CHROMOSOME ARCHITECTURE AND TOPOLOGICAL STRESS

Transcription

1 WORKSHOPS CURRENT TRENDS IN BIOMEDICINE 2018 SEDE ANTONIO MACHADO BAEZA, SPAIN CHROMOSOME ARCHITECTURE AND TOPOLOGICAL STRESS Baeza, Spain 8 th -10 th October 2018

2 Organized by: Felipe Cortés-Ledesma Erez Lieberman Aiden André Nussenzweig Sevilla, Spain. Houston, TX, USA. Bethesda, MD, USA. SCOPE The mechanisms by which chromosomes fold into the nucleus constitutes a major question in biology. Our 3.3 billion base-pair genome stretched from one end to the other would cover a length of a few meters. Yet DNA must be structured in such a way that it fits into the confines of the nucleus of only a few microns. This compaction becomes even more extreme when nascent DNA strands move to daughter cells during mitosis. How does the cell accomplish this packaging of DNA while avoiding the formation of knots, entanglements and breakage? How can basic processes such as transcription and replication, which require readily accessible and unknotted DNA, occur within the confined space of the nucleus? How do topoisomerases, which remove knots from crowded DNA molecules, distinguish knotted DNA from unknotted ones? The purpose of this workshop is to improve our understanding of how the genetic material is folded up without entanglements in such a way that it can manage to be properly decoded inside the nucleus. FORMAT OF THE WORKSHOP The workshop will bring together a maximum of 15 speakers and 35 participants, to form a group of around 50 people. The scientific programme will start in the morning of Monday, October 8 th, and will end

3 around noon on Wednesday, October 10 th. Ample time for informal discussion will be reserved. Participants will be invited to present a poster. VENUE OF THE WORKSHOP The workshop will be held in Baeza, at the Sede Antonio Machado, a XVII century building turned into a Conference Centre of the Universidad Internacional de Andalucía (UNIA). This Seat includes a residence, where participants will be accommodated. Baeza is a World Historic Heritage town, renowned for its Renaissance and Gothic buildings. SPEAKERS Luis Aragón Cell Cycle Group, Medical Research Council, Clinical Sciences Centre, Imperial College London. London, UK. Camilla Björkegren Department of Cell and Molecular Biology / Department of Biosciences and Nutrition; Karolinska Institutet. Stockholm / Huddinge; Sweden. Keith W. Caldecott Genome Damage and Stability Centre, University of Sussex. Brighton, UK. Rafael Casellas Center of Cancer Research, NCI, NIH. Bethesda, MD, USA. Felipe Cortés-Ledesma Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC- Universidad de Sevilla-Universidad Pablo de Olavide. Sevilla, Spain.

4 Oscar Fernández-Capetillo Spanish National Cancer Research Centre (CNIO). Madrid, Spain // Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute. Stockholm, Sweden. José Luis Gómez-Skarmeta Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide. Sevilla, Spain. Erez Lieberman Aiden Center for Theoretical Biological Physics, Rice University / Center for Genome Architecture, Baylor College of Medicine. Houston, TX, USA. Darío G. Lupiáñez Epigenetics and Sex Development Group, Berlin Institute for Medical Systems Biology, Max- Delbrück Center for Molecular Medicine. Berlin- Buch, Germany. Peter J. McKinnon Department of Genetics, St. Jude Children's Research Hospital. Memphis, TN, USA. André Nussenzweig Laboratory of Genome Integrity, National Cancer Institute, NIH. Bethesda, MD, USA. Benjamin D. Rowland Division of Gene Regulation, The Netherlands Cancer Institute. Amsterdam, The Netherlands. Andrzej Stasiak Center for Integrative Genomics, University of Lausanne / SIB Swiss Institute of Bioinformatics. Lausanne, Switzerland.

5 Michael D. Wilson Gordana Wutz Hospital for Sick Children / Department of Molecular Genetics, University of Toronto. Toronto, ON, Canada. Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC). Vienna, Austria. DEADLINE: 20 th JULY 2018 MORE APPLICATIONS WILL BE ACCEPTED IN CHRONOLOGICAL ORDER UNTIL COMPLETING THE WORKSHOP MORE INFORMATION AND APPLICATION: workshops.biomed@unia.es Universidad Internacional de Andalucía Sede Antonio Machado Palacio de Jabalquinto Plaza de Santa Cruz, s/n Baeza (Jaén), Spain Tel: Fax: baeza@unia.es