Guo-Bo Chen, Ph.D. CURRICULUM VITAE

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1 Guo-Bo Chen, Ph.D. CURRICULUM VITAE Queensland Brain Institute, University of Queensland Tel: guobo.chen@uq.edu.au Address: QBI Building, University of Queensland, St Lucia, Queensland, 4072, Australia Updated on February 15, 2012 EDUCATION 10/2011 present, Postdoctoral Fellow, Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia. Mentors: Drs Naomi Wray, and Peter Visscher. 3/2010 8/2011, Postdoctoral Fellow, Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, US. Mentors: Drs Xiang- Yang Lou, and Nianjun Liu. 9/2009 2/2010, Postdoctoral Fellow, Zhejiang University, Hangzhou, China. Mentor: Dr Longjiang Fan. 9/2003 6/2009, Ph.D., Crop Sciences, Institute of Bioinformatics, Department of Agronomy, Zhejiang University, Hangzhou, China. Advisor: Dr Jun Zhu. 1/2007 8/2008, Visiting Graduate Student, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, US. Mentors: Drs Ming D. Li, and Xiang- Yang Lou. 9/1999 6/2003, B.S., Landscape Architecture, Department of Horticulture, Zhejiang University, Hangzhou, China. CONTINUED EDUCATION Genome- wide Association: Analyze This! The Genes, Environment, and Health Initiative, NIH, Bethesda, Maryland, US, August 4-5, Short Course on the Genetics and Epigenetics of Addiction, National Institute on Drug Abuse, Bethesda, Maryland, US, March 31 April 4, High Performance and Parallel Computing Bootcamp, The University of Virginia Alliance for Computational Science and Engineering, University of Virginia, Charlottesville, Virginia, US, January 7-11, AWARDS 2011, UAB Postdoctoral Research Day Presentation, 3rd Place. 2009, Travel Fellowship Award, 18th Annual International Genetic Epidemiology Society Conference, Kahuku, HI, US. GENETIC SOFTWARE DEVELOPED QGAStation, On the Analysis of Quantitative Traits with Mixed Linear Models Approaches Available: (C++) GMDR, Generalized Multifactor Dimensionality Reduction Available: Source code: (Java, facilitated with Perl scripts) 1

2 SVN Repository url: PedGMDR, Pedigree- based Multifactor Dimensionality Reduction Source code: (Java, facilitated with Perl scripts) SVN Repository url: PEER-REVIEWED PUBLICATIONS Chen, G. B., Z. X. Zhu, F. T. Zhang, X. Y. Lou, J. Zhu. (2012) Quantitative genetic analysis station: on the genetic analysis of complex traits. Chinese Science Bulletin (Accepted). Liu, H., Y. Lin, G. B. Chen, Y. Shen, J. Liu, and S. Zhang. (2012) Genome- scale identification of resistance gene analogs and the development of their intron length polymorphism markers in maize. Molecular Breeding, 29: Klimentidis, Y. C., G. B. Chen, M. López- Alarcón, J. J. Harris, C. W. Duarte, J. R. Fernández. (2011) Associations of obesity genes with obesity- related outcomes in multiethnic children. Archives of Medical Research, 42: PMID: Chen, G. B., J. Zhu, and X. Y. Lou. (2011) A faster pedigree- based generalized multifactor dimensionality reduction method for detecting gene- gene interaction. Statistics and Its Interface, 4: PMID: Chen, G. B., K. H. Ingram, G. de los Campos, N. Yi, X. Y. Lou, D. Pomp, D. B. Allison. (2011) A two- step modeling strategy for testing and estimating genetic susceptibility to the ill- effects of adiposity: Illustration in an outbred F2 mice population. International Journal of Obesity Supplements, S2:21. Chen, G. B., Y. Xu, H. M. Xu, M. D. Li, J. Zhu, and X. Y. Lou. (2011) Practical and theoretical considerations in study design for detecting gene- gene interactions using MDR and GMDR approaches. PLoS ONE, 6:e PMID: Li, M. D., J. E. Mangold, C. Seneviratne, G. B. Chen, J. Z. Ma et al. (2009) Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African- American populations. PLoS ONE, 4:e7055. PMID: Seneviratne, C., N. Ait- Daoud, J. Ma, G. B. Chen, B. Johnson et al. (2009) Susceptibility locus in neurokinin- 1 receptor gene associated with alcohol dependence. Neuropsychopharmacology, 34: PMID: Lou, X. Y., G. B. Chen, L. Yan, J. Z. Ma, J. E. Mangold et al. (2008) A combinatorial approach to detecting gene- gene and gene- environment interactions in family studies. American Journal Human Genetics, 83: PMID: Chen, G. B., T. J. Payne, X. Y. Lou, J. Z. Ma, J. Zhu et al. (2008) Association of amyloid precursor protein- binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Human Genetics, 124: PMID: Mangold, J. E., T. J. Payne, J. Z. Ma, G. B. Chen and M. D. Li. (2008) Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. Journal of Medical Genetics, 45: PMID: Li, M. D., X. Y. Lou, G. B. Chen, J. Z. Ma and R. C. Elston. (2008) Gene- gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biological Psychiatry, 64: PMID: Wu, J.S., H. K. Zhou, G. B. Chen, and G. F. Liu. (2008) Mapping and Detection of QTLs for Grain Weight and per 1000 Grain Weight in Rice. Chinese Journal Rice Science, 22: Lou, X. Y., G. B. Chen, L. Yan, J. Z. Ma, J. Zhu et al. (2007) A generalized combinatorial approach for detecting gene- by- gene and gene- by- environment interactions with application to nicotine dependence. American Journal Human 2

