AUDITORY BRAINSTEM IMPLANT ARTIFICIAL RETINA Artificial Retina (Continued) ARTIFICIAL PANCREAS MARKET OPPORTUNITY FOR

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1 INTRODUCTION... XVII REASON FOR STUDY AND ITS IMPORTANCE... XVII INTENDED AUDIENCE OF THIS REPORT... XVII SCOPE AND CONTENT OF THE REPORT... XVII METHODOLOGY AND INFORMATION SOURCES... XVIII ANALYST S CREDENTIALS... XVIII RELEVANT BCC REPORTS... XIX MONTHLY NEWSLETTERS... XX BCC ON-LINE SERVICES... XX SUMMARY... XXI SUMMARY TABLE GLOBAL MARKET FOR BIOMEDICAL NANOSCALE DEVICES, THROUGH 2007 ($ MILLIONS)... XXI SUMMARY FIGURE GLOBAL MARKET FOR BIOMEDICAL NANOSCALE DEVICES, ($ MILLIONS)... XXII OVERVIEW... 1 COVERAGE DEFINED... 1 COVERAGE DEFINED (CONTINUED)... 2 NANOMEDICINE... 3 TABLE 1 NANOMEDICINE TAXONOMY... 3 NANOTECHNOLOGY... 4 Nanotechnology (Continued)... 5 TABLE 2 SIZES OF NANOSCALE OBJECTS NATURE VS. MANUFACTURE... 6 BIOTECHNOLOGY VS. NANOTECHNOLOGY... 6 Biotechnology vs. Nanotechnology (Continued)... 7 Biotechnology vs. Nanotechnology (Continued)... 8 LITHOGRAPHY... 9 OBSTACLES TO THE DEVELOPMENT OF NANOTECHNOLOGY FEAR OF NANO Fear of Nano (Continued) Fear of Nano (Continued) SHORTAGE OF EXPERTS HYPE HYPE (Continued) REGULATION REGULATION OF DRUGS AND BIOMEDICAL DEVICES REGULATION IN THE U.S Devices Devices (Continued) TABLE 3 FOOD AND DRUG ADMINISTRATION BODIES INVOLVED IN MEDICAL DEVICE REGULATION Devices (Continued) Drugs and Biologicals TABLE 4 STAGES OF DRUG CANDIDATE REVIEW... 18

2 Diagnostics Orphan Product Status INTERNATIONAL ISSUES ISO GENERAL REGULATION OF NANOTECHNOLOGY GENERAL REGULATION OF NANOTECHNOLOGY (CONTINUED) TYPICAL NANOSCALE DEVICES CONCEPTS AND REALITIES THE ASSEMBLER The Assembler (Continued) The Assembler (Continued) DENDRIMERS ARTIFICIAL ANTIBODIES APTAMERS LIQUID CRYSTAL DESIGNER MACROMOLECULES PROTEINS WITH NON-NATURAL AMINO ACIDS SELF-ASSEMBLING NANOSTRUCTURES PORPHYRIN POLYMERS BUILDING WITH VIRUSES MODIFIED SPIDER SILK RIBOZYMES MEMS/NEMS Mems/Nems (Continued) MOLECULAR MOTORS SPECIAL PURPOSE MOTORS NANOTUBES FLUORESCENCE NANOTUBE THERMOMETER Spiral-Shaped Nanotubes from Organic Chemicals Thin Films APPLICATIONS FOR NANOSCALE DEVICES TABLE 5 NANOSCALE DEVICES AND APLICATIONS TABLE 6 BIOMEDICAL MARKETS POTENTIALLY ADDRESSABLE BY NANODEVICES, TABLE 7 GLOBAL PROJECTED SALES OF BIOMEDICAL NANOSCALE DEVICES BY APPLICATION, THROUGH 2007 ($ MILLIONS) ARTIFICIAL CELLS ARTIFICIAL CELLS (CONTINUED) ARTIFICIAL CELLS (CONTINUED) MARKET OPPORTUNITY FOR ARTIFICIAL CELLS TABLE 8 GLOBAL BIOMEDICAL MARKET REVENUES FROM ARTIFICIAL CELLS, THROUGH 2007 ($ MILLIONS) ARTIFICIAL ORGAN IMPLANTS... 46

