NIH K AWARD WORKSHOP Feb 19, 2015

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1 UCLA CTSI Clinical and Translational Science Institute NIH K AWARD WORKSHOP Feb 19, 2015 brings UCLA innovations to the greatest health needs in Los Angeles Christina Wang, MD Associate Director, Clinical and Translational Science Institute Los Angeles Biomedical Research Institute /Harbor-UCLA Medical Center

2 UCLA CTSI Research Resources Clinical Research Research Cores Biostatistics Data Repositories Education & Training Pilot Funding Translational Science Grants Facilitation Discoveries -to-products Community Engagement 2

3 University of California, Los Angeles CTSA Regional Consortia

4 UC Biomedical Research Acceleration Integration and Development (UC BRAID) 4

5 UC Research Exchange (UC-ReX) A UC-shared Data Resource Enables search of 12 million de-identified patient records from the 5 UC medical centers with one query Complete NIH targeted Enrollment Tables by providing counts of eligible patients by gender, race and ethnicity Increase cohort identification for the study of rare diseases Allows expansion from a single to a multi-site proposal Obtain coordinated data provisioning support through UC ReX 5

6 Los Angeles Data Resource (LADR) Vision Link patient data across all LA providers (including CTSI) More comprehensive data than any single institution Current members: UCLA, Cedars-Sinai Future members: LA DHS, USC, Harbor-UCLA Distinct Patients Total Facts Cedars-Sinai 2,424,482 19,468,005 UCLA 4,180,722 67,507,617

7 Augmenting human cognitive capacity in translational research 1000 facts per decision Clinical data Genetics and proteomics Human cognitive capacity Proteomics Functional genetics (Gene expression profiles) Structural genetics (e.g. SNPs, haplotypes) Decisions by clinical phenotype Adapted from W. Stead et al, Biomedical Informatics: Changing What Physicians Need to Know and How They Learn, Academic Medicine, Vol. 84, No. 4 / April 2011

8 NCATS Goals for the CTSAs 2015 and beyond Goal 1: Prepare the translational workforce to conduct high-quality, multidisciplinary team science. Goal 2: Engage stakeholder communities across the translational spectrum and disseminate successful models of collaboration. Goal 3: Integrate translational science across the lifespan and within special populations, especially those experiencing health disparities. Goal 4: Improve methods and processes to accelerate scientific translation, overcome key roadblocks and support multisite research. Goal 5: Provide strong leadership to support the full spectrum of highquality, translational research within our CTSA hub and across the national network (For NCATS).

9 Clinical and Translational Research Center (CTRC) Ambulatory Clinical Research Facilities at LA Biomed Clinical and Research with Open 23 hours / day/2 Sleep Study Facilities weeks/month >5,000 sq ft outpatient area Rooms: 5 rooms with bed for Bionutrition Core overnight studies, 5 exam Dexa and body composition rooms, 2 consult rooms

10 Biostatistical Consults Core Services Pilot Funding Biostatistical Consults > 1,700 projects for > 1,000 investigators Technology Core Vouchers 906 applications, 293 awards to date up to $10K, 300 word application junior investigators receive priority Pilot Funding Awarded 280 peer-reviewed pilot grants to date 13

11 Opportunities Vouchers Core services at UCLA institutions Grants up to $10,000, RFA released 3x/year Team Science Awards Multidisciplinary, translational science leading to larger proposals Up to $200,000 for 1-2 years 14

12 Team Science Awards Supports multidisciplinary teams Enables teams to obtain preliminary data for extramural grants Co-funded by CTSI and other entities Issued in amounts up to $200,000 for one or two years Non-renewable and awarded through competitive, peer-review using an open RFA

13 K Awards Interdisciplinary, mentored research with training NIH KL2 awards doubled to 23 with institutional funds ~$100K salary and benefits support, $25K project support

14 KL2 Y4 Awardees Nicholas Bernthal, MD Assistant Professor, UCLA Novel Antibacterial Coatings Preventing Implant Infections Hyong Jin Cho, MD, PhD Assistant Professor, UCLA Sleep Loss as a Vulnerability Factor for Inflammation-Induced Depressive Symptoms in Older Women Eugenio Cingolani, MD Assistant Professor-in-Residence, Cedars-Sinai Biological Pacemaker in a Pre-Clinical Model of Heart Block 22

15 KL2 Y4 Awardees Tiane Dai, MD, PhD Assistant Professor, LA BioMed at Harbor-UCLA An innovative approach to the preservation of peritoneal membrane Thanh Huynh, MD, MSHS Clinical Instructor, UCLA Understanding Inappropriate Treatment in Critically Ill Patients Jenny Shen, MD, MS Assistant Professor, LA BioMed at Harbor-UCLA Racial and Ethnic Differences in the Initiation of Peritoneal Dialysis 23