quick and customized Biotecnologia Innovativa per Ricerca e Diagnostica CATALOGUE 2015 Human Molecular Diagnostics

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1 quick and customized Biotecnologia Innovativa per Ricerca e Diagnostica CATALOGUE 2015 Human Molecular Diagnostics

2 Export CATALOGUE 2015 BIRD R&D division can interact with customers to develop special products, according to particular needs, although not included in the product list. Thanks to a sound and long-lasting experience in molecular diagnostics, we are able to quickly develop kits, protocols and reagents for the detection of pathogens, gene mutations or expression profiles on the main platforms of molecular diagnostics: PCR, Real-Time PCR, sequencing, microarrays, beads arrays. Thanks to this formula, we can cover a virtually unlimited range of niche applications and experimental diagnostics, merging flexibility and customization with industrial criteria of quality and standardization. A direct collaboration with customers often results in long-lasting partnerships. The request for custom product development can be activated by direct contact with BIRD after a preliminary interaction with our agents in the area. We believe that molecular diagnostics, that has today become an established diagnostic tool in the clinical laboratory, is still far from having expressed its full potential, either in terms of technology and application range. That is the reason why we consider the proposals of our customers as a way to broaden the list of useful applications, based and still unmet on real needs stemming from the clinical setting. BIRD is affiliated to Toscana Life Sciences The Toscana Life Sciences (TLS) Foundation is a non-profit organization with the objective of supporting research activities in the Life Sciences and, in particular, of sustaining the development of projects from basic research to industrial application. HEADQUARTER via Montarioso 9c Monteriggioni (SI) tel fax info@birdsrl.it pec: birdsrl@pec.it web: R&D and MANUFACTURING via Papa Giovanni XXIII 75a Rezzato (BS) tel fax rd@birdsrl.it

3 THROMBOPHILIA G001 FII G20210A identification of G20210A FII gene polymorphism G002 FV G1691A (Leiden) identification of factor V polymorphism G1691A G003 FV Y1702C identification of the coagulation Factor V Y1702C polymorphism G004 FV H1299R identification of the coagulation Factor V H1299R polymorphism G005 MTHFR C677T identification of methylene-tetrahydrofolate reductase gene C677T polymorphism G006 MTHFR A1298C identification of methylene-tetrahydrofolate reductase gene A1298C polymorphism G007 MTHFR multiplex simultaneous identification of methylene-tetrahydrofolate reductase gene C677T and A1298C polymorphism 50x2 RT G008 Coag Panel identification of coagulation factors FII G20 210A, FV G1691A and Y1702C and MTHFR C677T and A1298C polimorphisms and mutations 50x4 RT G009 APO E identification of the polymorphisms C112R e R158C associated with the ApoE HAEMOCROMATOSIS G010 HFE C282Y identification of HFE gene C282Y mutation G011 HFE H63D identification of HFE gene H63D mutation G012 HFE S65C identification of HFE gene S65C mutation G013 HFE Panel simultaneous identification of HFE gene C282Y, S65C and H63D mutation, associated with haemochromatosis. 50x3 RT Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue

4 VIROLOGY V001 EBV V002 CMV V003 HSV1 V004 HSV2 V005 HHV6 V006 HHV8 V007 VZV V008 Herpes panel V009 Adenovirus V010 JCV V011 BKV V013 Parvovirus B19 V014 Enterovirus identification and quantification of the Erpstein Barr Virus genome by amplification of the EBNA leader protein gene identification and quantification of the Human Cytomegalovirus genome by amplification of the Pol gene identification and quantification of the Herpes simplex Virus 1 genome by amplification of HSV1 specific sequence within US4 gene identification and quantification of the Herpes simplex Virus 2 genome by amplification of HSV2 specific sequence within US4 gene identification and quantification of the Herpes Virus 6 genome by amplification of specific DNA sequence within the 13R gene identification and quantification of the Herpes Virus 8 genome by amplification of a specific DNA sequence within ORF 26 gene identification and quantification of Varicella-Zoster Virus genome by amplification of a specific DNA sequence within ORF 38 gene identification of HSV1, HSV2, HHV6, HHV8, EBV and VZV genomes by parallel amplification of specific DNA sequences in the same assay identification and quantification of the Adenovirus genome by amplification of the Hexon gene identification and quantification of the JC Virus genome by amplification of the large T antigen gene identification and quantification of the BK Virus genome by amplification of the small T antigen gene identification and quantification of the Parvovirus B19 genome by amplification of the VP1 gene identification of the Enterovirus spp. genome by reverse transcription and amplification of a specific sequence in the 5ʼ UTR region 10 RT V015 HSV1+HSV2 multiplex simultaneous identification of HSV1 and HSV2 genome 50x2 RT HPV01 HPV12 HR Screening Quant quantitative detection of HPV (16,18,31,33,35,39,45,51,52,56,58,59) genoypes 100 RT HPV02 HPV14 Screening amplification and detection test for HPV screening 50 G HPV03 HPV 14 HR Typing Quant quantitative detection and typing of HPV 16,18,31,33,35,39,45,51,52,56,58,59,66,68 genotypes 100 RT 4 Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue 2014