3 Genetics, 80: PMID: Huang, W. S., Y. Zheng, G. B. Chen, and W. R. Wu. (2006) Studies of methods and exploitation of computer software for mapping interactive genes. Hereditas (Beijing), 28: PMID: MANUSCRIPTS IN PREPARATION A unified generalized multifactor dimensionality reduction approach for detecting gene- gene interactions for family and unrelated samples correcting population stratification. Chen, G. B., Xiaofeng Zhu (Case Western Reserve University), Degui Zhi, Nianjun Liu, and Xiang- Yang Lou. Gene- Gene interaction analysis accounting for family structure using ASSOC in S.A.G.E. Junghyun Namkung, G. B. Chen, Daniel Baechle, Kevin Cartier, and Robert C Elston (Case Western Reserve University). A hidden Markov model for haplotype inference for present absent genotype data using previously identified haplotype and haplotype patterns. Jihua Wu, G. B. Chen, Degui Zhi, Nianjun Liu, and Kui Zhang. ORAL PRESENTATIONS Generalized multifactor dimensionality reduction method for detecting gene- gene interactions. The 4th Animal and Plant Quantitative Genetics Conference of China, Chengdu, Sichuan, China, August 25-28, A two- step modeling strategy for testing and estimating genetic susceptibility to the ill- effects of adiposity: Illustration in an outbred F2 mice population. The 2011 Joint Statistical Meetings, Miami, Florida, US, July 30- August 4, 2011; The 9th International Symposium on In Vivo Body Composition Studies, Hangzhou, China, May 21-24, 2011; UAB Postdoctoral Research Day, Birmingham, Alabama, February 21, The story of statistical genetics. Presented at Zhejiang University, Hangzhou, Zhejiang, China, May 26, POSTERS & ABSTRACTS Chen, G. B., J. Zhu, and X. Y. Lou, A faster pedigree- based generalized multifactor dimensionality reduction method for detecting gene- gene interactions. UAB School of Public Health 3nd Annual Research Day, Birmingham, Alabama, US, April 5, Wu, J., G. B. Chen, D. Zhi, N. Liu, and K. Zhang, A Hidden Markov Model for haplotype inference for present- absent genotype data using previously identified haplotype and haplotype Patterns. The Eastern North American Region of the International Biometric Society 2011 Spring Meeting, Miami, Florida, US, March 20-23, Chen, G. B., J. Zhu, and X. Y. Lou, A faster pedigree- based generalized multifactor dimensionality reduction method for detecting gene- gene interactions. The 60th Annual Meeting of the American Society of Human Genetics, Washington DC, US, November 2-6, Namkung, J., G. B. Chen, D. Beachle, K. Cartier, and R. C. Elston, Gene- Gene interaction analysis accounting for family structure using ASSOC in S.A.G.E. The 19th Annual Meeting of the International Genetic Epidemiology Society, Boston, Massachusetts, US, October 10-12, Chen, G. B., and X. Y. Lou, MDR and its extensions for identification of interactions, Section on Statistical Genetics Retreat 2010, Birmingham, Alabama, US, August 9-10, Chen, G. B., and X. Y. Lou, A faster pedigree- based generalized multifactor dimensionality reduction method for 3

