ZANETTI GIULIA VIA DEI PARADISI N 15/5, 38122, TRENTO, ITALY , June, 1989 TRENTO, (TN), ITALY ITALIAN

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1 Giulia Zanetti Curriculum Vitae et Studiorum Via dei Paradisi 15/5, 38122, Trento (TN), Italy CURRICULUM VITAE EUROPEAN FORMAT PERSONAL INFORMATION Surname, name: Address: Telephone: Date of birth: Birth place: Nationality: ZANETTI GIULIA VIA DEI PARADISI N 15/5, 38122, TRENTO, ITALY gzanetti89@gmail.com 5, June, 1989 TRENTO, (TN), ITALY ITALIAN RESEARCH INTEREST Biochemistry. Molecular biology. Microbiology. Pharmaceutical chemistry. EDUCATION 1 NOV 2015-PRESENT PhD Student in Biomedical Science Department of Biomedical Sciences, neurotoxin, neuroparalysis and regeneration group headed by Prof. Cesare Montecucco, University of Padova, via Ugo Bassi 58/B, Padova (Italy) 10 DECEMBER 2013 Degree in Chemistry and Pharmaceutical Technology (Biotechnology) FACULTY OF PHARMACY, University of Padova, Padova (Italy) LM-13 Master of Science in Pharmacy and industrial pharmacy FINAL SCORE: 104/110 TUTOR: Prof. Fabio Di Lisa CO-TUTOR: Prof. Cesare Montecucco THESIS: "Role of thioredoxin in the entrance of the botulinum neurotoxin in Neurons" JULY 2008 High school diploma Liceo scientifico Galileo Galilei of Trento (TN), Italy FINAL SCORE: 68/100 Curriculum vitae et Studiorum di Zanetti Giulia pagina 1/5

2 WORK EXPERIENCE 1 NOV 2017-PRESENT Postdoctoral fellowship Fondazione Caritro 1 NOV OCT 2017 PhD Student in Biomedical Science Dept. Biomedical sciences, Neurotoxin, neuroparalysis and regeneration group headed by Prof. C. Montecucco, University of Padova, via Ugo Bassi 58/B, Padova (Italy) As a PhD student, my project focuses on the development of new inhibitors that can block the action of clostridial neurotoxins. cesare.montecucco@gmail.com MAR 2014-OCT 2014 Research Scholarship Title: "Searching for new inhibitors of botulinum neurotoxin type F and G and creating a cell line sensitive to botulinum toxin type A" at the Department of Biomedical Sciences of Padua under the direction of Prof. Cesare Montecucco. MAR 2013-DEC 2013 Master Thesis in the Laboratory of Microbial Pathogenesis, Department of Biomedical Sciences of Padua, Italy TUTOR: Prof. Cesare Montecucco CO-TUTOR: Dr. Marco Pirazzini MAIN ACTIVITIES: Study of molecules which show inhibitory action towards thioredoxin-thioredoxin reductase system in order to develop chemicals that can block the action of botulinum neurotoxin (serotypes A, E and C). Investigation of the location of the thioredoxin-thioredoxin reductase system at the neuromuscular junction. MAY 2012-SEPT 2012/FEB 2013 Pharmacy Internship Pharmacy «Alla Madonna» owned by Trotter Giorgio and Damiano snc Via Guadagnini 28, Fiera Di Primiero (TN), Italy tel: trottergiorgio@gmail.com DEC 2011-JAN 2012 Internship in the Laboratory of Biochemical and Microbiological Analyses Presidio Ospedaliero S. Chiara, Ospedale di Trento L.go Medaglie d'oro, 9, TRENTO (TN), Italy Tel: +39(0461) Fax: +39(0461) JOB-RELATED SKILLS Biochemical techniques; Fluorescence and confocal microscopy; Preparation of primary neuronal cultures; Ability to work aseptically; Knowledge of in vivo assays; Electrophysiological analysis; Knowledge of the most common techniques of molecular biology. Curriculum vitae et Studiorum di Giulia Zanetti pagina 2/5

3 IT PROFICIENCY Microsoft Office Acquisition and analysis software (WB: Quantity One and Image Studio; IF: LAS AF Lite and ImageJ) Electrophysiological analysis software (WinEDR and Clampfit software) Bioinformatics tools (PubMed, Uniprot etc.) LANGUAGE SKILLS MOTHER TONGUE OTHER LANGUAGES ITALIAN (Native) ENGLISH COMMUNICATION AND ORGANIZATION SKILLS Excellent skills of teamwork and communication, good problem solving skills. Courteous and helpful able to relate very well with colleagues. Good autonomy in managing work and respecting of deadlines. CONFERENCE ATTENDED DECEMBER MAY 2015 SFET 2014, Paris, France CNR RETREAT 2015, Pisa, Italy SEPTEMBER 2015 ABCD 2015, Bologna, Italy SEPTEMBER SEPTEMBER 2016 CNR RETREAT 2016, Padova, Italy Antidotes and Depth 2016, Pavia, Italy JANUARY SEPTEMBER SEPTEMBER 2017 TOXINS 2017: Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins, Madrid, Spain Poster and oral presentation SIPMeT 2017, Milano, Italy ABCD 2017, Bologna, Italy Curriculum vitae et Studiorum di Giulia Zanetti pagina 3/5

