Biomedical Sciences, Ph.D.

Transcription

1 Biomedical Sciences, Ph.D. 1 Biomedical Sciences, Ph.D. LEWIS KATZ SCHOOL OF MEDICINE ( About the Program The Ph.D. program is aimed at broad interdisciplinary and translational training in Biomedical Sciences and provides in-depth training in one of five areas of concentration. All students participate in an interdisciplinary first-year experience and then select an area of concentration from among Cancer Biology and Genetics, Infectious Disease and Immunity, Molecular and Cellular Biosciences, Neuroscience, and Organ Systems and Translational Medicine. The curriculum provides students with an interdisciplinary approach to research training, providing new pathways for learning and discovery. The Ph.D. program is intended to educate premier biomedical scientists who will be tomorrow s leaders in research, education, and government. Time Limit for Degree Completion: 7 years Campus Location: Health Sciences. With the permission of the student's Research Advisory Committee, elective courses not offered on the Health Sciences Campus may be taken at other campuses. Full-Time/Part-Time Status: The Ph.D. degree program is designed as a full-time day program of study. Interdisciplinary Study: The graduate program in Biomedical Sciences is interdisciplinary and emphasizes translational research. Students have the opportunity to work with faculty in disease-based research centers at the Lewis Katz School of Medicine, including the Center for Inflammation, Translational and Clinical Lung Research; Center for Metabolic Disease Research; Center for Neurovirology; Center for Substance Abuse Research; Center for Translational Research; Comprehensive NeuroAIDS Center; Fels Institute for Cancer Research and Molecular Biology; Independence Blue Cross Cardiovascular Research Center; Shriners Hospitals Pediatric Research Center; Sol Sherry Thrombosis Research Center; and Temple Autoimmunity Center. Ranking: The 2014 U.S. News and World Report ranked Temple University's School of Medicine number 54 in Research and among the Best Medical Schools. Areas of Specialization: This interdisciplinary Biomedical Sciences graduate program offers five areas of concentration for students who plan to earn the Ph.D.: Cancer Biology and Genetics Infectious Disease and Immunity Molecular and Cellular Biosciences Neuroscience Organ Systems and Translational Medicine Job Prospects: This well-balanced program has been designed to be individually tailored to meet the interests and needs of each student and to fully prepare each student for a Biomedical Sciences career in academia, industry, and government. The graduate program is designed to provide training in the theory and practice of Biomedical Sciences for eventual placement in research and teaching positions. Non-Matriculated Student Policy: Non-matriculated students may enroll in some courses with permission from the course instructor and approval from the Office of Graduate Studies at the Lewis Katz School of Medicine. Financing Opportunities: All students are provided with a competitive stipend, health insurance, and tuition remission. First-year students are supported by Medical School fellowships. After the first year, students receive financial support from extramural funds available to their research mentor, including training grants, research assistantships, and fellowships. Students are expected to work full-time toward the completion of the degree requirements. A satisfactory level of performance must be maintained at all times. Exceptionally qualified students who apply to the program may be nominated for Presidential, University, and Future Faculty Fellowships. In order to be considered for nomination, prospective students must submit all application materials to the department by February 15. Admission Requirements and Deadlines Pre-Application Deadline for International Applicants Only: All international applicants who have not earned a degree in the United States or from an institution where English is the sole language of instruction are required to complete a Pre-Application for approval before applying. The Pre-Application is found on the Biomedical Sciences website at medicine.temple.edu/education/biomedical-sciences-graduate-program/admissions/pre-application-international-applicants and must be submitted electronically by October 31. Application Deadline:

2 2 Biomedical Sciences, Ph.D. Fall: February 15 Applications are processed as they are received. APPLY ONLINE to this graduate program. Letters of Reference: Number Required: 3 From Whom: Letters of recommendation should be obtained from faculty and supervisors of research experiences. Coursework Required for Admission Consideration: Applicants should have undergraduate training in the life sciences such as Biology, Biochemistry, Cell Biology, or Molecular Biology and Genetics. Students are also expected to have training in Chemistry and Mathematics. Master's Degree in Discipline/Related Discipline: A master's degree is not required. Bachelor's Degree in Discipline/Related Discipline: A baccalaureate degree in the Biological or Chemical Sciences is required. Statement of Goals: Approximately 500 to 1,000 words include your interest in Temple's Biomedical Sciences graduate program; your research interests and past experiences; your future career goals; and your academic and research achievements. Standardized Test Scores: GRE: Required. Acceptance by Temple University requires submission of verbal, quantitative, and analytical GRE scores. GRE scores below the 50th percentile are outside the norm set by the Graduate School, and no individual score in the verbal, quantitative, or analytical sections should be below that