5 BACTERIOLOGY HPV04 HPV 12 HR Typing HPV05 HPV 12HR & 2LR Typing amplification and detection test of HPV 16,18,31,33,35,39,45,52,56,58,59,66 genotypes amplification and detection of HPV Low (6,11) and High Risk genotyopes (16,18,31,45,33,35,39,51,52,56,58,59,68) 50 G 50 G B001 Borrelia burgdorferi identification of the Borrelia burgdorferi genome by amplification of the NapA gene B002 Bartonella henselae identification of the Bartonella henselae genome by amplification of the ribc gene B003 Brucella spp. identification of the Brucella spp. genome by amplification of bcsp31 gene B004 Rickettsia spp. identification of the Rickettsia spp. genome by amplification of glta gene B005 Pseudomonas aeruginosa identification of the Pseudomonas aeruginosa genome by amplification of oprl gene B006 Staphylococcus aureus methicillin resistance identification of the Streptococcus aureus genome and the detection of methicillin resistance by amplification of nuc and meca genes B007 Campylobacter spp. identification of the Campylobacter genus genome by amplification of inia gene B035 Campylobacter jejuni identification of the Campylobacter jejuni genus by amplification of 16SrRNA gene B008 Mycoplasma spp. identification of the Mycoplasma spp. genome by amplification of the P1 gene B009 Mycoplasma genitalium B010 Mycoplasma hominis B011 Ureaplasma urealyticum identification of the Mycoplasma genitalium genome by amplification of the B subunit of the DNA gyrase gene identification of the Mycoplasma hominis genome by amplification of the 16S rrna gene identification of the Ureaplasma urealyticum genome by amplification of the Urease gene B012 Ureaplasma parvum identification of the Ureaplasma parvum genome by amplification of the tuf gene B013 Chlamydia trachomatis identification of the Chlamydia trachomatis genome by amplification of the ORF6 gene of the cryptic plasmid B014 Mycoplasma pneumoniae identification of the Mycoplasma pneumoniae genome by amplification of the P1 gene Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue

6 BACTERIOLOGY B015 Helycobacter pylori identification of the Helycobacter pylori genome by amplification of the UreC gene B016 Helycobacter pylori chlaritromycin resistance identification of the H. pylori genome and chlarytromicyn resistance by amplification of the gene coding for 23S rrna B017 Listeria monocytogenes identification of the Listeria monocytogenes genome by amplification of the inla gene B018 Salmonella spp. identification of the Salmonella spp. genome by amplification of the Nuclease gene B019 Yersinia enterocolitica identification of the Yersinia enterocolitica genome by amplification of the Yst gene B020 Shigella spp. identification of the Shigella spp. genome by amplification of the Yst gene B021 Streptococcus pyogenes identification of the Streptococcus pyogenes genome by amplification of the 16S rrna gene B022 Legionella pneumophila B023 Chlamydia pneumoniae identification of the Legionella pneumophila genome by amplification of the MP gene identification of the Chlamydia pneumoniae genome by amplification of the OMP gene B036 Mycobacterium tuberculosis complex B024 Mycobacterium avium B025 Mycobacterium avium subsp. paratuberculosis identification of the Mycobacterium tuberculosis complex genome by amplification of the IS6110 Specific Insertion Sequence identification of the Mycobacterium avium genome by amplification of the 16S rrna gene identification of the Mycobacterium avium subsp. paratuberculosis genome by amplification of the IS900 gene B026 Clostridium difficile identification of the Clostridium difficile tcda and tcdb toxin genes B027 Neisseria gonorrhoeae B028 Treponema pallidum B030 Gardnerella vaginalis B031 Atopobium vaginae identification of the Neisseria gonorrhoeae genome by amplification of a specific region of the pora pseudogene identification of the Treponema pallidum genome by amplification of a specific region of the 47kDa lipoprotein gene identification of the Gardnerella vaginalis genome by amplification of a specific region of the ITS 16S-23S region identification of the Atopobium vaginae genome by amplification of a specific region of the ITS 16S-23S Coming soon 6 Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue 2014

