Building the interface between the universe and data

Transcription

1 Building the interface between the universe and data Benjamin L. Miller University of Rochester

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3 Sensors: the ultimate A/D interface SENSOR

4 The Prototype Large and heavy A CRT as the output? Why do you need one device for sensing, and another for communication? The tricorder wasn t imaginative enough and in many ways we re moving well beyond it

5 Anthrax?

6 Anthrax?

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8 (Photonics Spectra 2017 Reader Poll)

9 (Photonics Spectra 2017 Reader Poll)

10 The promise of Label-Free, Multiplex Detection A capture molecule (or responsive chemical coating) on one sensor element is not affected by other sensor elements For the first time, this allows for detection of many targets as simply as one, given an ability to put many elements on chip (easy), an ability to address them all independently (easy), and an ability to make them different chemically (harder, depending on scale)

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12 Applications of AIR: A QR Code for influenza

13 Can we develop mix and match components to address all markets? (Siemens) Home Benchtop/ Point-of-care/ Point-of-need High-volume Clinical lab Previous methods have involved tradeoffs leading to different systems depending on user environment and requirements. Integrated photonics may provide a universal solution.

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15 Photonic Design Kit (PDK) Chip Design Multi-Project Wafer (MPW) Test, Assembly, and Packaging (TAP)

16 Sensor project consortium Ben Miller (Lead; University of Rochester). Co-Personnel: Todd Stievater (NRL), Carl Meinhart (UCSB), Nate Cady (SUNY-Poly), Ray Jakubowicz (Ortho-Clinical Diagnostics), Skip Warren (Ortho-Clinical Diagnostics), Will Green (IBM), Eric Zhang (IBM), Chi Zhong (IBM), Ehsan Hosseini (Analog Photonics), Scott Holmstrom (University of Tulsa), Twan Korthorst (PhoeniX), Jason Guicheteau (Army/ECBC), Rick Stevens (Lockheed-Martin Co.), Mark Peterman (OndaVia) Intentionally draws from academia, DoD, large and small industry Also mixes expertise in different technology platforms and market spaces

17 AIM Sensors development strategy Design components, test optical performance, and expand AIM PDK Bio sensing Chem sensing Chem/Bio sensing Test component sensing performance for key applications Several components designed and tested at non-traditional wavelengths (750 nm, 850 nm, 1064 nm, 1280 nm, ) Includes AWGs, filters, edge couplers. Integrate into systems

18 Photonic sensors are just like paper towel tubes.

19 A possible solution Interface Interface Waveguide Light Source Transducer/ Modulator Detector/ Spectrometer

20 Example: properties of a ring resonator Off-resonance On-resonance Waveguide Light Source Transducer/ Modulator Detector/ Spectrometer

21 How do these things work for biosensing? λ=2πn eff /m n eff, 1 λ=λ res,a λ=λ res,b Expose to analyte I n eff, 2 λ On-resonance

22 Human serum: needles in (wet) haystacks Wikipedia: serum reference ranges IL6 reference: 4.8 pg/ml 10 8 difference Total protein: mg/ml

23 Representative biological targets Human C-reactive protein (PDB 1 GNH) Molecular weight: 25,106 (x 5) Reference range: ng/ml elevated in infection or inflammation to as much as 500 ng/ml Human Interleukin-6 (PDB 1 ALU) Molecular weight: 21,000 Reference range: 4.8 pg/ml Elevated in infection or inflammation to as much as 250 pg/ml

24 Successful CRP Detection: paving the way for a photonics - enabled test for heart attack

25 Quantitative detection of IL-6 and CRP in human serum Single ring Endpoint detection (incubate, rinse, dry, measure) All values are relative to an anti-fitc ring to normalize for nonspecific binding of serum (rather than using a cladded reference) LOD

26 Chemical sensing: Waveguide-Enhanced Raman Spectroscopy (WERS) Pump Stokes Signal Pump 1 cm path length, vs. 5.6 cm

27 Preliminary results for WERS-based sensing of CWA simulants Differential Raman Signal (counts) Wavelength (nm) a) b) c) AIM LLOD: 300 ppb 330 ppb DEMP 660 ppb DEMP 980 ppb DEMP 1300 ppb DEMP Differential Raman Signal (counts) AIM LLOD: 150 ppb 170 ppb DMMP 330 ppb DMMP 500 ppb DMMP 660 ppb DMMP Differential Raman signal (counts) AIM LLOD: 100 ppb 120 ppb DMSO 250 ppb DMSO 370 ppb DMSO 490 ppb DMSO Stokes Shift (cm-1) Stokes Shift (cm-1) Stokes Shift (cm-1)

28 Photonic sensors: addressing applications from high volume / low cost to low volume / high value (Siemens) Decreasing Volume / Increasing price point (wikipedia) (Genalyte) (