level. For applicants whose native language is not English, the TOEFL, IELTS, or PTE Academic exam is required: TOEFL: 79 ibt or 550 PBT minimum IELTS: 6.5 minimum PTE Academic: 53 minimum Advanced Standing: Students who enter the Ph.D. program in Biomedical Sciences may be considered for advanced standing, based on the successful completion of graduate-level courses in the Biological Sciences or Chemistry. The credits must be equivalent to coursework offered at Temple, and the grades earned must be a "B" or better. The Graduate Admissions Committee makes the recommendation on a case-by-case basis as the application is reviewed. The maximum number of advanced standing credits awarded is 24. Test Waivers: Upon review of the student's background by the Graduate Admissions Committee, applicants with high levels of performance in one or more areas can gain favorable consideration for an application that is otherwise outside the acceptance matrix. Program Requirements General Program Requirements: Number of Didactic Credits Required Beyond the Baccalaureate: 37 Required Courses: Code Title Credit Hours All students participate in a common first-year interdisciplinary experience that includes the following core courses: Molecules to Cells Organ Systems: Function, Dysfunction and Therapies Scientific Design and Biostatistics Scientific Communications Bioinformatics Scientific Integrity Scientific Grant Writing Advanced elective courses in area of concentration/cluster Cluster-Based Seminar/Specialized Journal Club Additional Requirements: Research Advisory Committee Meetings:

3 Biomedical Sciences, Ph.D. 3 Students are required to meet with their Research Advisory Committee each term to evaluate their progress toward the degree. Outside Research Proposal: In the Spring term of the second year of study, students are required to prepare and defend an NIH-style grant proposal in their area of concentration on a topic that is distinct from the student's research. This is a requirement for elevation to candidacy. Culminating Events: Dissertation Proposal: The dissertation proposal demonstrates the student's knowledge of and ability to conduct the proposed research. The proposal should describe the context and background surrounding a particular research problem and a methodological plan for investigating the problem. The proposal is a requirement for admission to candidacy and should be submitted and approved during the Fall term of the third year in the program. Dissertation: The Ph.D. degree in Biomedical Sciences is a research degree. Research training begins with three research rotations in the first year of the graduate program and continues with the selection of an area of concentration and a Dissertation Research Advisor, who is a member of the Graduate Faculty from within the selected area of concentration. The areas of concentration include Cancer Biology and Genetics, Infectious Disease and Immunity, Molecular and Cellular Biosciences, Neuroscience, and Organ Systems and Translational Medicine. Under the direction of the Dissertation Research Advisor, the student develops an original research project. Dissertation research involves meaningful, critical thinking and the execution of ideas in the laboratory through the use of the scientific method. Dissertation research conducted by the student should be an original contribution to scientific knowledge. The quality of the student's Ph.D. dissertation research should be equivalent to that found in reputable biomedical sciences journals. Upon selection of an area of concentration and a Dissertation Research Advisor, a Research Advisory Committee is formed for each student. This Committee is responsible for the review of the student's research and academic progress twice yearly. It determines whether the content of the student's research is sufficient for the Ph.D. dissertation. The student submits the dissertation in complete form not less than 14 days prior to the date of the final examination. The dissertation must have been read and approved by the Dissertation Research Advisor prior to distribution. After the student has arranged the time, date, and room for the dissertation defense, the "Announcement of Dissertation Defense" form, found in TUportal under the Tools tab within University Forms, is completed and forwarded to the Graduate School on Main Campus and to the Office of Graduate Studies on the Health Sciences Campus at least 10 working days before the defense. Announcements of the defense are posted and ed to all members of the cluster/area of concentration. The Final Examination Committee evaluates the student's dissertation and demonstration of competence within the field of the dissertation and related areas. This Committee consists of five faculty members, including the Dissertation Research Advisor, Research Advisory Committee, and one additional faculty member from another cluster. The Committee evaluates the quality of the dissertation research and the student's ability to express, both in writing and orally, her/his research question, methodological approach, primary findings, and implications. The Committee votes to pass or fail the dissertation and the defense at the conclusion of the public presentation and private question/answer period. Contacts Program Web Address: Department Information: Biomedical Sciences Graduate Program Lewis Katz School of Medicine at Temple University 3500 N. Broad Street, MERB 1111 Philadelphia, PA tusmgrad@temple.edu Mailing Address for Application Materials: Graduate Division Lewis Katz School of Medicine at Temple University 3500 N. Broad Street, MERB 1111 (556-00) Philadelphia, PA Department Contacts: Admissions and Program Coordinators: Dianne Soprano, Ph.D.

