self appraisal & seek continuous learning D- Use different sources of information to obtain data D6- Work in teams as well as a member in larger teams D7- Manage scientific meetings and appropriately utilize time

25 Department Of: Immunology δllergy Teaching methods vs ourse matri Lecture X Practical/linical X rainstorming X Discussion Groups X Problem Solving ase Study Field Training Role playing Training Workshops Self-Directed Learning e-learning Project