3 AUDITORY BRAINSTEM IMPLANT ARTIFICIAL RETINA Artificial Retina (Continued) ARTIFICIAL PANCREAS MARKET OPPORTUNITY FOR ARTIFICIAL ORGANS TABLE 9 GLOBAL REVENUES DERIVED FROM NANOSCALE ARTIFICIAL ORGANS, THROUGH 2007 ($ MILLIONS) BIOTAGS TABLE 10 PROPERTIES OF SELECTED BIOTAGS DIAGNOSTICS AND ANALYTICS TABLE 11 MEDICAL ANALYSIS AT DIFFERENT LEVELS OF RESOLUTION TABLE 12 COMMONLY USED TOOLS FOR BIOMOLECULAR ANALYSIS BIOSENSORS TABLE 13 BIOSENSOR COMPONENTS TABLE 13 (CONTINUED) Biosensors (Continued) TABLE 14 BIOASSAYS EMPLOYING NANSCALE COMPONENTS RESONANCE LIGHT SCATTERING SURFACE PLASMON RESONANCE THIN FILM PLANAR WAVE-GUIDE TECHNOLOGY OLFACTORY RECEPTOR SENSORS THE ARTIFICIAL NOSE Olfactory Receptor Sensors The Artificial (Continued) CANTILEVERS NANOPARTICLE-BASED ASSAYS Nanoparticle-Based Assays (Continued) Nanoparticle-Based Assays (Continued) MAGNETIC RESISTANCE ASSAYS MEMBRANES PIEZOELECTRIC ACOUSTIC ASSAYS MICRO/NANO TRANSPONDERS LIVING CELL BIOSENSORS NANOCRYSTAL ANTENNA TRANSDUCER PROTEIN BENDING BIOSWITCHES ELECTRICAL FLOW THROUGH DNA POROUS GLASS SENSORS MICRO- AND NANOFLUIDICS Micro- and Nanofluidics (Continued) QUANTUM DOTS NANOARRAYS MARKET OPPORTUNITY FOR DIAGNOSTICS AND ANALYTICS Market Opportunity foranalytics (Continued) TABLE 15 GLOBAL REVENUES FOR DIAGNOSTICS AND ANALYTICS EMPLOYING NANOSCALE DEVICES, THROUGH 2007 ($ MILLIONS)... 80

4 FIGURE 1 GLOBAL REVENUES FOR DIAGNOSTICS AND ANALYTICS EMPLOYING NANOSCALE DEVICES, ($ MILLIONS) DRUGS AND DRUG DELIVERY TABLE 16 NANOSCALE DEVICES USED FOR DRUG DELIVERY TABLE 16 (CONTINUED) FULLERENES HOMING QUANTUM DOTS NANOCLINIC MOLECULAR TRANSPORT IMPLANTABLE CHIPS NANOPARTICLES Nanoparticles (Continued) Nanoparticles (Continued) Nanoparticles (Continued) Nanoparticles (Continued) INTRACELLULAR DELIVERY REGULATION LIPOSOMES AND OTHER VESICLES Liposomes and Other Vesicles (Continued) Liposomes and Other Vesicles (Continued) NANOEMULSIONS NANOSHELLS PUMPS ANTIVIRAL GEL MARKET OPPORTUNITY FOR DRUGS AND DRUG DELIVERY TABLE 17 GLOBAL REVENUES FOR DRUGS AND DRUGS DELIVERY, THROUGH 2007 ($ MILLIONS) FIGURE 2 GLOBAL REVENUES FOR DRUGS AND DRUGS DELIVERY, ($ MILLIONS) IMAGING AND NANOTOOLS ATOMIC FORCE AND SCANNING TUNNELING MICROSCOPES Atomic Force and Scanning Tunneling (Continued) ANGSTROVISION NANOMANIPULATORS X-RAY TUBES X-Ray Tubes (Continued) IMAGING FROM INSIDE THE BODY CONTRAST AGENTS Contrast Agents (Continued) MARKET OPPORTUNITIES FOR IMAGING AND NANOTOOLS AFM, STM and Accessories X-ray Cathodes Contrast Agents