7 BACTERIOLOGY B032 Lactobacillus spp. B033 Lactobacillus iners B034 Lactobacillus crispatus identification of the Lactobacillus spp. genome by amplification of a specific region of the ITS 16S-23S Coming soon identification of the Lactobacillus iners genome by amplification of a specific region of the ITS 16S-23S Coming soon identification of the Lactobacillus crispatus genome by amplification of a specific region of the ITS 16S-23S Coming soon B038 Mycoplasma Multiplex1 simultaneous identification of M. genitalium, M. hominis, U. urealyticum B037 Mycoplasma Multiplex2 simultaneous identification of M. genitalium, T. vaginalis B039 Mycoplasma Multiplex3 simultaneous identification of M. genitalium, U. urealyticum Available on request B040 Mycoplasma Multiplex4 simultaneous identification of M. hominis, U. parvum Available on request B041 STI Combo Available on request 20 RT PARASITOLOGY P001 Toxoplasma gondii P003 Leishmania spp P004 Leishmania infantum/donovani complex P005 Leishmania major complex P006 Leishmania mexicana complex P007 Leishmania (Viannia) identification and quantification of the Toxoplasma gondii genome by DNA amplification of the region B1 identification and quantification of the Leishmania infantum genome by DNA amplification of the minicircle DNA identification and quantification of the L. donovani complex genome by DNA amplification and detection of the r18s gene identification and quantification of the L. major complex genome by DNA amplification and detection of r18s gene Coming soon identification and quantification of the L. mexicana complex genome by DNA amplification and detection of the r18s gene Coming soon identification and quantification of the L./ Viannia complex genome by DNA amplification and detection of the r18s gene target region Coming soon Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue

8 PARASITOLOGY P038 Leishmania Multiplex1 P039 Leishmania Multiplex2 simultaneous identification of L. spp, L. infantum simultaneous identification of L spp, L. infantum, L.tropica/major P008 Plasmodium spp. P009 Plasmodium falciparum P010 Plasmodium vivax P011 Plasmodium ovale P012 Plasmodium malariae identification and quantification of the Plasmodium spp. genome by DNA amplification and detection of the 18S rdna gene identification and quantification of the Plasmodium falciparum genome by DNA amplification and detection of the 18S rdna gene identification and quantification of the Plasmodium vivax genome by DNA amplification and detection of the 18S rdna gene identification and quantification of the Plasmodium ovale genome by DNA amplification and detection of the 18S rdna gene identification and quantification of the Plasmodium malariae genome by DNA amplification and detection of the18s rdna gene Coming soon P035 Plasmodium Multiplex1 P036 Plasmodium Multiplex2 simultaneous identification of P. spp, P. falciparum simultaneous identification of P. vivax, P. ovale, P. malariae Coming soon P037 Plasmodium Combo Available on request 20 RT P014 Trypanosoma cruzi P015 Trypanosoma brucei P016 Entamoeba histolytica P017 Entamoeba dispar P018 Entamoeba moshkowskii P019 Dientamoeba fragilis identification and quantification of the Trypanosoma cruzi genome by DNA amplification and detection of the 18S rdna gene identification and quantification of the Trypanosoma brucei genome by DNA amplification and detection of the 18S rdna gene Coming soon identification of the Entamoeba histolytica genome by DNA amplification and detection of the 18S rdna gene identification of the Entamoeba dispar genome by DNA amplification and detection of the 18S rdna gene identification of the Entamoeba moshkowskii genome by DNA amplification and detection of the18s rdna gene identification of the Dientamoeba fragilis genome by DNA amplification and detection of the 18S rdna gene P040 Amoebae Multiplex1 simultaneous identification of E. histolytica, E. dispar Coming soon 8 Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue 2014

9 PARASITOLOGY P041 Amoebae Multiplex2 simultaneous identification of E. histolytica, E. dispar, E. moshkovskii Coming soon P042 Amoebae Combo Available on request 20 RT P020 Blastocystis hominis P021 Babesia spp. P022 Babesia microti identification of the Blastocystis hominis genome by DNA amplification and detection of the 18S rdna gene identification of the Babesia spp. genome by DNA amplification and detection of the 18S rdna gene identification of the Babesia microti genome by DNA amplification and detection of the 18S rdna gene Coming soon P049 Babesia Duplex simultaneous identification of B. microbi, B. divergens Coming soon P024 Ancylostoma duodenale P025 Ascaris lumbricoides P026 Strongyloides stercoralis P027 Trichuris trichiura P028 Schistosoma mansoni P029 Schistosoma hematobium P030 Giardia lamblia P031 Trichomonas vaginalis P033 Cryptosporidium parvum P034 Cryptosporidium hominum identification ation of the Ancylostoma duodenale genome by DNA amplification and detection of the ITS2 region Coming soon identification of the Ascaris lumbricoides genome by DNA amplification and detection of the ITS1 region Coming soon identification of the Strongyloides stercoralis genome by DNA amplification and detection of the 18S rdna gene identification of the Trichuris trichiura genome by DNA amplification and detection of the18s rdna gene Coming soon identification of the Schistosoma mansoni genome by DNA amplification and detection of the 121 bp tandem repeat sequence Coming soon identification of the Schistosoma hematobium genome by DNA amplification and detection of the 121 bp tandem repeat sequence Coming soon identification of the Giardia lamblia genome by DNA amplification and detection of the 18S rdna gene identification of the Trichomonas vaginalis genome by DNA amplification and detection of the G3 b tubulin gene identification of the Cryptosporidium parvum genome by DNA amplification and detection of the 18S rdna gene Coming soon identification of the Cryptosporidium hominum genome by DNA amplification and detection of the 18S rdna gene Coming soon P043 Schistosoma Duplex simultaneous identification of S. mansoni, S. hematobium Coming soon Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue

