Coordinated Research Infrastructures Building Enduring Life science services

Transcription

1 project.eu Coordinated Research Infrastructures Building Enduring Life science services Or as I call it: a perfect playground for DTL

2 BACKGROUND: EUROPE IS INVESTING IN RESEARCH INFRASTRUCTURES footer 2

3 BACKGROUND In 2015, eleven ESFRI Research Infrastructures from the field of BioMedical Science (BMS RI) joined their scientific capabilities and services to transform the understanding of biological mechanisms and accelerate its translation into medical care. biobanks curated databases marine model organisms systems biology translational research mouse disease models screening & medicinal chemistry microorganisms clinical trials structural biology biological/medical imaging 3

4 BACKGROUND 4 year project: partners in 11 BMS RIs budget: 14.8 million builds on BioMedBridges ( ) co coordinated by ELIXIR and BBMRI ERIC 4

5 MISSION Modern biological and biomedical research involves complex projects and a variety of different technologies. Some of the most important discoveries are made at the interface between different disciplines. CORBEL will harmonise access and services for complex research projects involving more than one RI that offer: biological and medical technologies biological samples and data services 5

6 MISSION By creating a platform of user aligned services, CORBEL will support European research in bridging the translation gap between the understanding of biological mechanisms and innovative medicines and personalising diagnostics and treatments. 6

7 PROJECT OVERVIEW IS ON WEBSITE footer 7

8 IMPLEMENTATION (THIS IS THE INTERESTING BIT) The place to demonstrate the DTL community tools (and gain users) Selected use cases in health and bioscience, developed as part of certain work packages (WPs), will identify the optimal pathway (innovation pipeline) and the needed underlying services for the translation of basic biological research to societal innovation. 8

9 HEALTH USE CASES AND COMMUNITY ENGAGEMENT (WP3, led by ECRIN) validation of the mouse model as predictive system for human diseases use cases: asthma, diabetes development of a common IT framework to support data handling and analysis in clinical and pre clinical biomarker research applicable to any disease area use case 1: osteoarthritis for clinical biomarkers use case 2: colon cancer for pre clinical/imaging biomarkers integration of population cohorts to derive prognostic biomarkers use case: pancreatic cancer Here we can find Dutch: Jan Willem Boiten, Stefan Klein, Gert Jan van Ommen 9

10 BIOSCIENCE USE CASES AND COMMUNITY ENGAGEMENT (WP4, led by partners from Euro BioImaging and ISBE) Objectives establishment of an infrastructure platform for integrated services for life sciences support of advanced pilot research projects that require joint services between different Bio Medical research infrastructures building the framework for transnational open user access for the sustainable use of the joint services Less Dutchies as far as I have discovered, too bad. 10

11 DATA ACCESS, MANAGEMENT AND INTEGRATION (WP6, led by ELIXIR) implementation of core, sustainable services necessary to support inter RI data standardisation, integration, management, deposition and access identifier standards and infrastructure supporting data management, deposition on access access to semantic standards secure access to sensitive data This is where we partner, and where we bridge to ELIXIR NL activities on interoperability. Opportunity: link tools 11

12 TRAINING (WP9, led by BBMRI ERIC) development and delivery of training for RI staff to fill the existing gaps in data management and integration physical access ethics innovation Typical place where developers fall short, while spearhead of ELIXIR NL Opportunity: ask for courses 12

13 Why do I care?

14 Want to move beyond logo jungle Internationale community Veel diverse partijen OC&W Ministeries EZ VWS Funding anders dan ESFRI ZonMW NWO Patiëntenorganisaties Diverse patiëntenorganisaties Standaardisatie instituten Partners in PPP Diverse collectzbusfondsen Overlegplatforms NEN NICTIZ CRO s Pharma FP7 / FP8 IMI BMS.NL DTL PSI/Life Lines Ziekenhuizen Diverse andere ziekenhuizen NFU projecten Registratie aan de Bron Platform Klinisch Onderzoek Kennisorganisaties UMC Utrecht Radboud MC VSNU - Beta faculteiten MKB / Spin off NFU Leveranciers escience Center LUMC VUmc AMC Erasmus MC UMCG Horizon 2020 MUMC NGI/NBIC TI Pharma / Mondriaan LSH plaza Topinstituten CTMM / TraIT BMM NL Roadmap grootschalige onderzoeksfaciliteiten / ESFRI Universiteiten SURF EPD leveranciers EATRIS-NL/ EATRIS - /ECRIN RIVM TNO DICA e.a. CBS Hubrecht Institute NKI Vancis/SARA/CIT e.a. Diensten binnen de UMC s, zoals LUMC- ADM Laboratorium tools / software IT bedrijven (IBM, Oracle, SAS etc.) TTP s Grootschalige apparatuur (Philips e.a.) NeCEN/ INSTRUCT BBMRI-NL / BBMRI BioImagingNL/ Bioimaging DTL/ ELIXIR source: NFU data4lifesciences

15 Morris Swertz University Medical Center Groningen Enter health-ri

16 How to cross the innova5on gap? research care innova5on

17 Insufficient QA of research data

18 Personalized Medicine & Health

19 Why is this important it is not only about expensive meds

20 Health RI: bundle and connect a wide range of resources including biobanks data collec5ons image collec5ons IT technologies facili5es processes into one large scale research infrastructure, to enable ground breaking personalized medicine and health research

21 Need for one harmonized and integrated Infrastructure for Personalized Medicine & Health research in the Netherlands Call for DREAMS 21

22 Layout of Health-RI Suite of facilities, tools and data ( app store ) Research tools FAIR data backbone Big Data technologies Privacy by design Components Biobanks, data collections (human & animals) Imaging centers, image collections Experimental facilities (e.g. microscopy, omics, biomarkers) Wearables, ehealth ehumanities

23 Internet of Data Biobanks, cohorts Wearables Clinical records MRI center Survey s Research laboratory Microscopy facility FAIR data backbone Twitter data

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25 HSR data service Groningen Support complete data cycle: collection, processing, storage and (re)use of research data Catalogues FAIR data Privacy Impact Analyses (PIA) Data management plans HPC data workflows Etc -> Search HSRD

26 Conclusion In my view, as DTL community we should discuss how to maximally participate in: 1. Cluster projects like CORBEL (they have a service call open now) 2. Build up Health-RI (we already call us that, join us at 1 december) 3. Our flagships into open science data cloud 4. Bridgehead all this sustainably into the institutes where our users/contributors reside Please build on 10y of development in NBIC/ DTL instead of looking outside NL all the time