Advances in Biochemical Engineering/ Biotechnology. Managing Editor: A. Fiechter

Transcription

1 Advances in Biochemical Engineering/ Biotechnology Managing Editor: A. Fiechter

2 Bioprocesses Including Animal Cell Culture With Contributions by J. P. Barford, J. Engels, C. Harbour, K.-S. Low, A. J. MacLeod, M. Morandi, H. Schwab, E. Uhlmann, A. Valeri With 41 Figures and 12 Tables I~~ Springer-Verlag Berlin Heidelberg NewYork London Paris Tokyo

3 ISBN X Springer-Verlag Berlin Heidelberg New York ISBN X Springer-Verlag New York Heidelberg Berlin This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. Springer-Verlag Berlin Heidelberg 1988 Library of Congress Catalog Coard Number Printed in GDR The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Bookbinding: Ltideritz & Bauer, Berlin 2152/ t0

4 Managing Editor Professor Dr. A. Fiechter Institut fiir Biotechnologie, Eidgen6ssische Technische Hochschule ETH -- H6nggerberg, CH-8093 Ztirich Editorial Board Prof. Dr. S. Aiba Prof. Dr. H. R. Bungay Prof. Dr. Ch. L. Cooney Prof. Dr. A. L. Demain Prof. Dr. S. Fukui Prof. Dr. K. Kieslich Prof. Dr. A. M. Klibanov Prof. Dr. R. M. Lafferty Prof. Dr. S. B. Primrose Prof. Dr. H. J. Rehm Prof. Dr. P. L. Rogers Prof. Dr. H. Sahm Prof. Dr. K. Schiigerl Prof. Dr. S. Suzuki Prof. Dr. G. T. Tsao Dr. K. Venkat Prof. Dr. E.-L. Winnacker Department of Fermentation Technology, Faculty of Engineering, Osaka University, Yamada-Kami, Suita-Shi, Osaka 565, Japan Rensselaer Polytechnic Institute, Dept. of Chem. and Environment. Engineering, Troy, NY /USA Massachusetts Institute of Technology, Department of Chemical Engineering, Cambridge, Massachusetts 02139/USA Massachusetts Institute of Technology, Dept, of Nutrition & Food Sc., Room Cambridge, Massachusetts 02139/USA Dept. of Industrial Chemistry, Faculty of Engineering, Sakyo-Ku, Kyoto 606, Japan Gesellschaft ffir Biotechnologie, Forschung mbh, Mascheroder Weg 1, D-3300 Braunschweig Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, Cambridge, Massachusetts 02139/ USA Techn. Hochschule Graz, Institut ffir Biochem. Technol., Schl6getgasse 9, A-8010 Graz General Manager, Molecular Biology Division, Amersham International ptc., White Lion Road Amersham, Buckinghamshire HP7 9LL, England Westf. Wilhelms Universit/it, Institut ffir Mikrobiologie, Corrensstr. 3, D-4400 Mtinster School of Biological Technology, The University of New South Wales, P.O. Box 1, Kensington, New South Wales, Australia 2033 Institut fiir Biotechnologie, Kernforschungsantage JiJlich, D-5170 Jfilich Institut ffir Technische Chemic, Universit~it Hannover, Callinstral~e 3, D-3000 Hannover Tokyo Institute of Technology, Nagatsuta Campus, Res. Lab. of Resources Utilization, 4259, Nagatsuta, Midori-ku, Yokohama 227/Japan Director, Lab. of Renewable Resources Eng., A. A. Potter Eng. Center, Purdue University, West Lafayette, 1N 47907/USA Corporate Director Science and Technology, H. J. Heinz Company U.S. Steel Building, P.O. Box 57, Pittsburgh, PA 15230/USA Universit/it Mfinchen, Institut f. Biochemie, Karlsstr. 23, D-8000 Mfinchen 2

5 Table of Contents Process Development for Hybridoma Cells C. Harbour0 J.-P. Barford, K.-S. Low The Use of Plasma Protein Fractions as Medium Supplements for Animal Cell Culture A. J. MacLeod Industrial Scale Production of J]-lnterferon M. Morandi, A. Valeri Gene Synthesis J. Engels, E. Uhlmann Strain ImprOvement in Industrial Microorganisms by Recombinant DNA Techniques H. Schwab Author Index Volumes