10 PARASITOLOGY P044 Intestinal Parasites Multiplex1 P045 Intestinal Parasites Multiplex2 P046 Intestinal Parasites Multiplex3 P047 Intestinal Parasites Combo simultaneous identification of G. lamblia, Cryptosporidium spp Coming soon simultaneous identification of E. histolytica, D. fragilis Coming soon simultaneous identification of G. lamblia, C., E. histolytica, D. fragilis Coming soon Available on request 20 RT MYCOLOGY M001 Aspergillus spp. M002 Aspergillus fumigatus M003 Aspergillus flavus M004 Aspergillus niger M005 Aspergillus terreus identification and quantification of the Aspergillus spp. genome by amplification of the ITS1-ITS2 region identification and quantification of the Aspergillus fumigatus genome by amplification of the ITS1-ITS2 region identification and quantification of the Aspergillus flavus genome by amplification of the ITS1-ITS2 region identification and quantification of the Aspergillus niger genome by amplification of the ITS1-ITS2 region identification and quantification of the Aspergillus terreus genome by amplification of the ITS1-ITS2 region M018 Aspergillus multiplex1 simultaneous identification and quantification of the A. spp, fumigatus genome M019 Aspergillus multiplex2 M020 Aspergillus multiplex3 simultaneous identification and quantification of the A. flavus, niger genome Coming soon simultaneous identification and quantification of the A. terreus, midulans genome Coming soon M021 Aspergillus Combo Available on request 20 RT M006 Candida spp. identification and quantification of the Candida species genome by DNA amplification and detection of the r18s gene 10 Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue 2014

11 MYCOLOGY M007 Candida albicans M008 Candida glabrata M009 Candida rugosa M010 Candida parapsilosis M011 Candida tropicalis M012 Candida dubliniensis identification and quantification of the Candida albicans genome by DNA amplification and detection of the r18s gene identification and quantification of the Candida glabrata genome by DNA amplification and detection of the r18s gene Coming soon identification and quantification of the Candida rugosa genome by DNA amplification and detection of the r18s gene Coming soon identification and quantification of the Candida parapsilosis genome by DNA amplification and detection of the r18s gene Coming soon Identification and quantification of the Candida tropicalis genome by DNA amplification and detection of the r18s gene Coming soon identification and quantification of the Candida dubliniensis genome by DNA amplification and detection of the r18s gene Coming soon M023 Candida Multiplex1 simultaneous identification of C. spp, C. albicans M024 Candida Multiplex2 simultaneous identification of C. glabrata, C. parapsilosis Coming soon M025 Candida Multiplex3 simultaneous identification of C. tropicalis, C. cruzei Coming soon M026 Candida Combo Available on request 20 RT M013 Pneumocystis carinii M014 Criptococcus neoformans M015 Histoplasma capsulatum M016 Fusarium spp M017 Microsporidium spp identification and quantification of the Pneumocystis carinii genome by amplification of the DHFR gene identification and quantification of the Criptococcus neoformans genome by amplification of the ITS2 region identification and quantification of the Histoplasma capsulatum genome by amplification of the ITS1-ITS2 region Coming soon identification and quantification of the Fusarium spp genome by amplification of the r18s gene Coming soon identification of the Microsporidium spp. genome by DNA amplification and detection of the 18S rdna gene Coming soon OTHERS G014 HLA B27 amplification of HLA type B27 gene associated with ankylosing spondylitis G015 DQ2/DQ8 identification of the HLA haplotypes conferring susceptibility to celiac disease Biotecnologia Innovativa per Ricerca e Diagnostica - Catalogue

12 HEADQUARTER via Montarioso 9c Monteriggioni (SI) tel fax info@birdsrl.it pec: birdsrl@pec.it web: R&D and MANUFACTURING via Papa Giovanni XXIII 75a Rezzato (BS) tel fax rd@birdsrl.it