4 4 Biomedical Sciences, Ph.D. Associate Dean for Graduate and M.D./Ph.D. Programs Admissions and Program Coordinators: Scott K. Shore, Ph.D. Associate Dean for Graduate Studies and Specialty Programs Courses BMSC Introduction to Biochemistry and Molecular Biology. 3 Credit Hours. Graduate level course that describes fundamentals of biochemistry and molecular biology. Topics include proteins, enzymes, ligand binding, energy metabolism, carbohydrate, lipid and amino acid metabolism, structure of RNA and DNA, chromosomes and genes, DNA replication and repair, RNA transcription, and protein translation, degradation, trafficking. BMSC Introduction to Cell Biology and Immunology. 3 Credit Hours. Graduate level course that describes fundamentals of cell biology and immunology. Topics include prokaryotic and eukaryotic cell biology, mitosis and meiosis, cell cycle control, membranes and membrane channels/transporters, cytoskeleton, cell differentiation, apoptosis, principles of immunology, antigens, cells of the immune system, humoral immune responses, autoimmunity, hypersensitivity and allergies, and host-pathogen interactions. BMSC Introduction to Molecular and Cell Biology. 3 Credit Hours. Graduate level course that describes fundamentals of molecular biology, genetics and cell biology. Topics include structure of DNA and RNA, chromosomes and genes, DNA replication and RNA, RNA transcription, protein translation, protein degradation and trafficking, prokaryotic and eukaryotic cell biology, mitosis and meiosis, cell cycle control, membranes and membrane channels/transporters, cytoskeleton, cell differentiation and apoptosis. BMSC Molecules to Cells. 6 Credit Hours. Graduate level course that describes fundamentals of biochemistry, molecular biology, cell biology and immunology. Biochemistry, molecular biology and cell biology will consider both prokaryotic and eukaryotic organisms. Immunology will include principles of immunology and host-pathogen interactions. BMSC Experimental Design and Biostatistics. 1 Credit Hour. This is a one-credit course designed to provide first year Biomedical Science graduate students basic information concerning experimental design and biostatistics. The emphasis of this course will be to provide practical information pertaining to the design of biomedical experiments and their analysis using a variety of statistical approaches. BMSC Scientific Integrity and Bioethics. 1 Credit Hour. This is a one-credit graduate course to provide Biomedical Science graduate students with instruction in ethical conduct of research.