4 detecting gene- gene interactions. UAB School of Public Health 2nd Annual Research Day, Birmingham, Alabama, US, April 5, Chen, G. B., X. Y. Lou, H. M. Xu, Y. Xu, J. Zhu, and M. D. Li, Power and design considerations for detecting gene- gene interactions: Analytical and simulation comparison of GMDR and MDR. The 18th Annual International Genetic Epidemiology Society, Kahuku Hawaii, US, October 18-20, Lou, X. Y., G. B. Chen, L. Yan, J. E. Mangold, J. Z. Ma, J. Zhu, R. C. Elston, and M. D. Li, A generalized combinatorial approach for detecting gene by gene and gene by environment interactions. The 17th Annual Meeting of the International Genetic Epidemiology Society, St. Louis, Missouri, US, September 14-16, Lou, X. Y., G. B. Chen, L. Yan, J. E. Ma, J. Zhu, R. C. Elston, and M. D. Li, GMDR: A novel strategy for detecting multifactor interactions. The 3rd International Conference of Quantitative Genetics, Hangzhou, China, August 19-24, Li, M. D., X. Y. Lou, G. B. Chen, J. Z. Ma, and R. C. Elston, Interactive contributions of CHRNA4, CHRNB2, BDNF and NTRK2 to nicotine dependence. The 57th Annual Meeting of the American Society of Human Genetics, San Diego, California, US, October 23-27, Chen, G. B., X. Y. Lou, L. Yan, J. Zhu, and M. D. Li, GMDR: A package for detecting gene- by- gene and gene- by- environment interactions underlying complex traits. The 57th Annual Meeting of the American Society of Human Genetics, San Diego, California, US, October 23-27, Lou, X. Y., G. B. Chen, L. Yan, J. Z. Ma, J. Zhu, R. C. Elston, and M. D. Li, A generalized combinatorial approach for detecting gene by gene and gene by environment interactions. The 57th Annual Meeting of the American Society of Human Genetics, San Diego, California, US, October 23-27, TEACHING EXPERIENCE University of Alabama at Birmingham, Birmingham, Alabama, US B775: Statistical Methods in Genetic Analysis (Dr Kui Zhang), guest lectured section on Transmission Disequilibrium Test & Its Extension, Department of Biostatistics, Fall Semester, Zhejiang University, Hangzhou, China Biostatistics, led biweekly computer lab, College of Agriculture and Biotechnology, Fall Semester, Linear Model and Statistical Analysis, guest lectured on Fundamentals for Statistics, Department of Horticulture, Fall Semester, Short Courses Short Course on the Genetics and Epigenetics of Addiction, teaching assistant on the section for linkage analysis of nicotine addiction lectured by Dr. Ming D Li, National Institute on Drug Abuse, Bethesda, Maryland, US, March 31- April 4, The 5th Workshop on the Analysis of Quantitative Traits and QTLs, led computer lab, Institute of Bioinformatics, Hangzhou, China, December 10-15, Mentoring Mentored Yi Xu, whose undergraduate thesis was awarded outstanding graduate thesis of 2009 at the Department of Mathematics, Zhejiang University, and was merged to the paper published in PLoS ONE 6:e PEER REVIEWER FOR BMC Bioinformatics (2009), Chinese Rice Science (2006), Computational Statistics and Data Analysis (2011), Frontiers 4

5 in Evolutionary and Population Genetics (Review Editor for, ), Frontiers in Plant Genetics and Genomics (2011), Obesity (2010), Open Biology (2011), PLoS ONE ( ), International Journal of Obesity (2010). PROFESSIONAL ACTIVITIES Visiting Scholar, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, US, invited by Dr Robert C Elston, June 7-9, Microsoft Research Asia ehealth Workshop, Beijing, China, February 4-5, Organizing Committee, Joint Conference of the Society for Mathematical Biology and the Chinese Society for Mathematical Biology, Hangzhou, China, June 14-17, Organizing Committee, The China- UK Systems Biology Workshop, Hangzhou, China, June 20-21, Organizing Committee, 5th Workshop on the Analysis of Quantitative Traits and QTLs, Hangzhou, China, December 10-15, DEPARTMENTAL SERVICE China Connection Committee, Department of Biostatistics, University of Alabama at Birmingham,

6 REFERENCES David B. Allison, Ph.D., Distinguished Professor Department of Biostatistics & Nutrition Obesity Research Center, University of Alabama at Birmingham Ryals Building, Suite 327, 1665 University Boulevard, Birmingham, AL Phone: Fax: Robert C. Elston, Ph.D., Distinguished University Professor Department of Epidemiology & Biostatistics, Case Western Reserve University Wolstein Research Building, Room 1304, Euclid AVE, Cleveland, OH Phone: Nianjun Liu, Ph.D., Associate Professor Department of Biostatistics, University of Alabama at Birmingham Ryals Building, Suite 327, RD AVE S, Birmingham, AL, Phone: Xiang- Yang Lou, Ph.D., Associate Professor Department of Biostatistics, University of Alabama at Birmingham Ryals Building, Suite 327, RD AVE S, Birmingham, AL, Phone: Jun Zhu, Ph.D., Professor Institute of Bioinformatics, Zhejiang University Building A of Agricultural- Biological Sciences, Room 468, Zijingang Campus, Zhejiang University, 866 Yuhangtang Rd Hangzhou, Zhejiang Province, Phone: jzhu@zju.edu.cn 6