4 PUBLICATION LIST MOUSE PHRENIC NERVE HEMIDIAPHRAGM ASSAY (MPN) Giulia Zanetti*, Samuele Negro, Marco Pirazzini and Paola Caccin* Bio Protoc., 2018; *corresponding authors; DOI: /BioProtoc.2759 HSP90 AND THIOREDOXIN-THIOREDOXIN REDUCTASE ENABLE THE CATALYTIC ACTIVITY OF CLOSTRIDIAL NEUROTOXINS INSIDE NERVE TERMINALS Pirazzini M, Azarnia Tehran D, Zanetti G, Rossetto O, Montecucco C. Toxicon, 2017; DOI: /j.toxicon BOTULINUM NEUROTOXIN C MUTANTS REVEAL DIFFERENT EFFECTS OF SYNTAXIN OR SNAP-25 PROTEOLYSIS ON NEUROMUSCULAR TRANSMISSION Zanetti G., Sikorra S., Rummel A., Krez N., Duregotti E., Negro S., Henke T., Rossetto O., Binz T. and Pirazzini M. PLoS Pathog., 2017; DOI: /journal.ppat THE ABLATION OF S1P 3 RECEPTOR PROTECTS MOUSE SOLEUS FROM AGE- RELATED DROP OF MUSCLE MASS, FORCE AND REGENERATIVE CAPACITY Bondi M., Germinario E., Pirazzini M., Zanetti G., Cencetti F., Donati C., Gorza L., Betto R., Bruni P., and Danieli-Betto D. Am J Physiol Cell Physiol., 2017; DOI: /ajpcell A NOVEL INHIBITOR PREVENTS THE PERIPHERAL NEUROPARALYSIS OF BOTULINUM NEUROTOXINS Azarnia Tehran D.*, Zanetti G.*, Oneda L., Florigio L., Fillo S., Binz T., Clifford C.C., Rossetto O., Montecucco C., Paradisi C., Mattarei A., Pirazzini M. Sci. Rep., 2015; *co-first authors; DOI: /srep SNAKE AND SPIDER TOXINS INDUCE A RAPID RECOVERY OF FUNCTION OF BOTULINUM NEUROTOXIN PARALYSED NEUROMUSCULAR JUNCTION Duregotti E., Zanetti G., Scorzeto M., Megighian A., Montecucco C., Pirazzini M. and Rigoni M. Toxins (Basel), 2015; DOI: /toxins INHIBITION OF BOTULINUM NEUROTOXINS INTERCHAIN DISULFIDE BOND REDUCTION PREVENTS THE PERIPHERAL NEUROPARALYSIS OF BOTULISM Zanetti G.*, Azarnia Tehran D.*, Pirazzini M., Binz T., Shone C.C., Fillo S., Lista F., Rossetto O., Montecucco C. Biochem Pharmacol, 2015; *co-first authors; DOI: /j.bcp ON THE TRANSLOCATION OF BOTULINUM AND TETANUS NEUROTOXINS ACROSS THE MEMBRANE OF ACIDIC INTRACELLULAR COMPARTMENTS Pirazzini M., Azarnia Tehran D., Leka O., Zanetti G., Rossetto O., Montecucco C. Biochim Biophys Acta, 2015; DOI: /j.bbamem Curriculum vitae et Studiorum di Zanetti Giulia pagina 4/5

5 PUBLICATION LIST THE THIOREDOXIN REDUCTASE-THIOREDOXIN REDOX SYSTEM CLEAVES THE INTERCHAIN DISULPHIDE BOND OF BOTULINUM NEUROTOXINS ON THE CYTOSOLIC SURFACE OF SYNAPTIC VESICLES Pirazzini M., Azarnia Tehran D., Zanetti G., Lista F., Binz T., Shone C.C., Rossetto O., Montecucco C. Toxicon, 2015; DOI: /j.toxicon THIOREDOXIN AND ITS REDUCTASE ARE PRESENT ON SYNAPTIC VESICLES, AND THEIR INHIBITION PREVENTS THE PARALYSIS INDUCED BY BOTULINUM NEUROTOXINS Pirazzini M., Azarnia Tehran D., Zanetti G., Megighian A., Scorzeto M., Fillo S., Shone C.C., Binz T., Rossetto O., Lista F., Montecucco C. Cell Rep., 2014 ; DOI: /j.celrep Curriculum vitae et Studiorum di Zanetti Giulia pagina 5/5