5 Biomedical Sciences, Ph.D. 5 BMSC Introduction to Laboratory Research I. 1 Credit Hour. This is a one-credit graduate course to provide Biomedical Science graduate students with exposure to the research opportunities in the five Biomedical Science research clusters and to obtain supervised research experience in the laboratory. BMSC Organ Systems: Function, Dysfunction and Therapeutics. 4 Credit Hours. This graduate level course provides instruction in the physiological, pathophysiological and pharmacological aspects of various organ systems. Organ systems will include cardiovascular, pulmonary, renal, endocrine, musculoskeletal and neurological. BMSC Scientific Communications. 1 Credit Hour. This course will provide instruction in both written and oral scientific communications. Students will be guided in the preparation of power point presentations, abstracts and full manuscripts. BMSC Bioinformatics. 1 Credit Hour. This is a one-credit course to provide instruction in bioinformatic approaches to the conduct of biomedical research. BMSC Introduction to Laboratory Research II. 1 Credit Hour. This is a one-credit course to provide Biomedical Science graduate students with supervised research experiences within laboratories. BMSC Cell Structure & Function. 2 Credit Hours. The goal of this course is to learn the structure and function of basic tissues in the body. Emphasis will be on the study of the structure of different cell types in the body and how this relates to their function. BMSC Molecular, Cellular and Systems Signal Transduction. 2 Credit Hours. This course will discuss basic mechanisms of cell signaling in a variety of different cell types. BMSC Molecular Approaches to Research. 2 Credit Hours. The goal of the course is to give students an understanding of basic and novel molecular approaches to biomedical research. The following major issues are addressed: (i) what are the molecular approaches most frequently used in biomedical research; (ii) why a particular approach fits a specific question asked in the course of research, and how to select the most suitable approach; and (iii) what is the molecular basis of these experimental approaches, i.e. how and why the techniques used in the lab work. Areas of instruction will include methods for the study of DNA, RNA and protein, optical approaches, transgenic animals and other animal models of human disease and single-cell analysis using flow cytometry.

6 6 Biomedical Sciences, Ph.D. BMSC Scientific Grant Writing. 1 Credit Hour. The overall purpose of this course is to provide training to Biomedical Science graduate students in the preparation of a successful grant application. BMSC Cancer Biology and Genetics Student Seminar and Journal Club. 1 Credit Hour. This course will require that the student participate in two separate activities: (i) attend and participate in the student seminar series of the Cancer Biology and Genetics cluster and present a literature based seminar on a topic within this field of study, and (ii) attend and participate in a specialized journal club in an area of interest. The course director will provide students with detailed course/grading policies, schedules, and a list of journal clubs. BMSC Cancer Biology. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Cancer Biology and Genetics Cluster of the Biomedical Sciences Graduate Program. It is an interdisciplinary course taught by faculty from the School of Medicine and the Fox Chase Cancer Center. The goals of the course are 1) to provide students with a comprehensive background of cancer, from the patient to the transformed cell, 2) to provide a molecular understanding of the difference between normal and cancer cells and 3) to provide an understanding of the origins, treatments and prevention of cancer. Course syllabus will be provided by the course director. BMSC Genetics and Epigenetics. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Cancer Biology and Genetics Cluster of the Biomedical Sciences Graduate Program. The focus of this course is on Hereditary Mechanisms and Epigenetics. Mendelian diseases and complex phenotypes will be reviewed. The major focus will be on mechanisms of Epigenetic modifications and heritability, including its role in development and disease. Experimental approaches to epigenetics studies will be presented and papers from the literature will be the backbone of the course. Course syllabus will be provided by the course director. BMSC Special Topics in Cancer Biology and Genetics. 2 Credit Hours. This course is based on the breaking research findings in the area of Cancer Biology and Genetics and the interests of the faculty and students within this cluster. Topics will vary year to year. The course director will provide students with detailed course/grading policies, schedules and reading lists. BMSC Infectious Disease and Immunity Student Seminar and Journal Club. 1 Credit Hour. This course will require that the student participate in two separate activities: (i) attend and participate in the student seminar series of the Infectious Disease and Immunity cluster and present a literature based seminar on a topic within this field of study, and (ii) attend and participate in a specialized journal club in an area of interest. The course director will provide students with detailed course/grading policies, schedules and a list of journal clubs. BMSC The Biology of the Immune Response. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Infectious Disease and Immunity Cluster. The focus of this course is the study of the components of the immune system, their development and function, and their roles in various pathological processes. Readings are from the primary literature including landmark papers and recently published work. The successful completion of this course will allow the application of evidence based knowledge to the graduate student's own research project. Course syllabus is provided by the course director.