5 TABLE 18 GLOBAL PROJECTED REVENUES FROM IMAGING AND NANOTOOLS, THROUGH 2007 ($ MILLIONS) FIGURE 3 GLOBAL PROJECTED REVENUES FROM IMAGING AND NANOTOOLS, ($ MILLIONS) MOLECULAR MODELING MOLECULAR MODELING (CONTINUED) TABLE 19 PROPERTIES SUSCEPTIBLE TO MODELING MARKET OPPORTUNITY FOR MOLECULAR MODELING SOFTWARE TABLE 20 GLOBAL PROJECTED REVENUES FROM MOLECULAR MODELING, THROUGH 2007 ($ MILLIONS) FIGURE 4 GLOBAL PROJECTED REVENUES FROM MOLECULAR MODELING, ($ MILLIONS) BRAIN/MACHINE INTERFACE BRAIN/MACHINE INTERFACE (CONTINUED) BRAIN/MACHINE INTERFACE (CONTINUED) BRAIN/MACHINE INTERFACE (CONTINUED) BRAIN/MACHINE INTERFACE (CONTINUED) WIRELESS INTEGRATED MICROSYSTEMS (WIMS) IMPLANT SURFACE COMMERCIAL OPPORTUNITIES FOR BRAIN/MACHINE INTERFACE TABLE 21 GLOBAL REVENUES DERIVED FROM THE BRAIN MACHINE INTERFACE, THROUGH 2007 ($ MILLIONS) PRODUCTS NANOSCALE DEVICES AND TOOLS ARTIFICIAL ORGANS ARTIFICIAL RETINA OPTOBIONICS ASR MICROCHIP BIOTAGS Evident Technologies-Evidots (Nanocrystals) Nanoprobe Nanogold Labels Quantum Dot Corp. Streptavidin Conjugated Qdots DIAGNOSTICS AND ANALYTICS AMBRI SENSIDX SYSTEM BIACORE SYSTEMS (SURFACE PLASMON RESONANCE (SPR)) BIOFORCE NANOSCIENCES NANOPRO EVIDENT TECHNOLOGIES EVIARRAY (BIOTHREAT DETECTION SYSTEM) GENICON SCIENCE MICROARRAY TOOLKITS NANOSPHERE NANOPARTICLE PROBE ASSAYS PHARMASEQ TSUNAMI II FLOW READER AND ASSAY KITS ZEPTOSEN AG SENSICHIP PRODUCTS ZEPTOMARK HIGH PERFORMANCE PROTEIN MICROARRAYS

6 DIP-PEN NANOLITHOGRAPHY NANOINK S NSCRIPTOR DRUGS AND DRUG DELIVERY SYSTEMS ABI ACTICOAT (NUCRYST PHARMACEUTICALS) NANOGATE P80DOX-NP RENAZORB FLUIDICS FLUIDIGM TOPAZ PROTEIN CRYSTALIZATION SYSTEM NANOTOOLS RD -TECH NANOMANIPULATOR ASYLUM RESEARCH NANOFLOW FLUID CONTROLLER ASYLUM RESEARCH MOLECULAR FORCE PROBE THE BIORYX 200 SYSTEM HYSITRON TRIBOINDENTER Hysitron Triboindenter (Continued) JPK INSTRUMENTS NANOWIZARD ATOMIC FORCE MICROSCOPE MOLECULAR IMAGING PICO-SPM II SCANNING MICROSCOPE VEECO (DIGITAL IMAGING) BIOSCOPE ATOMIC FORCE MICROSCOPE VEECO DIMENSION 3100 SCANNING PROBE MICROSCOPE VEECO MULTIMODE PICOFORCE SYSTEM VEECO SCENTRIS CANTILEVER SENSOR RESEARCH TOOL ZYVEX S100 NANOMANIPULATOR MOLECULAR MODELING SOFTWARE ACCELRYS MATERIALS STUDIO TRIPOS MOLECULAR MODELING SOFTWARE Tripos Molecular Modeling Software (Continued) FUTURE PROSPECTS CONVERGING DISCIPLINES CONVERGING DISCIPLINES (CONTINUED) CONVERGING DISCIPLINES (CONTINUED) CONVERGING DISCIPLINES (CONTINUED) STATE OF THE INDUSTRY TABLE 22 SKILLS AND WORK STYLES OF ACADEMICS VS. INDUSTRY DIVISIONS OF LABOR IMAGING AND NANOTOOLS TABLE 23 COMPANIES INVOLVED IN IMAGING AND NANOTOOLS TABLE 23 (CONTINUED) DRUGS AND DRUG DELIVERY