7 Biomedical Sciences, Ph.D. 7 BMSC Molecular Genetics of Human Viruses. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Infectious Disease and Immunity Cluster. This course aims to provide graduate students with the opportunity to gain knowledge of human viruses and viruses of zoonotic origins. The research methods used in medical virology relevant to elucidating viral replication and pathogenesis will be covered. In addition, the ways for which viruses are used in genetic engineering, cancer treatment and basic research will be discussed. The course covers materials from seminal papers and latest published work. The successful completion of this course will allow the application of evidence based knowledge to the graduate student's own research. Course syllabus is provided by the course director. BMSC Cellular and Molecular Basis of Host-Microbe Interactions. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Infectious Disease and Immunity Cluster. The focus of this course is to understand the cellular and molecular mechanisms of microbial pathogenesis and the host response to the pathogen. Selected model organisms will be used for in depth exploration of host-pathogen interactions. In addition, certain general strategies of microbial survival and penetration, and of host recognition and response to danger signals, will be covered. Lectures present evidence for current concepts and theories from the primary literature and review articles. Conference hours cover recent relevant research papers. Course syllabus is provided by the course director. BMSC Special Topics in Infectious Disease and Immunity. 2 Credit Hours. This course is based on the breaking research findings in the area of Infectious Disease and Immunity and the interests of the faculty and students within this cluster. Topics will vary year to year. The course director will provide students with detailed course/grading policies, schedules and reading lists. BMSC Molecular and Cellular Biosciences Student Seminar and Journal Club. 1 Credit Hour. This course will require that the student participate in two separate activities: (i) attend and participate in the student seminar series of the Molecular and Cellular Biosciences cluster and present a literature based seminar on a topic within this field of study, and (ii) attend and participate in a specialized journal club in an area of interest. The course director will provide students with detailed course/grading policies, schedules and a list of journal clubs. BMSC Enzymes and Proteins. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Molecular and Cellular Biosciences Cluster. The overall goal of this course is to enable students to understand protein structural and catalytic aspects of contemporary biochemistry. The student who completes this course will be able to engage in dialog about protein structure and function. The student will be able to understand, visualize, reshape, present and discuss data from original sources. Course syllabus is provided by the course director. BMSC RNA and its Role in Gene Expression. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Molecular and Cellular Biosciences Cluster. The focus of this course is on the study of RNA and its multiple roles in gene expression. The structure, synthesis, processing and function including protein translation of both classic RNA molecules (mrna, trna and rrna) and nontraditional RNA molecules (such as mirnas, long noncoding RNAs, RNAs with enzymatic activity) are discussed. Both single molecule based approaches and genomic approaches are discussed. Readings are from the primary literature including landmark papers and recently published work. Course syllabus is provided by the course director.

8 8 Biomedical Sciences, Ph.D. BMSC Molecular Physiology of Ion Signaling. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Molecular and Cellular Biosciences Cluster. The overall focus of this course is on ion channels and their function in biological systems. Part 1 of the course focuses on ion balance, channel classes and channel structures. Part 2 focuses on the biological impact of ionic control of cytosolic Ca2+ concentration. Part 3 focuses on the impact of these changes on physiology and disease in multiple organ systems. Course syllabus is provided by the course director. BMSC Biophysical Approaches to Research. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Molecular and Cellular Biosciences Cluster. Students will learn to appreciate how biophysical principles can be used to understand and measure properties of biomolecules and cells. The areas covered in the course emphasize how to generate, analyze and interpret quantitative information about biological molecules or systems. Course syllabus is provided by the course director. BMSC Structure and Dynamics of Biomolecules and Assemblies. 2 Credit Hours. This is an advanced topics course offered for students in the second year of study in the Biomedical Sciences Graduate Program. The course will focus on understanding structure and behavior of biomolecules and assemblies, including the chemical basis for molecular interactions and techniques for studying macromolecular structure. BMSC Special Topics in Molecular and Cellular Biosciences. 