7 TABLE 24 DRUGS OR DRUG DELIVERY TABLE 24 (CONTINUED) DIAGNOSTICS AND ANALYTICS TABLE 25 COMPANIES THAT MAKE MOLECULAR DIAGNOSTICS OR ANALYTICS TABLE 25 (CONTINUED) MOLECULAR MODELING TABLE 26 COMPANIES SELLING SOFTWARE FOR MODELING MOLECULES OR NANOSCALE MATERIALS GENERIC NANOMATERIALS FOR MEDICAL DEVICES TABLE 27 COMPANIES THAT MAKE NANOMATERIALS FOR MEDICAL DEVICES GENERAL NANOBIOTECHNOLOGY TABLE 28 GENERAL NANOBIOTECHNOLOGY (UNCLASSIFIABLE) COMPANIES TABLE 29 DISTRIBUTION OF PUBLIC VS PRIVATE NANOBIOTECH COMPANIES FIGURE 5 DISTRIBUTION NANOBIOTECH COMPANIES BY TECHNOLOGY CATEGORY (%) MARKET LEADERS TABLE 30 REVENUES AND MARKET SHARE OF LEADING BIOMEDICAL NANOSCALE DEVICE COMPANIES, THROUGH COMPANY PROFILES RD TECH, INC OFFICERS: CORP OFFICERS: ACCELRYS INC OFFICERS: ADVECTUS INTERNATIONAL, LLC OFFICERS: AGAVE BIOSYSTEMS OFFICERS: AKUBIO OFFICERS: ALLEGRO TECHNOLOGIES, LTD OFFICERS: ALTAIR NANOTECHNOLOGIES OFFICERS: AMBRI, LTD OFFICERS AMERICAN PHARMACEUTICAL PARTNERS OFFICERS ANOSYS, INC OFFICERS: ARDESTA OFFICERS: APEX NANOTECHNOLOGIES OFFICERS:

8 APPLIED NANOTECH, INC OFFICERS: (S.I. DIAMOND) APPLIED NANOTECHNOLOGIES, INC OFFICERS: ARGONIDE NANOMATERIALS CORP OFFICERS: ARRYX OFFICERS: ASYLUM RESEARCH, INC OFFICERS: BAXTER HEALTHCARE OFFICERS: BIACORE OFFICERS: BIODELIVERY SCIENCES INTERNATIONAL OFFICERS: BIOELECTROSPEC OFFICERS: BIOFORCE NANOSCIENCES OFFICERS: BIOPHAN TECHNOLOGIES, INC OFFICERS: BIOSANTE PHARMACEUTICALS OFFICERS: BIOTROVE, INC OFFICERS: CALIBRANT BIOSYSTEMS OFFICERS: CANTION A/S OFFICERS: CAPSULUTION NANOSCIENCE AG OFFICERS: CHIPRX, INC OFFICERS: C SIXTY, INC OFFICERS: DENDRITIC NANOTECHNOLOGIES OFFICERS: EAGLE RESEARCH AND DEVELOPMENT OFFICERS: EIFFEL TECHNOLOGIES LMT OFFICERS: ELAN OFFICERS:

9 ENGENEOS OFFICERS: E-SPIN OFFICERS: EVIDENT TECHNOLOGIES OFFICERS: FLUIDIGM OFFICERS: GENEFLUIDICS OFFICERS: GENERAL NANOTECHNOLOGY, INC OFFICERS: GENICON SCIENCES OFFICERS: GENEOHM SCIENCES, INC OFFICERS: HANDYLAB OFFICERS: HEMOTEQ NANOCOATING DESIGN OFFICERS: HYBRID PLASTICS OFFICERS: HYSITRON OFFICERS: IATROQUEST OFFICERS: IMEDD INC OFFICERS: INTEL OFFICERS: INTERNATIONAL BUSINESS MACHINES (IBM) OFFICERS: INSERT THERAPEUTICS, INC OFFICERS: INTEGRATED NANOSYSTEMS, INC OFFICERS: ISSYS (INTEGRATED SENSING SYSTEMS) OFFICERS: JPK INSTRUMENTS AG OFFICERS: KEREOS OFFICERS: KLEINDIEK NANOTECHNIK OFFICERS:

10 KLOCKE NANOTECHNIK OFFICERS: LIFESENSORS, INC OFFICERS: LIPLASOME PHARMA A/S OFFICERS: LUNA NANOMATERIALS MAXWELL SENSORS OFFICERS: MEDITECH FEFER, INC OFFICERS: MEMGEN, INC OFFICERS: MICROCHIPS, INC OFFICERS: MICROMOD PARTIKELTECHNOLOGIE GMBH MOLECULAR IMAGING CORP MOLECULAR NANOSYSTEMS OFFICERS: NANOBACLABS, INC OFFICERS: NANOBIO CORP OFFICERS: NANOBIODYNAMICS OFFICERS: NANOBIOMAGNETICS, INC OFFICERS: NANOCARRIER OFFICERS: NANOFRAMES OFFICERS: NANOGEN OFFICERS: NANOINK, INC OFFICERS NANOLYTICS OFFICERS: NANOMED PHARMACEUTICALS OFFICERS: NANOMEDX GMBH OFFICERS: NANOPHARM AG OFFICERS: NANOPLEX TECHNOLOGIES, INC

11 OFFICERS: NANOPROBES, INC OFFICERS: NANOSENSORS GMBH OFFICERS: NANOSPECTRA BIOSCIENCES OFFICERS: NANOSPHERE, INC OFFICERS: NANOSYS INC OFFICERS: NANOTYPE GMBH OFFICERS: NASCACELL GMBH OFFICERS: NOMADICS LIFE SCIENCES OFFICERS: (NOMADICS, INC.) NOVAVAX, INC OFFICERS: NTERA LTD OFFICERS: NUCRYST PHARMACEUTICALS OFFICERS: OPTOBIONICS CORP OFFICERS: OXFORD BIOSENSORS LTD OFFICERS: PHARMASEQ OFFICERS: PICOLITER OFFICERS: PLATYPUS TECHNOLOGIES OFFICERS: PROTIVERIS TECHNOLOGIES OFFICERS: PSIVIDA OFFICERS: QUANTUM DOT OFFICERS: QUANTUM LOGIC OFFICERS: QUANTUM PRECISION INSTRUMENTS PTY. LTD OFFICERS: SKYE PHARMACEUTICALS, INC

12 OFFICERS: SOLEXA LTD OFFICERS: SPHERICS OFFICERS: STARPHARMA GROUP OFFICERS: SUNYX SURFACE TECHNOLOGIES GMBH OFFICERS: SURROMED OFFICERS: TARGESOME OFFICERS: TDA RESEARCH OFFICERS: THALES NANOTECHNOLOGY OFFICERS: TRITON BIOSYSTEMS OFFICERS: U.S. GENOMICS OFFICERS: VEECO INSTRUMENTS INC OFFICERS: VIALOGY CORP OFFICERS: XETAL BIOTECHNIKS, LTD OFFICERS: ZEPTOSENS AG OFFICERS: ZYVEX OFFICERS: APPENDIX ACRONYMS