2 Credit Hours. This course is based on the breaking research findings in the area of Molecular and Cellular Biosciences and the interests of the faculty and students within this cluster. Topics will vary year to year. The course director will provide students with detailed course/grading policies, schedules and reading lists. BMSC Neuroscience Student Seminar and Journal Club. 1 Credit Hour. This course will require that the student participate in two separate activities: (i) attend and participate in the student seminar series of the Neuroscience cluster and present a literature based seminar on a topic within this field of study, and (ii) attend and participate in a specialized journal club in an area of interest. The course director will provide students with detailed course/grading policies, schedules and a list of journal clubs. BMSC Essentials of Neuroscience. 1 to 2 Credit Hour. This is a REQUIRED Cluster-based Advanced Course offered by the Neuroscience Cluster of the Biomedical Sciences Graduate Program. This course is open to all graduate students in all disciplines with an interest in learning basic neuroscience. This course focuses on the basic neurophysiological and neuroanatomical aspects of the organization of the nervous system. Neuroanatomical structures and their function will be covered using a system based approach. Sensory, motor and special sensory systems will be included. Course syllabus is provided by the course director. BMSC Molecular and Cellular Neuroscience. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Neuroscience Cluster. The overall goal of this course is to provide an integrated approach to the understanding of the structure and function of neurons and glia. Topics include the cellular structure of neurons and glia, molecular mechanisms for neural transmission and plasticity, new concepts on neurogenesis and cell fate decisions, signaling pathways for neuronal polarization and neuritogenesis, molecular biology and function of glia, neuron-glia interactions, glial cell pathophysiology, neuroinflammation and the role of glia in the development and progression of various neurological disorders and diseases. Course syllabus is provided by the course director.

9 Biomedical Sciences, Ph.D. 9 BMSC Neuropharmacology. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Neuroscience Cluster. The overall goal of this course is to provide the basic aspects of neuropharmacology by investigating mechanism by which drugs influence and/or modulate different neural system activities and functions. The molecular, cellular and biochemistry characteristics of several classes of drugs with implications for human pathologies will be discussed. Four areas of emphasis will include: structure and function of the nervous system, neurotransmitters and neuromodulators, neuroinflammation and neurodegeneration. Course syllabus is provided by the course director. BMSC Pharmacology of Drugs of Abuse. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Neuroscience Cluster. The focus of this course is on the pharmacology of drugs of abuse. Topics include historical perspectives of drug abuse, cellular responses to acute and chronic exposure to drugs of abuse, effects of drugs of abuse on the immune system, and medical treatment of drug dependence. Specific drug classes that are covered include opioids, cocaine, amphetamines, spice and bath salts, club drugs, LSD and PCP, alcohol, caffeine, nicotine, benzodiazepines and sedatives, and cannabinoids. Course syllabus is provided by the course director. BMSC Translational Science of Nervous System Diseases. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Neuroscience Cluster. Students will gain knowledge of translational science regarding the molecular basis of various nervous system diseases, current treatments and rehabilitation, and advances in animal modeling of disease that address prevention and improved treatment modalities. Course syllabus is provided by the course director. BMSC Developmental Neurobiology. 2 Credit Hours. This course will focus on the molecular and cellular mechanisms that govern development of the mammalian central nervous system. Topics include but are not limited to: Development of the Cerebral Cortex, Retinal Development, Glial Development, White Matter Maturation, Neuroprogenitors Cells, Axonogenesis and Dendritogenesis. BMSC Special Topics in Neuroscience. 2 Credit Hours. This course is based on the breaking research findings in the area of Neuroscience and the interests of the faculty and students within this cluster. Topics will vary year to year. The course director will provide students with detailed course/grading policies, schedules and reading lists. BMSC Organ Systems and Translational Medicine Student Seminar and Journal Club. 1 Credit Hour. This course will require that the student participate in two separate activities: (i) attend and participate in the student seminar series of the Organ Systems and Translational Medicine cluster and present a literature based seminar on a topic within this field of study, and (ii) attend and participate in a specialized journal club in an area of interest. The course director will provide students with detailed course/grading policies, schedules and a list of journal clubs.

10 10 Biomedical Sciences, Ph.D. BMSC Mechanisms of Cardiovascular Pathophysiology. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Organ Systems and Translational Medicine Cluster. The overall goal of this teamtaught course is to introduce graduate students to the cellular and molecular mechanisms of multiple cardiovascular diseases, with a focus on experimental approaches. The approach will combine didactic presentation with relevant important scientific literature. Course syllabus is provided by the course director. BMSC Hemostasis and Thrombosis. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Organ Systems and Translational Medicine Cluster. Selected areas of Hemostasis and Thrombosis will be addressed from a historical perspective to state of the art technology and knowledge. This course will study molecular mechanisms and signal transduction events that regulate hemostasis through coagulation cascades and platelet function. The implications of treatments of bleeding disorders, thrombosis, and the therapeutics will be discussed. Students are expected to read seminal papers and participate in class by contributing to discussion. Each topic will have discrete study objectives. Course syllabus is provided by the course director. BMSC Translational Pulmonary Physiology - Experimental Basis. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Organ Systems and Translational Medicine Cluster. Selected areas of pulmonary physiology will be addressed from application, experimental, and historical perspectives. This course will study mechanisms that underlie major pulmonary diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma, and ventilator induced lung injury. How these diseases modify the function of the pulmonary system, the mechanical, circulatory and inflammatory profiles of the lung, and interventions to attenuate dysfunction will be discussed. Students are expected to read seminal papers and participate in class by contributing to discussion. Each topic will have discrete study objectives. Course syllabus is provided by the course director. BMSC Advanced Pharmacology and Translational Medicine. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Organ Systems and Translational Medicine Cluster. Pharmacology is the study of biochemical and physiological processes mediated through exogenous or endogenous substances that interact with living systems. Translational medicine aims to use pharmacological discoveries to develop novel therapies in treatment of human disease. The overall goal of this course is to introduce students to the subject of advanced pharmacology and then to focus on recent advances in methodologies used to develop new therapeutics with an emphasis on experimental approaches. The approach will combine didactic presentation with a combination of informal discussion of important scientific literature. Course materials will be handouts/lecture slides provided by each instructor, and selected research papers from the literature. Each lecture will provide a solid foundation for students to understand the methods and techniques used in experimental pharmacology and translational medicine in addition to the concepts. Student participation in the form of questions and discussion is encouraged. Course syllabus is provided by the course director. BMSC Development, Function and Diseases of the Musculoskeletal System. 2 Credit Hours. This is a Cluster-based Advanced Elective Course offered by the Organ Systems and Translational Medicine Cluster. Lecture topics will include: musculoskeletal histology, development of limbs, muscle, bone and joints, diagnostic imaging of musculoskeletal system and cartilage repair/fracture, cell biology of osteoblasts and osteoclasts, biomechanics of musculoskeletal system, skeletal pathologies and central nervous system/bone interactions. Course syllabus is provided by the course director.

11 Biomedical Sciences, Ph.D. 11 BMSC Organ Metabolism - Molecular Pathology and Experimental Models. 2 Credit Hours. This is an advanced topics course offered to students in the second year of study in the Biomedical Science Graduate Program. The overall goal of this course is to introduce students to the subject of systemic metabolism and organ metabolism and relate this to various key organ pathologies and diseases. Emphasis will be placed on recent advances in molecular pathways along with the experimental models and methodologies used to develop new therapeutics. BMSC Special Topics in Organ Systems and Translational Medicine. 2 Credit Hours. This course is based on the breaking research findings in the area of Organ Systems and Translational Medicine and the interests of the faculty and students within this cluster. Topics will vary year to year. The course director will provide students with detailed course/grading policies, schedules and reading lists. BMSC Biomedical Science Research. 1 to 6 Credit Hour. Students will perform supervised laboratory research. BMSC Preliminary Exam Preparation. 1 to 6 Credit Hour. Biomedical Science students will enroll in this course when they are preparing for the PhD Preliminary Examination. BMSC Master's Project. 1 to 6 Credit Hour. BMSC Master's Thesis. 1 to 6 Credit Hour. BMSC Postcandidacy Research. 1 to 6 Credit Hour. BMSC Dissertation Writing. 1 to 6 Credit Hour.